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IND.241: A Canadian Cancer Trials Group liquid-biopsy informed platform trial to evaluate treatment in CDK4/6-inhibitor resistant ER +/HER2-metastatic breast cancer Cosci, C.; Jamme, P.; Kumar, V.; Nadler, M. B.; Rayson, D.; Melvin, J.; Rushton, M.; Awan, A.; Levasseur, N.; Chia, S.; Bedard, P.; Hilton, J.; Finn, S.; Tu, W.; Antras, J. F.; Unger, T. J.; Cescon, D.; Seymour, L.; Pearce, L. 分享 收藏
Advancing patient-centric care: integrating patient reported outcomes for tolerability assessment in early phase clinical trials - insights from an expert virtual roundtable 推进以患者为中心的护理: 在早期临床试验中整合患者报告的结果进行耐受性评估-来自专家虚拟圆桌会议的见解 Yap, Christina; Aiyegbusi, Olalekan Lee; Alger, Emily; Basch, Ethan; Bell, Jill; Bhatnagar, Vishal; Cella, David; Collis, Philip; Dueck, Amylou C.; Gilbert, Alexandra; Gnanasakthy, Ari; Greystoke, Alastair; Hansen, Aaron R.; Kamudoni, Paul; Kholmanskikh, Olga; King-Kallimanis, Bellinda L.; Krumholz, Harlan; Minchom, Anna; O'Connor, Daniel; Petrie, Joan; Piccinin, Claire; Rantell, Khadija Rerhou; Rauz, Saaeha; Retzer, Ameeta; Rizk, Steven; Wagner, Lynne; Sasseville, Maxime; Seymour, Lesley K.; Weber, Harald A.; Wilson, Roger; Calvert, Melanie; Peipertf, John Devin 分享 收藏
Pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in Canada, Italy, and France: a phase 3, open-label, randomised controlled trial Chu, Quincy; Perrone, Francesco; Greillier, Laurent; Tu, Wei; Piccirillo, Maria Carmela; Grosso, Federica; Lo Russo, Giuseppe; Florescu, Marie; Mencoboni, Manlio; Morabito, Alessandro; Cecere, Fabiana Letizia; Ceresoli, Giovanni Luca; Dawe, David E.; Zucali, Paolo Andrea; Pagano, Maria; Goffin, John R.; Sanchez, Myriam Locatelli; Gridelli, Cesare; Zalcman, Gerard; Quantin, Xavier; Westeel, Virginie; Gargiulo, Piera; Delfanti, Sara; Tu, Dongsheng; Lee, Christopher W.; Leighl, Natasha; Sederias, Joana; Brown-Walker, Pamela; Luo, Yiwen; Lantuejoul, Sylvie; Tsao, Ming-Sound; Scherpereel, Arnaud; Bradbury, Penelope; Laurie, Scott A.; Seymour, Lesley 分享 收藏
Enhancing reporting quality and impact of early phase dose-finding clinical trials: CONSORT Dose-finding Extension (CONSORT-DEFINE) guidance 提高早期剂量发现临床试验的报告质量和影响: CONSORT剂量发现扩展 (CONSORT-DEFINE) 指南 Yap, Christina; Solovyeva, Olga; de Bono, Johann; Rekowski, Jan; Patel, Dhrusti; Jaki, Thomas; Mander, Adrian; Evans, Thomas R. Jeffry; Peck, Richard; Hayward, Kathryn S.; Hopewell, Sally; Ursino, Moreno; Rantell, Khadija Rerhou; Calvert, Melanie; Lee, Shing; Kightley, Andrew; Ashby, Deborah; Chan, An-Wen; Garrett-Mayer, Elizabeth; Isaacs, John; Golub, Robert; Kholmanskikh, Olga; Richards, Dawn; Boix, Oliver; Matcham, James; Seymour, Lesley; Ivy, S. Percy; Marshall, Lynley, V; Hommais, Antoine; Liu, Rong; Tanaka, Yoshiya; Berlin, Jordan; Espinasse, Aude; Dimairo, Munyaradzi; Weir, Christopher J. 分享 收藏
Enhancing quality and impact of early phase dose-finding clinical trial protocols: SPIRIT Dose-finding Extension (SPIRIT-DEFINE) guidance 提高早期剂量发现临床试验方案的质量和影响: 精神剂量发现扩展 (SPIRIT-DEFINE) 指南 Yap, Christina; Rekowski, Jan; Ursino, Moreno; Solovyeva, Olga; Patel, Dhrusti; Dimairo, Munyaradzi; Weir, Christopher J.; Chan, An-Wen; Jaki, Thomas; Mander, Adrian; Evans, Thomas R. Jeffry; Peck, Richard; Hayward, Kathryn S.; Calvert, Melanie; Rantell, Khadija Rerhou; Lee, Shing; Kightley, Andrew; Hopewell, Sally; Ashby, Deborah; Garrett-Mayer, Elizabeth; Isaacs, John; Golub, Robert; Kholmanskikh, Olga; Richards, Dawn P.; Boix, Oliver; Matcham, James; Seymour, Lesley; Ivy, S. Percy; Marshall, Lynley, V; Hommais, Antoine; Liu, Rong; Tanaka, Yoshiya; Berlin, Jordan; Espinasse, Aude; de Bono, Johann 分享 收藏
Association of Molecular Profiles and Mutational Status With Distinct Histological Lung Adenocarcinoma Subtypes. An Analysis of the LACE-Bio Data Kumar, Prashanth Ashok; Karimi, Maryam; Basnet, Alina; Seymour, Lesley; Kratzke, Robert; Brambilla, Elizabeth; Le-Chevalier, Thierry; Soria, Jean-Charles; Olaussen, Ken Andre; Devarakonda, Siddhartha; Govindan, Ramaswamy; Tsao, Ming-Sound; Shepherd, Frances A.; Michiels, Stefan; Graziano, Stephen 分享 收藏
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CCTG IND.239: A phase 2 study of combined CFI-400945 and durvalumab in patients with advanced triple negative breast cancer (aTNBC) Hilton, John; Cescon, David W.; Robinson, Andrew; Dhesy-Thind, Sukhbinder; Taylor, Sara; Awan, Arif; Ng, Terry L.; Rushton, Moira; Savard, Marie-France; Muyot, Lindsay; Reeves, Marie Claude; Hagerman, Linda; Lui, Hongbo; Bray, Mark; Tu, Dongsheng; Seymour, Lesley; Gaudreau, Pierre-Olivier 分享 收藏
A phase II study of CFI-400945 in patients with advanced/metastatic cancer: Canadian Cancer Trials Group (CCTG) IND.237 Cescon, David W.; Hilton, John; Bedard, Philippe; Blanchette, Phillip; Pezo, Rossanna C.; Bashir, Ayesha; Kumar, Vikaash; Ng, Terry L.; Awan, Arif; Lott, Anthony; Raphael, Jacques Antoun; Hagerman, Linda; Bray, Mark; Muyot, Lindsay; Antras, Jesus Fuentes; Seymour, Lesley; Tu, Dongsheng; Gaudreau, Pierre-Olivier; Rushton, Moira 分享 收藏
CCTG IND.236: A Phase 1b trial of combined CFI-402257 and weekly paclitaxel in patients with HER2-negative (HER2-) advanced breast cancer (aBC) Bedard, Philippe; Mates, Mihaela; Hilton, John; Levasseur, Nathalie; Awan, Arif; Srikanthan, Amirrtha; Cescon, David W.; Gelmon, Karen; Robinson, Andrew; Drummond-Ivars, Nancy; Li, Irene; Rastgou, Laleh; Edwards, Jackie; Hagerman, Linda; Zhang, Siwei; Bray, Mark; Seymour, Lesley; Rushton, Moira; Gaudreau, Pierre-Olivier 分享 收藏
Oncology phase I trial design and conduct: time for a change- MDICT Guidelines 2022 Araujo, D.; Greystoke, A.; Bates, S.; Bayle, A.; Calvo, E.; Castelo-Branco, L.; de Bono, J.; Drilon, A.; Garralda, E.; Ivy, P.; Kholmanskikh, O.; Melero, I.; Pentheroudakis, G.; Petrie, J.; Plummer, R.; Ponce, S.; Postel-Vinay, S.; Siu, L.; Spreafico, A.; Stathis, A.; Steeghs, N.; Yap, C.; Yap, T. A.; Ratain, M.; Seymour, L. 分享 收藏
Ontario, Canada. 7 加拿大安大略省。7 Shankar, Lalitha K.; Huang, Erich; Litiere, Saskia; Hoekstra, Otto S.; Schwartz, Larry; Collette, Sandra; Boellaard, Ronald; Bogaerts, Jan; Seymour, Lesley; deVries, Elisabeth G. E. 分享 收藏
Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies 富含DNA修复缺陷的晚期实体瘤患者CX-5461的I期CCTG IND.231试验结果 Hilton, John; Gelmon, Karen; Bedard, Philippe L.; Tu, Dongsheng; Xu, Hong; Tinker, Anna V.; Goodwin, Rachel; Laurie, Scott A.; Jonker, Derek; Hansen, Aaron R.; Veitch, Zachary W.; Renouf, Daniel J.; Hagerman, Linda; Lui, Hongbo; Chen, Bingshu; Kellar, Deb; Li, Irene; Lee, Sung-Eun; Kono, Takako; Cheng, Brian Y. C.; Yap, Damian; Lai, Daniel; Beatty, Sean; Soong, John; Pritchard, Kathleen I.; Soria-Bretones, Isabel; Chen, Eric; Feilotter, Harriet; Rushton, Moira; Seymour, Lesley; Aparicio, Samuel; Cescon, David W. 分享 收藏
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A phase Ib trial of CFI-402257 in combination with weekly paclitaxel in patients with advanced HER2-negative (HER2-) breast cancer (aBC) Bedard, P.; Mates, M.; Gelmon, K. A.; Hilton, J.; Tu, D.; Li, I.; Rastgou, L.; Drummond-Ivars, N.; Edwards, J.; Warr, D.; Lohrisch, C.; Song, X.; Srikanthan, A.; Robinson, A.; Hagerman, L.; Seymour, L. K.; Rushton, M.; Cescon, D. W. 分享 收藏
Canadian cancer trials group trial IND.231: A phase 1 trial evaluating CX-5461, a novel first-in-class G-quadruplex stabilizer in patients with advanced solid tumors enriched for DNA-repair deficiencies Hilton, John; Gelmon, Karen; Cescon, David; Tinker, Anna; Jonker, Derek; Goodwin, Rachel; Laurie, Scott; Hansen, Aaron; Aparicio, Samuel; Soong, John; Hagerman, Linda; Lui, Hongbo; Bedard, Philippe; Pritchard, Kathleen; Tu, Dongsheng; Seymour, Lesley 分享 收藏
A Canadian cancer trials group phase IB study of durvalumab (anti-PD-L1) plus tremelimumab (anti-CTLA-4) given concurrently or sequentially in patients with advanced, incurable solid malignancies 加拿大癌症试验组IB期研究durvalumab (anti-PD-L1) 联合tremelimumab (anti-CTLA-4) 同时或顺序给予晚期，无法治愈的实体恶性肿瘤患者 Nehra, J.; Bradbury, P. A.; Ellis, P. M.; Laskin, J.; Kollmannsberger, C.; Hao, D.; Juergens, R. A.; Goss, G.; Wheatley-Price, P.; Hotte, S. J.; Gelmon, K.; Tinker, A. V.; Brown-Walker, P.; Gauthier, I.; Tu, D.; Song, X.; Khan, A.; Seymour, Lesley; Smoragiewicz, M. 分享 收藏
A phase I study of vistusertib (dual mTORC1/2 inhibitor) in patients with previously treated glioblastoma multiforme: a CCTG study Lapointe, Sarah; Mason, Warren; MacNeil, Mary; Harlos, Craig; Tsang, Roger; Sederias, Joana; Luchman, H. Artee; Weiss, Samuel; Rossiter, John P.; Tu, Dongsheng; Seymour, Lesley; Smoragiewicz, Martin 分享 收藏
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