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J

Jan Jacob Schuringa

university medical center groningen
H指数:48
被引数:6,894

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SLIT2 modulates leukaemic cell proliferation and stromal support in acute myeloid leukaemia models

SLIT2调节急性髓系白血病模型中白血病细胞的增殖和基质支持

British Journal of Haematology
IF3.8
2026-09-290
PRE
Luise Albuquerque-Simões; Isabel Weinhäuser; Diego A. Pereira-Martins; César Alexander Ortiz Rojas; Lúcio Henrique Sousa Pinheiro; Livia Bassani Lins de Miranda; Thiago Mantello Bianco; Rita de Cássia Cavaglieri; Mariane Cristina do Nascimento; Lynn Quek; Steffen Boettcher; Jan Jacob Schuringa; Eduardo Magalhães Rego
Novel SERPINC1 variants in hereditary Antithrombin Deficiency: first pathogenic deep-intronic variant, revealed by multiple genomic and transcriptomic approaches

新型SERPINC1变异体在遗传性抗凝血酶缺陷症中：首个致病性深内含子变异体，由多种基因组学和转录组学方法揭示

Journal of Thrombosis and Haemostasis
IF5
2026-05-260
OAAI
P. Christian Remmelzwaal; René Mulder; Jelkje J. de Boer- Bergsma; Albertus Vinke; Hilde A.M. Kooistra; Nic J.G.M. Veeger; Albertus T.J. Wierenga; Jan Jacob Schuringa; Michaël V. Lukens; Karina Meijer
Quizartinib-induced resistance drives clonal emergence of MV4-11 cells with molecular alterations enabling multidrug antileukemic escape

Quizartinib诱导的耐药性驱动具有分子改变以实现多药抗白血病逃逸的MV4-11细胞的克隆出现

European Journal of Pharmacology
IF4.7
2026-04-150
OAAI
Livia Bassani Lins de Miranda; Keli Lima; Diego A. Pereira-Martins; Juan Luiz Coelho-Silva; Victoria Tomaz; Luiz Gustavo Ferreira Cortez; Marina de Franca Basto Silva; Rafael Lucas Muniz Guedes; Paulo Vidal Campregher; Dominique Sternadt; Eduardo Magalhães Rego; Fabiola Traina; Jan Jacob Schuringa; João Agostinho Machado-Neto
Autophagy inhibition potentiates the antileukemic effect of FLT3 inhibitors and overcomes resistance in FLT3-ITD acute myeloid leukemia

自噬抑制增强了FLT3抑制剂的抗白血病作用，并克服了FLT3-ITD急性髓系白血病中的耐药性。

Cell Death Discovery
IF7
2026-03-240
OAAI
Manuela Albuquerque de Melo; Brunno Gilberto Santos de Macedo; Diego A. Pereira-Martins; Antônio Bruno Alves-Silva; Natasha Peixoto Fonseca; Livia Bassani Lins de Miranda; Cleide Lucia Araújo Silva; Priscila Santos Scheucher; Jan Jacob Schuringa; João Agostinho Machado-Neto; Fabiola Traina
ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia

ΔNp73异构体定义了一个TP53突变样不良风险亚组的急性髓系白血病

Cell Reports Medicine
IF10.6
2026-01-080
OAAI
Diego A. Pereira-Martins; Cesar Ortiz; Isabel Weinhäuser; Albertus T.J. Wierenga; Vincent van den Boom; Fatemeh Mojallali; Dominique Sternadt; Nisha K. van der Meer; Shanna M. Hogeling; Thiago M. Bianco; Prodromos Chatzikyriakou; Douglas R. Silveira; Emanuele Ammatuna; Antonio R. Lucena-Araujo; Lynn Quek; Gerwin Huls; Eduardo M. Rego; Jan Jacob Schuringa
Metformin induces ferroptosis associated with lipidomic remodeling in AML

二甲双胍诱导与脂质组重塑相关的铁死亡在AML中

Blood Advances
IF7.1
2025-11-040
OAAI
Dominique Sternadt; Diego A. Pereira-Martins; Prodromos Chatzikyriakou; Luise Albuquerque-Simões; Ming Yang; Douglas R.A. Silveira; Albertus T.J. Wierenga; Isabel Weinhäuser; Shanna M. Hogeling; Lieve L. Oudejans; Pilar Casares Alaez; Jean-Emmanuel Sarry; Christian Frezza; Gerwin A. Huls; Lynn Quek; Jan Jacob Schuringa
High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability

高mtDNA含量可识别氧化磷酸化驱动的急性髓性白血病，并代表治疗脆弱性

Signal Transduction and Targeted Therapy
IF52.7
2025-07-140
OAAI
Diego A. Pereira-Martins; Isabel Weinhäuser; Emmanuel Griessinger; Juan L. Coelho-Silva; Douglas R. Silveira; Dominique Sternadt; Ayşegül Erdem; Bruno Kosa L. Duarte; Prodromos Chatzikyriakou; Lynn Quek; Antonio Bruno Alves-Silva; Fabiola Traina; Sara T. Olalla Saad; Jacobien R. Hilberink; Amanda Moreira-Aguiar; Maria L. Salustiano-Bandeira; Marinus M. Lima; Pedro L. Franca-Neto; Marcos A. Bezerra; Nisha K. van der Meer; Emanuele Ammatuna; Eduardo M. Rego; Gerwin Huls; Jan Jacob Schuringa; Antonio R. Lucena-Araujo
Skin autofluorescence, a measure for accumulation of advanced glycation end products, positively associates with blood neutrophil and monocyte counts in the general population, and particularly in men with prediabetes (vol 395, 117609, 2024)

皮肤自体荧光，作为晚期糖基化终末产物积累的测量指标，在普通人群中与血液中性粒细胞和单核细胞计数呈正相关，尤其是在糖尿病前期男性中（卷395，117609，2024）。

ATHEROSCLEROSIS
IF5.7
2025-04-010
PRE
Groenen, Anouk G.; Halmos, Benedek; van Zeventer, Isabelle A.; Salzbrunn, Jonas B.; Mayer, Marianne L.; La Rose, Nikita D.; Nolte, Ilja M.; Schuringa, Jan Jacob; Huls, Gerwin; Westerterp, Marit
DGATI Inhibition Enhances Metformin-Induced Ferroptosis in AML By Targeting Lipid Metabolism

DGATI 抑制通过靶向脂质代谢增强二甲双胍诱导的AML中铁死亡

BLOOD
IF23.1
2024-11-051
PRE
Sternadt, Dominique; Pereira-Martins, Diego A.; Silveira, Douglas R. A.; Weinhaeuser, Isabel; Yang, Ming; Chatzikyriakou, Prodromos; Alaez, Pilar Casares; Erdem, Aysegul; Oudejans, Lieve; Hogeling, Shanna; Ammatuna, Emanuele; Huls, Gerwin; Frezza, Christian; Quek, Lynn; Schuringa, Jan Jacob
The Oncogenic ΔNp73α Isoform Contributes to Aggressiveness in APL By Leading to ATRA Resistance through NANOG/BMP4 Axis Upregulation

癌基因ΔNp73α异构体通过上调NANOG/BMP4轴导致ATRA耐药性，从而促进APL的侵袭性。

BLOOD
IF23.1
2024-11-050
PRE
Rojas, Cesar Alexander Ortiz; Pereira-Martins, Diego A.; Thome, Carol; Ferreira, Germano; Bianco, Thiago Mantello; Weinhauser, Isabel; Silva, Cleide Lucia Araujo; Pontes, Lorena; Faca, Vitor; Ammatuna, Emanuele; Huls, Gerwin; Schuringa, Jan Jacob; Rego, Eduardo M.
The Oncogenic Function of the Intrinsically Disordered Transcriptional Regulator MN1 Depends on the Chaperone DNAJB6b

内源无序转录调控因子MN1的致癌功能依赖于分子伴侣DNAJB6b

BLOOD
IF23.1
2024-11-050
PRE
Pereira-Martins, Diego A.; van den Boom, Vincent; Weinhaeuser, Isabel; van der Meer, Nisha; Chatzikyriakou, Prodromos; van Dijk, Noortje; Zheng, Xuesen; Pinheiro, Lucio H.; Silveira, Douglas R. A.; Bianco, Thiago Mantello; Rojas, Cesar Alexander Ortiz; Rego, Eduardo M.; Rushworth, Stuart A.; Lucena-Araujo, Antonio R.; Quek, Lynn; Huls, Gerwin; Schuringa, Jan Jacob

研究方向

暂未获取到该数据
E
Edo Vellenga
H 指数:97论文数:846被引数:3.9万
G
Gerwin Huls
H 指数:44论文数:287被引数:7,736
D
Diego A. Pereira‐Martins
H 指数:16论文数:159被引数:870
E
Eduardo Magalhães Rego
H 指数:44论文数:651被引数:8,333
I
Isabel Weinhäuser
H 指数:9论文数:66被引数:570
G
Gerwin Huls
H 指数:26论文数:140被引数:4,079
A
Albertus T.J. Wierenga
H 指数:25论文数:78被引数:1,856
I
Isabelle A. van Zeventer
H 指数:10论文数:28被引数:490
A
André B. Mulder
H 指数:29论文数:175被引数:2,987
E
Emanuele Ammatuna
H 指数:30论文数:176被引数:3,717