Alexander Biederstädt

The University of Texas MD Anderson Cancer Center

H指数:12

被引数:1,415

个人简介

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Engineered natural killer cells for cancer therapy

工程化自然杀伤细胞用于癌症治疗

Cancer Cell

IF44.5

2025-10-230

PRE

Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency

全基因组CRISPR筛选鉴定出增强CAR-NK细胞抗肿瘤效力的关键靶点

Cancer Cell

IF44.5

2025-08-210

OAAI

Alexander Biederstädt; Rafet Basar; Jeong-Min Park; Nadima Uprety; Rejeena Shrestha; Francia Reyes Silva; Merve Dede; John Watts; Sunil Acharya; Donghai Xiong; Bin Liu; May Daher; Hind Rafei; Pinaki Banerjee; Ping Li; Sanjida Islam; Huihui Fan; Mayra Shanley; Jingling Jin; Bijender Kumar; Vernikka Woods; Paul Lin; Silvia Tiberti; Ana Karen Nunez Cortes; Xin Ru Jiang; Inci Biederstädt; Patrick Zhang; Ye Li; Seema Rawal; Enli Liu; Luis Muniz-Feliciano; Gary M. Deyter; Elizabeth J. Shpall; Natalie Wall Fowlkes; Ken Chen; Katayoun Rezvani

CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells

Rafei, H.; Basar, R.; Acharya, S.; Hsu, Y.-S.; Liu, P.; Zhang, D.; Bohn, T.; Liang, Q.; Mohanty, V.; Upadhyay, R.; 等. CREM是NK细胞中CAR和IL-15信号通路的调控检查点。Nature 2025, 643, 1076–1086. [Google Scholar] [CrossRef] [PubMed]

Nature

IF48.5

2025-06-040

OAAI

Hind Rafei; Rafet Basar; Sunil Acharya; Yu-Sung Hsu; Pinghua Liu; Deqiang Zhang; Toszka Bohn; Qingnan Liang; Vakul Mohanty; Ranjan Upadhyay; Ping Li; Pravin Phadatare; Merve Dede; Donghai Xiong; Huihui Fan; Corry Mathew Jones; Sebastian Kunz; May Daher; Ana Karen Nunez Cortes; Mayra Shanley; Bin Liu; Sadie Mae Moseley; Chenyu Zhang; Dexing Fang; Pinaki Banerjee; Nadima Uprety; Ye Li; Rejeena Shrestha; Xinhai Wan; Hong Shen; Vernikka Woods; April Lamour Gilbert; Seema Rawal; Jinzhuang Dou; Yukun Tan; Jeong-Min Park; Francia Reyes Silva; Alexander Biederstädt; Mecit Kaplan; Xin Ru Jiang; Inci Biederstädt; Bijender Kumar; Silvia Tiberti; Madison Moore; Jingling Jin; Ryan Z. Yang; Luis Muniz-Feliciano; Samuel Rosemore; Paul Lin; Gary M. Deyter; Natalie Wall Fowlkes; Abhinav K. Jain; David Marin; Anirban Maitra; Ken Chen; Tobias Bopp; Elizabeth J. Shpall; Katayoun Rezvani

BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-09-110

PRE

Kumar, Bijender; Singh, Anand; Basar, Rafet; Uprety, Nadima; Li, Ye; Fan, Huihui; Cortes, Ana Karen Nunez; Kaplan, Mecit; Acharya, Sunil; Shaim, Hila; Xu, Anna C.; Wu, Manrong; Ensley, Emily; Fang, Dexing; Banerjee, Pinaki P.; Garcia, Luciana Melo; Tiberti, Silvia; Lin, Paul; Rafei, Hind; Munir, Maliha Nuzhat; Moore, Madison; Shanley, Mayra; Mendt, Mayela; Kerbauy, Lucila N.; Liu, Bin; Biederstaedt, Alexander; Gokdemir, Elif; Ghosh, Susmita; Kundu, Kiran; Reyes-Silva, Francia; Jiang, Xin Ru; Wan, Xinhai; Gilbert, April L.; Dede, Merve; Mohanty, Vakul; Dou, Jinzhuang; Zhang, Patrick; Liu, Enli; Muniz-Feliciano, Luis; Deyter, Gary M.; Jain, Abhinav K.; Rodriguez-Sevilla, Juan Jose; Colla, Simona; Garcia-Manero, Guillermo; Shpall, Elizabeth J.; Chen, Ken; Abbas, Hussein A.; Rai, Kunal; Rezvani, Katayoun; Daher, May

CD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3ζ/ZAP70 Signaling Axis

CANCER DISCOVERY

IF33.3

2024-07-223

PRE

Acharya, Sunil; Basar, Rafet; Daher, May; Rafei, Hind; Li, Ping; Uprety, Nadima; Ensley, Emily; Shanley, Mayra; Kumar, Bijender; Banerjee, Pinaki P.; Melo Garcia, Luciana; Lin, Paul; Mohanty, Vakul; Kim, Kun H.; Jiang, Xianli; Pan, Yuchen; Li, Ye; Liu, Bin; Cortes, Ana K. Nunez; Zhang, Chenyu; Fathi, Mohsen; Rezvan, Ali; Montalvo, Melisa J.; Cha, Sophia L.; Reyes-Silva, Francia; Shrestha, Rejeena; Guo, Xingliang; Kundu, Kiran; Biederstadt, Alexander; Muniz-Feliciano, Luis; Deyter, Gary M.; Kaplan, Mecit; Jiang, Xin R.; Liu, Enli; Jain, Antrix; Roszik, Janos; Fowlkes, Natalie W.; Solis Soto, Luisa M.; Raso, Maria G.; Khoury, Joseph D.; Lin, Pei; Vega, Francisco; Varadarajan, Navin; Chen, Ken; Marin, David; Shpall, Elizabeth J.; Rezvani, Katayoun

KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape (vol 28, pg 2133, 2022)

NATURE MEDICINE

IF50

2024-01-050

Li, Ye; Basar, Rafet; Wang, Guohui; Liu, Enli; Moyes, Judy S.; Li, Li; Kerbauy, Lucila N.; Uprety, Nadima; Fathi, Mohsen; Rezvan, Ali; Banerjee, Pinaki P.; Muniz-Feliciano, Luis; Laskowski, Tamara J.; Ensley, Emily; Daher, May; Shanley, Mayra; Mendt, Mayela; Acharya, Sunil; Liu, Bin; Biederstaedt, Alexander; Rafei, Hind; Guo, Xingliang; Melo Garcia, Luciana; Lin, Paul; Ang, Sonny; Marin, David; Chen, Ken; Bover, Laura; Champlin, Richard E.; Varadarajan, Navin; Shpall, Elizabeth J.; Rezvani, Katayoun

Multiplexed engineering and precision gene editing in cellular immunotherapy

FRONTIERS IN IMMUNOLOGY

IF5.9

2022-11-2210

OAAI

KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape

NATURE MEDICINE

IF50

2022-09-2983

Li, Ye; Basar, Rafet; Wang, Guohui; Liu, Enli; Moyes, Judy S.; Li, Li; Kerbauy, Lucila N.; Uprety, Nadima; Fathi, Mohsen; Rezvan, Ali; Banerjee, Pinaki P.; Muniz-Feliciano, Luis; Laskowski, Tamara J.; Ensley, Emily; Daher, May; Shanley, Mayra; Mendt, Mayela; Acharya, Sunil; Liu, Bin; Biederstadt, Alexander; Rafei, Hind; Guo, Xingliang; Melo Garcia, Luciana; Lin, Paul; Ang, Sonny; Marin, David; Chen, Ken; Bover, Laura; Champlin, Richard E.; Varadarajan, Navin; Shpall, Elizabeth J.; Rezvani, Katayoun

Natural killer cells in antitumour adoptive cell immunotherapy

抗肿瘤过继细胞免疫治疗中的自然杀伤细胞

NATURE REVIEWS CANCER

IF66.8

2022-07-25331

OAAI

RACE-trial: neoadjuvant radiochemotherapy versus chemotherapy for patients with locally advanced, potentially resectable adenocarcinoma of the gastroesophageal junction-a randomized phase III joint study of the AIO, ARO and DGAV

BMC CANCER

IF3.4

2020-09-1534

OAAI

Paclitaxel plus ramucirumab versus paclitaxel alone in patients with squamous-cell carcinoma of the esophagus, refractory or intolerant to combination therapy with fluoropyrimidine and platinum-based drugs - RAMOS, a randomized phase II trial of the German Gastric Group of the AIO