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收藏Article γ-Secretase exosites as targets for substrate-selective lowering of Aβ generationγ-分泌酶外位点作为选择性降低Aβ生成的靶点
Maruyama, Riki; Fukumori, Akio; Funamoto, Satoru; Okada, Ken; Akamine, Shoshin; Yanagida, Kanta; Shinohara, Mitsuru; Sato, Naoyuki; Okochi, Masayasu; Kudo, Takashi; Steiner, Harald 分享 收藏 γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds (vol 17, 49, 2025)γ-分泌酶调节剂抵抗性在一种具有攻击性的阿尔茨海默病致病性早衰素突变体中，可以通过一组先进化合物在杂合患者状态下被克服（卷17，49，2025）Trambauer, J; Sarmiento, RMR; Garringer, HJ; Salbaum, K; Pedro, LD; Crusius, D; Vidal, R; Ghetti, B; Paquet, D; Baumann, K; Lindemann, L; Steiner, H 分享 收藏 γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compoundsTrambauer, Johannes; Sarmiento, Rosa Maria Rodriguez; Garringer, Holly J.; Salbaum, Katja; Pedro, Liliana D.; Crusius, Dennis; Vidal, Ruben; Ghetti, Bernardino; Paquet, Dominik; Baumann, Karlheinz; Lindemann, Lothar; Steiner, Harald 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Membrane lipid remodeling modulates γ-secretase processivityDawkins, Edgar; Derks, Rico J. E.; Schifferer, Martina; Trambauer, Johannes; Winkler, Edith; Simons, Mikael; Paquet, Dominik; Giera, Martin; Kamp, Frits; Steiner, Harald 分享 收藏 分享 收藏 Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activityGuener, Goekhan; Assfalg, Marlene; Zhao, Kai; Dreyer, Tobias; Lahiri, Shibojyoti; Lo, Yun; Slivinschi, Bianca Ionela; Imhof, Axel; Jocher, Georg; Strohm, Laura; Behrends, Christian; Langosch, Dieter; Bronger, Holger; Nimsky, Christopher; Bartsch, Joerg W.; Riddell, Stanley R.; Steiner, Harald; Lichtenthaler, Stefan F. 分享 收藏 分享 收藏 Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue基于碳硼烷的氟比洛芬类似物对 γ-分泌酶活性的调节Saretz, Stefan; Basset, Gabriele; Useini, Liridona; Laube, Markus; Pietzsch, Jens; Draca, Dijana; Maksimovic-Ivanic, Danijela; Trambauer, Johannes; Steiner, Harald; Hey-Hawkins, Evamarie 分享 收藏 Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque depositionColombo, Alessio Vittorio; Sadler, Rebecca Katie; Llovera, Gemma; Singh, Vikramjeet; Roth, Stefan; Heindl, Steffanie; Monasor, Laura Sebastian; Verhoeven, Aswin; Peters, Finn; Parhizkar, Samira; Kamp, Frits; de Aguero, Mercedes Gomez; MacPherson, Andrew J.; Winkler, Edith; Herms, Jochen; Benakis, Corinne; Dichgans, Martin; Steiner, Harald; Giera, Martin; Haass, Christian; Tahirovic, Sabina; Liesz, Arthur 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effectsVoeglein, Jonathan; Willem, Michael; Trambauer, Johannes; Schoenecker, Sonja; Dieterich, Marianne; Biskup, Saskia; Giudici, Camilla; Utz, Kathrin; Oberstein, Timo; Brendel, Matthias; Rominger, Axel; Danek, Adrian; Steiner, Harald; Haass, Christian; Levin, Johannes 分享 收藏 分享 收藏 分享 收藏 Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage调节APP跨膜结构域中的铰链柔性会改变 γ-分泌酶的切割Goetz, Alexander; Mylonas, Nadine; Hoegel, Philipp; Silber, Mara; Heinel, Hannes; Menig, Simon; Vogel, Alexander; Feyrer, Hannes; Huster, Daniel; Luy, Burkhard; Langosch, Dieter; Scharnagl, Christina; Muhle-Goll, Claudia; Kamp, Frits; Steiner, Harald 分享 收藏 
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