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A

Alfred C.O. Vertegaal

leiden university medical center
H指数:48
被引数:8,305

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荣誉奖项

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Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control

化学遗传泛素E1抑制剂TAK-243 CRISPR筛选揭示HAPSTR1/HUWE1轴在染色质蛋白质稳态和细胞周期调控中的作用

Science Advances
IF12.5
2026-10-160
OAAI
Nila K. van Overbeek; Linda Clijsters; Martina Wirth; Ilona J. de Graaf; Klaas de Lint; Sidrit Uruci; Amina F. A. S. Teunisse; Vyacheslav Akimov; Arnoud H. de Ru; Maja Vukic; Idil Kirdök; Lucia Daxinger; Peter A. van Veelen; Blagoy Blagoev; Martijn S. Luijsterburg; Rob M. F. Wolthuis; Ilana Berlin; Alfred C. O. Vertegaal
Survey of the human proteostasis network: the ubiquitin-proteasome system

人类蛋白质稳态网络的调查：泛素-蛋白酶体系统

Autophagy
IF14.3
2026-01-010
OA
Suzanne Elsasser; Evan T. Powers; Thomas Stoeger; Xiaojing Sui; Roy D. Kurtzbard; Patricia Martínez-Botía; Margaret A. Wangeline; Alejandro Rodríguez Gama; Edward L. Huttlin; Lisa P. Elia; Jeffery W. Kelly; Jason E. Gestwicki; Judith Frydman; Steven M. Finkbeiner; Eugenia M. Clérico; Richard I. Morimoto; Miguel A. Prado; Alfred C.O. Vertegaal; Kay Hofmann; Daniel J. Finley
LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype
CLINICAL AND TRANSLATIONAL MEDICINE
IF6.8
2024-12-190
OAAI
Cobo-Vuilleumier, Nadia; Rodriguez-Fernandez, Silvia; Lopez-Noriega, Livia; Lorenzo, Petra I.; Franco, Jaime M.; Lachaud, Christian C.; Vazquez, Eugenia Martin; Legido, Raquel Araujo; Dorronsoro, Akaitz; Lopez-Fernandez-Sobrino, Raul; Fernandez-Santos, Beatriz; Serrano, Carmen Espejo; Salas-Lloret, Daniel; van Overbeek, Nila; Ramos-Rodriguez, Mireia; Mateo-Rodriguez, Carmen; Hidalgo, Lucia; Marin-Canas, Sandra; Nano, Rita; Arroba, Ana I.; Caro, Antonio Campos; Vertegaal, Alfred C. O.; Montalvo, Alejandro Martin; Martin, Franz; Aguilar-Diosdado, Manuel; Piemonti, Lorenzo; Pasquali, Lorenzo; Prieto, Roman Gonzalez; Sanchez, Maria Isabel Garcia; Eizirik, Decio L.; Martinez-Brocca, Maria Asuncion; Vives-Pi, Marta; Gauthier, Benoit R.
The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics
NATURE COMMUNICATIONS
IF15.7
2024-07-290
OAAI
Schiffmacher, Diana A. Llerena; Lee, Shun-Hsiao; Kliza, Katarzyna W.; Theil, Arjan F.; Akita, Masaki; Helfricht, Angela; Bezstarosti, Karel; Gonzalo-Hansen, Camila; van Attikum, Haico; Verlaan-de Vries, Matty; Vertegaal, Alfred C. O.; Hoeijmakers, Jan H. J.; Marteijn, Jurgen A.; Lans, Hannes; Demmers, Jeroen A. A.; Vermeulen, Michiel; Sixma, Titia K.; Ogi, Tomoo; Vermeulen, Wim; Pines, Alex
Exome sequencing links the SUMO protease SENP7 with fatal arthrogryposis multiplex congenita, early respiratory failure and neutropenia
JOURNAL OF MEDICAL GENETICS
IF3.7
2023-07-174
OA
Samra, Nadra; Jansen, Nicolette S.; Morani, Ilham; Kakun, Reli Rachel; Zaid, Rinat; Paperna, Tamar; Garcia-Dominguez, Mario; Viner, Yuri; Frankenthal, Hilel; Shinwell, Eric S.; Portnov, Igor; Bakry, Doua; Shalata, Adel; Shapira Rootman, Mika; Kidron, Dvora; Claessens, Laura A.; Wevers, Ron A.; Mandel, Hanna; Vertegaal, Alfred C. O.; Weiss, Karin
A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2023-03-097
OAAI
van den Heuvel, Diana; Kim, Mihyun; Wondergem, Annelotte P.; van der Meer, Paula J.; Witkamp, Myrese; Lambregtse, Ferdy; Kim, Hyun-Suk; Kan, Folkert; Apelt, Katja; Kragten, Angela; Gonzalez-Prieto, Roman; Vertegaal, Alfred C. O.; Yeo, Jung-Eun; Kim, Byung-Gyu; van Doorn, Remco; Scharer, Orlando D.; Luijsterburg, Martijn S.

研究方向

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R
Román González‐Prieto
H 指数:24论文数:102被引数:2,018
M
Martijn S. Luijsterburg
H 指数:44论文数:104被引数:6,288
I
Ivo A. Hendriks
H 指数:30论文数:95被引数:4,458
H
Haico van Attikum
H 指数:53论文数:136被引数:9,225
J
Joost Schimmel
H 指数:17论文数:35被引数:2,253
M
Matthias Mann
H 指数:250论文数:1,440被引数:29.9万
S
Sabine A.G. Cuijpers
H 指数:9论文数:21被引数:548
K
Katja Apelt
H 指数:10论文数:19被引数:500
M
Matty Verlaan–de Vries
H 指数:18论文数:28被引数:2,643
H
Huib Ovaa
H 指数:78论文数:366被引数:2.3万