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S

Sarah T. Diepstraten

the walter and eliza hall institute of medical research
H指数:13
被引数:1,329

个人简介

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教育背景

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工作经历

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荣誉奖项

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A high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

高密度CRISPR激活平台用于体外和体内绘制癌症依赖性和耐药通路

Science Advances
IF12.5
2026-09-180
OA
Sarah T. Diepstraten; Yexuan Deng; Margaret A. Potts; Amy Heidersbach; Christina König; Kristel M. Dorighi; Lin Tai; Andrew J. Kueh; Lauren Whelan; Catherine Chang; Felix Brown; Gemma L. Kelly; Jean-Philippe Fortin; Benjamin Haley; John E. La Marca; Marco J. Herold
Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma

全基因组活体内CRISPR筛选鉴定GATOR1复合物为Myc驱动的淋巴瘤的肿瘤抑制因子

Nature Communications
IF15.7
2025-08-210
OAAI
Margaret A. Potts; Shinsuke Mizutani; Yexuan Deng; Srimayee Vaidyanathan; Keziah E. Ting; Göknur Giner; Shruti Sridhar; Girija Shenoy; Yang Liao; Sarah T. Diepstraten; Andrew J. Kueh; Martin Pal; Geraldine Healey; Lin Tai; Zilu Wang; Christina König; Deeksha Kaloni; Lauren Whelan; Michael J. G. Milevskiy; Hannah D. Coughlan; Giovanna Pomilio; Andrew H. Wei; Jane E. Visvader; Anthony T. Papenfuss; Stephen Wilcox; Anand D. Jeyasekharan; Wei Shi; Emily J. Lelliott; Gemma L. Kelly; Kristin K. Brown; Andreas Strasser; Marco J. Herold
Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

通过结合AsCas12a基因敲入小鼠与超紧凑型筛选技术，推进基因工程工具箱的发展。

NATURE COMMUNICATIONS
IF15.7
2025-01-300
OA
Jin, Wei; Deng, Yexuan; La Marca, John E.; Lelliott, Emily J.; Diepstraten, Sarah T.; Konig, Christina; Tai, Lin; Snetkova, Valentina; Dorighi, Kristel M.; Hoberecht, Luke; Hedditch, Millicent G.; Whelan, Lauren; Healey, Geraldine; Fayle, Dan; Lau, Kieran; Potts, Margaret A.; Chen, Moore Z.; Johnston, Angus P. R.; Liao, Yang; Shi, Wei; Kueh, Andrew J.; Haley, Benjamin; Fortin, Jean-Philippe
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells
CANCER DISCOVERY
IF33.3
2023-10-2422
OAAI
Wang, Zilu; Burigotto, Matteo; Ghetti, Sabrina; Vaillant, Francois; Tan, Tao; Capaldo, Bianca D.; Palmieri, Michelle; Hirokawa, Yumiko; Tai, Lin; Simpson, Daniel S.; Chang, Catherine; Huang, Allan Shuai; Lieschke, Elizabeth; Diepstraten, Sarah T.; Kaloni, Deeksha; Riffkin, Chris; Huang, David C. S.; Li Wai Suen, Connie S. N.; Garnham, Alexandra L.; Gibbs, Peter; Visvader, Jane E.; Sieber, Oliver M.; Herold, Marco J.; Fava, Luca L.; Kelly, Gemma L.; Strasser, Andreas
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells (Feb,10.1038/s41418-023-01122-3, 2023)
CELL DEATH AND DIFFERENTIATION
IF15.4
2023-02-240
OAAI
Wang, Zilu; Hu, Huimin; Heitink, Luuk; Rogers, Kelly; You, Yue; Tan, Tao; Suen, Connie Li Wai; Garnham, Alex; Chen, Hao; Lieschke, Elizabeth; Diepstraten, Sarah T.; Chang, Catherine; Chen, Tianwei; Moujalled, Diane; Sutherland, Kate; Lessene, Guillaume; Sieber, Oliver M.; Visvader, Jane; Kelly, Gemma L.; Strasser, Andreas
Generation of a CRISPR activationmouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance (vol 13, 4739, 2022)
NATURE COMMUNICATIONS
IF15.7
2022-08-250
OAAI
Deng, Yexuan; Diepstraten, Sarah T.; Potts, Margaret A.; Giner, Goknur; Trezise, Stephanie; Ng, Ashley P.; Healey, Gerry; Kane, Serena R.; Cooray, Amali; Behrens, Kira; Heidersbach, Amy; Kueh, Andrew J.; Pal, Martin; Wilcox, Stephen; Tai, Lin; Alexander, Warren S.; Visvader, Jane E.; Nutt, Stephen L.; Strasser, Andreas; Haley, Benjamin; Zhao, Quan; Kelly, Gemma L.; Herold, Marco J.
Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance
NATURE COMMUNICATIONS
IF15.7
2022-08-1214
OAAI
Deng, Yexuan; Diepstraten, Sarah T.; Potts, Margaret A.; Giner, Goeknur; Trezise, Stephanie; Ng, Ashley P.; Healey, Gerry; Kane, Serena R.; Cooray, Amali; Behrens, Kira; Heidersbach, Amy; Kueh, Andrew J.; Pal, Martin; Wilcox, Stephen; Tai, Lin; Alexander, Warren S.; Visvader, Jane E.; Nutt, Stephen L.; Strasser, Andreas; Haley, Benjamin; Zhao, Quan; Kelly, Gemma L.; Herold, Marco J.

研究方向

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G
Gemma L. Kelly
H 指数:36论文数:262被引数:8,074
A
Andreas Strasser
H 指数:135论文数:816被引数:8.4万
M
Marco J. Herold
H 指数:58论文数:416被引数:1.3万
J
John E. La Marca
H 指数:9论文数:40被引数:353
C
Catherine Chang
H 指数:18论文数:197被引数:2,119
L
Lin Tai
H 指数:20论文数:214被引数:2,568
J
Jane E. Visvader
H 指数:84论文数:465被引数:3.7万
Z
Zilu Wang
H 指数:34论文数:193被引数:6,980
M
Margaret A. Potts
H 指数:5论文数:19被引数:150
A
Andrew J. Kueh
H 指数:30论文数:148被引数:3,967