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Andrew McGown

university of sussex
H指数:14
被引数:1,174

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In vitro screening of compounds for targeting gastric cancer with Y220C p53 mutation: a molecule combining zinc chelation and a Michael acceptor drives CDKN1 and BBC3 expression to restore a p53-dependent cytotoxicity

靶向Y220C p53突变的胃癌体外化合物筛选：一种结合锌螯合和Michael受体的分子通过驱动CDKN1和BBC3表达恢复p53依赖性细胞毒性

Journal of Enzyme Inhibition and Medicinal Chemistry
IF5.4
2026-05-210
OA
Simon Nannini; Céline Sieffert; Andrew McGown; Xin-Yue Gao; Amanda Jarvis; Georges E. Kostakis; Antal Galvacsi; Csilla Kallay; Ruxandra Moraru; Matthias G. Baud; Sebastian Mandel; Dimitros-Ilias Balourdas; Andreas C. Joerger; Christophe Orvain; Simon Peschard; Audrey Nion; Georg Mellitzer; Sophie Lottiaux; John Spencer; Isabelle Gross; Christian Gaiddon
Use of Aldehyde-Alkyne-Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers

使用醛-炔-胺偶联产生药物化学相关的连接体

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2025-01-250
OAAI
Mcgown, Andrew; Vetma, Vesna; Crepin, Damien; Lin, Yan; Adcock, Claire; Craigon, Conner; Nafie, Jordan; von Emloh, Daniel; Sutton, Lea; Bailey, Kiera; Edmunds, Lewis; Sharma, Manvendra; Wilden, Jonathan D.; Coles, Simon J.; Tizzard, Graham J.; Farnaby, William; Ciulli, Alessio; Kostakis, George E.; Spencer, John
Characterization of the Active Enantiomer and Mapping of the Stereospecific Intermolecular Pattern of a Reference P2X7 Allosteric Antagonist

活性对映异构体的表征及参考P2X7别构拮抗剂立体特异性分子间模式的映射

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
2025-01-220
PRE
Mcgown, A; Renault, N; Barczyk, A; Nafie, J; Barluzzi, L; Guest, D; Tizzard, GJ; Coles, SJ; Leach, D; von Emloh, D; Sutton, L; Bailey, K; Edmunds, L; Greenland, BW; Millet, R; Spencer, J; Dezitter, X
Chirality: a key parameter in chemical probes
RSC CHEMICAL BIOLOGY
IF3.1
2023-01-014
OAAI
McGown, Andrew; Nafie, Jordan; Otayfah, Mohammed; Hassell-Hart, Storm; Tizzard, Graham J. J.; Coles, Simon J. J.; Banks, Rebecca; Marsh, Graham P. P.; Maple, Hannah J. J.; Kostakis, George E. E.; Silvestri, Ilaria Proietti; Colbon, Paul; Spencer, John
Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PLpro
CHEMISTRY-A EUROPEAN JOURNAL
IF3.7
2021-11-2351
OAAI
Gil-Moles, Maria; Tuerck, Sebastian; Basu, Uttara; Pettenuzzo, Andrea; Bhattacharya, Saurav; Rajan, Ananthu; Ma, Xiang; Buessing, Rolf; Woelker, Jessica; Burmeister, Hilke; Hoffmeister, Henrik; Schneeberg, Pia; Prause, Andre; Lippmann, Petra; Kusi-Nimarko, Josephine; Hassell-Hart, Storm; McGown, Andrew; Guest, Daniel; Lin, Yan; Notaro, Anna; Vinck, Robin; Karges, Johannes; Cariou, Kevin; Peng, Kun; Qin, Xue; Wang, Xing; Skiba, Joanna; Szczupak, Lukasz; Kowalski, Konrad; Schatzschneider, Ulrich; Hemmert, Catherine; Gornitzka, Heinz; Milaeva, Elena R.; Nazarov, Alexey A.; Gasser, Gilles; Spencer, John; Ronconi, Luca; Kortz, Ulrich; Cinatl, Jindrich; Bojkova, Denisa; Ott, Ingo

研究方向

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J
John Spencer
H 指数:69论文数:778被引数:1.9万
S
Simon J. Coles
H 指数:61论文数:3,266被引数:2.0万
G
Graham J. Tizzard
H 指数:28论文数:406被引数:2,494
J
Jordan Nafie
H 指数:10论文数:53被引数:414
D
Daniel Guest
H 指数:8论文数:24被引数:241
G
George E. Κostakis
H 指数:38论文数:502被引数:5,650
B
Barnaby W. Greenland
H 指数:27论文数:101被引数:4,326
F
Frances M. Platt
H 指数:85论文数:384被引数:2.6万
D
Damien Crépin
H 指数:10论文数:22被引数:480
M
Manvendra Sharma
H 指数:11论文数:37被引数:343