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Second generation RNA Polymerase I inhibitor PMR-116 targets ribsomal RNA synthesis to potently treat a broad spectrum of malignancies Ferreira, Rita; Hannan, Katherine M.; Panov, Konstantin; Udumanne, Thejanni; George, Amee J.; Yuen, Zaka; Poh, Perlita; Kusnadi, Eric; Huglo, Alisee; Lawrence, Mitchell; Haddach, Mustapha; Drygin, Denis; Furic, Luc; Hannan, Ross D.; Hein, Nadine 分享 收藏
Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere (vol 17, pg 1146, 2007) 着丝粒RNA是核蛋白在核仁和着丝粒组装的关键成分 (第17卷，1146页，2007页) Wong, Lee H.; Brettingham-Moore, Kate H.; Chan, Lyn; Quach, Julie M.; Anderson, Melissa A.; Northrop, Emma L.; Hannan, Ross; Saffery, Richard; Shaw, Margaret L.; Williams, Evan; Choo, K. H. Andy 分享 收藏
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CX-5461 sensitizes DNA damage repair-proficient castrate-resistant prostate cancer to PARP inhibition Lawrence, Mitchell G.; Porter, Laura H.; Choo, Nicholas; Sanij, Elaine; Taylor, Renea; Pearson, Richard; Simpson, Kaylene J.; Hannan, Ross D.; Sandhu, Shahneen; Furic, Luc 分享 收藏
Comprehensive translational profiling and STE AI uncover rapid control of protein biosynthesis during cell stress 全面的翻译分析和STE AI揭示了细胞应激过程中蛋白质生物合成的快速控制 Horvath, Attila; Janapala, Yoshika; Woodward, Katrina; Mahmud, Shafi; Cleynen, Alice; Gardiner, Elizabeth E.; Hannan, Ross D.; Eyras, Eduardo; Preiss, Thomas; Shirokikh, Nikolay E. 分享 收藏
PMR-116, a second generation RNA Polymerase I inhibitor Furic, Luc; Hein, Nadine; Ferreira, Rita; Panov, Konstantin; Huglo, Alisee; Rebello, Richard; Kusnadi, Eric; Drygin, Denis; Haddach, Mustapha; Hannan, Ross 分享 收藏
Targeting mutant dicer tumorigenesis in pleuropulmonary blastoma via inhibition of RNA polymerase I 通过抑制RNA聚合酶I靶向胸膜肺母细胞瘤的突变dicer肿瘤发生 Wong, Megan Rui En; Lim, Kia Hui; Hee, Esther Xuan Yi; Chen, Huiyi; Kuick, Chik Hong; Aw, Sze Jet; Chang, Kenneth Tou En; Sulaiman, Nurfarhanah Syed; Low, Sharon Y. Y.; Hartono, Septian; Tran, Anh Nguyen Tuan; Ahamed, Summaiyya Hanum; Lam, Ching Mei Joyce; Soh, Shui Yen; Hannan, Katherine M.; Hannan, Ross D.; Coupland, Lucy A.; Loh, Amos Hong Pheng 分享 收藏
PMR-116, a novel inhibitor of ribosome biogenesis with antitumor activity in preclinical models of prostate cancer Huglo, Alisee; Hedwards, Shelley; Lawrence, Mitchell; Rebello, Richard; Clark, Ashlee; Risbridger, Gail; Taylor, Renea; Drygin, Denis; Haddach, Mustapha; Hannan, Katherine M.; Hannan, Ross D.; Furic, Luc 分享 收藏
Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies 在骨肉瘤中靶向RNA聚合酶I转录活性: 临床前分子和动物治疗研究 Kang, Chang-Won; Blackburn, Anneke C.; Loh, Amos Hong Pheng; Hong, Kuick Chick; Goh, Jian Yuan; Hein, Nadine; Drygin, Denis; Parish, Chris R.; Hannan, Ross D.; Hannan, Katherine M.; Coupland, Lucy A. 分享 收藏
mTOR-Dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF Hannan, KM; Brandenburger, Y; Jenkins, A; Sharkey, K; Cavanaugh, A; Rothblum, L; Moss, T; Poortinga, G; McArthur, GA; Pearson, RB; Hannan, RD 分享 收藏
Cell death and barrier disruption by clinically used iodine concentrations 临床使用的碘浓度导致的细胞死亡和屏障破坏 Steins, Anne; Carroll, Christina; Choong, Fui Jiun; George, Amee J.; He, Jin-Shu; Parsons, Kate M.; Feng, Shouya; Man, Si Ming; Kam, Cathelijne; van Loon, Lex M.; Poh, Perlita; Ferreira, Rita; Mann, Graham J.; Gruen, Russell L.; Hannan, Katherine M.; Hannan, Ross; Schulte, Klaus-Martin 分享 收藏
Psi promotes Drosophila wing growth via direct transcriptional activation of cell and of inhibitors Psi通过细胞和抑制剂的直接转录激活促进果蝇翅膀的生长 Zaytseva, Olga; Mitchell, Naomi C.; Muckle, Damien; Delandre, Caroline; Nie, Zuqin; Werner, Janis K.; Lis, John T.; Eyras, Eduardo; Hannan, Ross D.; Levens, David L.; Marshall, Owen J.; Quinn, Leonie M. 分享 收藏
Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway p53的核稳定需要功能性核仁监视途径 Hannan, Katherine M.; Soo, Priscilla; Wong, Mei S.; Lee, Justine K.; Hein, Nadine; Poh, Perlita; Wysoke, Kira D.; Williams, Tobias D.; Montellese, Christian; Smith, Lorey K.; Al-Obaidi, Sheren J.; Nunez-Villacis, Lorena; Pavy, Megan; He, Jin-Shu; Parsons, Kate M.; Loring, Karagh E.; Morrison, Tess; Diesch, Jeannine; Burgio, Gaetan; Ferreira, Rita; Feng, Zhi-Ping; Gould, Cathryn M.; Madhamshettiwar, Piyush B.; Flygare, Johan; Gonda, Thomas J.; Simpson, Kaylene J.; Kutay, Ulrike; Pearson, Richard B.; Engel, Christoph; Watkins, Nicholas J.; Hannan, Ross D.; George, Amee J. 分享 收藏
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The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma RNA聚合酶I转录抑制剂CX-5461在子宫平滑肌肉瘤中的治疗潜力 Kang, Chang-Won; Hannan, Katherine M.; Blackburn, Anneke C.; Loh, Amos H. P.; Hong, Kuick Chik; Yuan, Goh Jian; Hein, Nadine; Drygin, Denis; Hannan, Ross D.; Coupland, Lucy A. 分享 收藏
CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition CX-5461使DNA损伤修复熟练的去势抵抗性前列腺癌对PARP抑制敏感 Lawrence, Mitchell G.; Porter, Laura H.; Choo, Nicholas; Pook, David; Grummet, Jeremy P.; Pezaro, Carmel J.; Sandhu, Shahneen; Ramm, Susanne; Luu, Jennii; Bakshi, Andrew; Goode, David L.; Sanij, Elaine; Pearson, Richard B.; Hannan, Ross D.; Simpson, Kaylene J.; Taylor, Renea A.; Risbridger, Gail P.; Furic, Luc 分享 收藏
Cohesin mutations are synthetic lethal with stimulation of WNT signaling Cohesin突变对WNT信号的刺激是合成致死的 Chin, Chue Vin; Antony, Jisha; Ketharnathan, Sarada; Labudina, Anastasia; Gimenez, Gregory; Parsons, Kate M.; He, Jinshu; George, Amee J.; Pallotta, Maria Michela; Musio, Antonio; Braithwaite, Antony; Guilford, Parry; Hannan, Ross D.; Horsfield, Julia A. 分享 收藏
The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer RNA聚合酶I转录抑制剂CX-5461通过增强同源重组熟练的高级浆液性卵巢癌中的DNA损伤反应来与拓扑异构酶1抑制协同作用 Yan, Shunfei; Xuan, Jiachen; Brajanovski, Natalie; Tancock, Madeleine R. C.; Madhamshettiwar, Piyush B.; Simpson, Kaylene J.; Ellis, Sarah; Kang, Jian; Cullinane, Carleen; Sheppard, Karen E.; Hannan, Katherine M.; Hannan, Ross D.; Sanij, Elaine; Pearson, Richard B.; Chan, Keefe T. 分享 收藏
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