Richard M. Siegel - Publications, H-index & Citations

Richard M. Siegel

national institutes of health

73H指数

285论文数

2.1W被引数

收录论文 117

发表时间

Multi-omic profiling reveals immune cell priming signature linked to lupus prognosis 多组学分析揭示了与系统性红斑狼疮预后相关的免疫细胞预激特征

Arthritis & Rheumatology

IF10.9

2026-02-24

OAAI

Michael A. Smith; Dominic Sinibaldi PhD; Saifur Rahman PhD, MBA; Chia-Chien Chiang PhD; Anna M. Hansen PhD; Jill Henault PhD; Carlos P. Roca PhD; Shu Wang; Kamelia Zerrouki MS; Rebecca Filippi; Christopher Groves; Zerai Manna MS; Jun Chu MSN, CRNP; Michael Davis MSN, CRNP; Sarthak Gupta MD; Christopher Morehouse MS; Melissa de los Reyes MS; Rachel Ettinger PhD; Roland Kolbeck PhD; Mariana J. Kaplan MD; Miguel A. Sanjuan PhD; Richard M. Siegel MD, PhD; Sarfaraz A. Hasni MD, MSc; Kerry A. Casey PhD

Caspase 1-deficient humans survive into late adulthood despite dramatically lower canonical inflammasome activity Caspase 1 缺陷型人类尽管经典炎症小体活性显著降低，仍可存活至晚年。

Journal of Allergy and Clinical Immunology

IF11.2

2025-10-14

OAAI

John Dominy; Christopher Koch; Christelle Arnold; Vinney George; Maleeha Zaman Khan; Shareef Khalid; Aneeqa Bano; Muhammad Rehan Mian; Wafa Gul; Muhammad Bilal Liaqat; Lubna Kamani; Nazish Butt; Marium Dahar; Namra Saqib; Anjum Jalal; Shahid Abbas; Riffat Sultana; Musfireh Siddiqeh; Syed Shahzaib Raza; Muhammad Haroon; Asadullah Khan; Javed Iqbal; Faizan Aslam; Khalid Parvez Babar; Muhammad Sadik Memon; Ambreen Muddassir; Syed Asif Raza Zaidi; Mateen Akram; Aflak Rasheed; Saima Naz Mohsin; Samreen Bughti; Tariq Mehmood; Abdul Lateef Rodeni; Shahid Mukhtar; Tahir Rasool; Adil Mahmood; Muhammad Noor Wazir; Sheraz Jamal Khan; Muhammad Asghar Khan; Rahmat Ghaffar; Sanaullah Jan; Noor Ul Hadi; Asif Rasheed; Karine Jeanneau; Thomas Le Meur; Agnes Chassang; Jonas Zierer; Richard M. Siegel; Ursula Bodendorf; Allan Gurtan; Danish Saleheen

Interaction of histone Acetylases and deacetylases in vivo

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Yamagoe, S; Kanno, T; Kanno, Y; Sasaki, S; Siegel, RM; Lenardo, MJ; Humphrey, G; Wang, YH; Nakatani, Y; Howard, BH; Ozato, K

Translating from mouse to man to better understand immune-mediated inflammatory diseases

CELL REPORTS MEDICINE

IF10.6

2023-03-01

OAAI

Aschenbrenner, Dominik; Siegel, Richard M.

Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis 狼疮性肾炎中常驻和单核细胞衍生的巨噬细胞的独特致病作用

JCI INSIGHT

IF6.1

2022-11-08

OAAI

Richoz, Nathan; Tuong, Zewen K.; Loudon, Kevin W.; Patino-Martinez, Eduardo; Ferdinand, John R.; Portet, Anais; Bashant, Kathleen R.; Thevenon, Emeline; Rucci, Francesca; Hoyler, Thomas; Junt, Tobias; Kaplan, Mariana J.; Siegel, Richard M.; Clatworthy, Menna R.

Super-Resolution Imaging of Fas/CD95 Reorganization Induced by Membrane-Bound Fas Ligand Reveals Nanoscale Clustering Upstream of FADD Recruitment

CELLS

IF5.2

2022-06-12

OAAI

Frazzette, Nicholas; Cruz, Anthony C.; Wu, Xufeng; Hammer, John A.; Lippincott-Schwartz, Jennifer; Siegel, Richard M.; Sengupta, Prabuddha

Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype NEMO的遗传程序化选择性剪接介导自身炎症性疾病表型

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2022-03-15

OAAI

Lee, Younglang; Wessel, Alex W.; Xu, Jiazhi; Reinke, Julia G.; Lee, Eries; Kim, Somin M.; Hsu, Amy P.; Zilberman-Rudenko, Jevgenia; Cao, Sha; Enos, Clinton; Brooks, Stephen R.; Deng, Zuoming; Lin, Bin; de Jesus, Adriana A.; Hupalo, Daniel N.; Piotto, Daniela G. P.; Terreri, Maria T.; Dimitriades, Victoria R.; Dalgard, Clifton L.; Holland, Steven M.; Goldbach-Mansky, Raphaela; Siegel, Richard M.; Hanson, Eric P.

TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

CELL REPORTS

IF6.9

2021-11-01

107

OAAI

Willemsen, Joschka; Neuhoff, Marie-Therese; Hoyler, Thomas; Noir, Emma; Tessier, Clemence; Sarret, Sophie; Thorsen, Tara N.; Littlewood-Evans, Amanda; Zhang, Juan; Hasan, Maroof; Rush, James S.; Guerini, Danilo; Siegel, Richard M.

Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

NATURE COMMUNICATIONS

IF15.7

2021-05-12

OAAI

Geiger, Sarah S.; Traba, Javier; Richoz, Nathan; Farley, Taylor K.; Brooks, Stephen R.; Petermann, Franziska; Wang, Lingdi; Gonzalez, Frank J.; Sack, Michael N.; Siegel, Richard M.

Distribution and Functional Consequences of Somatic MAP2K1 Variants in Affected Skin Associated with Bone Lesions in Melorheostosis

JOURNAL OF INVESTIGATIVE DERMATOLOGY

IF5.7

2021-03-01

OAAI

Jha, Smita; Ivovic, Aleksandra; Kang, Heeseog; Meylan, Francoise; Hanson, Eric P.; Rimland, Casey; Lange, Eileen; Katz, James; McBride, Alison; Warner, Andrew C.; Edmondson, Elijah F.; Cowen, Edward W.; Marini, Joan C.; Siegel, Richard M.; Bhattacharyya, Timothy

Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2020-08-31

OAAI

Perez-Diez, Ainhoa; Wong, Chun-Shu; Liu, Xiangdong; Mystakelis, Harry; Song, Jian; Lu, Yong; Sheikh, Virginia; Bourgeois, Jeffrey S.; Lisco, Andrea; Laidlaw, Elizabeth; Cudrici, Cornelia; Zhu, Chengsong; Li, Quan-Zhen; Freeman, Alexandra F.; Williamson, Peter R.; Anderson, Megan; Roby, Gregg; Tsang, John S.; Siegel, Richard; Sereti, Irini

Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-06-15

125

OAAI

Jing, Chenzhi; Castro-Dopico, Tomas; Richoz, Nathan; Tuong, Zewen K.; Ferdinand, John R.; Lok, Laurence S. C.; Loudon, Kevin W.; Banham, Gemma D.; Mathews, Rebeccah J.; Cader, Zaeem; Fitzpatrick, Susan; Bashant, Kathleen R.; Kaplan, Mariana J.; Kaser, Arthur; Johnson, Randall S.; Murphy, Michael P.; Siegel, Richard M.; Clatworthy, Menna R.

Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2020-03-31

OAAI

Kang, Heeseog; Jha, Smita; Ivovic, Aleksandra; Fratzl-Zelman, Nadja; Deng, Zuoming; Mitra, Apratim; Cabral, Wayne A.; Hanson, Eric P.; Lange, Eileen; Cowen, Edward W.; Katz, James; Roschger, Paul; Klaushofer, Klaus; Dale, Ryan K.; Siegel, Richard M.; Bhattacharyya, Timothy; Marini, Joan C.

Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus

SCIENTIFIC REPORTS

IF3.9

2020-03-10

OAAI

Smith, Michael A.; Chiang, Chia-Chien; Zerrouki, Kamelia; Rahman, Saifur; White, Wendy, I; Streicher, Katie; Rees, William A.; Schiffenbauer, Adam; Rider, Lisa G.; Miller, Frederick W.; Manna, Zerai; Hasni, Sarfaraz; Kaplan, Mariana J.; Siegel, Richard; Sinibaldi, Dominic; Sanjuan, Miguel A.; Casey, Kerry A.

Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti-IgE Monoclonal Antibody in Systemic Lupus Erythematosus

ARTHRITIS & RHEUMATOLOGY

IF10.9

2019-05-08

OAAI

Hasni, Sarfaraz; Gupta, Sarthak; Davis, Michael; Poncio, Elaine; Temesgen-Oyelakin, Yenealem; Joyal, Elizabeth; Fike, Alice; Manna, Zerai; Auh, Sungyoung; Shi, Yinghui; Chan, Diana; Carlucci, Philip; Biehl, Ann; Dema, Barbara; Charles, Nicolas; Balow, James E.; Waldman, Meryl; Siegel, Richard M.; Kaplan, Mariana J.; Rivera, Juan

Insights into rheumatic diseases from next-generation sequencing

NATURE REVIEWS RHEUMATOLOGY

IF32.7

2019-04-18

OAAI

Donlin, Laura T.; Park, Sung-Ho; Giannopoulou, Eugenia; Ivovic, Aleksandra; Park-Min, Kyung-Hyun; Siegel, Richard M.; Ivashkiv, Lionel B.

T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2019-02-25

129

OAAI

Yamamoto, Tori N.; Lee, Ping-Hsien; Vodnala, Suman K.; Gurusamy, Devikala; Kishton, Rigel J.; Yu, Zhiya; Eidizadeh, Arash; Eil, Robert; Fioravanti, Jessica; Gattinoni, Luca; Kochenderfer, James N.; Fry, Terry J.; Aksoy, Bulent Arman; Hammerbacher, Jeffrey E.; Cruz, Anthony C.; Siegel, Richard M.; Restifo, Nicholas P.; Klebanoff, Christopher A.

Melorheostotic Bone Lesions Caused by Somatic Mutations in MAP2K1 Have Deteriorated Microarchitecture and Periosteal Reaction

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2019-01-22

OAAI

Fratzl-Zelman, Nadja; Roschger, Paul; Kang, Heeseog; Jha, Smita; Roschger, Andreas; Blouin, Stephane; Deng, Zuoming; Cabral, Wayne A.; Ivovic, Aleksandra; Katz, James; Siegel, Richard M.; Klaushofer, Klaus; Fratzl, Peter; Bhattacharyya, Timothy; Marini, Joan C.

Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology 视黄酸受体 α 抑制Th9转录和表观基因组程序以减少过敏病理

IMMUNITY

IF26.3

2019-01-01

OAAI

Schwartz, Daniella M.; Farley, Taylor K.; Richoz, Nathan; Yao, Chen; Shih, Han-Yu; Petermann, Franziska; Zhang, Yuan; Sun, Hong-Wei; Hayes, Erika; Mikami, Yohei; Jiang, Kan; Davis, Fred P.; Kanno, Yuka; Milner, Joshua D.; Siegel, Richard; Laurence, Arian; Meylan, Francoise; O'Shea, John J.

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease

PLOS GENETICS

IF3.7

2018-09-10

OAAI

Richard, Arianne C.; Peters, James E.; Savinykh, Natalia; Lee, James C.; Hawley, Eric T.; Meylan, Francoise; Siegel, Richard M.; Lyons, Paul A.; Smith, Kenneth G. C.

研究方向