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J

John K. Lee

University of California Los Angeles
H指数:45
被引数:7,716

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tRNA dosage regulates lineage dependency and resistance in prostate cancer

tRNA剂量调控前列腺癌细胞谱系依赖性和耐药性

Nature
IF48.5
2026-10-070
OA
Yeon Soo Kim; Sonali Arora; Dave Young; Ava Tsou; Amy Shiuan; Cynthia L. Wladyka; Dmytro Rudoy; Jin Yeong Kim; Jennifer A. Waters; Samantha L. Schuster; Ilsa M. Coleman; Mridu Kapur; Marek Sobczyk; Christopher D. Katanski; Amin M. Bayat Tork; Wen Zhang; Peter S. Nelson; Gavin Ha; Michael C. Haffner; Eva Corey; Colm Morrissey; Yuzhuo Wang; Arvind R. Subramaniam; John K. Lee; Susan L. Ackerman; Tao Pan; Andrew C. Hsieh
Recurrent prostate adenocarcinoma after radical prostatectomy: Principles of multidisciplinary management across a spectrum of disease

根治性前列腺切除术后的复发性前列腺腺癌：不同疾病阶段的多学科管理原则

CA-A Cancer Journal for Clinicians
IF232.4
2026-09-290
OAAI
Amar U. Kishan MD; Yulia Zekster MD; Adam E. Singer MD, PhD; Kekoa Taparra MD, PhD, MPH; Luca F. Valle MD; Michael L. Steinberg MD; Nicholas G. Nickols MD, PhD; Robert E. Reiter MD, MBA; Johannes Czernin MD; Jeremie Calais MD, PhD; John K. Lee MD, PhD; Lawrence R. Hardesty BS; Matthew B. Rettig MD
Evolution and heterogeneity of lethal metastatic bladder cancer subtypes

致死性转移性膀胱癌亚型的演化和异质性

Nature
IF48.5
2026-09-160
OAAI
Pushpa Itagi; Samantha L. Schuster; Sonali Arora; Thomas W. Persse; Jennifer A. Waters; Michael Yang; Alan Min; Pooja Chandra; Mohamed Adil; Patricia C. Galipeau; Dmytro Rudoy; Allie S. Kreitman; Yixin Lin; Minjeong Ko; Erolcan Sayar; Robert D. Patton; Lori Kollath; Abby Meis; Samuel Lindergren; Nathan Ji; Khursheed Ali; Hrishi Venkatesh; Cynthia L. Wladyka; A. Patrick McDeed; Claire B. Mills; Manasvita Vashisth; Jin Yeong Kim; Rosa Nadal; Jessica E. Hawley; Todd A. Yezefski; Sarah P. Psutka; John L. Gore; Daniel W. Lin; Peter S. Nelson; Heather H. Cheng; Michael T. Schweizer; Lawrence Fong; John K. Lee; Evan Y. Yu; Eva Corey; Colm Morrissey; Petros Grivas; Robert B. Montgomery; Jonathan L. Wright; Michael C. Haffner; Funda Vakar-Lopez; Omar Y. Mian; Hung-Ming Lam; Andrew C. Hsieh; Gavin Ha
Systematic analysis of hippo pathway signaling identifies TEAD1 as a transcriptional regulator of neuroendocrine prostate cancer

系统分析 Hippo 通路信号传导确定了 TEAD1 是神经内分泌前列腺癌的转录调控因子

Neoplasia
IF7.7
2026-05-300
OAAI
Lisha G. Brown; Ilsa M. Coleman; Tony L.H. Chu; Erolcan Sayar; Radhika A. Patel; Brian Hanratty; Mohamed Adil; Dapei Li; Yongtao Li; Holly M. Nguyen; Conner J. Sessions; Erin L. Sweeney; Joshi J. Alumkal; Rui M. Gil da Costa; Yuzhuo Wang; Daniel W. Lin; Lawrence D. True; Ruth Dumpit; Eva Corey; John K. Lee
Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering

通过捕捉键工程克服T细胞对肿瘤自身抗原的耐受性

Science
IF45.8
2026-03-190
PRE
Xiaojing Chen; Zhiyuan Mao; E. Motunrayo Kolawole; Margherita Persechino; Kevin M. Jude; Masato Ogishi; Kelvin C. Mo; Jami McLaughlin; Donghui Cheng; Xinyu Xiang; Xinbo Yang; Caitlin Gee; Shiqin Liu; Aerin Yang; Matthias Obenaus; Nan Wang; Miyako Noguchi; Tanya Stoyanova; John K. Lee; Zinaida Good; Naomi R. Latorraca; Brian D. Evavold; Owen N. Witte; K. Christopher Garcia
Collagen-binding IL-12-armoured STEAP1 CAR-T cells reduce toxicity and treat prostate cancer in mouse models

胶原蛋白结合IL-12装甲STEAP1 CAR-T细胞可降低毒性并治疗小鼠模型中的前列腺癌

Nature Biomedical Engineering
IF26.6
2025-10-230
OAAI
Koichi Sasaki; Vipul Bhatia; Yuta Asano; Jakob Bakhtiari; Pooja Kaur; Chuyi Wang; Takumi Matsuo; Olivier Dubois; Po-Chuan Chiu; Donny Gun; Charanjit Singh; Ioanna Panagi; Laurine Noblecourt; Maria Nikolaidi; Truman Chong; Gerardo Javier; Saul J. Priceman; Aude G. Chapuis; John K. Lee; Jun Ishihara
Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery

靶向PD-L1的融合蛋白工程化改造的实体瘤CAR-T细胞，用于局部IL-12递送

Nature Biomedical Engineering
IF26.6
2025-10-010
OAAI
John P. Murad; Lea Christian; Reginaldo Rosa; Yuwei Ren; Alyssa J. Buckley; Eric Hee Jun Lee; Lupita S. Lopez; Anthony K. Park; Jason Yang; Yukiko Yamaguchi; Candi Trac; Lauren N. Adkins; Wen-Chung Chang; Catalina Martinez; Carl H. June; Stephen J. Forman; Jun Ishihara; John K. Lee; Lawrence A. Stern; Saul J. Priceman
Modulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer

通过调节PPARγ通路上调NECTIN4，并增强膀胱癌中嵌合抗原受体（CAR）T细胞疗法。Nat. Commun. 16 (1), 8215

Nature Communications
IF15.7
2025-09-100
OAAI
Kevin Chang; Henry M. Delavan; Elizabeth Yip; Corynn Kasap; Jun Zhu; Roshan Lodha; Sheng-You Liao; Sarah C. Berman; Alberto Carretero-Gonzalez; Merve Basar; Gamze Gokturk Ozcan; Min Yuen Teo; David B. Solit; Jonathan E. Rosenberg; Hikmat Al-Ahmadie; Cornelia C. K. Ding; Emily Chan; Veronica Steri; Sima P. Porten; Vadim S. Koshkin; Terence W. Friedlander; Felix Y. Feng; John K. Lee; Arun P. Wiita; Carissa E. Chu; Jonathan Chou
Functional, sustained recovery of hearing in Otoferlin-deficient mice using DB-OTO, a hair cell-specific AAV based dual vector gene therapy

使用DB-OTO（一种基于毛细胞特异性AAV的双载体基因疗法）实现 otoferlin 缺陷小鼠功能性、持续性的听力恢复

Molecular Therapy Methods & Clinical Development
IF4.7
2025-08-250
OAAI
Yoojin Chung; Seth D. Koehler; Sarah Cancelarich; Tyler M. Gibson; Gabriela Pregernig; Lars Becker; Quynh-Anh Artinian; Joseph W. Goodliffe; Ning Pan; Tera M. Quigley; Arun Senapati; Peter G. Slade; Lillian M. Smith; Kathy S. So; Xichun Zhang; C. Eduardo Corrales; Peter Weber; Lynn E. Macdonald; Brian Zambrowicz; Aris N. Economides; Christos A. Kyratsous; Joseph C. Burns; Adam T. Palermo; Leah R. Sabin; John Lee; Vassili Valayannopoulos; Jonathon P. Whitton; Meghan C. Drummond
PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2024-11-260
OAAI
Varuzhanyan, Grigor; Chen, Chia-Chun; Freeland, Jack; He, Tian; Tran, Wendy; Song, Kai; Wang, Liang; Cheng, Donghui; Xu, Shili; Dibernardo, Gabriella A.; Esedebe, Favour N.; Bhatia, Vipul; Han, Mingqi; Abt, Evan R.; Park, Jung Wook; Memarzadeh, Sanaz; Shackelford, David B.; Lee, John K.; Graeber, Thomas G.; Shirihai, Orian S.; Witte, Owen N.
Assessment of TROP2, CEACAM5 and DLL3 in metastatic prostate cancer: Expression landscape and molecular correlates
NPJ PRECISION ONCOLOGY
IF8
2024-05-173
OAAI
Ajkunic, Azra; Sayar, Erolcan; Roudier, Martine P.; Patel, Radhika A.; Coleman, Ilsa M.; De Sarkar, Navonil; Hanratty, Brian; Adil, Mohamed; Zhao, Jimmy; Zaidi, Samir; True, Lawrence D.; Sperger, Jamie M.; Cheng, Heather H.; Yu, Evan Y.; Montgomery, Robert B.; Hawley, Jessica E.; Ha, Gavin; Persse, Thomas; Galipeau, Patricia; Lee, John K.; Harmon, Stephanie A.; Corey, Eva; Lang, Joshua M.; Sawyers, Charles L.; Morrissey, Colm; Schweizer, Michael T.; Gulati, Roman; Nelson, Peter S.; Haffner, Michael C.
Multiomic characterization of colorectal cancer using MICS technology reveals interaction of antigen presenting cancer associated fibroblasts and T cells
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Neil, Emily; Hennessey, Rebecca C.; Agorku, David; Park, Dongju; Femel, Julia; DiBuono, Michael; Lafayette, Hanna; Lloyd, Erica; Lo, Hsinyi; Makrigiorgos, Alex; Lu, Shaina; Lee, John; Soliman, Sameh; Dominic, Mangiardi; Praveen, Paurush; Strobel, Philip; Ruberg, Silvia; Staubach, Fabian; Hindman, Ryan; Rothmann, Thomas; Hardt, Olaf; Meyer, Hansueli; Wantenaar, Tanya; Wang, Jinling; Mueller, Werner; Pinard, Robert; Bosio, Andreas
Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models

肿瘤衍生的生物标志物预测B7H3抗体-药物偶联物治疗转移性前列腺癌模型的疗效

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2023-11-153
OAAI
Agarwal, Supreet; Fang, Lei; Mcgowen, Kerry; Yin, Juanjuan; Bowman, Joel; Ku, Anson T.; Alilin, Aian Neil; Corey, Eva; Roudier, Martine P.; True, Lawrence D.; Dumpit, Ruth; Coleman, Ilsa; Lee, John K.; Nelson, Peter S.; Capaldo, Brian J.; Mariani, Aida; Hoover, Clare; Senatorov, Ilya S.; Beshiri, Michael; Sowalsky, Adam G.; Hurt, Elaine M.; Kelly, Kathleen

研究方向

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R
Robert M. Stroud
H 指数:85论文数:527被引数:2.9万
P
Peter S. Nelson
H 指数:113论文数:1,484被引数:6.6万
I
Ilsa M. Coleman
H 指数:62论文数:641被引数:1.7万
O
Owen N. Witte
H 指数:122论文数:760被引数:4.7万
E
Eva Corey
H 指数:65论文数:929被引数:1.5万
C
Colm Morrissey
H 指数:62论文数:572被引数:1.7万
J
Jiaoti Huang
H 指数:90论文数:732被引数:2.6万
L
Lawrence D. True
H 指数:82论文数:726被引数:3.9万
M
Michael C. Haffner
H 指数:51论文数:533被引数:9,697
J
Jung Wook Park
H 指数:23论文数:45被引数:3,112