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M

Malcolm G. Dunlop

University of Edinburgh
H指数:91
被引数:3.6万

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Germline haploinsufficiency of MUTYH causes mutational signature SBS18 in multiple tumour types and specifically raises colorectal cancer risk

MUTYH的生殖系杂合不足在多种肿瘤类型中导致突变特征SBS18，并特异性地增加结直肠癌风险

npj Precision Oncology
IF8
2026-05-060
OAAI
Kitty Sherwood; Juan Fernandez-Tajes; Güler Gül; Steve Thorn; Joseph C. Ward; James F. Wilson; Claire Palles; D. Timothy Bishop; Richard S. Houlston; Malcolm G. Dunlop; Ian P. M. Tomlinson
Non-gonadal PIWIL1/Aubergine drives regenerative and tumorigenic stem cell proliferation and tumorigenesis in the intestine

非性腺PIWIL1/Aubergine驱动肠道再生和肿瘤发生中的干细胞增殖及肿瘤发生

Cell Reports
IF6.9
2026-03-260
OAAI
Karen Bellec; Lynsey R. Carroll; Kathryn A.F. Pennel; Yuanliangzi Tian; Yachuan Yu; Aslihan Bastem Akan; Caroline V. Billard; Nora Doleschall; Alexander R. Cameron; Fabiana Herédia; Alisson M. Gontijo; Anna M. Ochocka-Fox; James P. Blackmur; Farhat V.N. Din; Malcolm G. Dunlop; Joanne Edwards; Kevin Myant; Rippei Hayashi; Julia B. Cordero
Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility

混合模型和全转录组关联分析识别与结直肠癌易感性相关的转录因子和基因

Nature Communications
IF15.7
2026-01-150
OAAI
Zhishan Chen; Wenqiang Song; Qing Li; Chao Li; Wanqing Wen; Jeroen R. Huyghe; Philip J. Law; Ceres Fernandez-Rozadilla; Maria N. Timofeeva; Minta Thomas; Stephanie L. Schmit; Vicente Martin; Matthew Devall; Christopher Dampier; Ferran Moratalla-Navarro; Qiuyin Cai; Jifeng Wang; Jiajun Shi; Sun-Seog Kweon; Chizu Tanikawa; Wei-Hua Jia; Xiang Shu; Jirong Long; Jing Gao; Jeongseon Kim; Aesun Shin; Keitaro Matsuo; Sun Ha Jee; Keum Ji Jung; Nan Wang; Dong-Hyun Kim; Jie Ping; Gong Yang; Min-Ho Shin; Zefang Ren; Jae Hwan Oh; Isao Oze; Yoon-Ok Ahn; Yu-Tang Gao; Zhi-Zhong Pan; Yoichiro Kamatani; Luc Van Kaer; Lan Wu; Bingshan Li; Koichi Matsuda; Xiao-Ou Shu; Li Hsu; Malcolm G. Dunlop; Stephen B. Gruber; Richard Houlston; Ian Tomlinson; Li Li; Ken S. Lau; Victor Moreno; Graham Casey; Ulrike Peters; Wei Zheng; Xingyi Guo
Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure

全基因组范围的基因-环境交互作用研究利用精确的周围UVB测量发现了162个维生素D状态变异。

Nature Communications
IF15.7
2025-11-280
OAAI
Rasha Shraim; Maria Timofeeva; Cathy Wyse; Jos van Geffen; Michiel van Weele; Roman Romero-Ortuno; Lorna M. Lopez; Marcus E. Kleber; Stefan Pilz; Winfried März; Benjamin S. Fletcher; James F. Wilson; Evropi Theodoratou; Malcolm G. Dunlop; Ross McManus; Lina Zgaga
Accelerated biological aging and its hallmarks in DNA methylation drive the association between unhealthy lifestyles and the onset of colorectal cancer

加速的生物衰老及其在DNA甲基化中的标志物驱动不健康生活方式与结直肠癌发病之间的关联

eBioMedicine
IF10.8
2025-11-050
OAAI
Jing Sun; Min Liu; Xiaoqian Zhang; Xinxuan Li; Jingyu Ye; Jianhui Zhao; Siyun Zhou; Haosen Ji; Yuqian Tan; Zilong Bian; Dongfeng Zhang; Malcolm G. Dunlop; Mingyang Song; Stephanie A. Smith-Warner; Hao Wu; Evropi Theodoratou; Qian Cao; Xue Li
Clinical impact of double-faecal immunochemical testing following implementation into standard triage and investigation of primary care referrals in patients with lower gastrointestinal symptoms

在初级保健转诊中，将双重粪便免疫化学检测纳入标准分诊和检查流程后，其在下消化道症状患者中的临床影响。

BJS Open
IF4.5
2025-09-080
OA
Adam D Gerrard; Yasuko Maeda; Colin Noble; Frances Gunn; Lorna Porteous; Rebecca Cheesbrough; Alastair Thomson; Malcolm G Dunlop; Farhat V N Din; Edinburgh Colorectal Group
A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

对10,000个个体的全基因组关联研究将血浆N-糖组与肝脏疾病和抗炎蛋白联系起来

Nature Communications
IF15.7
2025-07-010
OAAI
Sodbo Sharapov; Anna Timoshchuk; Olga Zaytseva; Denis E. Maslov; Anna Soplenkova; Elizaveta E. Elgaeva; Evgeny S. Tiys; Massimo Mangino; Clemens Wittenbecher; Lennart Karssen; Maria Timofeeva; Arina Nostaeva; Frano Vuckovic; Irena Trbojević-Akmačić; Tamara Štambuk; Sofya Feoktistova; Nadezhda A. Potapova; Viktoria Voroshilova; Frances Williams; Dragan Primorac; Jan Van Zundert; Michel Georges; Karsten Suhre; Massimo Allegri; Nishi Chaturvedi; Malcolm Dunlop; Matthias B. Schulze; Tim Spector; Yakov A. Tsepilov; Gordan Lauc; Yurii S. Aulchenko
Loss of colonic fidelity enables multilineage plasticity and metastasis

结肠特异性的丧失促进多谱系可塑性和转移

Nature
IF48.5
2025-06-040
OAAI
Patrizia Cammareri; Michela Raponi; Yourae Hong; Caroline V. Billard; Nat Peckett; Yujia Zhu; Fausto D. Velez-Bravo; Nicholas T. Younger; Donnchadh S. Dunican; Sebastian Ö.-G. Pohl; Aslihan Bastem Akan; Nora J. Doleschall; John Falconer; Mark White; Jean Quinn; Kathryn Pennel; Roberta Garau; Sudhir B. Malla; Philip D. Dunne; Richard R. Meehan; Owen J. Sansom; Joanne Edwards; Malcolm G. Dunlop; Farhat V. N. Din; Sabine Tejpar; Colin W. Steele; Kevin B. Myant
Trans-ancestry transcriptome-wide association and functional studies to uncover novel susceptibility genes and therapeutic targets for colorectal cancer (vol 9, 124, 2025)

跨祖先转录组-wide关联及功能研究，以揭示结直肠癌的新型易感基因和 therapeutic targets (vol 9, 124, 2025)

NPJ PRECISION ONCOLOGY
IF8
2025-05-270
OA
Wang, Lijuan; Hu, Lidan; Sun, Jing; Zhao, Jianhui; Zhou, Siyun; Liu, Lexin; Yu, Wei; Hu, Yeting; Zhou, Dan; Meng, Xiangrui; Yuan, Zhongshang; Zhang, Honghe; Farrington, Susan; Timofeeva, Maria; Ding, Kefeng; Little, Julian; Dunlop, Malcolm; Theodoratou, Evropi; Li, Xue
Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank (vol 16, 99, 2025)

深度学习和全基因组关联荟萃分析研究英国生物银行中骨髓脂肪含量（vol 16, 99, 2025）

NATURE COMMUNICATIONS
IF15.7
2025-05-090
OA
Xu, Wei; Mesa-Eguiagaray, Ines; Morris, David M.; Wang, Chengjia; Gray, Calum D.; Sjostrom, Samuel; Papanastasiou, Giorgos; Badr, Sammy; Paccou, Julien; Li, Xue; Timmers, Paul R. H. J.; Timofeeva, Maria; Farrington, Susan M.; Dunlop, Malcolm G.; Semple, Scott I.; MacGillivray, Tom; Theodoratou, Evropi; Cawthorn, William P.
Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank

深度学习和全基因组关联荟萃分析在UK Biobank中的骨髓脂肪含量研究

NATURE COMMUNICATIONS
IF15.7
2025-01-020
OA
Xu, Wei; Mesa-Eguiagaray, Ines; Morris, David M.; Wang, Chengjia; Gray, Calum D.; Sjostrom, Samuel; Papanastasiou, Giorgos; Badr, Sammy; Paccou, Julien; Li, Xue; Timmers, Paul R. H. J.; Timofeeva, Maria; Farrington, Susan M.; Dunlop, Malcolm G.; Semple, Scott I.; Macgillivray, Tom; Theodoratou, Evropi; Cawthorn, William P.
Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study

环境空气污染对结直肠癌风险和生存的影响: 来自前瞻性队列和表观遗传孟德尔随机研究的见解

EBIOMEDICINE
IF10.8
2024-05-019
OAAI
Jiang, Fangyuan; Zhao, Jianhui; Sun, Jing; Chen, Wenxi; Zhao, Yuyuan; Zhou, Siyun; Yuan, Shuai; Timofeeva, Maria; Law, Philip J.; Larsson, Susanna C.; Chen, Dong; Houlston, Richard S.; Dunlop, Malcolm G.; Theodoratou, Evropi; Li, Xue

研究方向

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S
Susan M. Farrington
H 指数:62论文数:356被引数:1.6万
E
Evropi Τheodoratou
H 指数:80论文数:528被引数:3.4万
R
Richard S. Houlston
H 指数:120论文数:1,252被引数:6.2万
M
Maria Timofeeva
H 指数:41论文数:163被引数:6,979
A
Albert Tenesa
H 指数:73论文数:258被引数:2.5万
H
Harry Campbell
H 指数:109论文数:538被引数:7.1万
I
Ian Tomlinson
H 指数:129论文数:1,284被引数:6.1万
X
Xue Li
H 指数:48论文数:556被引数:1.0万
F
Farhat V N Din
H 指数:19论文数:56被引数:2,050
P
Philip Law
H 指数:34论文数:265被引数:3,849