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J

James A. Roper

galecto biotech aps
H指数:19
被引数:1,965

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An Orally Available Halothiazole Glycomimetic as a Cancer-Targeting Dual Galectin-1 and Galectin-3 Inhibitor

一种口服可用的卤代噻唑类糖模拟物作为靶向癌细胞的半乳糖凝集素-1和半乳糖凝集素-3双重抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-04-290
PRE
Fredrik R. Zetterberg; Kristoffer Peterson; Ulf J. Nilsson; Carl Diehl; Maria Håkansson; Barbro Kahl-Knutson; Alison C. MacKinnon; Hanna Klein; Hakon Leffler; James A. Roper; Robert J. Slack; Henrik von Wachenfeldt; Anders Pedersen
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer

发现选择性和口服Galectin-1抑制剂GB1908作为肺癌的潜在治疗方法

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-05-287
PRE
Zetterberg, Fredrik R.; Peterson, Kristoffer; Nilsson, Ulf J.; Dahlgren, Kajsa Andreasson; Diehl, Carl; Holyer, Ian; Hakansson, Maria; Khabut, Areej; Kahl-Knutson, Barbro; Leffler, Hakon; MacKinnon, Alison C.; Roper, James A.; Slack, Robert J.; Zarrizi, Reihaneh; Pedersen, Anders
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease

用于治疗纤维化疾病的首个高效且可口服的Galectin-3抑制剂的发现和优化

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-09-2647
OAAI
Zetterberg, Fredrik R.; MacKinnon, Alison; Brimert, Thomas; Gravelle, Lise; Johnsson, Richard E.; Kahl-Knutson, Barbro; Leffler, Hakon; Nilsson, Ulf J.; Pedersen, Anders; Peterson, Kristoffer; Roper, James A.; Schambye, Hans; Slack, Robert J.; Tantawi, Susan
Pharmacological characterisation of GSK3335103, an oral αvβ6 integrin small molecule RGD-mimetic inhibitor for the treatment of fibrotic disease
EUROPEAN JOURNAL OF PHARMACOLOGY
IF4.7
2021-12-018
PRE
Wilkinson, Alex L.; John, Alison E.; Barrett, John W.; Gower, E.; Morrison, Valerie S.; Man, Yim; Pun, K. Tao; Roper, James A.; Luckett, Jeni C.; Borthwick, Lee A.; Barksby, Ben S.; Burgoyne, Rachel A.; Barnes, Rory; Fisher, Andrew J.; Procopiou, Panayiotis A.; Hatley, Richard J. D.; Barrett, Tim N.; Marshall, Richard P.; Macdonald, Simon J. F.; Jenkins, R. Gisli; Slack, Robert J.
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis
NATURE COMMUNICATIONS
IF15.7
2020-09-1679
OAAI
John, Alison E.; Graves, Rebecca H.; Pun, K. Tao; Vitulli, Giovanni; Forty, Ellen J.; Mercer, Paul F.; Morrell, Josie L.; Barrett, John W.; Rogers, Rebecca F.; Hafeji, Maryam; Bibby, Lloyd I.; Gower, Elaine; Morrison, Valerie S.; Man, Yim; Roper, James A.; Luckett, Jeni C.; Borthwick, Lee A.; Barksby, Ben S.; Burgoyne, Rachel A.; Barnes, Rory; Le, Joelle; Flint, David J.; Pyne, Susan; Habgood, Anthony; Organ, Louise A.; Joseph, Chitra; Edwards-Pritchard, Rochelle C.; Maher, Toby M.; Fisher, Andrew J.; Gudmann, Natasja Staehr; Leeming, Diana J.; Chambers, Rachel C.; Lukey, Pauline T.; Marshall, Richard P.; Macdonald, Simon J. F.; Jenkins, R. Gisli; Slack, Robert J.
Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-08-055
OAAI
Barrett, Tim N.; Taylor, Jonathan A.; Barker, Daniel; Procopiou, Panayiotis A.; Thompson, James D. F.; Barrett, John; Le, Joelle; Lynn, Sean M.; Pogany, Peter; Pratley, Cassie; Pritchard, John M.; Roper, James A.; Rowedder, James E.; Slack, Robert J.; Vitulli, Giovanni; Macdonald, Simon J. F.; Kerr, William J.

研究方向

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R
Robert J. Slack
H 指数:29论文数:116被引数:2,938
F
Fredrik R. Zetterberg
H 指数:20论文数:68被引数:1,408
A
Alison C. MacKinnon
H 指数:42论文数:157被引数:8,060
U
Ulf J. Nilsson
H 指数:61论文数:366被引数:1.1万
S
Stephen J. Lolait
H 指数:47论文数:96被引数:1.3万
K
Kristoffer Peterson
H 指数:13论文数:37被引数:603
M
Mark D. Bass
H 指数:25论文数:41被引数:2,976
S
Simon J. F. Macdonald
H 指数:41论文数:189被引数:6,372
H
Hakon Leffler
H 指数:85论文数:420被引数:2.5万
R
Rosalind C. Williamson
H 指数:13论文数:31被引数:681