Alex Avdeef

St. John's University

H指数:61

被引数:1.2万

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Using mixtures of linoleic acid, a long-chain polyunsaturated fatty acid, and its monoglyceride in lipid-based formulations to increase drug loading and enhance aqueous microemulsification

使用亚油酸及其单甘酯的混合物，在脂质基制剂中增加药物负载并增强水性微乳液化（亚油酸是一种长链多不饱和脂肪酸）

International Journal of Pharmaceutics

IF5.2

2026-09-010

PRE

Imipramine solubility-pH profiles: self-aggregation vs. commonion effect

阿米替林溶解度-pH曲线：自聚集与同离子效应

ADMET and DMPK

IF4.3

2025-12-010

Highly increasing solubility of clofazimine, an extremely water-insoluble basic drug, in lipid-based SEDDS using digestion products of long-chain lipids

通过长链脂质消化产物，显著提高脂质基自乳化药物递送系统（SEDDS）中，一种极难溶于水的碱性药物氯法齐明的溶解度。

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2025-06-010

PRE

Often neglected steps in transforming drug solubility from single measurement in pure water to physiologically-appropriate solubility-pH

ADMET AND DMPK

IF4.3

2025-02-260

OAAI

Effects of Different Weak Small Organic Acids on Clofazimine Solubility in Aqueous Media

PHARMACEUTICS

IF5.5

2024-12-020

OAAI

Supersolubilization and Amorphization of a Weakly Acidic Drug, Flurbiprofen, by applying Acid-Base supersolubilization (ABS) principle

通过应用酸碱超增溶 (ABS) 原理对弱酸性药物氟比洛芬进行超增溶和非晶化

INTERNATIONAL JOURNAL OF PHARMACEUTICS

IF5.2

2024-09-012

PRE

A comparison of USP 2 and μDISS Profiler™ apparatus for studying dissolution phenomena of ibuprofen and its salts

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2024-02-012

Mechanistically transparent models for predicting aqueous solu-bility of rigid, slightly flexible, and very flexible drugs (MW<2000) Accuracy near that of random forest regression

ADMET AND DMPK

IF4.3

2023-08-212

OAAI

Anomalous salting-out, self-association and pKa effects in the practically-insoluble bromothymol blue

ADMET AND DMPK

IF4.3

2023-05-233

OAAI

Understanding the pH Dependence of Supersaturation State-A Case Study of Telmisartan

PHARMACEUTICS

IF5.5

2022-08-054

OAAI

Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development

PHARMACEUTICS

IF5.5

2022-01-133

OAAI

Is equilibrium slurry pH a good surrogate for solid surface pH during drug dissolution?

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2022-01-018

Salt Solubility and Disproportionation - Uses and Limitations of Equations for pHmax and the In-silico Prediction of pHmax

盐的溶解度和歧化-pHmax方程式的使用和局限性以及pHmax的计算机预测

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2022-01-0113

OAAI

The Critical Role of Passive Permeability in Designing Successful Drugs

被动渗透性在设计成功药物中的关键作用

CHEMMEDCHEM

IF3.4

2020-09-1076

PREAI

Do you know your r2?

ADMET AND DMPK

IF4.3

2020-08-3016

OAAI

Findings of the Second Challenge to Predict Aqueous Solubility

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2020-08-1443

PREAI

Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling

电位法CheqSol和标准化摇瓶溶解度法是理化分析中的补充工具

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2020-05-010

OAAI

Can small drugs predict the intrinsic aqueous solubility of 'beyond Rule of 5' big drugs?

ADMET AND DMPK

IF4.3

2020-04-2511

OAAI

Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database

ADMET AND DMPK

IF4.3

2020-03-0444

OAAI

Solubility Challenge Revisited after Ten Years, with Multilab Shake-Flask Data, Using Tight (SD ∼ 0.17 log) and Loose (SD ∼ 0.62 log) Test Sets

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2019-05-0145

PREAI

Alex Avdeef

个人简介

教育背景

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