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Developing an adaptive platform trial for evaluation of medical treatments for Crohn's disease 开发一个适应性平台试验，用于评估克罗恩病的医疗治疗方法 Noor, Nurulamin M.; Radford, Shellie J.; Choodari-Oskooei, Babak; Gordon, Morris; Hart, Ailsa L.; Hepburn, Trish; Juszczak, Ed; Lindsay, James O.; Kennedy, Nicholas A.; Parmar, Mahesh K. B.; Jairath, Vipul; Moran, Gordon W. 分享 收藏
Comparison of endoscopic remission and MRI defined remission using the simplified MaRIA score at week 48 from the PROFILE trial Bhandari, M.; Noor, N.; Paverd, H.; De Paepe, K.; Godfrey, E.; Hickman, K.; Khwaja, S.; Lee, J.; Raine, T.; Kennedy, N.; Upponi, S.; Parkes, M.; PROFILE Study Grp 分享 收藏
Weight-loss medications and bariatric surgery are infrequently used in obese patients with inflammatory bowel disease in North and East Devon in the United Kingdom (UK) Hodges, P.; Roberts, C.; Badrulhsisham, F.; Pamment, D.; Smith, R.; Cairnes, V; Bewshea, C.; Kennedy, N.; Goodhand, J.; Ahmad, T. 分享 收藏
Establishment and validation of a central reader pool for magnetic resonance enterography (MRE) for use in Crohn's disease clinical trials Pillay, L.; Paverd, H.; Noor, N.; Hickman, K.; De Paepe, K.; Godfrey, E. M.; Khwaja, S.; Upponi, S.; Kennedy, N. A.; Parkes, M.; Raine, T. 分享 收藏
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Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study Chanchlani, Neil; Lin, Simeng; Bewshea, Claire; Hamilton, Benjamin; Thomas, Amanda; Smith, Rebecca; Roberts, Christopher; Bishara, Maria; Nice, Rachel; Lees, Charlie W.; Sebastian, Shaji; Irving, Peter M.; Russell, Richard K.; McDonald, Timothy J.; Goodhand, James R.; Ahmad, Tariq; Kennedy, Nicholas A. 分享 收藏
A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial Noor, Nurulamin M.; Lee, James C.; Bond, Simon; Dowling, Francis; Brezina, Biljana; Patel, Kamal, V; Ahmad, Tariq; Banim, Paul J.; Berrill, James W.; Cooney, Rachel; Negro, Juan De La Revilla; de Silva, Shanika; Din, Shahida; Durai, Dharmaraj; Gordon, John N.; Irving, Peter M.; Johnson, Matthew; Kent, Alexandra J.; Kok, Klaartje B.; Moran, Gordon W.; Mowat, Craig; Patel, Pritash; Probert, Chris S.; Raine, Tim; Saich, Rebecca; Seward, Abigail; Sharpstone, Dan; Smith, Melissa A.; Subramanian, Sreedhar; Upponi, Sara S.; Wiles, Alan; Williams, Horace R. T.; van den Brink, Gijs R.; Vermeire, Severine; Jairath, Vipul; D'Haens, Geert R.; McKinney, Eoin F.; Lyons, Paul A.; Lindsay, James; Kennedy, Nicholas A.; Smith, Kenneth G. C.; Parkes, Miles 分享 收藏
Antibody Responses to Influenza Vaccination are Diminished in Patients With Inflammatory Bowel Disease on Infliximab or Tofacitinib 使用英夫利昔单抗或托法替尼的炎症性肠病患者对流感疫苗的抗体反应减弱 Liu, Zhigang; Alexander, James L.; Eng, Kai Yee; Ibraheim, Hajir; Anandabaskaran, Sulak; Saifuddin, Aamir; Constable, Laura; Seoane, Rocio Castro; Bewshea, Claire; Nice, Rachel; D'Mello, Andrea; Jones, Gareth R.; Balarajah, Sharmili; Fiorentino, Francesca; Sebastian, Shaji; Irving, Peter M.; Hicks, Lucy C.; Williams, Horace R. T.; Kent, Alexandra J.; Linger, Rachel; Parkes, Miles; Kok, Klaartje; Patel, Kamal, V; Teare, Julian P.; Altmann, Daniel M.; Boyton, Rosemary J.; Hart, Ailsa L.; Lees, Charlie W.; Goodhand, James R.; Kennedy, Nicholas A.; Pollock, Katrina M.; Ahmad, Tariq; Powell, Nick 分享 收藏
Baseline TREM-1 Whole Blood Gene Expression Does Not Predict Response to Adalimumab Treatment in Patients with Ulcerative Colitis or Crohn's Disease in the SERENE Studies Verstockt, Bram; Pivorunas, Valerie; Al Mahi, Naim; Smaoui, Nizar; Guay, Heath; Kennedy, Nicholas A.; Goodhand, James R.; Lin, Simeng; Bai, Benjamin Y. H.; Hanauer, Stephen B.; Ferrante, Marc; Panes, Julian; Vermeire, Severine 分享 收藏
Neutralising antibody responses against SARS-CoV-2 Omicron BA.4/5 and wild-type virus in patients with inflammatory bowel disease following three doses of COVID-19 vaccine (VIP): a prospective, multicentre, cohort study 炎症性肠病患者在三剂新型冠状病毒肺炎疫苗 (VIP) 后中和针对SARS-CoV-2 Omicron BA.4/5和野生型病毒的抗体反应: 一项前瞻性、多中心、队列研究 Liu, Zhigang; Alexander, James L.; Le, Kaixing; Zhou, Xin; Ibraheim, Hajir; Anandabaskaran, Sulak; Saifuddin, Aamir; Lin, Kathy Weitung; McFarlane, Leon R.; Constable, Laura; Seoane, Rocio Castro; Anand, Nikhil; Bewshea, Claire; Nice, Rachel; D'Mello, Andrea; Jones, Gareth R.; Balarajah, Sharmili; Fiorentino, Francesca; Sebastian, Shaji; Irving, Peter M.; Hicks, Lucy C.; Williams, Horace R. T.; Kent, Alexandra J.; Linger, Rachel; Parkes, Miles; Kok, Klaartje; Patel, Kamal V.; Teare, Julian P.; Altmann, Daniel M.; Boyton, Rosemary J.; Hart, Ailsa L.; Lees, Charlie W.; Goodhand, James R.; Kennedy, Nicholas A.; Pollock, Katrina M.; Ahmad, Tariq; Powell, Nick 分享 收藏
Baseline Expression of Immune Gene Modules in Blood is Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease Patients Bai, Benjamin Y. H.; Reppell, Mark; Smaoui, Nizar; Waring, Jeffrey F.; Pivorunas, Valerie; Guay, Heath; Lin, Simeng; Chanchlani, Neil; Bewshea, Claire; Goodhand, James R.; Kennedy, Nicholas A.; Ahmad, Tariq; Anderson, Carl A. 分享 收藏
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Whole Blood DNA Methylation Changes Are Associated with Anti-TNF Drug Concentration in Patients with Crohn's Disease 克罗恩病患者全血DNA甲基化改变与抗TNF药物浓度相关 Lin, Simeng; Hannon, Eilis; Reppell, Mark; Waring, Jeffrey F.; Smaoui, Nizar; Pivorunas, Valerie; Guay, Heath; Chanchlani, Neil; Bewshea, Claire; Bai, Benjamin Y. H.; Kennedy, Nicholas A.; Goodhand, James R.; Mill, Jonathan; Ahmad, Tariq 分享 收藏
Prevalence of NUDT15 Genetic Variants and Incidence of Thiopurine-induced Leukopenia in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis 炎症性肠病中NUDT15基因变异的患病率和硫嘌呤诱导的白细胞减少症的发生率: 系统回顾和荟萃分析 Yu, Natalie; Sriranganathan, Danujan; Walker, Gareth J.; Sazonovs, Aleksejs; Wilding, Helen; Roberts, Christopher; Kennedy, Nicholas A.; Ahmad, Tariq; Boyapati, Ray K.; Ding, Nik S.; Segal, Jonathan P. 分享 收藏
Neutralising antibody potency against SARS-CoV-2 wild- type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study Liu, Zhigang; Le, Kaixing; Zhou, Xin; Alexander, James L.; Lin, Simeng; Bewshea, Claire; Chanchlani, Neil; Nice, Rachel; McDonald, Timothy J.; Lamb, Christopher A.; Sebastian, Shaji; Kok, Klaartje; Lees, Charlie W.; Hart, Ailsa L.; Pollok, Richard C.; Boyton, Rosemary J.; Altmann, Daniel M.; Pollock, Katrina M.; Goodhand, James R.; Kennedy, Nicholas A.; Ahmad, Tariq; Powell, Nick 分享 收藏
The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients Alexander, James L.; Mullish, Benjamin H.; Danckert, Nathan P.; Liu, Zhigang; Olbei, Marton L.; Saifuddin, Aamir; Torkizadeh, Melissa; Ibraheim, Hajir; Blanco, Jesus Miguens; Roberts, Lauren A.; Bewshea, Claire M.; Nice, Rachel; Lin, Simeng; Prabhudev, Hemanth; Sands, Caroline; Horneffer-van der Sluis, Verena; Lewis, Matthew; Sebastian, Shaji; Lees, Charlie W.; Teare, Julian P.; Hart, Ailsa; Goodhand, James R.; Kennedy, Nicholas A.; Korcsmaros, Tamas; Marchesi, Julian R.; Ahmad, Tariq; Powell, Nick 分享 收藏
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