P. Anton van der Merwe - Publications, H-index & Citations

P. Anton van der Merwe

University of Oxford

72H指数

400论文数

1.6W被引数

收录论文 94

发表时间

Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors 通过工程改造共信号受体生成具有降低的离靶交叉反应性的T细胞

Nature Biomedical Engineering

IF26.6

2026-01-02

OAAI

Jose Cabezas-Caballero; Anna Huhn; Mikhail A. Kutuzov; Violaine Andre; Alina Shomuradova; Bas W. A. Peeters; Geraldine M. Gillespie; P. Anton van der Merwe; Omer Dushek

Platforms for studying cell-cell recognition by immune cells 研究免疫细胞细胞间识别的平台

IMMUNOLOGY AND CELL BIOLOGY

IF3

2025-05-29

OAAI

Jordan Kramer; P Anton van der Merwe; Omer Dushek

The molecular reach of antibodies crucially underpins their viral neutralisation capacity (vol 16, 338, 2025)抗体的分子作用范围对其病毒中和能力至关重要 (vol 16, 338, 2025)

NATURE COMMUNICATIONS

IF15.7

2025-03-20

OAAI

Huhn, Anna; Nissley, Daniel; Wilson, Daniel B.; Kutuzov, Mikhail A.; Donat, Robert; Tan, Tiong Kit; Zhang, Ying; Barton, Michael I.; Liu, Chang; Dejnirattisai, Wanwisa; Supasa, Piyada; Mongkolsapaya, Juthathip; Townsend, Alain; James, William; Screaton, Gavin; van der Merwe, P. Anton; Isaacson, Samuel A.

Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering (vol 43, 114761, 2024)配体诱导的从大细胞表面磷酸酶中的分离是γδTCR触发的关键步骤（vol 43, 114761, 2024）

CELL REPORTS

IF6.9

2024-10-01

OAAI

Li, Fenglei; Roy, Sobhan; Niculcea, Jacob; Gould, Keith; Adams, Erin J.; van der Merwe, P. Anton; Choudhuri, Kaushik

Ligand requirements for immunoreceptor triggering

COMMUNICATIONS BIOLOGY

IF5.1

2024-09-13

OAAI

Barton, Michael I.; Paterson, Rachel L.; Denham, Eleanor M.; Goyette, Jesse; van der Merwe, Philip Anton

Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering 配体诱导的从大细胞表面磷酸酶的分离是γδ TCR触发的关键步骤

CELL REPORTS

IF6.9

2024-09-01

OAAI

Li, Fenglei; Roy, Sobhan; Niculcea, Jacob; Gould, Keith; Adams, Erin J.; van der Merwe, P. Anton; Choudhuri, Kaushik

Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells Car-t细胞失去了tcr-t细胞中共刺激受体对时间细胞因子产生的调节

IMMUNOTHERAPY ADVANCES

IF4.9

2024-06-19

OAAI

Patel, Ashna; Kutuzov, Mikhail A.; Dustin, Michael L.; van der Merwe, P. Anton; Dushek, Omer

Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors 使用CombiCells，一种用于滴定和组合展示细胞表面配体的平台，研究辅助受体对T细胞抗原敏感性的调节

EMBO JOURNAL

IF8.3

2023-12-18

OAAI

Patel, Ashna; Andre, Violaine; Eguiguren, Sofia Bustamante; Barton, Michael, I; Burton, Jake; Denham, Eleanor M.; Pettmann, Johannes; Morch, Alexander M.; Kutuzov, Mikhail A.; Siller-Farfan, Jesus A.; Dustin, Michael L.; van der Merwe, P. Anton; Dushek, Omer

Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors 辅助受体的低效利用降低了嵌合抗原受体的敏感性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-01-04

OAAI

Burton, Jake; Siller-Farfan, Jesus A.; Pettmann, Johannes; Salzer, Benjamin; Kutuzov, Mikhail; van der Merwe, P. Anton; Dushek, Omer

Mechanical forces impair antigen discrimination by reducing differences in T-cell receptor/peptide-MHC off-rates 机械力通过减少T细胞受体/肽-MHC脱离速率的差异来削弱抗原的辨别能力

EMBO JOURNAL

IF8.3

2022-12-09

OAAI

Pettmann, Johannes; Awada, Lama; Rozycki, Bartosz; Huhn, Anna; Faour, Sara; Kutuzov, Mikhail; Limozin, Laurent; Weikl, Thomas R.; van der Merwe, P. Anton; Robert, Philippe; Dushek, Omer

Biomarkers of response to PD-1 pathway blockade

BRITISH JOURNAL OF CANCER

IF6.8

2022-02-28

OAAI

Li, Hanxiao; van der Merwe, P. Anton; Sivakumar, Shivan

Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-02-23

OAAI

Goyette, Jesse; Depoil, David; Yang, Zhengmin; Isaacson, Samuel A.; Allard, Jun; van der Merwe, P. Anton; Gaus, Katharina; Dustin, Michael L.; Dushek, Omer

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics SARS-CoV-2刺突RBD及其配体，人类ACE2受体中常见突变对结合亲和力和动力学的影响

ELIFE

IF0

2021-08-26

259

OAAI

Barton, Michael, I; MacGowan, Stuart A.; Kutuzov, Mikhail A.; Dushek, Omer; Barton, Geoffrey John; van der Merwe, P. Anton

The discriminatory power of the T cell receptor

ELIFE

IF0

2021-05-25

OAAI

Pettmann, Johannes; Huhn, Anna; Abu Shah, Enas; Kutuzov, Mikhail A.; Wilson, Daniel B.; Dustin, Michael L.; Davis, Simon J.; van der Merwe, P. Anton; Dushek, Omer

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

CELLS

IF5.2

2021-02-18

OAAI

Robert, Philippe; Limozin, Laurent; van der Merwe, P. Anton; Bongrand, Pierre

TCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2019-07-17

OAAI

Limozin, Laurent; Bridge, Marcus; Bongrand, Pierre; Dushek, Omer; van der Merwe, Philip Anton; Robert, Philippe

Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2016-11-01

OAAI

Banerji, Suneale; Lawrance, William; Metcalfe, Clive; Briggs, David C.; Yamauchi, Akira; Dushek, Omer; van der Merwe, P. Anton; Day, Anthony J.; Jackson, David G.

The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding

SCIENTIFIC REPORTS

IF3.9

2016-10-13

OAAI

Zhang, Hao; Lim, Hong-Sheng; Knapp, Berhard; Deane, Charlotte M.; Aleksic, Milos; Dushek, Omer; van der Merwe, P. Anton

Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose 最小信号通路的结构解释了T细胞对抗原亲和力和剂量变化100万倍的反应

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-10-04

OAAI

Lever, Melissa; Lim, Hong-Sheng; Kruger, Philipp; Nguyen, John; Trendel, Nicola; Abu-Shah, Enas; Maini, Philip Kumar; van der Merwe, Philip Anton; Dushek, Omer

Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response

BIOPHYSICAL JOURNAL

IF3.1

2016-04-01

OAAI

Mukhopadhyay, Himadri; de Wet, Ben; Clemens, Lara; Maini, Philip K.; Allard, Jun; van der Merwe, P. Anton; Dushek, Omer

研究方向