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H

Haico van Attikum

Leiden University Medical Center
H指数:53
被引数:9,225
浏览量:0

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Site-saturation functional screens identify PALB2 missense variants associated with increased breast cancer risk

位点饱和度功能筛选确定与乳腺癌风险增加相关的PALB2错义变异

Nature Communications
IF15.7
2026-01-190
OAAI
Rick A.C.M. Boonen; Sabine C. Knaup; Roberta Menafra; Merel E. Braspenning; Magdalena B. Rother; Petra Kleiblova; Marketa Janatova; Dina Ruano; Chunling Hu; Huaizhi Huang; Vijai Joseph; Michael Conry; Stephan Heijl; Bas Vroling; Jelle J. Goeman; Matthew Varga; Marcy E. Richardson; Susan L. Kloet; Fergus J. Couch; Maaike P. G. Vreeswijk; Haico van Attikum
CFAP20 salvages arrested RNAPII from the path of co-directional replisomes

CFAP20救助从同向复制体的路径中逮捕了RNAPII

Nature
IF48.5
2026-01-140
OAAI
Sidrit Uruci; Daphne E. C. Boer; Paul W. Chrystal; Maxime Lalonde; Andreas Panagopoulos; George Yakoub; Idil Kirdök; Klaas de Lint; Melanie van der Woude; Tiemen J. Wendel; Sem J. Brussee; Annelotte P. Wondergem; Nila K. van Overbeek; Nini Schotman; Jolanthe Lingeman; Mats Ljungman; Alexander van Oudenaarden; Haico van Attikum; Alfred C. O. Vertegaal; Sylvie M. Noordermeer; Rob M. F. Wolthuis; Matthias Altmeyer; Stephan Hamperl; Vincent Tropepe; Jeroen van den Berg; Diana van den Heuvel; Martijn S. Luijsterburg
The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics
NATURE COMMUNICATIONS
IF15.7
2024-07-290
OAAI
Schiffmacher, Diana A. Llerena; Lee, Shun-Hsiao; Kliza, Katarzyna W.; Theil, Arjan F.; Akita, Masaki; Helfricht, Angela; Bezstarosti, Karel; Gonzalo-Hansen, Camila; van Attikum, Haico; Verlaan-de Vries, Matty; Vertegaal, Alfred C. O.; Hoeijmakers, Jan H. J.; Marteijn, Jurgen A.; Lans, Hannes; Demmers, Jeroen A. A.; Vermeulen, Michiel; Sixma, Titia K.; Ogi, Tomoo; Vermeulen, Wim; Pines, Alex
EXO1 protects BRCA1-deficient cells against toxic DNA lesions
MOLECULAR CELL
IF16.6
2024-02-0110
OAAI
van de Kooij, Bert; Schreuder, Anne; Pavani, Raphael; Garzero, Veronica; Uruci, Sidrit; Wendel, Tiemen J.; Hoeck, Arne van; Alonso, Marta San Martin; Everts, Marieke; Koerse, Dana; Callen, Elsa; Boom, Jasper; Mei, Hailiang; Cuppen, Edwin; Luijsterburg, Martijn S.; van Vugt, Marcel A. T. M.; Nussenzweig, Andre; van Attikum, Haico; Noordermeer, Sylvie M.
XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
NATURE COMMUNICATIONS
IF15.7
2022-08-1311
OAAI
Blessing, Charlotte; Apelt, Katja; van den Heuvel, Diana; Gonzalez-Leal, Claudia; Rother, Magdalena B.; van der Woude, Melanie; Gonzalez-Prieto, Roman; Yifrach, Adi; Parnas, Avital; Shah, Rashmi G.; Kuo, Tia Tyrsett; Boer, Daphne E. C.; Cai, Jin; Kragten, Angela; Kim, Hyun-Suk; Scharer, Orlando D.; Vertegaal, Alfred C. O.; Shah, Girish M.; Adar, Sheera; Lans, Hannes; van Attikum, Haico; Ladurner, Andreas G.; Luijsterburg, Martijn S.
A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair

破坏PALB2相互作用的BRCA1卷曲螺旋结构域变体促进乳腺肿瘤的发展，并在同源重组修复中赋予可靶向的缺陷

CANCER RESEARCH
IF16.6
2021-12-157
OA
Pulver, Emilia M.; Mukherjee, Chirantani; van de Kamp, Gerarda; Roobol, Stefan J.; Rother, Magdalena B.; van der Gulden, Hanneke; de Bruijn, Roebi; Lattanzio, Maria Valeria; van der Burg, Eline; Drenth, Anne Paulien; Verkaik, Nicole S.; Hahn, Kerstin; Klarenbeek, Sjoerd; De Korte-Grimmerink, Renske; van de Ven, Marieke; Pritchard, Colin E. J.; Huijbers, Ivo J.; Xia, Bing; van Gent, Dik C.; Essers, Jeroen; van Attikum, Haico; Chaudhuri, Arnab Ray; Bouwman, Peter; Jonkers, Jos

研究方向

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M
Martijn S. Luijsterburg
H 指数:44论文数:104被引数:6,288
W
Wouter W. Wiegant
H 指数:28论文数:53被引数:3,492
M
Magdalena B. Rother
H 指数:19论文数:60被引数:1,419
A
Alfred C.O. Vertegaal
H 指数:48论文数:156被引数:8,305
A
Angela Helfricht
H 指数:13论文数:29被引数:723
R
Rick A.C.M. Boonen
H 指数:13论文数:40被引数:1,691
S
Susan M. Gasser
H 指数:97论文数:380被引数:3.1万
T
Trey Ideker
H 指数:108论文数:635被引数:12.0万
R
Rohith Srivas
H 指数:19论文数:48被引数:5,816
F
Fred van Leeuwen
H 指数:41论文数:126被引数:6,062