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S

Stephen R. Wedge

AstraZeneca
H指数:50
被引数:1.0万

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荣誉奖项

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Targeting the MDM2-p53 interaction: Time- and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Willmore, Elaine; Ahn, Maria; Kyle, Suzanne; Zhao, Yan; Thomas, Huw; Rankin, Kenneth S.; Bevan, Luke; Fazal, Lynsey; Hearn, Keisha; Wilsher, Nicola; Kucia-Tran, Justyna; Ferrari, Nicola; Wallis, Nicola; Thompson, Neil; Lyons, John; Miller, Duncan; Cano, Celine; Noble, Martin E.; Hardcastle, Ian R.; Howard, Steven; Chessari, Gianni; Lunec, John; Newell, David R.; Wedge, Steve R.
Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile
CANCER RESEARCH
IF16.6
2024-03-221
PRE
Ahn, Maria; Bevan, Luke; Buck, Ildiko; Cano, Celine; Castro, Juan; Cons, Ben; Endicott, Jane; Fazal, Lynsey; Ferrari, Nicola; Hardcastle, Ian; Hearn, Keisha; Holvey, Rhian; Howard, Steven; Johnson, Chris; Jennings, Claire; Kucia-Tran, Justyna; Kyle, Suzanne; Lunec, John; Lyons, John; Miller, Duncan; Rees, David; Noble, Martin; Newell, David R.; Reeks, Judith; Saini, Harpreet; Denis, Jeffrey St.; Tamanini, Emiliano; Thomas, Huw; Thompson, Neil; Vinkovic, Mladen; Ward, George; Wallis, Nicola; Walton, Hugh; Wedge, Stephen; Williams, Pamela; Willmore, Elaine; Wilshire, Nicola; Zhao, Yan; Chessari, Gianni
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-04-253
OAAI
Miller, Duncan C.; Reuillon, Tristan; Molyneux, Lauren; Blackburn, Timothy; Cook, Simon J.; Edwards, Noel; Endicott, Jane A.; Golding, Bernard T.; Griffin, Roger J.; Hardcastle, Ian; Harnor, Suzannah J.; Heptinstall, Amy; Lochhead, Pamela; Martin, Mathew P.; Martin, Nick C.; Myers, Stephanie; Newell, David R.; Noble, Richard A.; Phillips, Nicole; Rigoreau, Laurent; Thomas, Huw; Tucker, Julie A.; Wang, Lan-Zhen; Waring, Michael J.; Wong, Ai-Ching; Wedge, Stephen R.; Noble, Martin E. M.; Cano, Celine
An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-07-029
OAAI
Al-Khawaldeh, Islam; Al Yasiri, Mohammed J.; Aldred, Gregory G.; Basmadjian, Christine; Bordoni, Cinzia; Harnor, Suzannah J.; Heptinstall, Amy B.; Hobson, Stephen J.; Jennings, Claire E.; Khalifa, Shaimaa; Lebraud, Honorine; Martin, Mathew P.; Miller, Duncan C.; Shrives, Harry J.; de Souza, Joao, V; Stewart, Hannah L.; Temple, Max; Thomas, Huw D.; Totobenazara, Jane; Tucker, Julie A.; Tudhope, Susan J.; Wang, Lan Z.; Bronowska, Agnieszka K.; Cano, Celine; Endicott, Jane A.; Golding, Bernard T.; Hardcastle, Ian R.; Hickson, Ian; Wedge, Stephen R.; Willmore, Elaine; Noble, Martin E. M.; Waring, Michael J.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-03-2435
OA
Chessari, Gianni; Hardcastle, Ian R.; Ahn, Jong Sook; Anil, Burcu; Anscombe, Elizabeth; Bawn, Ruth H.; Bevan, Luke D.; Blackburn, Timothy J.; Buck, Ildiko; Cano, Celine; Carbain, Benoit; Castro, Juan; Cons, Ben; Cully, Sarah J.; Endicott, Jane A.; Fazal, Lynsey; Golding, Bernard T.; Griffin, Roger J.; Haggerty, Karen; Harnor, Suzannah J.; Hearn, Keisha; Hobson, Stephen; Holvey, Rhian S.; Howard, Steven; Jennings, Claire E.; Johnson, Christopher N.; Lunec, John; Miller, Duncan C.; Newell, David R.; Noble, Martin E. M.; Reeks, Judith; Revill, Charlotte H.; Riedinger, Christiane; St Denis, Jeffrey D.; Tamanini, Emiliano; Thomas, Huw; Thompson, Neil T.; Vinkovic, Mladen; Wedge, Stephen R.; Williams, Pamela A.; Wilsher, Nicola E.; Zhang, Bian; Zhao, Yan
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2019-11-2558
OAAI
Willoughby, Catherine E.; Jiang, Yanyan; Thomas, Huw D.; Willmore, Elaine; Kyle, Suzanne; Wittner, Anita; Phillips, Nicole; Zhao, Yan; Tudhope, Susan J.; Prendergast, Lisa; Junge, Gesa; Lourenco, Luiza Madia; Finlay, M. Raymond V.; Turner, Paul; Munck, Joanne M.; Griffin, Roger J.; Rennison, Tommy; Pickles, James; Cano, Celine; Newell, David R.; Reeves, Helen L.; Ryan, Anderson J.; Wedge, Stephen R.
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2019-09-0116
OAAI
Myers, Stephanie M.; Miller, Duncan C.; Molyneux, Lauren; Arasta, Mercedes; Bawn, Ruth H.; Blackburn, Timothy J.; Cook, Simon J.; Edwards, Noel; Endicott, Jane A.; Golding, Bernard T.; Griffin, Roger J.; Hammonds, Tim; Hardcastle, Ian R.; Harnor, Suzannah J.; Heptinstall, Amy B.; Lochhead, Pamela A.; Martin, Mathew P.; Martin, Nick C.; Newell, David R.; Owen, Paul J.; Pang, Leon C.; Reuillo, Tristan; Rigoreau, Laurent J. M.; Thomas, Huw D.; Tucker, Julie A.; Wang, Lan-Zhen; Wong, Ai-Ching; Noble, Martin E. M.; Wedge, Stephen R.; Cano, Celine

研究方向

暂未获取到该数据
H
Huw D. Thomas
H 指数:35论文数:209被引数:9,233
D
David R. Newell
H 指数:61论文数:430被引数:1.4万
C
CanoCeline
H 指数:25论文数:106被引数:2,010
S
Simon T. Barry
H 指数:57论文数:552被引数:1.4万
I
Ian R. Hardcastle
H 指数:35论文数:133被引数:4,223
R
Richard A. Noble
H 指数:5论文数:11被引数:245
D
Duncan C. Miller
H 指数:14论文数:31被引数:520
S
Suzannah J. Harnor
H 指数:12论文数:28被引数:451
I
Ian J. Stratford
H 指数:72论文数:552被引数:2.0万
M
M.E.M. Noble
H 指数:72论文数:299被引数:1.9万