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M

Michael R. Duchen

University of London
H指数:103
被引数:4.0万

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Pathogenic variants in the autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation

EPG5自噬连接因子中的致病性变异通过线粒体功能障碍和固有免疫激活驱动神经退行性变

Nature Communications
IF15.7
2026-05-011
PRE
Singh, Kritarth; Dafsari, Hormos Salimi; Gillham, Olivia; Chi, Haoyu; Mandzhukova, Ivet; Kourouzidou, Ioanna; Sheshadri, Preethi; Chung, Chih-Yao; Pingitore, Valeria; Vansenne, Fleur; Selwood, David L.; Pendin, Diana; Szabadkai, Gyorgy; Fanto, Manolis; Jungbluth, Heinz; Duchen, Michael R.
An iPSC-derived neuronal model reveals manganese’s role in neuronal endocytosis, calcium flux and mitochondrial bioenergetics

iPSC来源的神经元模型揭示了锰在神经元内吞作用、钙离子流和线粒体生物能量学中的作用

iScience
IF4.1
2025-08-060
OAAI
Dimitri Budinger; Sharmin Alhaque; Ramón González-Méndez; Chris Dadswell; Katy Barwick; Arianna Ferrini; Charlotte Roth; Conor J. McCann; Karin Tuschl; Fatma Al Jasmi; Maha S. Zaki; Julien H. Park; Russell C. Dale; Shekeeb Mohammad; John Christodoulou; Dale Moulding; Michael R. Duchen; Serena Barral; Manju A. Kurian
Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function

抑制PI3K-AKT-MTORC1轴通过促进线粒体吞噬和改善线粒体功能来减轻m.3243A>G mtDNA突变的负担

AUTOPHAGY
IF14.3
2024-12-120
OAAI
Chung, Chih-Yao; Singh, Kritarth; Sheshadri, Preethi; Valdebenito, Gabriel E.; Chacko, Anitta R.; Besada, Maria Alicia Costa; Liang, Xiao Fei; Kabir, Lida; Pitceathly, Robert D. S.; Szabadkai, Gyorgy; Duchen, Michael R.
Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency
JOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
2024-11-190
OAAI
Blanco, Elena; Camps, Carme; Bahal, Sameer; Kerai, Mohit D.; Ferla, Matteo P.; Rochussen, Adam M.; Handel, Adam E.; Golwala, Zainab M.; Spiridou Goncalves, Helena; Kricke, Susanne; Klein, Fabian; Zhang, Fang; Zinghirino, Federica; Evans, Grace; Keane, Thomas M.; Lizot, Sabrina; Kusters, Maaike A. A.; Iro, Mildred A.; Patel, Sanjay V.; Morris, Emma C.; Burns, Siobhan O.; Radcliffe, Ruth; Vasudevan, Pradeep; Price, Arthur; Gillham, Olivia; Valdebenito, Gabriel E.; Stewart, Grant S.; Worth, Austen; Adams, Stuart P.; Duchen, Michael; Andre, Isabelle; Adams, David J.; Santili, Giorgia; Gilmour, Kimberly C.; Hollaender, Georg A.; Davies, E. Graham; Taylor, Jenny C.; Griffiths, Gillian M.; Thrasher, Adrian J.; Dhalla, Fatima; Kreins, Alexandra Y.

研究方向

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G
György Szabadkai
H 指数:53论文数:207被引数:2.6万
A
Andrey Y. Abramov
H 指数:86论文数:309被引数:2.5万
M
Michelangelo Campanella
H 指数:47论文数:159被引数:2.7万
T
Thomas S. Blacker
H 指数:15论文数:38被引数:3,310
S
Sean M. Davidson
H 指数:83论文数:405被引数:2.3万
M
Mervyn Singer
H 指数:106论文数:919被引数:8.8万
V
Vassilios N. Kotiadis
H 指数:14论文数:16被引数:1,164
L
Laura D. Osellame
H 指数:20论文数:54被引数:1.1万
K
Kritarth Singh
H 指数:21论文数:50被引数:1,365
A
Anthony H.V. Schapira
H 指数:127论文数:902被引数:7.2万