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S

Stefani Spranger

MIT
H指数:48
被引数:1.8万

个人简介

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Rewiring STAT signaling from the cell surface with Trikine immunotherapeutics

使用Trikine免疫治疗剂重塑细胞表面的STAT信号通路

Science
IF45.8
2026-02-190
PRE
Grayson E. Rodriguez; Yang Zhao; Yoko Nishiga; Frank Peprah; Jiao Shen; Gita C. Abhiraman; Masato Ogishi; Chenyu Zhang; Justin Saco; Deepa Waghray; Mamatha Serasanambati; Leonel Torres; Brandon W. Simone; Leon Su; Steven C. Wilson; Aerin Yang; Qinli Sun; Lora Picton; Robert A. Saxton; Vidit Bhandarkar; Madeline J. Lee; Elizabeth Andrews; Hua Jiang; Matthias Obenaus; Michelle Yen; Tavus Atajanova; Catherine A. Blish; Stefani Spranger; E. John Wherry; Amanda Kirane; Antoni Ribas; David H. Raulet; Anusha Kalbasi; Stephanie K. Dougan; Michael Dougan; Julien Sage; K. Christopher Garcia
Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer

突变型p53利用增强子来提高免疫抑制性趋化因子表达并削弱免疫检查点抑制剂在胰腺癌中的作用

Immunity
IF26.3
2025-06-300
OA
Dig B. Mahat; Heena Kumra; Sarah A. Castro; Emily Metcalf; Kim Nguyen; Ryo Morisue; William W. Ho; Ivy Chen; Brandon Sullivan; Leon H. Yim; Arundeep Singh; Jiayu Fu; Sean K. Waterton; Yu-Chi Cheng; Enrico Moiso; Vikash P. Chauhan; Hernandez Moura Silva; Stefani Spranger; Rakesh K. Jain; Phillip A. Sharp
Transforming ovarian cancer care by targeting minimal residual disease

通过针对最小残留疾病转变卵巢癌护理

MED
IF11.8
2023-11-011
OAAI
Jazaeri, Amir A.; Grisham, Rachel; Knisely, Anne; Spranger, Stefani; Zamarin, Dmitriy; Hillman, R. Tyler; Lawson, Barrett C.; Burns, Kathleen H.; Lee, Sanghoon; Westin, Shannon N.; Moiso, Enrico; Williams, Marc J.; Bardhan, Neelkanth M.; Pisanic, Thomas; Matulonis, Ursula; Weigelt, Britta; Shih, Ieming; Konstantinopoulos, Panagiotis A.; Gaillard, Stephanie; Wang, Linghua; Aghajanian, Carol; D'Andrea, Alan D.; Hammond, Paula; Shah, Sohrab; Wucherpfennig, Kai W.; Lu, Karen H.
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti- CTLA-4 antibodies

肿瘤内调节性T细胞耗竭和CTLA-4拮抗作用都是抗CTLA-4抗体的最大功效所必需的

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2023-07-2411
OAAI
Lax, Brianna M.; Palmeri, Joseph R.; Lutz, Emi A.; Sheen, Allison; Stinson, Jordan A.; Duhamel, Lauren; Santollani, Luciano; Kennedy, Alan; Rothschilds, Adrienne M.; Spranger, Stefani; Sansom, David M.; Wittrup, K. Dane
A prime editor mouse to model a broad spectrum of somatic mutations in vivo

prime editor小鼠在体内建立广泛的体细胞突变模型

NATURE BIOTECHNOLOGY
IF41.7
2023-05-1120
OA
Ely, Zackery A.; Mathey-Andrews, Nicolas; Naranjo, Santiago; Gould, Samuel I.; Mercer, Kim L.; Newby, Gregory A.; Cabana, Christina M.; Rideout III, William M.; Jaramillo, Grissel Cervantes; Khirallah, Jennifer M.; Holland, Katie; Randolph, Peyton B.; Freed-Pastor, William A.; Davis, Jessie R.; Kulstad, Zachary; Westcott, Peter M. K.; Lin, Lin; Anzalone, Andrew V.; Horton, Brendan L.; Pattada, Nimisha B.; Shanahan, Sean-Luc; Ye, Zhongfeng; Spranger, Stefani; Xu, Qiaobing; Sanchez-Rivera, Francisco J.; Liu, David R.; Jacks, Tyler
Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation

瓶刷前药释放TLR7/8激动剂的工程动力学使肿瘤集中免疫刺激成为可能

SCIENCE ADVANCES
IF12.5
2023-04-2120
OAAI
Bhagchandani, Sachin H.; Vohidov, Farrukh; Milling, Lauren E.; Tong, Evelyn Yuzhou; Brown, Christopher M.; Ramseier, Michelle L.; Liu, Bin; Fessenden, Timothy B.; Nguyen, Hung V. -T.; Kiel, Gavin R.; Won, Lori; Langer, Robert S.; Spranger, Stefani; Shalek, Alex K.; Irvine, Darrell J.; Johnson, Jeremiah A.
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer

组织特异性丰富的干扰素-γ 驱动调节性T细胞抑制细胞毒性T细胞对肺癌的DC1-mediated引发

IMMUNITY
IF26.3
2023-02-0149
OA
Zagorulya, Maria; Yim, Leon; Morgan, Duncan M.; Edwards, Austin; Torres-Mejia, Elen; Momin, Noor; McCreery, Chloe V.; Zamora, Izabella L.; Horton, Brendan L.; Fox, James G.; Wittrup, K. Dane; Love, J. Christopher; Spranger, Stefani

研究方向

暂未获取到该数据
T
Thomas F. Gajewski
H 指数:95论文数:639被引数:5.5万
B
Brendan Horton
H 指数:16论文数:123被引数:3,278
M
Maria Zagorulya
H 指数:12论文数:34被引数:1,287
K
K. Dane Wittrup
H 指数:78论文数:558被引数:2.3万
V
Vidit Bhandarkar
H 指数:4论文数:18被引数:585
N
Noor Momin
H 指数:15论文数:199被引数:1,850
D
Duncan M. Morgan
H 指数:13论文数:52被引数:1,491
E
Elen Torres-Mejia
H 指数:3论文数:27被引数:282
E
Emi A. Lutz
H 指数:10论文数:21被引数:953
L
Leon Yim
H 指数:4论文数:28被引数:516