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Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease 粘膜转录组学突出了与溃疡性结肠炎，克罗恩病和乳糜泻有关的lncRNAs Braun, Tzipi; Sosnovski, Katya E.; Amir, Amnon; BenShoshan, Marina; VanDussen, Kelli L.; Karns, Rebekah; Levhar, Nina; Abbas-Egbariya, Haya; Hadar, Rotem; Efroni, Gilat; Castel, David; Avivi, Camila; Rosen, Michael J.; Grifiths, Anne M.; Walters, Thomas D.; Mack, David R.; Boyle, Brendan M.; Ali, Syed Asad; Moore, Sean R.; Schirmer, Melanie; Xavier, Ramnik J.; Kugathasan, Subra; Jegga, Anil G.; Weiss, Batya; Mayer, Chen; Barshack, Iris; Ben-Horin, Shomron; Ulitsky, Igor; Beucher, Anthony; Ferrer, Jorge; Hyams, Jeffrey S.; Denson, Lee A.; Haberman, Yael 分享 收藏
SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension Walters, Rachel; Vasilaki, Eleni; Aman, Jurjan; Chen, Chien-Nien; Wu, Yukyee; Liang, Olin D.; Ashek, Ali; Dubois, Olivier; Zhao, Lin; Sabrin, Farah; Cebola, Ines; Ferrer, Jorge; Morrell, Nicholas W.; Klinger, James R.; Wilkins, Martin R.; Zhao, Lan; Rhodes, Christopher J. 分享 收藏
Matters arising: Insufficient evidence that pancreatic b cells are derived from adult ductal Neurog3-expressing progenitors Magenheim, Judith; Maestro, Miguel Angel; Sharon, Nadav; Herrera, Pedro L.; Murtaugh, L. Charles; Kopp, Janel; Sander, Maike; Gu, Guoqiang; Melton, Douglas A.; Ferrer, Jorge; Dor, Yuval 分享 收藏
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Hnf1α (MODY3) Controls Tissue-Specific Transcriptional Programs and Exerts Opposed Effects on Cell Growth in Pancreatic Islets and Liver Hnf1α (MODY3) 控制组织特异性转录程序，并对胰岛和肝脏的细胞生长产生相反的影响 Servitja, Joan-Marc; Pignatelli, Miguel; Angel Maestro, Miguel; Cardalda, Carina; Boj, Sylvia F.; Lozano, Juanjo; Blanco, Enrique; Lafuente, Amalia; McCarthy, Mark I.; Sumoy, Lauro; Guigo, Roderic; Ferrer, Jorge 分享 收藏
Pancreatic microexons regulate islet function and glucose homeostasis Juan-Mateu, Jonas; Bajew, Simon; Miret-Cuesta, Marta; iniguez, Luis P.; Lopez-Pascual, Amaya; Bonnal, Sophie; Atla, Goutham; Bonas-Guarch, Silvia; Ferrer, Jorge; Valcarcel, Juan; Irimia, Manuel 分享 收藏
Current challenges in understanding the role of enhancers in disease 了解增强剂在疾病中的作用的当前挑战 Zaugg, Judith Barbara; Sahlen, Pelin; Andersson, Robin; Alberich-Jorda, Meritxell; de Laat, Wouter; Deplancke, Bart; Ferrer, Jorge; Mandrup, Susanne; Natoli, Gioacchino; Plewczynski, Dariusz; Rada-Iglesias, Alvaro; Spicuglia, Salvatore 分享 收藏
The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A Beucher, Anthony; Miguel-Escalada, Irene; Balboa, Diego; De Vas, Matias G.; Angel Maestro, Miguel; Garcia-Hurtado, Javier; Bernal, Aina; Gonzalez-Franco, Roser; Vargiu, Pierfrancesco; Heyn, Holger; Ravassard, Philippe; Ortega, Sagrario; Ferrer, Jorge 分享 收藏
Genetic regulation of RNA splicing in human pancreatic islets Atla, Goutham; Bonas-Guarch, Silvia; Cuenca-Ardura, Mirabai; Beucher, Anthony; Crouch, Daniel J. M.; Garcia-Hurtado, Javier; Moran, Ignasi; Irimia, Manuel; Prasad, Rashmi B.; Gloyn, Anna L.; Marselli, Lorella; Suleiman, Mara; Berney, Thierry; de Koning, Eelco J. P.; Kerr-Conte, Julie; Pattou, Francois; Todd, John A.; Piemonti, Lorenzo; Ferrer, Jorge 分享 收藏
Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway 胰腺导管细胞中Arid1a和Pten的丢失通过YAP/TAZ途径诱导导管内肾小管乳头状肿瘤 Fukunaga, Yuichi; Fukuda, Akihisa; Omatsu, Mayuki; Namikawa, Mio; Sono, Makoto; Masuda, Tomonori; Araki, Osamu; Nagao, Munemasa; Yoshikawa, Takaaki; Ogawa, Satoshi; Hiramatsu, Yukiko; Muta, Yu; Tsuda, Motoyuki; Maruno, Takahisa; Nakanishi, Yuki; Ferrer, Jorge; Tsuruyama, Tatsuaki; Masui, Toshihiko; Hatano, Etsuro; Seno, Hiroshi 分享 收藏
Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster Miguel-Escalada, Irene; Maestro, Miguel Angel; Balboa, Diego; Elek, Anamaria; Bernal, Aina; Bernardo, Edgar; Grau, Vanessa; Garcia-Hurtado, Javier; Sebe-Pedros, Arnau; Ferrer, Jorge 分享 收藏
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation 2型糖尿病的多血统遗传研究突出了不同人群发现和翻译的力量 Mahajan, Anubha; Spracklen, Cassandra N.; Zhang, Weihua; Ng, Maggie C. Y.; Petty, Lauren E.; Kitajima, Hidetoshi; Yu, Grace Z.; Rueger, Sina; Speidel, Leo; Kim, Young Jin; Horikoshi, Momoko; Mercader, Josep M.; Taliun, Daniel; Moon, Sanghoon; Kwak, Soo-Heon; Robertson, Neil R.; Rayner, Nigel W.; Loh, Marie; Kim, Bong-Jo; Chiou, Joshua; Miguel-Escalada, Irene; Parolo, Pietro della Briotta; Lin, Kuang; Bragg, Fiona; Preuss, Michael H.; Takeuchi, Fumihiko; Nano, Jana; Guo, Xiuqing; Lamri, Amel; Nakatochi, Masahiro; Scott, Robert A.; Lee, Jung-Jin; Huerta-Chagoya, Alicia; Graff, Mariaelisa; Chai, Jin-Fang; Parra, Esteban J.; Yao, Jie; Bielak, Lawrence F.; Tabara, Yasuharu; Hai, Yang; Steinthorsdottir, Valgerdur; Cook, James P.; Kals, Mart; Grarup, Niels; Schmidt, Ellen M.; Pan, Ian; Sofer, Tamar; Wuttke, Matthias; Sarnowski, Chloe; Gieger, Christian; Nousome, Darryl; Trompet, Stella; Long, Jirong; Sun, Meng; Tong, Lin; Chen, Wei-Min; Ahmad, Meraj; Noordam, Raymond; Lim, Victor J. Y.; Tam, Claudia H. T.; Joo, Yoonjung Yoonie; Chen, Chien-Hsiun; Raffield, Laura M.; Lecoeur, Cecile; Prins, Bram Peter; Nicolas, Aude; Yanek, Lisa R.; Chen, Guanjie; Jensen, Richard A.; Tajuddin, Salman; Kabagambe, Edmond K.; An, Ping; Xiang, Anny H.; Choi, Hyeok Sun; Cade, Brian E.; Tan, Jingyi; Flanagan, Jack; Abaitua, Fernando; Adair, Linda S.; Adeyemo, Adebowale; Aguilar-Salinas, Carlos A.; Akiyama, Masato; Anand, Sonia S.; Bertoni, Alain; Bian, Zheng; Bork-Jensen, Jette; Brandslund, Ivan; Brody, Jennifer A.; Brummett, Chad M.; Buchanan, Thomas A.; Canouil, Mickael; Chan, Juliana C. N.; Chang, Li-Ching; Chee, Miao-Li; Chen, Ji; Chen, Shyh-Huei; Chen, Yuan-Tsong; Chen, Zhengming; Chuang, Lee-Ming; Cushman, Mary; Das, Swapan K.; de Silva, H. Janaka; Dedoussis, George; Dimitrov, Latchezar; Doumatey, Ayo P.; Du, Shufa; Duan, Qing; Eckardt, Kai-Uwe; Emery, Leslie S.; Evans, Daniel S.; Evans, Michele K.; Fischer, Krista; Floyd, James S.; Ford, Ian; Fornage, Myriam; Franco, Oscar H.; Frayling, Timothy M.; Freedman, Barry, I; Fuchsberger, Christian; Genter, Pauline; Gerstein, Hertzel C.; Giedraitis, Vilmantas; Gonzalez-Villalpando, Clicerio; Gonzalez-Villalpando, Maria Elena; Goodarzi, Mark O.; Gordon-Larsen, Penny; Gorkin, David; Gross, Myron; Guo, Yu; Hackinger, Sophie; Han, Sohee; Hattersley, Andrew T.; Herder, Christian; Howard, Annie-Green; Hsueh, Willa; Huang, Mengna; Huang, Wei; Hung, Yi-Jen; Hwang, Mi Yeong; Hwu, Chii-Min; Ichihara, Sahoko; Ikram, Mohammad Arfan; Ingelsson, Martin; Islam, Md Tariqul; Isono, Masato; Jang, Hye-Mi; Jasmine, Farzana; Jiang, Guozhi; Jonas, Jost B.; Jorgensen, Marit E.; Jorgensen, Torben; Kamatani, Yoichiro; Kandeel, Fouad R.; Kasturiratne, Anuradhani; Katsuya, Tomohiro; Kaur, Varinderpal; Kawaguchi, Takahisa; Keaton, Jacob M.; Kho, Abel N.; Khor, Chiea-Chuen; Kibriya, Muhammad G.; Kim, Duk-Hwan; Kohara, Katsuhiko; Kriebel, Jennifer; Kronenberg, Florian; Kuusisto, Johanna; Lall, Kristi; Lange, Leslie A.; Lee, Myung-Shik; Lee, Nanette R.; Leong, Aaron; Li, Liming; Li, Yun; Li-Gao, Ruifang; Ligthart, Symen; Lindgren, Cecilia M.; Linneberg, Allan; Liu, Ching-Ti; Liu, Jianjun; Locke, Adam E.; Louie, Tin; Luan, Jian'an; Luk, Andrea O.; Luo, Xi; Lv, Jun; Lyssenko, Valeriya; Mamakou, Vasiliki; Mani, K. Radha; Meitinger, Thomas; Metspalu, Andres; Morris, Andrew D.; Nadkarni, Girish N.; Nadler, Jerry L.; Nalls, Michael A.; Nayak, Uma; Nongmaithem, Suraj S.; Ntalla, Ioanna; Okada, Yukinori; Orozco, Lorena; Patel, Sanjay R.; Pereira, Mark A.; Peters, Annette; Pirie, Fraser J.; Porneala, Bianca; Prasad, Gauri; Preissl, Sebastian; Rasmussen-Torvik, Laura J.; Reiner, Alexander P.; Roden, Michael; Rohde, Rebecca; Roll, Kathryn; Sabanayagam, Charumathi; Sander, Maike; Sandow, Kevin; Sattar, Naveed; Schonherr, Sebastian; Schurmann, Claudia; Shahriar, Mohammad; Shi, Jinxiu; Shin, Dong Mun; Shriner, Daniel; Smith, Jennifer A.; So, Wing Yee; Stancakova, Alena; Stilp, Adrienne M.; Strauch, Konstantin; Suzuki, Ken; Takahashi, Atsushi; Taylor, Kent D.; Thorand, Barbara; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tomlinson, Brian; Torres, Jason M.; Tsai, Fuu-Jen; Tuomilehto, Jaakko; Tusie-Luna, Teresa; Udler, Miriam S.; Valladares-Salgado, Adan; van Dam, Rob M.; van Klinken, Jan B.; Varma, Rohit; Vujkovic, Marijana; Wacher-Rodarte, Niels; Wheeler, Eleanor; Whitsel, Eric A.; Wickremasinghe, Ananda R.; van Dijk, Ko Willems; Witte, Daniel R.; Yajnik, Chittaranjan S.; Yamamoto, Ken; Yamauchi, Toshimasa; Yengo, Loic; Yoon, Kyungheon; Yu, Canqing; Yuan, Jian-Min; Yusuf, Salim; Zhang, Liang; Zheng, Wei; Raffel, Leslie J.; Igase, Michiya; Ipp, Eli; Redline, Susan; Cho, Yoon Shin; Lind, Lars; Province, Michael A.; Hanis, Craig L.; Peyser, Patricia A.; Ingelsson, Erik; Zonderman, Alan B.; Psaty, Bruce M.; Wang, Ya-Xing; Rotimi, Charles N.; Becker, Diane M.; Matsuda, Fumihiko; Liu, Yongmei; Zeggini, Eleftheria; Yokota, Mitsuhiro; Rich, Stephen S.; Kooperberg, Charles; Pankow, James S.; Engert, James C.; Chen, Yii-Der Ida; Froguel, Philippe; Wilson, James G.; Sheu, Wayne H. H.; Kardia, Sharon L. R.; Wu, Jer-Yuarn; Hayes, M. Geoffrey; Ma, Ronald C. W.; Wong, Tien-Yin; Groop, Leif; Mook-Kanamori, Dennis O.; Chandak, Giriraj R.; Collins, Francis S.; Bharadwaj, Dwaipayan; Pare, Guillaume; Sale, Michele M.; Ahsan, Habibul; Motala, Ayesha A.; Shu, Xiao-Ou; Park, Kyong-Soo; Jukema, J. Wouter; Cruz, Miguel; McKean-Cowdin, Roberta; Grallert, Harald; Cheng, Ching-Yu; Bottinger, Erwin P.; Dehghan, Abbas; Tai, E-Shyong; Dupuis, Josee; Kato, Norihiro; Laakso, Markku; Kottgen, Anna; Koh, Woon-Puay; Palmer, Colin N. A.; Liu, Simin; Abecasis, Goncalo; Kooner, Jaspal S.; Loos, Ruth J. F.; North, Kari E.; Haiman, Christopher A.; Florez, Jose C.; Saleheen, Danish; Hansen, Torben; Pedersen, Oluf; Magi, Reedik; Langenberg, Claudia; Wareham, Nicholas J.; Maeda, Shiro; Kadowaki, Takashi; Lee, Juyoung; Millwood, Iona Y.; Walters, Robin G.; Stefansson, Kari; Myers, Simon R.; Ferrer, Jorge; Gaulton, Kyle J.; Meigs, James B.; Mohlke, Karen L.; Gloyn, Anna L.; Bowden, Donald W.; Below, Jennifer E.; Chambers, John C.; Sim, Xueling; Boehnke, Michael; Rotter, Jerome, I; McCarthy, Mark, I; Morris, Andrew P. 分享 收藏
Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice Nagao, Munemasa; Fukuda, Akihisa; Omatsu, Mayuki; Namikawa, Mio; Sono, Makoto; Fukunaga, Yuichi; Masuda, Tomonori; Araki, Osamu; Yoshikawa, Takaaki; Ogawa, Satoshi; Masuo, Kenji; Goto, Norihiro; Hiramatsu, Yukiko; Muta, Yu; Tsuda, Motoyuki; Maruno, Takahisa; Nakanishi, Yuki; Taketo, Makoto Mark; Ferrer, Jorge; Tsuruyama, Tatsuaki; Nakanuma, Yasuni; Taura, Kojiro; Uemoto, Shinji; Seno, Hiroshi 分享 收藏
TIGER: The gene expression regulatory variation landscape of human pancreatic islets 老虎: 人类胰岛的基因表达调控变异景观 Alonso, Lorena; Piron, Anthony; Moran, Ignasi; Guindo-Martinez, Marta; Bonas-Guarch, Silvia; Atla, Goutham; Miguel-Escalada, Irene; Royo, Romina; Puiggros, Montserrat; Garcia-Hurtado, Xavier; Suleiman, Mara; Marselli, Lorella; Esguerra, Jonathan L. S.; Turatsinze, Jean-Valery; Torres, Jason M.; Nylander, Vibe; Chen, Ji; Eliasson, Lena; Defrance, Matthieu; Amela, Ramon; Mulder, Hindrik; Gloyn, Anna L.; Groop, Leif; Marchetti, Piero; Eizirik, Decio L.; Ferrer, Jorge; Mercader, Josep M.; Cnop, Miriam; Torrents, David 分享 收藏
CRISPR-based genome editing in primary human pancreatic islet cells Bevacqua, Romina J.; Dai, Xiaoqing; Lam, Jonathan Y.; Gu, Xueying; Friedlander, Mollie S. H.; Tellez, Krissie; Miguel-Escalada, Irene; Bonas-Guarch, Silvia; Atla, Goutham; Zhao, Weichen; Kim, Seung Hyun; Dominguez, Antonia A.; Qi, Lei S.; Ferrer, Jorge; MacDonald, Patrick E.; Kim, Seung K. 分享 收藏
Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene Akerman, Ildem; Maestro, Miguel Angel; De Franco, Elisa; Grau, Vanessa; Flanagan, Sarah; Garcia-Hurtado, Javier; Mittler, Gerhard; Ravassard, Philippe; Piemonti, Lorenzo; Ellard, Sian; Hattersley, Andrew T.; Ferrer, Jorge 分享 收藏
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