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E

Elizabeth A. Winzeler

University of California San Diego
H指数:83
被引数:3.6万

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Plasmodium falciparum HSP90 inhibitors show divergent resistance despite a shared ATP-binding site

恶性疟原虫HSP90抑制剂表现出差异性耐药性，尽管具有共同的ATP结合位点

Cell Reports
IF6.9
2026-07-010
PRE
Ko, Fu-Hsuan; Lukens, Amanda K.; de Souza, Mariana Laureano; Foy, Alex; Hsiao, Jason; Ndiaye, Tolla; Okombo, John; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Boonyalai, Nonlawat; Kumpornsin, Krittikorn; Girling, Gareth; Pasaje, Charisse; Godoy, Luiz; Kapoor, Priyan; Durst, Gregory L.; Ottilie, Sabine; Chatterjee, Arnab; Niles, Jacquin; Lee, Marcus; Fidock, David A.; Wirth, Dyann F.; Winzeler, Elizabeth A.
AI-Accelerated Structure Elucidation of Boavistamides A–C; Cyclic Depsipeptides from a Marine Filamentous Cyanobacterium Collected in Cabo Verde

AI加速的博阿维斯塔酰胺A–C结构解析；来自佛得角采集的海生丝状蓝藻的环状脂肽

Journal of Natural Products
IF3.6
2026-06-240
PRE
Marine Cuau; Nicole E. Avalon; Byeol Ryu; Evgenia Glukhov; Jehad Almaliti; Adriana Rego; Thaiz R. Teixeira; Mai Shingyoji; Mariana L De Souza; Alma Trinidad-Javier; Krittikorn Kumpornsin; Joseph Chen; Case W. McNamara; Conor R. Caffrey; Elizabeth A. Winzeler; Vitor M. Vasconcelos; Pedro N. Leão; William H. Gerwick
Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

ZY19489与哌喹之间的交叉高敏性中和了PfCRT介导的药物外排和恶性疟原虫抗性

Nature Communications
IF15.7
2026-04-010
OAAI
John Okombo; Tolla Ndiaye; Tarrick Qahash; Igor M. R. Moura; Eva Gil-Iturbe; Laura M. Hagenah; Jessica L. Bridgford; Vinicius Bonatto; Kurt E. Ward; Tomas Yeo; Sunil K. Narwal; Lily V. Orta; Isla Anderson; Satish K. Dhingra; Charisse Flerida A. Pasaje; Heekuk Park; Jonathan Kim; Rafael V. C. Guido; Maria Belén Jiménez-Diaz; Iñigo Angulo-Barturen; Jacquin C. Niles; Filippo Mancia; Anne-Catrin Uhlemann; Sachel Mok; Matthias Quick; Elizabeth A. Winzeler; Didier Leroy; Manuel Llinás; Vandana Thathy; David A. Fidock
Discovery of Potent Orally Active Plasmodium N -Myristoyltransferase Inhibitors Using Fragment-Linking Approaches

利用片段连接方法发现强效、口服活性的疟原虫N-十四酰基转移酶抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-01-010
OA
Andrew Reid Bell; Jennie A. Hutton; J.A. Brannigan; Nicole B. Trainor; Munira Grainger; Stephan Meister; Roger V. Bonnert; Jeremy Nicholas Burrows; Brice Campo; Richard J. Wall; Abhijit Kundu; Anthony J. Wilkinson; Anthony A. Holder; Elizabeth A. Winzeler; Rita Tewari; Robin J. Leatherbarrow; Edward W. Tate
Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

作者更正：多样性导向合成产生了新颖的多阶段抗疟抑制剂

Nature
IF48.5
2025-11-280
PRE
Nobutaka Kato; Eamon Comer; Tomoyo Sakata-Kato; Arvind Sharma; Manmohan Sharma; Micah Maetani; Jessica Bastien; Nicolas M. Brancucci; Joshua A. Bittker; Victoria Corey; David Clarke; Emily R. Derbyshire; Gillian L. Dornan; Sandra Duffy; Sean Eckley; Maurice A. Itoe; Karin M. J. Koolen; Timothy A. Lewis; Ping S. Lui; Amanda K. Lukens; Emily Lund; Sandra March; Elamaran Meibalan; Bennett C. Meier; Jacob A. McPhail; Branko Mitasev; Eli L. Moss; Morgane Sayes; Yvonne Van Gessel; Mathias J. Wawer; Takashi Yoshinaga; Anne-Marie Zeeman; Vicky M. Avery; Sangeeta N. Bhatia; John E. Burke; Flaminia Catteruccia; Jon C. Clardy; Paul A. Clemons; Koen J. Dechering; Jeremy R. Duvall; Michael A. Foley; Fabian Gusovsky; Clemens H. M. Kocken; Matthias Marti; Marshall L. Morningstar; Benito Munoz; Daniel E. Neafsey; Amit Sharma; Elizabeth A. Winzeler; Dyann F. Wirth; Christina A. Scherer; Stuart L. Schreiber
Mechanistic insights into dual-active liver and blood-stage antiplasmodials

双活性肝期和血期抗疟原虫药物的机制研究

MBIO
IF4.7
2025-11-010
PRE
Rawat, Mukul; Boonyalai, Nonlawat; Smidt, Cindy; Luth, Madeline R.; Chen, Daisy; Plater, Andrew; Post, John; De Lin; McMillan, Joel; Eadsforth, Thomas; Moliner-Cubel, Sonia; Billker, Oliver; Rayner, Julian C.; Gamo, Fransisco-Javier; Baragana, Beatriz; Winzeler, Elizabeth A.; Lee, Marcus C. S.
Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

靶向Aurora Kinases这一关键细胞周期调控因子，以递送针对Plasmodium Falciparum的多阶段抗疟药。

Angewandte Chemie International Edition
IF16.9
2025-10-230
OAAI
Henrico Langeveld; Keletso Maepa; Marché Maree; Jessica L. Thibaud; Nicolaas Salomane; Rosie Bridgwater; Mufuliat T. Famodimu; Luiz C. Godoy; Charisse Flerida A. Pasaje; Nonlawat Boonyalai; Mariana Laureano de Souza; Justin Fong; Tayla Rabie; Mariëtte van der Watt; Rensu P. Theart; Sonja Ghidelli-Disse; Jacquin C. Niles; Marcus C. S. Lee; Elizabeth A. Winzeler; Michael J. Delves; Kelly Chibale; Kathryn J. Wicht; Lauren B. Coulson; Lyn-Marié Birkholtz
Disruption of P. falciparum amino acid transporter elevates intracellular proline and induces resistance to Prolyl-tRNA synthetase inhibitors

恶性疟原虫氨基酸转运蛋白的破坏提高了细胞内脯氨酸水平，并诱导了对脯氨酰-tRNA合成酶抑制剂的抗性。

Cell Chemical Biology
IF7.2
2025-10-070
PRE
Selina Bopp; Lọla Fagbami; Amy Deik; Claudia Taccheri; Akansha Pant; Madeline Luth; Daisy Chen; Mark A. Tye; Imran Ullah; Johannes Kreuzer; Robert Morris; Wilhelm Haas; Elizabeth A. Winzeler; Clary Clish; Amanda K. Lukens; Ralph Mazitschek; Dyann F. Wirth
Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

Plasmodium falciparum蛋白激酶6和血红素晶体的形成被一种具有抗疟疾活性的II型人源激酶抑制剂所抑制

Cell Chemical Biology
IF7.2
2025-07-070
PRE
Flore Nardella; Tiantian Jiang; Lushun Wang; Monica J. Bohmer; Subhoja Chakraborty; John Okombo; Jaeson Calla; Tatiane Macedo Silva; Samuel Pazicky; Jianwei Che; Jin Jeon; Evie Vincent; Nonlawat Boonyalai; Rachael Coyle; Mairi J. Buchanan; Samuel Schaefer; Daisy Chen; Amaan Khan; Emily Mayville; Mariana Laureano De Souza; Mayland Treat; Jordan Charlton; Patrick K. Tumwebaze; Seth Tjia; Lukas Montejo; Karen Cover; Philip J. Rosenthal; Roland A. Cooper; Zbynek Bozdech; Marcus C.S. Lee; Ratna Chakrabarti; Sanjay A. Desai; David A. Fidock; Jinhua Wang; Nathanael S. Gray; Elizabeth A. Winzeler; Debopam Chakrabarti
Inner-mitochondrial membrane protein PfMPV17 is linked to P. falciparum in vitro resistance to the indoloquinolizidine alkaloid alstonine

线粒体内膜蛋白PfMPV17与恶性疟原虫在体外对吲哚奎诺里西丁生物碱阿斯东碱的抗性相关联。

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
IF3.6
2025-05-280
OA
Macdonald, J. R.; Arnold, M. S.; Luth, M. R.; Cihalova, D.; Quinn, R. J.; Winzeler, E. A.; Lee, M. C.; van Dooren, G. G.; Maier, A. G.; Skinner-Adams, T. S.; Andrews, K. T.; Fisher, G. M.
In vivo screen of Plasmodium targets for mosquito-based malaria control

基于蚊媒疟疾控制的疟原虫体内靶点筛选

NATURE
IF48.5
2025-05-210
OA
Probst, Alexandra S.; Paton, Douglas G.; Appetecchia, Federico; Bopp, Selina; Adams, Kelsey L.; Rinvee, Tasneem A.; Pou, Sovitj; Winter, Rolf; Du, Esrah W.; Yahiya, Sabrina; Vidoudez, Charles; Singh, Naresh; Rodrigues, Janneth; Castaneda-Casado, Pablo; Tammaro, Chiara; Chen, Daisy; Godinez-Macias, Karla P.; Jaramillo, Jasmine L.; Poce, Giovanna; Rubal, Michael J.; Nilsen, Aaron; Winzeler, Elizabeth A.; Baum, Jake; Burrows, Jeremy N.; Riscoe, Michael K.; Wirth, Dyann F.; Catteruccia, Flaminia
Plasma Lipid Metabolites, Clinical Glycemic Predictors, and Incident Type 2 Diabetes

血浆脂质代谢物、临床血糖预测因子和2型糖尿病发病

DIABETES CARE
IF16.6
2025-01-060
PRE
Begzati, Arjana; Godinez-Macias, Karla P.; Long, Tao; Watrous, Jeramie D.; Moranchel, Rafael; Kantz, Edward D.; Tuomilehto, Jaakko; Havulinna, Aki S.; Niiranen, Teemu J.; Jousilahti, Pekka; Salomaa, Veikko; Yu, Bing; Norby, Faye; Rebholz, Casey M.; Selvin, Elizabeth; Winzeler, Elizabeth A.; Cheng, Susan; Alotaibi, Mona; Goyal, Ravi; Ideker, Trey; Jain, Mohit; Majithia, Amit R.
Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b

针对线粒体蛋白，细胞色素b的环丙基甲酰胺的抗疟活性的探索和表征

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-12-010
OAAI
Awalt, Jon Kyle; Su, Wenyin; Nguyen, William; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Ramesh, Saishyam; Fairhurst, Kate J.; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Maity, Bikash Chandra; De, Nirupam; Mukherjee, Partha; Chakraborty, Arnish; Churchyard, Alisje; Famodimu, Mufuliat T.; Delves, Michael J.; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth A.; Papenfuss, Anthony T.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Maier, Alexander G.; van Dooren, Giel G.; Baud, Delphine; Brand, Stephen; Fidock, David A.; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.
Tambjamines as Fast-Acting Multistage Antimalarials
ACS INFECTIOUS DISEASES
IF3.8
2024-11-110
PRE
Kumar, Amrendra; Li, Yuexin; Dodean, Rozalia A.; Roth, Alison; Caridha, Diana; Madejczyk, Michael S.; Jin, Xiannu; Dennis, William E.; Lee, Patricia J.; Pybus, Brandon S.; Martin, Monica; Pannone, Kristina; Dinh, Hieu T.; Blount, Cameron; Chetree, Ravi; Deluca, Jesse; Evans, Martin; Nadeau, Robert; Vuong, Chau; Leed, Susan; Black, Chad; Sousa, Jason; Nolan, Christina; Ceja, Frida G.; Rasmussen, Stephanie A.; Tumwebaze, Patrick K.; Rosenthal, Philip J.; Cooper, Roland A.; Rottmann, Matthias; Orjuela-Sanchez, Pamela; Meister, Stephan; Winzeler, Elizabeth A.; Delves, Michael J.; Matthews, Holly; Baum, Jake; Kirby, Robert W.; Burrows, Jeremy N.; Duffy, James; Peyton, David H.; Reynolds, Kevin A.; Kelly, Jane X.; Kancharla, Papireddy

研究方向

暂未获取到该数据
D
David A. Fidock
H 指数:95论文数:427被引数:3.3万
S
Sabine Ottilie
H 指数:31论文数:69被引数:3,464
S
Stephan Meister
H 指数:33论文数:51被引数:9,290
M
Madeline R. Luth
H 指数:19论文数:47被引数:1,356
D
Dyann F. Wirth
H 指数:81论文数:407被引数:2.0万
D
David Plouffe
H 指数:31论文数:71被引数:7,941
F
Francisco‐Javier Gamo
H 指数:40论文数:153被引数:7,809
L
Lee M
H 指数:48论文数:356被引数:1.0万
A
Amanda K. Lukens
H 指数:29论文数:70被引数:3,480
Y
Yevgeniya Antonova‐Koch
H 指数:16论文数:33被引数:1,054