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G

Gemma L. Kelly

the walter and eliza hall institute of medical research
H指数:36
被引数:8,074

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A high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

高密度CRISPR激活平台用于体外和体内绘制癌症依赖性和耐药通路

Science Advances
IF12.5
2026-09-180
OA
Sarah T. Diepstraten; Yexuan Deng; Margaret A. Potts; Amy Heidersbach; Christina König; Kristel M. Dorighi; Lin Tai; Andrew J. Kueh; Lauren Whelan; Catherine Chang; Felix Brown; Gemma L. Kelly; Jean-Philippe Fortin; Benjamin Haley; John E. La Marca; Marco J. Herold
Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma

全基因组活体内CRISPR筛选鉴定GATOR1复合物为Myc驱动的淋巴瘤的肿瘤抑制因子

Nature Communications
IF15.7
2025-08-210
OAAI
Margaret A. Potts; Shinsuke Mizutani; Yexuan Deng; Srimayee Vaidyanathan; Keziah E. Ting; Göknur Giner; Shruti Sridhar; Girija Shenoy; Yang Liao; Sarah T. Diepstraten; Andrew J. Kueh; Martin Pal; Geraldine Healey; Lin Tai; Zilu Wang; Christina König; Deeksha Kaloni; Lauren Whelan; Michael J. G. Milevskiy; Hannah D. Coughlan; Giovanna Pomilio; Andrew H. Wei; Jane E. Visvader; Anthony T. Papenfuss; Stephen Wilcox; Anand D. Jeyasekharan; Wei Shi; Emily J. Lelliott; Gemma L. Kelly; Kristin K. Brown; Andreas Strasser; Marco J. Herold
Mouse models to investigate in situ cell fate decisions induced by p53
EMBO JOURNAL
IF8.3
2024-08-190
OAAI
Lieschke, Elizabeth; Thomas, Annabella F.; Kueh, Andrew; Atkin-Smith, Georgia K.; Baldoni, Pedro L.; La Marca, John E.; Young, Savannah; Huang, Allan Shuai; Ross, Aisling M.; Whelan, Lauren; Kaloni, Deeksha; Tai, Lin; Smyth, Gordon K.; Herold, Marco J.; Hawkins, Edwin D.; Strasser, Andreas; Kelly, Gemma L.
Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma
HAEMATOLOGICA
IF7.9
2024-06-061
OAAI
Davies, Nicholas; Francis, Tegan; Oldreive, Ceri; Azam, Maria; Wilson, Jordan; Byrd, Philip J.; Burley, Megan; Sharma-Oates, Archana; Keane, Peter; Alatawi, Sael; Higgs, Martin R.; Rudzki, Zbigniew; Ibrahim, Maha; Perry, Tracey; Agathanggelou, Angelo; Hewitt, Anne-Marie; Smith, Edward; Bonifer, Constanze; O'Connor, Mark; Forment, Josep V.; Murray, Paul G.; Fennell, Eanna; Kelly, Gemma; Chang, Catherine; Stewart, Grant S.; Stankovic, Tatjana; Kwok, Marwan; Taylor, Alexander Malcolm
Cancer Hallmarks: Piecing the Puzzle Together
CANCER DISCOVERY
IF33.3
2024-04-042
OA
Alcolea, Maria P.; Alonso-Curbelo, Direna; Ambrogio, Chiara; Bullman, Susan; Correia, Ana Luisa; Ernst, Aurelie; Halbrook, Christopher J.; Kelly, Gemma L.; Lund, Amanda W.; Quail, Daniela F.; Ruscetti, Marcus; Shema, Efrat; Stromnes, Ingunn M.; Tam, Wai Leong
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells
CANCER DISCOVERY
IF33.3
2023-10-2422
OAAI
Wang, Zilu; Burigotto, Matteo; Ghetti, Sabrina; Vaillant, Francois; Tan, Tao; Capaldo, Bianca D.; Palmieri, Michelle; Hirokawa, Yumiko; Tai, Lin; Simpson, Daniel S.; Chang, Catherine; Huang, Allan Shuai; Lieschke, Elizabeth; Diepstraten, Sarah T.; Kaloni, Deeksha; Riffkin, Chris; Huang, David C. S.; Li Wai Suen, Connie S. N.; Garnham, Alexandra L.; Gibbs, Peter; Visvader, Jane E.; Sieber, Oliver M.; Herold, Marco J.; Fava, Luca L.; Kelly, Gemma L.; Strasser, Andreas
Apoptotic cell death in disease-Current understanding of the NCCD 2023

疾病中的凋亡细胞死亡-对NCCD 2023的当前理解

CELL DEATH AND DIFFERENTIATION
IF15.4
2023-04-26143
OAAI
Vitale, Ilio; Pietrocola, Federico; Guilbaud, Emma; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostini, Massimiliano; Agostinis, Patrizia; Alnemri, Emad S.; Altucci, Lucia; Amelio, Ivano; Andrews, David W.; Aqeilan, Rami, I; Arama, Eli; Baehrecke, Eric H.; Balachandran, Siddharth; Bano, Daniele; Barlev, Nickolai A.; Bartek, Jiri; Bazan, Nicolas G.; Becker, Christoph; Bernassola, Francesca; Bertrand, Mathieu J. M.; Bianchi, Marco E.; Blagosklonny, Mikhail V.; Blander, J. Magarian; Blandino, Giovanni; Blomgren, Klas; Borner, Christoph; Bortner, Carl D.; Bove, Pierluigi; Boya, Patricia; Brenner, Catherine; Broz, Petr; Brunner, Thomas; Damgaard, Rune Busk; Calin, George A.; Campanella, Michelangelo; Candi, Eleonora; Carbone, Michele; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K-M; Chen, Guo-Qiang; Chen, Quan; Chen, Youhai H.; Cheng, Emily H.; Chipuk, Jerry E.; Cidlowski, John A.; Ciechanover, Aaron; Ciliberto, Gennaro; Conrad, Marcus; Cubillos-Ruiz, Juan R.; Czabotar, Peter E.; D'Angiolella, Vincenzo; Daugaard, Mads; Dawson, Ted M.; Dawson, Valina L.; De Maria, Ruggero; De Strooper, Bart; Debatin, Klaus-Michael; Deberardinis, Ralph J.; Degterev, Alexei; Del Sal, Giannino; Deshmukh, Mohanish; Di Virgilio, Francesco; Diederich, Marc; Dixon, Scott J.; Dynlacht, Brian D.; El-Deiry, Wafik S.; Elrod, John W.; Engeland, Kurt; Fimia, Gian Maria; Galassi, Claudia; Ganini, Carlo; Garcia-Saez, Ana J.; Garg, Abhishek D.; Garrido, Carmen; Gavathiotis, Evripidis; Gerlic, Motti; Ghosh, Sourav; Green, Douglas R.; Greene, Lloyd A.; Gronemeyer, Hinrich; Haecker, Georg; Hajnoczky, Gyorgy; Hardwick, J. Marie; Haupt, Ygal; He, Sudan; Heery, David M.; Hengartner, Michael O.; Hetz, Claudio; Hildeman, David A.; Ichijo, Hidenori; Inoue, Satoshi; Jaeaettelae, Marja; Janic, Ana; Joseph, Bertrand; Jost, Philipp J.; Kanneganti, Thirumala-Devi; Karin, Michael; Kashkar, Hamid; Kaufmann, Thomas; Kelly, Gemma L.; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N.; Klionsky, Daniel J.; Kluck, Ruth; Krysko, Dmitri, V; Kulms, Dagmar; Kumar, Sharad; Lavandero, Sergio; Lavrik, Inna N.; Lemasters, John J.; Liccardi, Gianmaria; Linkermann, Andreas; Lipton, Stuart A.; Lockshin, Richard A.; Lopez-Otin, Carlos; Luedde, Tom; MacFarlane, Marion; Madeo, Frank; Malorni, Walter; Manic, Gwenola; Mantovani, Roberto; Marchi, Saverio; Marine, Jean-Christophe; Martin, Seamus J.; Martinou, Jean-Claude; Mastroberardino, Pier G.; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Gerry; Melino, Sonia; Miao, Edward A.; Moll, Ute M.; Munoz-Pinedo, Cristina; Murphy, Daniel J.; Niklison-Chirou, Maria Victoria; Novelli, Flavia; Nunez, Gabriel; Oberst, Andrew; Ofengeim, Dimitry; Opferman, Joseph T.; Oren, Moshe; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M.; Pentimalli, Francesca; Pereira, David M.; Pervaiz, Shazib; Peter, Marcus E.; Pinton, Paolo; Porta, Giovanni; Prehn, Jochen H. M.; Puthalakath, Hamsa; Rabinovich, Gabriel A.; Rajalingam, Krishnaraj; Ravichandran, Kodi S.; Rehm, Markus; Ricci, Jean-Ehrland; Rizzuto, Rosario; Robinson, Nirmal; Rodrigues, Cecilia M. P.; Rotblat, Barak; Rothlin, Carla, V; Rubinsztein, David C.; Rudel, Thomas; Rufini, Alessandro; Ryan, Kevin M.; Sarosiek, Kristopher A.; Sawa, Akira; Sayan, Emre; Schroder, Kate; Scorrano, Luca; Sesti, Federico; Shao, Feng; Shi, Yufang; Sica, Giuseppe S.; Silke, John; Simon, Hans-Uwe; Sistigu, Antonella; Stephanou, Anastasis; Stockwell, Brent R.; Strapazzon, Flavie; Strasser, Andreas; Sun, Liming; Sun, Erwei; Sun, Qiang; Szabadkai, Gyorgy; Tait, Stephen W. G.; Tang, Daolin; Tavernarakis, Nektarios; Troy, Carol M.; Turk, Boris; Urbano, Nicoletta; Vandenabeele, Peter; Vanden Berghe, Tom; Vander Heiden, Matthew G.; Vanderluit, Jacqueline L.; Verkhratsky, Alexei; Villunger, Andreas; von Karstedt, Silvia; Voss, Anne K.; Vousden, Karen H.; Vucic, Domagoj; Vuri, Daniela; Wagner, Erwin F.; Walczak, Henning; Wallach, David; Wang, Ruoning; Wang, Ying; Weber, Achim; Wood, Will; Yamazaki, Takahiro; Yang, Huang-Tian; Zakeri, Zahra; Zawacka-Pankau, Joanna E.; Zhang, Lin; Zhang, Haibing; Zhivotovsky, Boris; Zhou, Wenzhao; Piacentini, Mauro; Kroemer, Guido; Galluzzi, Lorenzo
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells (Feb,10.1038/s41418-023-01122-3, 2023)
CELL DEATH AND DIFFERENTIATION
IF15.4
2023-02-240
OAAI
Wang, Zilu; Hu, Huimin; Heitink, Luuk; Rogers, Kelly; You, Yue; Tan, Tao; Suen, Connie Li Wai; Garnham, Alex; Chen, Hao; Lieschke, Elizabeth; Diepstraten, Sarah T.; Chang, Catherine; Chen, Tianwei; Moujalled, Diane; Sutherland, Kate; Lessene, Guillaume; Sieber, Oliver M.; Visvader, Jane; Kelly, Gemma L.; Strasser, Andreas
Generation of a CRISPR activationmouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance (vol 13, 4739, 2022)
NATURE COMMUNICATIONS
IF15.7
2022-08-250
OAAI
Deng, Yexuan; Diepstraten, Sarah T.; Potts, Margaret A.; Giner, Goknur; Trezise, Stephanie; Ng, Ashley P.; Healey, Gerry; Kane, Serena R.; Cooray, Amali; Behrens, Kira; Heidersbach, Amy; Kueh, Andrew J.; Pal, Martin; Wilcox, Stephen; Tai, Lin; Alexander, Warren S.; Visvader, Jane E.; Nutt, Stephen L.; Strasser, Andreas; Haley, Benjamin; Zhao, Quan; Kelly, Gemma L.; Herold, Marco J.
Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance
NATURE COMMUNICATIONS
IF15.7
2022-08-1214
OAAI
Deng, Yexuan; Diepstraten, Sarah T.; Potts, Margaret A.; Giner, Goeknur; Trezise, Stephanie; Ng, Ashley P.; Healey, Gerry; Kane, Serena R.; Cooray, Amali; Behrens, Kira; Heidersbach, Amy; Kueh, Andrew J.; Pal, Martin; Wilcox, Stephen; Tai, Lin; Alexander, Warren S.; Visvader, Jane E.; Nutt, Stephen L.; Strasser, Andreas; Haley, Benjamin; Zhao, Quan; Kelly, Gemma L.; Herold, Marco J.

研究方向

暂未获取到该数据
A
Andreas Strasser
H 指数:135论文数:816被引数:8.4万
M
Marco J. Herold
H 指数:58论文数:416被引数:1.3万
S
Sarah T. Diepstraten
H 指数:13论文数:209被引数:1,329
C
Catherine Chang
H 指数:18论文数:197被引数:2,119
A
Andrew Bell
H 指数:47论文数:91被引数:5,768
A
Alan B. Rickinson
H 指数:108论文数:462被引数:4.0万
L
Lin Tai
H 指数:20论文数:214被引数:2,568
A
Andrew J. Kueh
H 指数:30论文数:148被引数:3,967
J
John E. La Marca
H 指数:9论文数:40被引数:353
B
Brandon J. Aubrey
H 指数:16论文数:42被引数:4,083