未登录 Urinary Kidney Injury Biomarker Profiles in Healthy Individuals and After Nephrotoxic and Ischemic Injury Waikar, Sushrut S.; Mogg, Robin; Baker, Amanda F.; Frendl, Gyorgy; Topper, Michael; Adler, Scott; Sultana, Stefan; Zhao, Runqi; King, Nicholas M. P.; Piccoli, Steven P.; Sauer, John-Michael; Hoffmann, Steve; Nunes, Irene; Sistare, Frank D. 分享 收藏
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Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity Gant, Timothy W.; Auerbach, Scott S.; Von Bergen, Martin; Bouhifd, Mounir; Botham, Philip A.; Caiment, Florian; Currie, Richard A.; Harrill, Joshua; Johnson, Kamin; Li, Dongying; Rouquie, David; van Ravenzwaay, Ben; Sistare, Frank; Tralau, Tewes; Viant, Mark R.; van de Laan, Jan Willem; Yauk, Carole 分享 收藏
Using human genetics to improve safety assessment of therapeutics 利用人类遗传学改善治疗药物的安全性评估 Carss, Keren J.; Deaton, Aimee M.; Del Rio-Espinola, Alberto; Diogo, Dorothee; Fielden, Mark; Kulkarni, Diptee A.; Moggs, Jonathan; Newham, Peter; Nelson, Matthew R.; Sistare, Frank D.; Ward, Lucas D.; Yuan, Jing 分享 收藏
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies Corton, J. Christopher; Mitchell, Constance A.; Auerbach, Scott; Bushel, J. Pierre; Ellinger-Ziegelbauer, Heidrun; Escobar, Patricia A.; Froetschl, Roland; Harrill, Alison H.; Johnson, Kamin; Klaunig, James E.; Pandiri, Arun R.; Podtelezhnikov, Alexei A.; Rager, Julia E.; Tanis, Keith Q.; van der Laan, Jan Willem; Vespa, Alisa; Yauk, Carole L.; Pettit, Syril D.; Sistare, Frank D. 分享 收藏
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin Vlasakova, Katerina; Bourque, Jennifer; Bailey, Wendy J.; Patel, Shetal; Besteman, Elizabeth G.; Gonzalez, Raymond J.; Sistare, Frank D.; Glaab, Warren E. 分享 收藏
Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats Glaab, Warren E.; Holder, Daniel; He, Yudong D.; Bailey, Wendy J.; Gerhold, David L.; Beare, Carolann; Erdos, Zoltan; Lane, Pamela; Michna, Laura; Muniappa, Nagaraja; Lawrence, Jeffrey W.; Tanis, Keith Q.; Sina, Joseph F.; Skopek, Thomas R.; Sistare, Frank D. 分享 收藏
Evaluation of Urinary Renal Biomarkers for Early Prediction of Acute Kidney Injury Following Partial Nephrectomy: A Feasibility Study Lane, Brian R.; Babitz, Stephen K.; Vlasakova, Katerina; Wong, Allen; Noyes, Sabrina L.; Boshoven, William; Grady, Pam; Zimmerman, Cindy; Engerman, Susan; Gebben, Maureen; Tanen, Michael; Glaab, Warren E.; Sistare, Frank D. 分享 收藏
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Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury Monroe, James J.; Tanis, Keith Q.; Podtelezhnikov, Alexei A.; Truyen Nguyen; Machotka, Sam, V; Lynch, Donna; Evers, Raymond; Palamanda, Jairam; Miller, Randy R.; Pippert, Todd; Cabalu, Tamara D.; Johnson, Timothy E.; Aslamkhan, Amy G.; Kang, Wen; Tamburino, Alex M.; Mitra, Kaushik; Agrawal, Nancy G. B.; Sistare, Frank D. 分享 收藏
Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline Kang, Wen; Podtelezhnikov, Alexei A.; Tanis, Keith Q.; Pacchione, Stephen; Su, Ming; Bleicher, Kimberly B.; Wang, Zhibin; Laws, George M.; Griffiths, Thomas G.; Kuhls, Matthew C.; Chen, Qing; Knemeyer, Ian; Marsh, Donald J.; Mitra, Kaushik; Lebron, Jose; Sistare, Frank D. 分享 收藏
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Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities Podtelezhnikov, Alexei A.; Monroe, James J.; Aslamkhan, Amy G.; Pearson, Kara; Qin, Chunhua; Tamburino, Alex M.; Loboda, Andrey P.; Glaab, Warren E.; Sistare, Frank D.; Tanis, Keith Q. 分享 收藏
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Polyethlyene Glycol 200 Can Protect Rats Against Drug-Induced Kidney Toxicity Through Inhibition of the Renal Organic Anion Transporter 3 Gu, Yi-Zhong; Chu, Xiaoyan; Houle, Robert; Vlasakova, Katerina; Koeplinger, Kenneth A.; Bourgeois, Isabelle; Palyada, Kiran; Anderson, Kenneth D.; Brynczka, Christopher; Bhatt, Bhavana; Chen, Feifei; Smith, Roger; Amin, Rupesh; Glaab, Warren E.; Lebron, Jose; Cox, Kathleen; Sistare, Frank D. 分享 收藏
Can Galactose Be Converted to Glucose in HepG2 Cells? Improving the in Vitro Mitochondria! Toxicity Assay for the Assessment of Drug Induced Liver Injury Xu, Quwei; Liu, Liping; Vu, Heather; Kuhls, Matthew; Aslamkban, Amy G.; Liaw, Andy; Yu, Yan; Kaczor, Allen; Ruth, Michael; Wei, Christina; Imredy, John; Lebron, Jose; Pearson, Kara; Gonzalez, Raymond; Mitra, Kaushik; Sistare, Frank D. 分享 收藏
AhR Activation in Pharmaceutical Development: Applying Liver Gene Expression Biomarker Thresholds to Identify Doses Associated With Tumorigenic Risks in Rats Qin, Chunhua; Aslamkhan, Amy G.; Pearson, Kara; Tanis, Keith Q.; Podtelezhnikov, Alexei; Frank, Erika; Pacchione, Stephen; Pippert, Todd; Glaab, Warren E.; Sistare, Frank D. 分享 收藏
Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity Li, Yutai; Evers, Raymond; Hafey, Michael J.; Cheon, Kyeongmi; Duong, Hong; Lynch, Donna; LaFranco-Scheuch, Lisa; Pacchione, Stephen; Tamburino, Alex M.; Tanis, Keith Q.; Geddes, Kristin; Holder, Daniel; Zhang, Nanyan Rena; Kang, Wen; Gonzalez, Raymond J.; Galijatovic-Idrizbegovic, Alema; Pearson, Kara M.; Lebron, Jose A.; Glaab, Warren E.; Sistare, Frank D. 分享 收藏
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