Michael R. Duchen - Publications, H-index & Citations

Michael R. Duchen

university college london

103H指数

409论文数

4.1W被引数

收录论文 129

发表时间

Experimental sepsis causes SERCA2 expression in white adipose tissue but not classical browning 实验性脓毒症导致白色脂肪组织中SERCA2表达，但不会引起经典生褐

Scientific Reports

IF3.9

2026-07-03

OAAI

Robert Tidswell; Ali Alqallaf; Joseph Harris; Jonathan Falconer; Pelin A. Golforoush; Nishkantha Arulkumaran; Anna Kleyman; David Brealey; Matthew S. Rodeheffer; Ketan Patel; Michael R. Duchen; Mervyn Singer

Chromatin- and actin-mediated mitochondrial streaming leads to patterning of mitochondrial distribution in oocytes 染色质和肌动蛋白介导的线粒体流动导致卵母细胞中线粒体分布的模式化

Nature Communications

IF15.7

2026-05-18

OAAI

In-Won Lee; Morteza Nazari; Jazmine Yuson; Sanjeev Uthishtran; Ross Stocker; Deepak Adhikari; Zhong-Wei Wang; Gyorgy Szabadkai; Michael R. Duchen; Senthil Arumugam; Reza Nosrati; John Carroll

A transcription termination mechanism for maintaining homogeneous protein expression 一种维持均一蛋白质表达的转录终止机制

NUCLEIC ACIDS RESEARCH

IF13.1

2025-11-26

OAAI

Esteban-Serna, Sofia; Widen, Tove; Gwynne, Mags; Farquhar, Iseabail; Duchen, Michael R.; Swain, Peter S.; Granneman, Sander

Letter Concerning Biallelic Variants in EPG5 Gene Are Associated with Parkinson's Disease 关于EPG5基因中的双等位基因变异与帕金森病相关性的信件

Annals of Neurology

IF7.7

2025-10-29

PREAI

Hormos Salimi Dafsari MD; Celine Deneubourg PhD; Kritarth Singh PhD; Reza Maroofian PhD; Michael R. Duchen PhD; Adam Antebi PhD; Henry Houlden MD, PhD; Manolis Fanto PhD; Heinz Jungbluth MD, PhD

An iPSC-derived neuronal model reveals manganese’s role in neuronal endocytosis, calcium flux and mitochondrial bioenergetics iPSC来源的神经元模型揭示了锰在神经元内吞作用、钙离子流和线粒体生物能量学中的作用

iScience

IF4.1

2025-08-06

OAAI

Dimitri Budinger; Sharmin Alhaque; Ramón González-Méndez; Chris Dadswell; Katy Barwick; Arianna Ferrini; Charlotte Roth; Conor J. McCann; Karin Tuschl; Fatma Al Jasmi; Maha S. Zaki; Julien H. Park; Russell C. Dale; Shekeeb Mohammad; John Christodoulou; Dale Moulding; Michael R. Duchen; Serena Barral; Manju A. Kurian

Redox-dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells 氧化还原依赖性结合和构象平衡调控活细胞中NAD(P)H的荧光衰减

FEBS Letters

IF3

2025-07-25

OAAI

Thomas S. Blacker; Nimit Mistry; Nicoletta Plotegher; Elizabeth R. Westbrook; Michael D. E. Sewell; John Carroll; Gyorgy Szabadkai; Angus J. Bain; Michael R. Duchen

Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2025-02-13

OAAI

Whitehead, Michael; Harvey, Joshua P.; Sladen, Paul E.; Becchi, Giada; Singh, Kritarth; Sun, Yujiao Jennifer; Burgoyne, Thomas; Duchen, Michael R.; Yu-Wai-Man, Patrick; Cheetham, Michael E.

Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function 抑制PI3K-AKT-MTORC1轴通过促进线粒体吞噬和改善线粒体功能来减轻m.3243A>G mtDNA突变的负担

AUTOPHAGY

IF14.3

2024-12-12

OAAI

Chung, Chih-Yao; Singh, Kritarth; Sheshadri, Preethi; Valdebenito, Gabriel E.; Chacko, Anitta R.; Besada, Maria Alicia Costa; Liang, Xiao Fei; Kabir, Lida; Pitceathly, Robert D. S.; Szabadkai, Gyorgy; Duchen, Michael R.

Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2024-11-19

OAAI

Blanco, Elena; Camps, Carme; Bahal, Sameer; Kerai, Mohit D.; Ferla, Matteo P.; Rochussen, Adam M.; Handel, Adam E.; Golwala, Zainab M.; Spiridou Goncalves, Helena; Kricke, Susanne; Klein, Fabian; Zhang, Fang; Zinghirino, Federica; Evans, Grace; Keane, Thomas M.; Lizot, Sabrina; Kusters, Maaike A. A.; Iro, Mildred A.; Patel, Sanjay V.; Morris, Emma C.; Burns, Siobhan O.; Radcliffe, Ruth; Vasudevan, Pradeep; Price, Arthur; Gillham, Olivia; Valdebenito, Gabriel E.; Stewart, Grant S.; Worth, Austen; Adams, Stuart P.; Duchen, Michael; Andre, Isabelle; Adams, David J.; Santili, Giorgia; Gilmour, Kimberly C.; Hollaender, Georg A.; Davies, E. Graham; Taylor, Jenny C.; Griffiths, Gillian M.; Thrasher, Adrian J.; Dhalla, Fatima; Kreins, Alexandra Y.

Delocalized quinolinium-macrocyclic peptides, an atypical chemotype for CNS penetration

SCIENCE ADVANCES

IF12.5

2024-07-12

OAAI

Pingitore, Valeria; Pancholi, Jessica; Hornsby, Thomas W.; Warne, Justin; Pryce, Gareth; Mccormick, Laura J.; Hill, Julia; Bhosale, Gauri; Peng, Jing; Newton, Lydia S.; Towers, Greg J.; Coles, Simon J.; Chan, Ah Wing Edith; Duchen, Michael R.; Szabadkai, Gyorgy; Baker, David; Selwood, David L.

Nrf2 regulates glucose uptake and metabolism in neurons and astrocytes Nrf2调节神经元和星形胶质细胞的葡萄糖摄取和代谢

REDOX BIOLOGY

IF11.9

2023-06-01

OAAI

Esteras, Noemi; Blacker, Thomas S.; Zherebtsov, Evgeny A.; Stelmashuk, Olga A.; Zhang, Ying; Wigley, W. Christian; Duchen, Michael R.; Dinkova-Kostova, Albena T.; Abramov, Andrey Y.

PolyQ length-dependent metabolic alterations and DNA damage drive human astrocyte dysfunction in Huntington's disease

PROGRESS IN NEUROBIOLOGY

IF6.1

2023-06-01

OAAI

Lange, Jenny; Gillham, Olivia; Flower, Michael; Ging, Heather; Eaton, Simon; Kapadia, Sneha; Neueder, Andreas; Duchen, Michael R.; Ferretti, Patrizia; Tabrizi, Sarah J.

The mitochondrial ATP synthase as an ATP consumer-a surprising therapeutic target

EMBO JOURNAL

IF8.3

2023-04-06

OAAI

Valdebenito, Gabriel E.; Chacko, Anitta R.; Duchen, Michael R.

NAD(P)H binding configurations revealed by time-resolved fluorescence and two-photon absorption

BIOPHYSICAL JOURNAL

IF3.1

2023-04-01

OAAI

Blacker, Thomas S.; Duchen, Michael R.; Bain, Angus J.

Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB

CELLULAR AND MOLECULAR LIFE SCIENCES

IF6.2

2022-07-21

OAAI

D'Acunto, E.; Gianfrancesco, L.; Serangeli, I; D'Orsi, M.; Sabato, V; Guadagno, N. A.; Bhosale, G.; Caristi, S.; Failla, A., V; De Jaco, A.; Cacci, E.; Duchen, M. R.; Lupo, G.; Galliciotti, G.; Miranda, E.

Rewiring cell signalling pathways in pathogenic mtDNA mutations

TRENDS IN CELL BIOLOGY

IF18.1

2022-05-01

OAAI

Chung, Chih-Yao; Valdebenito, Gabriel E.; Chacko, Anitta R.; Duchen, Michael R.

The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases

BIOLOGICAL REVIEWS

IF11.7

2022-04-26

OAAI

Almeida, Liliana M.; Pinho, Brigida R.; Duchen, Michael R.; Oliveira, Jorge M. A.

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

ELIFE

IF0

2022-02-21

PREAI

De la Rossa, Andres; Laporte, Marine H.; Astori, Simone; Marissal, Thomas; Montessuit, Sylvie; Sheshadri, Preethi; Ramos-Fernandez, Eva; Mendez, Pablo; Khani, Abbas; Quairiaux, Charles; Taylor, Eric B.; Rutter, Jared; Nunes, Jose Manuel; Carleton, Alan; Duchen, Michael R.; Sandi, Carmen; Martinou, Jean-Claude

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation PI3K-Akt-mTORC1途径的组成型激活维持m.3243 A > G mtDNA突变

NATURE COMMUNICATIONS

IF15.7

2021-11-04

OAAI

Chung, Chih-Yao; Singh, Kritarth; Kotiadis, Vassilios N.; Valdebenito, Gabriel E.; Ahn, Jee Hwan; Topley, Emilie; Tan, Joycelyn; Andrews, William D.; Bilanges, Benoit; Pitceathly, Robert D. S.; Szabadkai, Gyorgy; Yuneva, Mariia; Duchen, Michael R.

Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation

LIFE SCIENCES

IF5.1

2021-11-01

OAAI

Pinho, Brigida R.; Almeida, Liliana M.; Duchen, Michael R.; Oliveira, Jorge M. A.

研究方向