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Humoral epitope dominance and immune imprinting by SARS-CoV-1 and SARS-CoV-2 vaccines SARS-CoV-1和SARS-CoV-2疫苗诱导的体液表位优势和免疫印迹 Burnett, Deborah L.; Moxon, Ania; Aggarwal, Anupriya; Jackson, Katherine J. L.; Cotter, Catherine; Akerman, Anouschka; Russell, Amanda; Kalman, Rachel; Langley, David; Henry, Jake Y.; Christ, Daniel; Bull, Rowena A.; Brink, Robert; Kelleher, Anthony D.; Jack, Hans-Martin; Turville, Stuart; Moss, Bernard; Goodnow, Christopher C. 分享 收藏
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease 一种体细胞诱变的三联因素在自身反应性B细胞中汇聚，导致病毒诱导的自身免疫性疾病。 Young, Clara; Singh, Mandeep; Jackson, Katherine J. L.; Field, Matt A.; Peters, Timothy J.; Angioletti-Uberti, Stefano; Frenkel, Daan; Ravishankar, Shyamsundar; Gupta, Money; Wang, Jing J.; Agapiou, David; Faulks, Megan L.; Al-Eryani, Ghamdan; Luciani, Fabio; Gordon, Tom P.; Reed, Joanne H.; Danta, Mark; Carr, Andrew; Kelleher, Anthony D.; Dore, Gregory J.; Matthews, Gail; Brink, Robert; Bull, Rowena A.; Suan, Dan; Goodnow, Christopher C. 分享 收藏
The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury AMPK激活剂ATX-304改变细胞代谢以保护顺铂诱导的急性肾损伤 Katerelos, Marina; Gleich, Kurt; Harley, Geoff; Loh, Kim; Oakhill, Jonathan S.; Kemp, Bruce E.; de Souza, David P.; Narayana, Vinod K.; Coughlan, Melinda T.; Laskowski, Adrienne; Ling, Naomi X. Y.; Murray-Segal, Lisa; Brink, Robert; Lee, Mardiana; Power, David A.; Mount, Peter F. 分享 收藏
Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic disease Pan, Ziyan; El Sharkway, Rasha; Bayoumi, Ali; Metwally, Mayada; Gloss, Brian S.; Brink, Robert; Lu, David Bo; Liddle, Christopher; Alqahtani, Saleh A.; Yu, Jun; O'Connell, Philip J.; George, Jacob; Eslam, Mohammed 分享 收藏
Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2 Nguyen, Tina; Lau, Anthony; Bier, Julia; Cooke, Kristen C.; Lenthall, Helen; Ruiz-Diaz, Stephanie; Avery, Danielle T.; Brigden, Henry; Zahra, David; Sewell, William A.; Droney, Luke; Okada, Satoshi; Asano, Takaki; Abolhassani, Hassan; Chavoshzadeh, Zahra; Abraham, Roshini S.; Rajapakse, Nipunie; Klee, Eric W.; Church, Joseph A.; Williams, Andrew; Wong, Melanie; Burkhart, Christoph; Uzel, Gulbu; Croucher, David R.; James, David E.; Ma, Cindy S.; Brink, Robert; Tangye, Stuart G.; Deenick, Elissa K. 分享 收藏
CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells Masle-Farquhar, Etienne; Jeelall, Yogesh; White, Jacqueline; Bier, Julia; Deenick, Elissa K.; Brink, Robert; Horikawa, Keisuke; Goodnow, Christopher Carl 分享 收藏
Skin y8 T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol Frascoli, Michela; Ferraj, Enxhi; Miu, Bing; Malin, Justin; Spidale, Nicholas A.; Cowan, Jennifer; Shissler, Susannah C.; Brink, Robert; Xu, Ying; Cyster, Jason G.; Bhandoola, Avinash; Kang, Joonsoo; Reboldi, Andrea 分享 收藏
An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells Ceglia, Simona; Berthelette, Alyssa; Howley, Kelsey; Li, Yun; Mortzfeld, Benedikt; Bhattarai, Shakti K.; Yiew, Nicole K. H.; Xu, Ying; Brink, Robert; Cyster, Jason G.; Hooper, Lora V.; Randolph, Gwendalyn J.; Bucci, Vanni; Reboldi, Andrea 分享 收藏
STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+T cell dysregulation and accumulation STAT3功能获得性突变通过病理性NKG2Dhi CD8 T细胞失调和积累将白血病与自身免疫性疾病联系起来 Masle-Farquhar, Etienne; Jackson, Katherine J. L.; Peters, Timothy J.; Al-Eryani, Ghamdan; Singh, Mandeep; Payne, Kathryn J.; Rao, Geetha; Avery, Danielle T.; Apps, Gabrielle; Kingham, Jennifer; Jara, Christopher J.; Skvortsova, Ksenia; Swarbrick, Alexander; Ma, Cindy S.; Suan, Daniel; Uzel, Gulbu; Chua, Ignatius; Leiding, Jennifer W.; Heiskanen, Kaarina; Preece, Kahn; Kainulainen, Leena; O'Sullivan, Michael; Cooper, Megan A.; Seppaeuronen, Mikko R. J.; Mustjoki, Satu; Brothers, Shannon; Vogel, Tiphanie P.; Brink, Robert; Tangye, Stuart G.; Reed, Joanne H.; Goodnow, Christopher C. 分享 收藏
Blocking AMPK?1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis 阻断AMPK？1豆蔻酰化增强AMPK活性并保护小鼠免受高脂饮食诱导的肥胖和肝脂肪变性 Neopane, Katyayanee; Kozlov, Natalie; Negoita, Florentina; Murray-Segal, Lisa; Brink, Robert; Hoque, Ashfaqul; Ovens, Ashley J.; Tjin, Gavin; McAloon, Luke M.; Yu, Dingyi; Ling, Naomi X. Y.; Sanders, Matthew J.; Oakhill, Jonathan S.; Scott, John W.; Steinberg, Gregory R.; Loh, Kim; Kemp, Bruce E.; Sakamoto, Kei; Galic, Sandra 分享 收藏
Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency Munoz, Marcia A.; Skinner, Oliver P.; Masle-Farquhar, Etienne; Jurczyluk, Julie; Xiao, Ya; Fletcher, Emma K.; Kristianto, Esther; Hodson, Mark P.; O'Donoghue, Sean I.; Kaur, Sandeep; Brink, Robert; Zahra, David G.; Deenick, Elissa K.; Perry, Kristen A.; Robertson, Avril A. B.; Mehr, Sam; Hissaria, Pravin; Mulders-Manders, Catharina M.; Simon, Anna; Rogers, Michael J. 分享 收藏
Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells Quast, Isaak; Dvorscek, Alexandra R.; Pattaroni, Celine; Steiner, Thiago M.; McKenzie, Craig I.; Pitt, Catherine; O'Donnell, Kristy; Ding, Zhoujie; Hill, Danika L.; Brink, Robert; Robinson, Marcus J.; Zotos, Dimitra; Tarlinton, David M. 分享 收藏
Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta Chandrakanthan, Vashe; Rorimpandey, Prunella; Zanini, Fabio; Chacon, Diego; Olivier, Jake; Joshi, Swapna; Kang, Young Chan; Knezevic, Kathy; Huang, Yizhou; Qiao, Qiao; Oliver, Rema A.; Unnikrishnan, Ashwin; Carter, Daniel R.; Lee, Brendan; Brownlee, Chris; Power, Carl; Brink, Robert; Mendez-Ferrer, Simon; Enikolopov, Grigori; Walsh, William; Gottgens, Berthold; Taoudi, Samir; Beck, Dominik; Pimanda, John E. 分享 收藏
IL-21 has a critical role in establishing germinal centers by amplifying early B cell proliferation IL-21通过扩增早期b细胞增殖在建立生发中心中起关键作用 Dvorscek, Alexandra R.; McKenzie, Craig, I; Robinson, Marcus J.; Ding, Zhoujie; Pitt, Catherine; O'Donnell, Kristy; Zotos, Dimitra; Brink, Robert; Tarlinton, David M.; Quast, Isaak 分享 收藏
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Epithelial-derived oxysterol production tunes intestinal IgA secretion against commensals and enteric pathogen in tissue Ceglia, Simona; Berthelette, Alyssa; Howley, Kelsey; Li, Yun; Yiew, Nicole K. H.; Xu, Ying; Brink, Robert Adrian; Cyster, Jason G.; Hooper, Lora V.; Randolph, Gwendalyn J.; Reboldi, Andrea 分享 收藏
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Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability Burnett, Deborah L.; Jackson, Katherine J. L.; Langley, David B.; Aggrawal, Anupria; Stella, Alberto Ospina; Johansen, Matt D.; Balachandran, Harikrishnan; Lenthall, Helen; Rouet, Romain; Walker, Gregory; Saunders, Bernadette M.; Singh, Mandeep; Li, Hui; Henry, Jake Y.; Jackson, Jennifer; Stewart, Alastair G.; Witthauer, Franka; Spence, Matthew A.; Hansbro, Nicole G.; Jackson, Colin; Schofield, Peter; Milthorpe, Claire; Martinello, Marianne; Schulz, Sebastian R.; Roth, Edith; Kelleher, Anthony; Emery, Sean; Britton, Warwick J.; Rawlinson, William D.; Karl, Rudolfo; Schaefer, Simon; Winkler, Thomas H.; Brink, Robert; Bull, Rowena A.; Hansbro, Philip M.; Jaeck, Hans-Martin; Turville, Stuart; Christ, Daniel; Goodnow, Christopher C. 分享 收藏
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies Rouet, Romain; Mazigi, Ohan; Walker, Gregory J.; Langley, David B.; Sobti, Meghna; Schofield, Peter; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Henry, Jake Y.; Abayasingam, Arunasingam; Burnett, Deborah; Kelleher, Anthony; Brink, Robert; Bull, Rowena A.; Turville, Stuart; Stewart, Alastair G.; Goodnow, Christopher C.; Rawlinson, William D.; Christ, Daniel 分享 收藏
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