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T

Thierry T. Diagana

Novartis
H指数:42
被引数:6,858

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Development of a Phase 1 Cryptosporidiosis Controlled Human Challenge Model in Healthy Volunteers Using Current Good Manufacturing Practice Cryptosporidium Parvum Oocysts and Conducted Under an Investigational New Drug Application

利用当前良好生产规范生产的微小隐孢子虫卵囊，在健康志愿者中开发一种1期隐孢子虫病受控人体挑战模型，并在新药研究申请下进行

The Journal of Infectious Diseases
IF0
2026-05-270
OA
Bridget D Stuart; Kristen Stevenson; Hanns-Christian Tillmann; Claire Middleton; Amanda Nguyen; Rajiv S Jumani; Xiaojun Zhao; Johanne Blais; Sofia Braud-Perez; Yiming Zhang; Joseph Etse; Kriti Arora; Natasha Aziz; Al-Ibrahim Mohamed; Thierry T Diagana; Ujjini H Manjunatha; null
Development of a Current Good Manufacturing Practice-Compliant Process for Producing Cryptosporidium parvum Oocysts for Clinical Use

开发一种符合现行药品生产质量管理规范的临床用微小隐孢子虫卵囊生产过程

Journal of Infectious Diseases
IF4.5
2026-03-010
PRE
Jumani, Rajiv S.; Thomas, Bryanna; Lakshman, Jay; Ostermeier, Christian; Nuber, Natko; Blusch, Juergen Hubert; Braud-Perez, Sofia; Wetty, Dean; Nouaime, Lizhuo; Dederichs, Juergen; Etse, Joseph; Grubesic, Slobodan; Lakshminarayana, Suresh B.; Watson, Lucy C.; Blais, Johanne; Thompson, Zachary; Jaber, Tareq Z.; Jones, Mark R.; Schaefer, Deborah A.; Riggs, Michael W.; Huston, Christopher D.; Diagana, Thierry T.; Manjunatha, Ujjini H.
Discovery of EGT710; an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor

EGT710的发现：一种口服非肽类拟似可逆共价SARS-CoV-2主蛋白酶抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-02-090
PRE
Julien P. N. Papillon; Jun Yuan; Matthew J. Hesse; Lei Zhang; Richard I. Robinson; Nathaniel F. Ware; Viktor Hornak; Rajeshri G. Karki; Tom Kirrane; Keira Garland; Sajan Joseph; Stephanie A. Moquin; Suresh B. Lakshminarayana; Laura Tandeske; Dustin Dovala; Mark Knapp; Elizabeth Ornelas; Daniel Fuller; Pei-i Ho; Xuping Xie; Katarina Vulic; Suzanne M. Skolnik; Jinhai Gao; Mark Zambrowski; Meike Spiess; José S. Duca; Scott A. Busby; Markus Schirle; Michael Robinson; Pei-Yong Shi; Heinz E. Moser; Christopher Sarko; James E. Bradner; Thierry T. Diagana; John A. Tallarico
Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2026-01-010
PRE
Rene, Olivier; Saldivia, Manuel; Dauphinais, Maxime; Zhang, Lei; Hollingsworth, Scott A.; Jiricek, Jan; Koester, Dennis C.; Miller, Sarah L.; Williams, Sarah L.; Ng, Pearly S.; Patra, Debjani; Jumani, Rajiv S.; Baxley, Grace M.; Osborne, Colin S.; Chen, Ying-Bo; Chen, Yen-Liang; Cheung, Harry; Lakshminarayana, Suresh B.; Galarneau, Jean-Rene; Diagana, Thierry T.; Sarko, Christopher; Rao, Srinivasa P. S.
Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis
Nature Microbiology
IF19.4
2024-10-080
OAAI
Ujjini H. Manjunatha; Suresh B. Lakshminarayana; Rajiv S. Jumani; Alexander T. Chao; Joseph M. Young; Jonathan E. Gable; Mark Knapp; Imad Hanna; Jean-Rene Galarneau; John Cantwell; Upendra Kulkarni; Michael Turner; Peichao Lu; Kristen H. Darrell; Lucy C. Watson; Katherine Chan; Debjani Patra; Mulugeta Mamo; Catherine Luu; Carlos Cuellar; Jacob Shaul; Linda Xiao; Ying-Bo Chen; Shannon K. Carney; Jay Lakshman; Colin S. Osborne; Jennifer A. Zambriski; Natasha Aziz; Christopher Sarko; Thierry T. Diagana
Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-09-270
OAAI
Barkan, David T.; Garland, Keira; Zhang, Lei; Eastman, Richard T.; Hesse, Matthew; Knapp, Mark; Ornelas, Elizabeth; Tang, Jenny; Cortopassi, Wilian Augusto; Wang, Yu; King, Frederick; Jia, Weiping; Nguyen, Zachary; Frank, Andreas O.; Chan, Ryan; Fang, Eric; Fuller, Daniel; Busby, Scott; Carias, Heidi; Donahue, Kristine; Tandeske, Laura; Diagana, Thierry T.; Jarrousse, Nadine; Moser, Heinz; Sarko, Christopher; Dovala, Dustin; Moquin, Stephanie; Marx, Vanessa M.
Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-08-227
OAAI
Koester, Dennis C.; Marx, Vanessa M.; Williams, Sarah; Jiricek, Jan; Dauphinais, Maxime; Rene, Olivier; Miller, Sarah L.; Zhang, Lei; Patra, Debjani; Chen, Yen-Liang; Cheung, Harry; Gable, Jonathan; Lakshminarayana, Suresh B.; Osborne, Colin; Galarneau, Jean-Rene; Kulkarni, Upendra; Richmond, Wendy; Bretz, Angela; Xiao, Linda; Supek, Frantisek; Wiesmann, Christian; Honnappa, Srinivas; Be, Celine; Maeser, Pascal; Kaiser, Marcel; Ritchie, Ryan; Barrett, Michael P.; Diagana, Thierry T.; Sarko, Christopher; Rao, Srinivasa P. S.
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-03-0116
OAAI
Taft, Benjamin R.; Yokokawa, Fumiaki; Kirrane, Tom; Mata, Anne-Catherine; Huang, Richard; Blaquiere, Nicole; Waldron, Grace; Zou, Bin; Simon, Oliver; Vankadara, Subramanyam; Chan, Wai Ling; Ding, Mei; Sim, Sandra; Straimer, Judith; Guiguemde, Armand; Lakshminarayana, Suresh B.; Jain, Jay Prakash; Bodenreider, Christophe; Thompson, Christopher; Lanshoeft, Christian; Shu, Wei; Fang, Eric; Qumber, Jafri; Chan, Katherine; Pei, Luying; Chen, Yen-Liang; Schulz, Hanna; Lim, Jessie; Abas, Siti Nurdiana; Ang, Xiaoman; Liu, Yugang; Angulo-Barturen, Inigo; Belen Jimenez-Diaz, Maria; Javier Gamo, Francisco; Crespo-Fernandez, Benigno; Rosenthal, Philip J.; Cooper, Roland A.; Tumwebaze, Patrick; Campos Aguiar, Anna Caroline; Campo, Brice; Campbell, Simon; Wagner, Jurgen; Diagana, Thierry T.; Sarko, Christopher
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

NITD-688是登革热病毒NS4B蛋白的泛血清型抑制剂，在临床前动物模型中显示出良好的药代动力学和疗效

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2021-02-0346
PREAI
Moquin, Stephanie A.; Simon, Oliver; Karuna, Ratna; Lakshminarayana, Suresh B.; Yokokawa, Fumiaki; Wang, Feng; Saravanan, Chandra; Zhang, Jin; Day, Craig W.; Chan, Katherine; Wang, Qing-Yin; Lu, Siyan; Dong, Hongping; Wan, Kah Fei; Lim, Siew Pheng; Liu, Wei; Seh, Cheah Chen; Chen, Yen-Liang; Xu, Haoying; Barkan, David T.; Kounde, Cyrille S.; Sim, Wei Lin Sandra; Wang, Gang; Yeo, Hui-Quan; Zou, Bin; Chan, Wai Ling; Ding, Mei; Song, Jae-Geun; Li, Min; Osborne, Colin; Blasco, Francesca; Sarko, Christopher; Beer, David; Bonamy, Ghislain M. C.; Sasseville, Vito G.; Shi, Pei-Yong; Diagana, Thierry T.; Yeung, Bryan K. S.; Gu, Feng
Hepatic spheroids used as an in vitro model to study malaria relapse
BIOMATERIALS
IF12.9
2019-09-0151
OAAI
Chua, Adeline C. Y.; Ananthanarayanan, Abhishek; Ong, Jessica Jie Ying; Wong, Jen Yi; Yip, Andy; Singh, Nisha Hari; Qu, Yinghua; Dembele, Laurent; McMillian, Michael; Ubalee, Ratawan; Davidson, Silas; Tungtaeng, Anchalee; Imerbsin, Rawiwan; Gupta, Kapish; Andolina, Chiara; Lee, Fan; Tan, Kevin S-W; Nosten, Francois; Russell, Bruce; Lange, Amber; Diagana, Thierry T.; Renia, Laurent; Yeung, Bryan K. S.; Yu, Hanry; Bifani, Pablo
Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages
NATURE COMMUNICATIONS
IF15.7
2019-08-1241
OAAI
Chua, Adeline C. Y.; Ong, Jessica Jie Ying; Malleret, Benoit; Suwanarusk, Rossarin; Kosaisavee, Varakorn; Zeeman, Anne-Marie; Cooper, Caitlin A.; Tan, Kevin S. W.; Zhang, Rou; Tan, Bee Huat; Abas, Siti Nurdiana; Yip, Andy; Elliot, Anne; Joyner, Chester J.; Cho, Jee Sun; Breyer, Kate; Baran, Szczepan; Lange, Amber; Maher, Steven P.; Nosten, Francois; Bodenreider, Christophe; Yeung, Bryan K. S.; Mazier, Dominique; Galinski, Mary R.; Dereuddre-Bosquet, Nathalie; Le Grand, Roger; Kocken, Clemens H. M.; Renia, Laurent; Kyle, Dennis E.; Diagana, Thierry T.; Snounou, Georges; Russell, Bruce; Bifani, Pablo
Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy
ELIFE
IF0
2018-12-2735
OA
Bertschi, Nicole L.; Voorberg-van der Wel, Annemarie; Zeeman, Anne-Marie; Schuierer, Sven; Nigsch, Florian; Carbone, Walter; Knehr, Judith; Gupta, Devendra K.; Hofman, Sam O.; van der Werff, Nicole; Nieuwenhuis, Ivonne; Klooster, Els; Faber, Bart W.; Flannery, Erika L.; Mikolajczak, Sebastian A.; Chuenchob, Vorada; Shrestha, Binesh; Beibel, Martin; Bouwmeester, Tewis; Kangwanrangsan, Niwat; Sattabongkot, Jetsumon; Diagana, Thierry T.; Kocken, Clemens H. M.; Roma, Guglielmo
Drug Discovery for Kinetoplastid Diseases: Future Directions
ACS INFECTIOUS DISEASES
IF3.8
2018-12-1376
OAAI
Rao, Srinivasa P. S.; Barrett, Michael P.; Dranoff, Glenn; Faraday, Christopher J.; Gimpelewicz, Claudio R.; Hailu, Asrat; Jones, Catherine L.; Kelly, John M.; Lazdins-Helds, Jams K.; Maser, Pascal; Mengel, Jose; Mottram, Jeremy C.; Mowbray, Charles E.; Sacks, David L.; Scott, Phillip; Spath, Gerald F.; Tarleton, Rick L.; Spector, Jonathan M.; Diagana, Thierry T.

研究方向

暂未获取到该数据
S
Suresh B. Lakshminarayana
H 指数:27论文数:53被引数:4,293
U
Ujjini H. Manjunatha
H 指数:32论文数:72被引数:4,755
B
Bryan K. S. Yeung
H 指数:25论文数:54被引数:3,897
K
Kelli Kuhen
H 指数:37论文数:93被引数:6,412
E
Elizabeth A. Winzeler
H 指数:83论文数:356被引数:3.6万
P
Pablo Bifani
H 指数:47论文数:129被引数:9,764
C
Clemens H. M. Kocken
H 指数:53论文数:165被引数:9,621
S
Srinivasa P. S. Rao
H 指数:32论文数:80被引数:5,276
M
Matthias Rottmann
H 指数:37论文数:197被引数:6,131
A
Arnab K. Chatterjee
H 指数:51论文数:162被引数:1.0万