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H1-0 is a specific mediator of the repressive ETV6::RUNX1 transcriptional landscape in preleukemia and B cell acute lymphoblastic leukemia H1-0是前白血病和B细胞急性淋巴细胞白血病中抑制性ETV6::RUNX1转录景观的特异性介导因子。 Jepsen, Vera H.; Hanel, Andrea; Picard, Daniel; Bhave, Rigveda; Hasselmann, Rebecca; Mehtonen, Juha; Schliehe-Diecks, Julian; Kath, Carla-Johanna; Suppiyar, Vithusan; Prasad, Yash; Schaal, Katerina; Tu, Jia-Wey; Ruechel, Nadine; Kameri, Ersen; Qin, Nan; Wang, Herui; Zhuang, Zhengping; Wagener, Rabea; Bluemel, Lena; Lautwein, Tobias; Hein, Daniel; Koppstein, David; Koegler, Gesine; Remke, Marc; Heinaeniemi, Merja; Borkhardt, Arndt; Fischer, Ute 分享 收藏
PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma PLK1阻断增强了MAPK抑制在胰腺导管腺癌中的抗肿瘤效果 Zhao, Ben; Fang, Rui; Schuermann, Hendrik; Hemmer, Erik Jan; Mayer, Gina Lauren; Trajkovic-Arsic, Marija; Althoff, Kristina; Yang, Jiajin; Godfrey, Laura; Liffers, Sven T.; Savvatakis, Konstantinos; Dorsch, Madeleine; Gruener, Barbara M.; Hahn, Stephan; Remke, Marc; Lueong, Smiths S.; Siveke, Jens T. 分享 收藏
Alpha/beta values in pediatric medulloblastoma: implications for tailored approaches in radiation oncology Jazmati, Danny; Sohn, Dennis; Hoerner-Rieber, Juliane; Qin, Nan; Boelke, Edwin; Haussmann, Jan; Schwarz, Rudolf; Niggemeier, Niklas David; Borkhardt, Arndt; Babor, Florian; Brozou, Triantafyllia; Felek, Melissa; Tamaskovics, Balint; Melchior, Patrick; Beez, Thomas; Timmermann, Beate; Remke, Marc; Corradini, Stefanie; Schulz, Remi Till; Preugschas, Ronja-Linda; Budach, Wilfried; Matuschek, Christiane 分享 收藏
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HERV-W ENVELOPE PROTEIN IS PRESENT IN MICROGLIAL CELLS OF THE HUMAN GLIOMA TUMOR MICROENVIRONMENT AND DIFFERENTIALLY MODULATES NEOPLASTIC CELL BEHAVIOR Reiche, L.; Plaack, B.; Lehmkuhl, M.; Weyers, V; Gruchot, J.; Picard, D.; Perron, H.; Remke, M.; Reifenberger, G.; Kuery, P.; Knobbe-Thomsen, C.; Kremer, D. 分享 收藏
A clinically compatible in vitro drug-screening platform identifies therapeutic vulnerabilities in primary cultures of brain metastases 临床兼容的体外药物筛选平台可确定脑转移原代培养物中的治疗脆弱性 Jeising, Sebastian; Nickel, Ann-Christin; Truebel, Johanna; Felsberg, Joerg; Picard, Daniel; Leprivier, Gabriel; Wolter, Marietta; Huynh, My Ky; Olivera, Marlene B.; Kaulich, Kerstin; Haeberle, Lena; Esposito, Irene; Klau, Gunnar W.; Steinmann, Julia; Beez, Thomas; Rapp, Marion; Sabel, Michael; Dietrich, Sascha; Remke, Marc; Cornelius, Jan F.; Reifenberger, Guido; Qin, Nan 分享 收藏
INTEGRATED MULTI-OMICS EXPLORATION OF MAPK PATHWAY INHIBITION IN PEDIATRIC PILOCYTIC ASTROCYTOMA Sigaud, Romain; Stefanski, Anja; Selt, Florian; Usta, Diren; Kocher, Daniela; Picard, Daniel; Buedenbender, Isabel; Remke, Marc; Pfister, Stefan M.; Jones, David T. W.; Brummer, Tilman; Witt, Olaf; Milde, Till 分享 收藏
mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism Levy, Tal; Voeltzke, Kai; Hruby, Laura; Alasad, Khawla; Bas, Zuelal; Snaebjoernsson, Marteinn; Marciano, Ran; Scharov, Katerina; Planque, Melanie; Vriens, Kim; Christen, Stefan; Funk, Cornelius M.; Hassiepen, Christina; Kahler, Alisa; Heider, Beate; Picard, Daniel; Lim, Jonathan K. M.; Stefanski, Anja; Bendrin, Katja; Vargas-Toscano, Andres; Kahlert, Ulf D.; Stuehler, Kai; Remke, Marc; Elkabets, Moshe; Gruenewald, Thomas G. P.; Reichert, Andreas S.; Fendt, Sarah-Maria; Schulze, Almut; Reifenberger, Guido; Rotblat, Barak; Leprivier, Gabriel 分享 收藏
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines Kocher, Daniela; Cao, Lei; Guiho, Romain; Langhammer, Melanie; Lai, Yun-Lu; Becker, Pauline; Hamdi, Hiba; Friedel, Dennis; Selt, Florian; Vonhoeren, David; Zaman, Julia; Valinciute, Gintvile; Herter, Sonja; Picard, Daniel; Rettenmeier, Johanna; Maass, Kendra K.; Pajtler, Kristian W.; Remke, Marc; von Deimling, Andreas; Pusch, Stefan; Pfister, Stefan M.; Oehme, Ina; Jones, David T. W.; Halbach, Sebastian; Brummer, Tilman; Martinez-Barbera, Juan Pedro; Witt, Olaf; Milde, Till; Sigaud, Romain 分享 收藏
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Proteogenomic profiling uncovers differential therapeutic vulnerabilities between TCF3::PBX1 and TCF3::HLF translocated B-cell acute lymphoblastic leukemia Bluemel, Lena; Bernardi, Flavia; Picard, Daniel; Diaz, Jacob Torrejon; Jepsen, Vera H.; Hasselmann, Rebecca; Schliehe-Diecks, Julian; Bartl, Jasmin; Qin, Nan; Bornhauser, Beat; Bhatia, Sanil; Marovka, Blerim; Marsaud, Veronique; Dingli, Florent; Loew, Damarys; Stanulla, Martin; Bourqin, Jean-Pierre; Borkhardt, Arndt; Remke, Marc; Ayrault, Olivier; Fischer, Ute 分享 收藏
The development of a hiPSC-based platform to identify tissue-dependencies of IDH1 R132H Mehjardi, N. Z.; Kessler, J.; Sanin, A. Y.; Picard, D.; Westhoff, P.; Nickel, Ann-Christin; Uhlmann, C.; Shi, W.; Steiger, H. J.; Remke, M.; Fischer, I.; Vordermark, D.; Croner, R. S.; Kahlert, U. D. 分享 收藏
Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+leukemia cells Vogt, Melina; Dienstbier, Niklas; Schliehe-Diecks, Julian; Scharov, Katerina; Tu, Jia-Wey; Gebing, Philip; Hogenkamp, Julian; Bilen, Berna-Selin; Furlan, Silke; Picard, Daniel; Remke, Marc; Yasin, Layal; Bickel, David; Kalia, Munishikha; Iacoangeli, Alfredo; Lenz, Thomas; Stuehler, Kai; Pandyra, Aleksandra A.; Hauer, Julia; Fischer, Ute; Wagener, Rabea; Borkhardt, Arndt; Bhatia, Sanil 分享 收藏
Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures 具有MYCN扩增的小儿高级别神经胶质瘤小鼠模型揭示了肿瘤内异质性和谱系特征 Schoof, Melanie; Godbole, Shweta; Albert, Thomas K.; Dottermusch, Matthias; Walter, Carolin; Ballast, Annika; Qin, Nan; Olivera, Marlena Baca; Goebel, Carolin; Neyazi, Sina; Holdhof, Doerthe; Kresbach, Catena; Peter, Levke-Sophie; Epplen, Gefion Dorothea; Thaden, Vanessa; Spohn, Michael; Blattner-Johnson, Mirjam; Modemann, Franziska; Mynarek, Martin; Rutkowski, Stefan; Sill, Martin; Varghese, Julian; Afflerbach, Ann-Kristin; Eckhardt, Alicia; Muenter, Daniel; Verma, Archana; Struve, Nina; Jones, David T. W.; Remke, Marc; Neumann, Julia E.; Kerl, Kornelius; Schueller, Ulrich 分享 收藏
The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma Qin, Nan; Paisana, Eunice; Picard, Daniel; Leprivier, Gabriel; Langini, Maike; Custodia, Carlos; Cascao, Rita; Conrad, Catleen; Peitzsch, Mirko; Stefanski, Anja; Stuehler, Kai; Fischer, Ute; Faria, Claudia C.; Dietrich, Sascha; Reifenberger, Guido; Remke, Marc 分享 收藏
A CLINICALLY COMPATIBLE IN VITRODRUG-SCREENING PLATFORM IDENTIFIES THERAPEUTIC VULNERABILITIES IN PRIMARY CULTURES OF BRAIN METASTASES Jeising, S.; Truebel, J.; Felsberg, J.; Picard, D.; Wolter, M.; Kaulich, K.; Haeberle, L.; Esposito, I.; Steinmann, J.; Cornelius, J.; Beez, T.; Rapp, M.; Sabel, M.; Nickel, A.; Remke, M.; Reifenberger, G.; Qin, N. 分享 收藏
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma 整合多组学揭示了两个生物学上不同的毛细胞星形细胞瘤组 Picard, Daniel; Felsberg, Joerg; Langini, Maike; Stachura, Pawel; Qin, Nan; Macas, Jadranka; Reiss, Yvonne; Bartl, Jasmin; Selt, Florian; Sigaud, Romain; Meyer, Frauke-D.; Stefanski, Anja; Stuehler, Kai; Roque, Lucia; Roque, Rafael; Pandyra, Aleksandra A.; Brozou, Triantafyllia; Knobbe-Thomsen, Christiane; Plate, Karl H.; Roesch, Alexander; Milde, Till; Reifenberger, Guido; Leprivier, Gabriel; Faria, Claudia C.; Remke, Marc 分享 收藏
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