Martine J. Smit - Publications, H-index & Citations

Martine J. Smit

VU University Amsterdam

65H指数

319论文数

1.4W被引数

收录论文 148

发表时间

GPCR kinase 3 couples atypical chemokine receptor 4 independent of G proteins GPCR激酶3在不依赖G蛋白的情况下偶联非典型趋化因子受体4

Molecular Pharmacology

IF3

2026-05-12

OAAI

Thomas D. Lamme; Isabel B. Sánchez Arroyo; Martine J. Smit; Christopher T. Schafer

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers 工程化纳米抗体之间的TR-FRET揭示了内源性CXCR4寡聚体的存在

Communications Biology

IF5.1

2025-12-16

OAAI

Joyce Heuninck; Vladimir Bobkov; Claire M. Grison; Amos Fumagalli; Mathias Lescuyer; Omolade Otun; Cherine Bechara; Laurent Lamarque; Eric Trinquet; Françoise Bachelerie; Philippe Marin; Bernard Mouillac; Sébastien Granier; Bas van der Woning; Hans de Haard; Martine J. Smit; Raimond Heukers; Thierry Durroux

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies 由反向激动剂纳米抗体揭示的非典型趋化因子受体的固有活性

Nature Communications

IF15.7

2025-12-02

OAAI

Claudia V. Perez Almeria; Omolade Otun; Roman Schlimgen; Thomas D. Lamme; Lotte Di Niro; Caitrin Crudden; Jan Paul Bebelman; Noureldine Youssef; Lejla Musli; Shawn Jenjak; Vladimir Bobkov; Julia Drube; Carsten Hoffmann; Brian F. Volkman; Sébastien Granier; Cherine Bechara; Marco Siderius; Raimond Heukers; Christopher T. Schafer; Martine J. Smit

Signal termination of the chemokine receptor CCR9 is governed by an arrestin-independent phosphorylation mechanism 趋化因子受体CCR9的信号终止由一种不依赖arrestin的磷酸化机制调控。

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2025-05-01

OAAI

Lamme, Thomas D.; Smit, Martine J.; Schafer, Christopher T.

Pharmacological characterization of a clinical candidate, TG-0 054, a small molecule inverse agonist targeting CXCR4 TG-0 054临床候选药物的药理学表征，TG-0 054是一种靶向CXCR4的小分子反向激动剂

MOLECULAR PHARMACOLOGY

IF3

2025-01-01

PREAI

Pan, Kylie S.; Wang, Ziming; Pfeil, Cy; Bergkamp, Nick D.; Mobach, Simon; Roth, Susanne; Rizk, Aurelien; Lohse, Martin J.; Annibale, Paolo; Siderius, Marco; Zimmermann, Mirjam; Smit, Martine J.; Bosma, Reggie

Learning from serum markers reflecting endothelial activation: longitudinal data in childhood-onset systemic lupus erythematosus

LUPUS SCIENCE & MEDICINE

IF3.5

2024-09-05

OAAI

Bergkamp, Sandy C.; Bergkamp, Nick D.; Wahadat, Mohamed Javad; Gruppen, Mariken P.; Rashid, Amara Nassar-Sheikh; Tas, Sander W.; Smit, Martine J.; Versnel, Marjan A.; van den Berg, J. Merlijn; Kamphuis, Sylvia; Schonenberg-Meinema, Dieneke

Multivalent CXCR4-targeting nanobody formats differently affect affinity, receptor clustering, and antagonism

BIOCHEMICAL PHARMACOLOGY

IF5.6

2024-09-01

OAAI

Anbuhl, Stephanie M.; Dervillez, Xavier; Neubacher, Saskia; Schriek, Angela I.; Bobkov, Vladimir; de Taeye, Steven W.; Szpakowska, Martyna; Siderius, Marco; Grossmann, Tom N.; Chevigne, Andy; Smit, Martine J.; Heukers, Raimond

Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies

NATURE COMMUNICATIONS

IF15.7

2024-05-30

OAAI

Schlimgen, Roman R.; Peterson, Francis C.; Heukers, Raimond; Smit, Martine J.; McCorvy, John D.; Volkman, Brian F.

A Pfs48/45-based vaccine to block Plasmodium falciparum transmission: phase 1, open-label, clinical trial

BMC MEDICINE

IF8.3

2024-04-23

OAAI

Alkema, M.; Smit, M. J.; Marin-Mogollon, C.; Totte, K.; Teelen, K.; van Gemert, G. J.; van de Vegte-Bolmer, M.; Mordmuller, B. G.; Reimer, J. M.; Lovgren-Bengtsson, K. L.; Sauerwein, R. W.; Bousema, T.; Plieskatt, J.; Theisen, M.; Jore, M. M.; Mccall, M. B. B.

Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates

hematology oncology

IF13.5

2023-11-23

OAAI

Wakileh, Gamal A.; Bierholz, Philipp; Kotthoff, Mara; Skowron, Margaretha A.; Bremmer, Felix; Stephan, Alexa; Anbuhl, Stephanie M.; Heukers, Raimond; Smit, Martine J.; Stroebel, Philipp; Nettersheim, Daniel

A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis

SCIENCE SIGNALING

IF6.6

2023-08-15

PREAI

Bergkamp, Nick D.; van Senten, Jeffrey R.; Brink, Hendrik J.; Bebelman, Maarten P.; van den Bor, Jelle; Cobanoglu, Tugce S.; Dinkla, Kasper; Koester, Johannes; Klau, Gunnar; Siderius, Marco; Smit, Martine J.

Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3 S

MOLECULAR PHARMACOLOGY

IF3

2023-07-12

OAAI

Zarca, Aurelien M.; Adlere, Ilze; Viciano, Cristina P.; Arimont-Segura, Marta; Meyrath, Max; Simon, Icaro A.; Bebelman, Jan Paul; Laan, Dennis; Custers, Hans G. J.; Janssen, Elwin; Versteegh, Kobus L.; Buzink, Maurice C. M. L.; Nesheva, Desislava N.; Bosma, Reggie; de Esch, Iwan J. P.; Vischer, Henry F.; Wijtmans, Maikel; Szpakowska, Martyna; Chevigne, Andy; Hoffmann, Carsten; de Graaf, Chris; Zarzycka, Barbara A.; Windhorst, Albert D.; Smit, Martine J.; Leurs, Rob

NanoB2 to monitor interactions of ligands with membrane proteins by combining nanobodies and NanoBRET

CELL REPORTS METHODS

IF4.5

2023-03-01

OAAI

van den Bor, Jelle; Bergkamp, Nick D.; Anbuhl, Stephanie M.; Dekker, Francoise; Comez, Dehan; Almeria, Claudia V. Perez; Bosma, Reggie; White, Carl W.; Kilpatrick, Laura E.; Hill, Stephen J.; Siderius, Marco; Smit, Martine J.; Heukers, Raimond

Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells

FRONTIERS IN IMMUNOLOGY

IF5.9

2022-11-23

OAAI

Comez, Dehan; Glenn, Jacqueline; Anbuhl, Stephanie M. M.; Heukers, Raimond; Smit, Martine J. J.; Hill, Stephen J. J.; Kilpatrick, Laura E. E.

Computationally designed GPCR quaternary structures bias signaling pathway activation

NATURE COMMUNICATIONS

IF15.7

2022-11-11

OAAI

Paradis, Justine S.; Feng, Xiang; Murat, Brigitte; Jefferson, Robert E.; Sokrat, Badr; Szpakowska, Martyna; Hogue, Mireille; Bergkamp, Nick D.; Heydenreich, Franziska M.; Smit, Martine J.; Chevigne, Andy; Bouvier, Michel; Barth, Patrick

Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3

ACS CHEMICAL BIOLOGY

IF3.8

2022-10-18

OAAI

Brink, Hendrik J.; van Senten, Jeffrey R.; De Vries-van Leeuwen, Ingrid J.; Pereira, Daniel da Costa; Piersma, Sander R.; Jimenez, Connie R.; Centorrino, Federica; Ottmann, Christian; Siderius, Marco; Smit, Martine J.; de Boer, Albertus H.

Structural Basis of Nanobody Induced ACKR3 Inhibition

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Schlimgen, Roman; Peterson, Francis; Heukers, Raimond; Smit, Martine; McCorvy, John; Volkman, Brian

D-dopachrome tautomerase contributes to lung epithelial repair via ACKR3-dependent Akt signaling

EUROPEAN RESPIRATORY JOURNAL

IF21

2021-11-25

PREAI

Song, Shanshan; Liu, Bin; Habibie, Habibie; Van den Bor, Jelle; Smit, Martine. J.; Gosens, Reinoud; Wu, Xinhui; Brandsma, Corry-Anke; Cool, Robbert. H.; Haisma, Hidde J.; Poelarends, Gerrit J.; Melgert, Barbro N.

Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies

NATURE COMMUNICATIONS

IF15.7

2021-07-21

OAAI

De Groof, Timo W. M.; Elder, Elizabeth G.; Lim, Eleanor Y.; Heukers, Raimond; Bergkamp, Nick D.; Groves, Ian J.; Wills, Mark; Sinclair, John H.; Smit, Martine J.

Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies

NATURE COMMUNICATIONS

IF15.7

2021-07-16

OAAI

De Groof, Timo W. M.; Bergkamp, Nick D.; Heukers, Raimond; Giap, Truc; Bebelman, Maarten P.; Goeij-de Haas, Richard; Piersma, Sander R.; Jimenez, Connie R.; Garcia, K. Christopher; Ploegh, Hidde L.; Siderius, Marco; Smit, Martine J.

研究方向