Malcolm G. Dunlop - Publications, H-index & Citations

Malcolm G. Dunlop

University of Edinburgh

91H指数

677论文数

3.6W被引数

收录论文 199

发表时间

Germline haploinsufficiency of MUTYH causes mutational signature SBS18 in multiple tumour types and specifically raises colorectal cancer risk MUTYH的生殖系杂合不足在多种肿瘤类型中导致突变特征SBS18，并特异性地增加结直肠癌风险

npj Precision Oncology

IF8

2026-05-06

OAAI

Kitty Sherwood; Juan Fernandez-Tajes; Güler Gül; Steve Thorn; Joseph C. Ward; James F. Wilson; Claire Palles; D. Timothy Bishop; Richard S. Houlston; Malcolm G. Dunlop; Ian P. M. Tomlinson

Non-gonadal PIWIL1/Aubergine drives regenerative and tumorigenic stem cell proliferation and tumorigenesis in the intestine 非性腺PIWIL1/Aubergine驱动肠道再生和肿瘤发生中的干细胞增殖及肿瘤发生

Cell Reports

IF6.9

2026-03-26

OAAI

Karen Bellec; Lynsey R. Carroll; Kathryn A.F. Pennel; Yuanliangzi Tian; Yachuan Yu; Aslihan Bastem Akan; Caroline V. Billard; Nora Doleschall; Alexander R. Cameron; Fabiana Herédia; Alisson M. Gontijo; Anna M. Ochocka-Fox; James P. Blackmur; Farhat V.N. Din; Malcolm G. Dunlop; Joanne Edwards; Kevin Myant; Rippei Hayashi; Julia B. Cordero

Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility 混合模型和全转录组关联分析识别与结直肠癌易感性相关的转录因子和基因

Nature Communications

IF15.7

2026-01-15

OAAI

Zhishan Chen; Wenqiang Song; Qing Li; Chao Li; Wanqing Wen; Jeroen R. Huyghe; Philip J. Law; Ceres Fernandez-Rozadilla; Maria N. Timofeeva; Minta Thomas; Stephanie L. Schmit; Vicente Martin; Matthew Devall; Christopher Dampier; Ferran Moratalla-Navarro; Qiuyin Cai; Jifeng Wang; Jiajun Shi; Sun-Seog Kweon; Chizu Tanikawa; Wei-Hua Jia; Xiang Shu; Jirong Long; Jing Gao; Jeongseon Kim; Aesun Shin; Keitaro Matsuo; Sun Ha Jee; Keum Ji Jung; Nan Wang; Dong-Hyun Kim; Jie Ping; Gong Yang; Min-Ho Shin; Zefang Ren; Jae Hwan Oh; Isao Oze; Yoon-Ok Ahn; Yu-Tang Gao; Zhi-Zhong Pan; Yoichiro Kamatani; Luc Van Kaer; Lan Wu; Bingshan Li; Koichi Matsuda; Xiao-Ou Shu; Li Hsu; Malcolm G. Dunlop; Stephen B. Gruber; Richard Houlston; Ian Tomlinson; Li Li; Ken S. Lau; Victor Moreno; Graham Casey; Ulrike Peters; Wei Zheng; Xingyi Guo

Promises under pressure: the modest predictive power of polygenic risk scores 压力下的承诺：多基因风险评分的适度预测能力

European Journal of Human Genetics

IF4.6

2026-01-08

PREAI

Rachel Horton; Malcolm Dunlop; Margaret McCartney; Amit Sud; Richard Sullivan; Ian Tomlinson; Clare Turnbull; Richard Houlston; Anneke Lucassen

Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure 全基因组范围的基因-环境交互作用研究利用精确的周围UVB测量发现了162个维生素D状态变异。

Nature Communications

IF15.7

2025-11-28

OAAI

Rasha Shraim; Maria Timofeeva; Cathy Wyse; Jos van Geffen; Michiel van Weele; Roman Romero-Ortuno; Lorna M. Lopez; Marcus E. Kleber; Stefan Pilz; Winfried März; Benjamin S. Fletcher; James F. Wilson; Evropi Theodoratou; Malcolm G. Dunlop; Ross McManus; Lina Zgaga

Accelerated biological aging and its hallmarks in DNA methylation drive the association between unhealthy lifestyles and the onset of colorectal cancer 加速的生物衰老及其在DNA甲基化中的标志物驱动不健康生活方式与结直肠癌发病之间的关联

eBioMedicine

IF10.8

2025-11-05

OAAI

Jing Sun; Min Liu; Xiaoqian Zhang; Xinxuan Li; Jingyu Ye; Jianhui Zhao; Siyun Zhou; Haosen Ji; Yuqian Tan; Zilong Bian; Dongfeng Zhang; Malcolm G. Dunlop; Mingyang Song; Stephanie A. Smith-Warner; Hao Wu; Evropi Theodoratou; Qian Cao; Xue Li

Single and double faecal immunochemical test strategies are effective in risk stratification for patients with symptoms of per rectal bleeding suggestive of colorectal cancer 单次和多次粪便免疫化学检测策略对于具有提示结直肠癌症状的直肠出血患者的风险分层是有效的。

BJS OPEN

IF4.5

2025-10-01

OAAI

Shah, Fatima; Gunn, Frances; Dunlop, Malcolm G.; Din, Farhat V. N.; Gerrard, Adam D.

Risk factors and clinical consequences of interval cancers arising within faecal immunochemical testing-based colorectal cancer screening programme 免疫化学粪便检测为基础的结直肠癌筛查计划中出现的间隔性癌的风险因素及临床后果

BJS OPEN

IF4.5

2025-10-01

OAAI

Gerrard, Adam D.; Garau, Roberta; Maeda, Yasuko; Thomson, Alastair; Theodoratou, Evropi; Dunlop, Malcolm G.; Din, Farhat V. N.

Clinical impact of double-faecal immunochemical testing following implementation into standard triage and investigation of primary care referrals in patients with lower gastrointestinal symptoms 在初级保健转诊中，将双重粪便免疫化学检测纳入标准分诊和检查流程后，其在下消化道症状患者中的临床影响。

BJS Open

IF4.5

2025-09-08

OAAI

Adam D Gerrard; Yasuko Maeda; Colin Noble; Frances Gunn; Lorna Porteous; Rebecca Cheesbrough; Alastair Thomson; Malcolm G Dunlop; Farhat V N Din; Edinburgh Colorectal Group

Trans-ancestry transcriptome-wide association and functional studies to uncover novel susceptibility genes and therapeutic targets for colorectal cancer (vol 9, 124, 2025)跨祖先转录组-wide关联及功能研究，以揭示结直肠癌的新型易感基因和 therapeutic targets (vol 9, 124, 2025)

NPJ PRECISION ONCOLOGY

IF8

2025-05-27

OAAI

Wang, Lijuan; Hu, Lidan; Sun, Jing; Zhao, Jianhui; Zhou, Siyun; Liu, Lexin; Yu, Wei; Hu, Yeting; Zhou, Dan; Meng, Xiangrui; Yuan, Zhongshang; Zhang, Honghe; Farrington, Susan; Timofeeva, Maria; Ding, Kefeng; Little, Julian; Dunlop, Malcolm; Theodoratou, Evropi; Li, Xue

Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank (vol 16, 99, 2025)深度学习和全基因组关联荟萃分析研究英国生物银行中骨髓脂肪含量（vol 16, 99, 2025）

NATURE COMMUNICATIONS

IF15.7

2025-05-09

OAAI

Xu, Wei; Mesa-Eguiagaray, Ines; Morris, David M.; Wang, Chengjia; Gray, Calum D.; Sjostrom, Samuel; Papanastasiou, Giorgos; Badr, Sammy; Paccou, Julien; Li, Xue; Timmers, Paul R. H. J.; Timofeeva, Maria; Farrington, Susan M.; Dunlop, Malcolm G.; Semple, Scott I.; MacGillivray, Tom; Theodoratou, Evropi; Cawthorn, William P.

Integration of multi-omics data to unveil the molecular landscape and role of piRNAs in early-onset colorectal cancer 整合多组学数据以揭示早期结直肠癌中piRNAs的分子景观与作用

BMC MEDICINE

IF8.3

2025-04-29

OAAI

Zhou, Siyun; Yu, Lili; Zhao, Jianhui; Xiao, Qian; Sun, Jing; Wang, Lijuan; Zhou, Yuan; Lu, Yadong; Dunlop, Malcolm G.; Theodoratou, Evropi; Zhang, Honghe; Ding, Kefeng; Li, Xue

Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank 深度学习和全基因组关联荟萃分析在UK Biobank中的骨髓脂肪含量研究

NATURE COMMUNICATIONS

IF15.7

2025-01-02

OAAI

Xu, Wei; Mesa-Eguiagaray, Ines; Morris, David M.; Wang, Chengjia; Gray, Calum D.; Sjostrom, Samuel; Papanastasiou, Giorgos; Badr, Sammy; Paccou, Julien; Li, Xue; Timmers, Paul R. H. J.; Timofeeva, Maria; Farrington, Susan M.; Dunlop, Malcolm G.; Semple, Scott I.; Macgillivray, Tom; Theodoratou, Evropi; Cawthorn, William P.

Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region

EBIOMEDICINE

IF10.8

2024-12-01

PREAI

Chen, Jie; Zhang, Han; Fu, Tian; Zhao, Jianhui; Nowak, Jan Krzysztof; Kalla, Rahul; Wellens, Judith; Yuan, Shuai; Noble, Alexandra; Ventham, Nicholas T.; Dunlop, Malcolm G.; Halfvarson, Jonas; Mao, Ren; Theodoratou, Evropi; Satsangi, Jack; Li, Xue

Diagnostic Performance of Faecal Immunochemical Testing (FIT) in Patients with Lynch Syndrome Scheduled for Colonoscopic Surveillance

DIAGNOSTICS

IF3.3

2024-10-30

OAAI

Gerrard, Adam D.; Maeda, Yasuko; Strachan, Judith; Speake, Doug; Dunlop, Malcolm G.; Din, Farhat V. N.

Colorectal cancer prevalence in faecal immunochemical test non-returners: potential for health inequality in symptomatic referral pathways

BJS OPEN

IF4.5

2024-10-15

OAAI

Gerrard, Adam D.; Coxon, Jonty; Maeda, Yasuko; Theodoratou, Evropi; Dunlop, Malcolm G.; Din, Farhat V. N.

Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk 结直肠癌风险潜在的功能变异和效应基因的系统优先排序

NATURE GENETICS

IF31.8

2024-09-16

OAAI

Law, Philip J.; Studd, James; Smith, James; Vijayakrishnan, Jayaram; Harris, Bradley T.; Mandelia, Maria; Mills, Charlie; Dunlop, Malcolm G.; Houlston, Richard S.

Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study 环境空气污染对结直肠癌风险和生存的影响: 来自前瞻性队列和表观遗传孟德尔随机研究的见解

EBIOMEDICINE

IF10.8

2024-05-01

OAAI

Jiang, Fangyuan; Zhao, Jianhui; Sun, Jing; Chen, Wenxi; Zhao, Yuyuan; Zhou, Siyun; Yuan, Shuai; Timofeeva, Maria; Law, Philip J.; Larsson, Susanna C.; Chen, Dong; Houlston, Richard S.; Dunlop, Malcolm G.; Theodoratou, Evropi; Li, Xue

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes 包括254,000多名东亚和欧洲后代的精细图谱分析确定了136个推定的结直肠癌易感基因

NATURE COMMUNICATIONS

IF15.7

2024-04-26

OAAI

Chen, Zhishan; Guo, Xingyi; Tao, Ran; Huyghe, Jeroen R.; Law, Philip J.; Fernandez-Rozadilla, Ceres; Ping, Jie; Jia, Guochong; Long, Jirong; Li, Chao; Shen, Quanhu; Xie, Yuhan; Timofeeva, Maria N.; Thomas, Minta; Schmit, Stephanie L.; Diez-Obrero, Virginia; Devall, Matthew; Moratalla-Navarro, Ferran; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Briggs, Sarah E. W.; Svinti, Victoria; Donnelly, Kevin; Farrington, Susan M.; Blackmur, James; Vaughan-Shaw, Peter G.; Shu, Xiao-Ou; Lu, Yingchang; Broderick, Peter; Studd, James; Harrison, Tabitha A.; Conti, David V.; Schumacher, Fredrick R.; Melas, Marilena; Rennert, Gad; Obon-Santacana, Mireia; Martin-Sanchez, Vicente; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun-Seog; Shin, Min-Ho; Shin, Aesun; Ahn, Yoon-Ok; Kim, Dong-Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu-Tang; Jia, Wei-Hua; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko; Pai, Rish K.; Figueiredo, Jane C.; Haile, Robert W.; Gallinger, Steven; Woods, Michael O.; Newcomb, Polly A.; Duggan, David; Cheadle, Jeremy P.; Kaplan, Richard; Kerr, Rachel; Kerr, David; Kirac, Iva; Bohm, Jan; Mecklin, Jukka-Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri A.; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan G.; Cajuso, Tatiana; Hanninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Mannisto, Satu; Albanes, Demetrius; Weinstein, Stephanie J.; Ruiz-Narvaez, Edward; Palmer, Julie R.; Buchanan, Daniel D.; Platz, Elizabeth A.; Visvanathan, Kala; Ulrich, Cornelia M.; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter T.; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha L.; Potter, John D.; Tsilidis, Kostas K.; Schulze, Matthias B.; Gunter, Marc J.; Murphy, Neil; Castells, Antoni; Castellvi-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Bishop, D. Timothy; Giles, Graham G.; Southey, Melissa C.; Idos, Gregory E.; McDonnell, Kevin J.; Abu-Ful, Zomoroda; Greenson, Joel K.; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu-Ru; Steinfelder, Robert; Keku, Temitope O.; van Guelpen, Bethany; Hudson, Thomas J.; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja I.; Hayes, Richard B.; Martinez, Marie Elena; Thomas, Sushma S.; Pharoah, Paul D. P.; Larsson, Susanna C.; Yen, Yun; Lenz, Heinz-Josef; White, Emily; Li, Li; Doheny, Kimberly F.; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew T.; Cruz-Correa, Marcia; Lindblom, Annika; Hunter, David J.; Joshi, Amit D.; Schafmayer, Clemens; Scacheri, Peter C.; Kundaje, Anshul; Schoen, Robert E.; Hampe, Jochen; Stadler, Zsofia K.; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Edlund, Christopher K.; Gauderman, W. James; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Chanock, Stephen J.; van Duijnhoven, Franzel; Feskens, Edith J. M.; Sakoda, Lori C.; Gago-Dominguez, Manuela; Wolk, Alicja; Pardini, Barbara; FitzGerald, Liesel M.; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie A.; Kooperberg, Charles; Li, Christopher I.; Lin, Yi; Prentice, Ross; Qu, Conghui; Bezieau, Stephane; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Le Marchand, Loic; Wu, Anna H.; Qu, Chenxu; McNeil, Caroline E.; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian J.; Harris, Sarah E.; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Lau, Ken S.; Zhao, Hongyu; Hsu, Li; Cai, Qiuyin; Dunlop, Malcolm G.; Gruber, Stephen B.; Houlston, Richard S.; Moreno, Victor; Casey, Graham; Peters, Ulrike; Tomlinson, Ian; Zheng, Wei

Systematic investigation of genetically determined plasma and urinary metabolites to discover potential interventional targets for colorectal cancer 对基因确定的血浆和尿液代谢产物进行系统研究，以发现大肠癌的潜在干预靶点

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

IF7.2

2024-04-22

OAAI

Sun, Jing; Zhao, Jianhui; Zhou, Siyun; Li, Xinxuan; Li, Tengfei; Wang, Lijuan; Yuan, Shuai; Chen, Dong; Law, Philip J.; Larsson, Susanna C.; Farrington, Susan M.; Houlston, Richard S.; Dunlop, Malcolm G.; Theodoratou, Evropi; Li, Xue

研究方向