Phillip T. Hawkins - Publications, H-index & Citations

Phillip T. Hawkins

Babraham Institute

76H指数

259论文数

2.4W被引数

收录论文 98

发表时间

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression PTEN蛋白磷酸酶活性参与胚胎发育和肿瘤抑制的证据

Cancer Science

IF4.3

2026-08-18

OAAI

Priyanka Tibarewal; Laura Spinelli; Nisha Kriplani; Helen Wise; Nadege Poncet; Giulia Marzano; Karen E. Anderson; Katarzyna M. Grzes; Zofia Varyova; Mahreen Adil; C. Peter Downes; Phillip T. Hawkins; Len R. Stephens; Kate G. Storey; Doreen A. Cantrell; Bart Vanhaesebroeck; Nicholas R. Leslie

P-Rex1 controls phagocytosis and the killing of bacteria by murine neutrophils independently of its catalytic activity P-Rex1通过独立于其催化活性的方式调控小鼠中性粒细胞的吞噬作用及对细菌的杀伤。

Frontiers in Immunology

IF5.9

2025-09-30

OAAI

Priota Islam; Julia Y. Chu†; Stephen A. Chetwynd†; Rachael Walker; Phillip T. Hawkins; Heidi C. E. Welch

FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism FGF诱导的磷脂酶Cγ信号通过在磷脂酰肌醇代谢中与PI3K竞争来调节泪腺分支。

Cell Reports

IF6.9

2025-07-23

PREAI

Qian Wang; Chenqi Tao; Yihua Wu; Karen E. Anderson; Neoklis Makrides; Abdul Hannan; John Peregrin; Chyuan-sheng Lin; Zhipeng Ding; Wei Li; Phillip Hawkins; Len Stephens; Xin Zhang

The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types CDS1与CDS2之间的合成致死相互作用是葡萄膜黑色素瘤以及多种肿瘤类型的易损性。

Nature Genetics

IF0

2025-07-04

OAAI

Pui Ying Chan; Diana Alexander; Ishan Mehta; Larissa Satiko Alcantara Sekimoto Matsuyama; Victoria Harle; Rebeca Olvera-León; Jun Sung Park; Fernanda G. Arriaga-González; Louise van der Weyden; Saamin Cheema; Vivek Iyer; Victoria Offord; David Barneda; Phillip T. Hawkins; Len Stephens; Zuza Kozik; Michael Woods; Kim Wong; Gabriel Balmus; Alessandro Vinceti; Nicola A. Thompson; Martin Del Castillo Velasco-Herrera; Lodewyk Wessels; Joris van de Haar; Emanuel Gonçalves; Sanju Sinha; Martha Estefania Vázquez-Cruz; Luisa Bisceglia; Francesco Raimondi; Jyoti Choudhary; Sumeet Patiyal; Anjan Venkatesh; Francesco Iorio; Colm J. Ryan; David J. Adams

Phosphoinositide acyl chain diversity: comparative analysis across species and mouse tissues 磷脂酰肌醇酰基链多样性：跨物种及小鼠组织的比较分析

biochimica et biophysica acta molecular and cell biology of lipids

IF0

2025-05-28

OAAI

David Barneda; Vishnu Janardan; John Swales; Maria Ciaccia; Richard Goodwin; Sabina Cosulich; Padinjat Raghu; Jonathan Clark; Len Stephens; Phillip Hawkins

Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling 肝脏基因表达及其在肝脂肪变性中的重塑由PI3Kα依赖性肝细胞信号通路调控

PLOS BIOLOGY

IF7.2

2025-04-14

OAAI

Regnier, Marion; Polizzi, Arnaud; Fougeray, Tiffany; Fougerat, Anne; Perrier, Prunelle; Anderson, Karen; Lippi, Yannick; Smati, Sarra; Lukowicz, Celine; Lasserre, Frederic; Fouche, Edwin; Huillet, Marine; Rives, Clemence; Tramunt, Blandine; Naylies, Claire; Garcia, Geraldine; Rousseau-Bacquie, Elodie; Bertrand-Michel, Justine; Canlet, Cecile; Chevolleau-Mege, Sylvie; Debrauwer, Laurent; Heymes, Christophe; Burcelin, Remy; Levade, Thierry; Gourdy, Pierre; Wahli, Walter; Blum, Yuna; Gamet-Payrastre, Laurence; Ellero-Simatos, Sandrine; Guillermet-Guibert, Julie; Hawkins, Phillip; Stephens, Len; Postic, Catherine; Montagner, Alexandra; Loiseau, Nicolas; Guillou, Herve

Co-designing a nutritional navigation guide for people with psoriasis: a user-centred design approach

PROCEEDINGS OF THE NUTRITION SOCIETY

IF4.5

2024-12-16

PREAI

Hawkins, P.; Earl, K.; Tektonidis, T. G.; Fallaize, R.

CDS2 expression regulates de novo phosphatidic acid synthesis

BIOCHEMICAL JOURNAL

IF4.3

2024-10-11

OAAI

Collins, Daniel M.; Janardan, Vishnu; Barneda, David; Anderson, Karen E.; Niewczas, Izabella; Taylor, Diane; Qiu, Danye; Jessen, Henning J.; Lopez-Clavijo, Andrea F.; Walker, Simon; Raghu, Padinjat; Clark, Jonathan; Stephens, Len R.; Hawkins, Phillip T.

The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2024-09-01

OAAI

Chan, Victoria; Camardi, Cristina; Zhang, Kai; Orofiamma, Laura A.; Anderson, Karen E.; Hoque, Jafarul; Bone, Leslie N.; Awadeh, Yasmin; Lee, Daniel K. C.; Fu, Norman J.; Chow, Jonathan T. S.; Salmena, Leonardo; Stephens, Len R.; Hawkins, Phillip T.; Antonescu, Costin N.; Botelho, Roberto J.

The perceived role of diet in the management of psoriasis in UK adults with psoriasis: a qualitative study

PROCEEDINGS OF THE NUTRITION SOCIETY

IF4.5

2024-01-08

OAAI

Hawkins, P.; Mason, S.; Earl, K.; Tektonidis, T.; Fallaize, R.

PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate PLEKHS1在PTEN无效的前列腺中驱动PI3Ks并重塑通路稳态

MOLECULAR CELL

IF16.6

2023-08-01

OAAI

Chessa, Tamara A. M.; Jung, Piotr; Anwar, Arqum; Suire, Sabine; Anderson, Karen E.; Barneda, David; Kielkowska, Anna; Sadiq, Barzan A.; Lai, Ieng Wai; Felisbino, Sergio; Turnham, Daniel J.; Pearson, Helen B.; Phillips, Wayne A.; Sasaki, Junko; Sasaki, Takehiko; Oxley, David; Spensberger, Dominik; Segonds-Pichon, Anne; Wilson, Michael; Walker, Simon; Okkenhaug, Hanneke; Cosulich, Sabina; Hawkins, Phillip T.; Stephens, Len R.

The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer- related alterations of the endosomal-autophagic-lysosomal system 合成的TRPML1激动剂ML-SA1挽救了阿尔茨海默氏症相关的内体-自噬-溶酶体系统的改变

JOURNAL OF CELL SCIENCE

IF3.6

2023-03-21

OAAI

Somogyi, Aleksandra; Kirkham, Emily D.; Lloyd-Evans, Emyr; Winston, Jincy; Allen, Nicholas D.; Mackrill, John J.; Anderson, Karen E.; Hawkins, Phillip T.; Gardiner, Sian E.; Waller-Evans, Helen; Sims, Rebecca; Boland, Barry; O'Neill, Cora

The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles 肌醇-3-磷酸合酶生物合成酶具有不同的催化和代谢作用

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-17

OAAI

Frej, Anna D.; Clark, Jonathan; Le Roy, Caroline I.; Lilla, Sergio; Thomason, Peter A.; Otto, Grant P.; Churchill, Grant; Insall, Robert H.; Claus, Sandrine P.; Hawkins, Phillip; Stephens, Len; Williams, Robin S. B.

FRONTIERS IN IMMUNOLOGY

IF5.9

2022-08-24

OAAI

Hornigold, Kirsti; Chu, Julia Y.; Chetwynd, Stephen A.; Machin, Polly A.; Crossland, Laraine; Pantarelli, Chiara; Anderson, Karen E.; Hawkins, Phillip T.; Segonds-Pichon, Anne; Oxley, David; Welch, Heidi C. E.

ARFs get the BioID treatment: what have we been missing?ARFs得到BioID治疗: 我们错过了什么？

EMBO JOURNAL

IF8.3

2022-08-05

OAAI

Barneda, David; Stephens, Len; Hawkins, Phillip

The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling

JOURNAL OF CELL BIOLOGY

IF6.4

2022-07-25

OAAI

Droubi, Alaa; Wallis, Connor; Anderson, Karen E.; Rahman, Saifur; de Sa, Aloka; Rahman, Taufiq; Stephens, Len R.; Hawkins, Philip T.; Lowe, Martin

Acyl chain selection couples the consumption and synthesis of phosphoinositides 酰基链选择耦合磷酸肌醇的消耗和合成

EMBO JOURNAL

IF8.3

2022-06-30

OAAI

Barneda, David; Janardan, Vishnu; Niewczas, Izabella; Collins, Daniel M.; Cosulich, Sabina; Clark, Jonathan; Stephens, Len R.; Hawkins, Phillip T.

Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase

NATURE CELL BIOLOGY

IF19.1

2022-04-28

OAAI

Walpole, Glenn F. W.; Pacheco, Jonathan; Chauhan, Neha; Clark, Jonathan; Anderson, Karen E.; Abbas, Yazan M.; Brabant-Kirwan, Danielle; Montano-Rendon, Fernando; Liu, Zetao; Zhu, Hongxian; Brumell, John H.; Deiters, Alexander; Stephens, Len R.; Hawkins, Phillip T.; Hammond, Gerald R., V; Grinstein, Sergio; Fairn, Gregory D.

PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naive and Differentiated CD4+ T Cells PI3Kδ 在幼稚和分化的CD4 T细胞的TCR信号小体上形成不同的多蛋白复合物

FRONTIERS IN IMMUNOLOGY

IF5.9

2021-03-08

OAAI

Luff, Daisy H.; Wojdyla, Katarzyna; Oxley, David; Chessa, Tamara; Hudson, Kevin; Hawkins, Phillip T.; Stephens, Len R.; Barry, Simon T.; Okkenhaug, Klaus

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

SCIENCE SIGNALING

IF6.6

2020-11-03

OAAI

Rynkiewicz, Natalie K.; Anderson, Karen E.; Suire, Sabine; Collins, Daniel M.; Karanasios, Eleftherios; Vadas, Oscar; Williams, Roger; Oxley, David; Clark, Jonathan; Stephens, Len R.; Hawkins, Phillip T.

研究方向