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P-glycoprotein as a chemotherapy resistance mechanism and biomarker of poor response in high-risk neuroblastoma Atkinson, Caroline; Kamili, Alvin; Tactacan, Carole M.; Jayatilleke, Nisitha; Rosser, Sebastian P. A.; Saletta, Federica; Gana, Christine C.; Graber, Philipp; Wanninayaka, Amanda; Ignacio, Rosa Mistica C.; Kavallaris, Maria; Gifford, Andrew J.; Lock, Richard B.; Norris, Murray D.; Haber, Michelle; Mayoh, Chelsea; Nath, Christa E.; Trahair, Toby N.; Fletcher, Jamie I. 分享 收藏
Polyamine depletion limits progression of acute leukaemia Gao, Weiman; Karsa, Mawar; Xiao, Lin; Spurling, Dayna; Karsa, Ayu; Ronca, Emma; Bongers, Angelika; Guo, Xinyi; Mayoh, Chelsea; Azfar, Mujahid; Verhelst, Steven H. L.; Tanaka, Katsunori; Cheung, Laurence C.; Kotecha, Rishi S.; Lock, Richard B.; Burns, Mark R.; Vangheluwe, Peter; Norris, Murray D.; Haber, Michelle; Somers, Klaartje 分享 收藏
Lessons learned from 20 years of preclinical testing in pediatric cancers 从20年的儿科癌症临床前测试中吸取的经验教训 Smith, Malcolm A.; Houghton, Peter J.; Lock, Richard B.; Maris, John M.; Gorlick, Richard; Kurmasheva, Raushan T.; Li, Xiao-Nan; Teicher, Beverly A.; Chuang, Jeffrey H.; Cruz, Filemon S. Dela; Dyer, Michael A.; Kung, Andrew L.; Lloyd, Michael W.; Mosse, Yael P.; Stearns, Timothy M.; Stewart, Elizabeth A.; Bult, Carol J.; Erickson, Stephen W. 分享 收藏
PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia Beck, Dominik; Cao, Honghui; Tian, Feng; Huang, Yizhou; Jiang, Miao; Zhao, Han; Tai, Xiaolu; Xu, Wenqian; Kosasih, Hansen J.; Kealy, David J.; Zhao, Weiye; Taylor, Samuel J.; Couttas, Timothy A.; Song, Gaoxian; Chacon-Fajardo, Diego; Walia, Yashna; Wang, Meng; Dowle, Adam A.; Holding, Andrew N.; Bridge, Katherine S.; Zhang, Chao; Wang, Jin; Mi, Jian-Qing; Lock, Richard B.; de Bock, Charles E.; Jing, Duohui 分享 收藏
The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia Toscan, Cara E.; McCalmont, Hannah; Ashoorzadeh, Amir; Lin, Xiaojing; Fu, Zhe; Doculara, Louise; Kosasih, Hansen J.; Cadiz, Roxanne; Zhou, Anthony; Williams, Sarah; Evans, Kathryn; Khalili, Faezeh; Cai, Ruilin; Yeats, Kristy L.; Gifford, Andrew J.; Pickford, Russell; Mayoh, Chelsea; Xie, Jinhan; Henderson, Michelle J.; Trahair, Toby N.; Patterson, Adam V.; Smaill, Jeff B.; de Bock, Charles E.; Lock, Richard B. 分享 收藏
Development of a precision medicine platform for paediatric acute myeloid leukaemia Connerty, P.; Xie, J.; El-Najjar, F.; Mao, J.; Cadiz, R.; Tax, G.; Dolman, M. E. M.; Jayatilleke, N.; Mayoh, C.; Moore, A. S.; Colgan, J.; Marshall, G. M.; Lock, R. B. 分享 收藏
TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells Truong, Peter; Shen, Sylvie; Joshi, Swapna; Islam, Md Imtiazul; Zhong, Ling; Raftery, Mark J.; Afrasiabi, Ali; Alinejad-Rokny, Hamid; Nguyen, Mary; Zou, Xiaoheng; Bhuyan, Golam Sarower; Sarowar, Chowdhury H.; Ghodousi, Elaheh S.; Stonehouse, Olivia; Mohamed, Sara; Toscan, Cara E.; Connerty, Patrick; Kakadia, Purvi M.; Bohlander, Stefan K.; Michie, Katharine A.; Larsson, Jonas; Lock, Richard B.; Walkley, Carl R.; Thoms, Julie A. I.; Jolly, Christopher J.; Pimanda, John E. 分享 收藏
PRECISION GUIDED THERAPY PROVIDES CLINICAL BENEFIT IN H3K27-ALTERED DIFFUSE MIDLINE GLIOMA McKay, Campbell; Power, Phoebe; Staunton, Jordan; Sriharan, Shampavi; Jessop, Sophie; Zhukova, Nataliya; Trinder, Sarah; Govender, Dinisha; Barahona, Paulette; Gifford, Andrew J.; Mignone, Cristina; Xie, Angela; Tax, Gabor; Tsoli, Maria; Dolman, Emmy; Mayoh, Chelsea; Wong, Marie; Cowley, Mark; Marshall, Glenn; Trahair, Toby; Lock, Richard B.; Ekert, Paul; Haber, Michelle; Tyrell, Vanessa; Lau, Loretta; Manoharan, Neevika; Ziegler, David S.; Khuong-Quang, Dong-Anh 分享 收藏
Precision-guided treatment in high-risk pediatric cancers Lau, Loretta M. S.; Khuong-Quang, Dong-Anh; Mayoh, Chelsea; Wong, Marie; Barahona, Paulette; Ajuyah, Pamela; Senapati, Akanksha; Nagabushan, Sumanth; Sherstyuk, Alexandra; Altekoester, Ann-Kristin; Fuentes-Bolanos, Noemi A.; Yeung, Veronica; Sullivan, Ashleigh; Omer, Natacha; Diamond, Yonatan; Jessop, Sophie; Battaglia, Lauren; Zhukova, Nataliya; Cui, Louise; Lin, Angela; Gifford, Andrew J.; Fleuren, Emmy D. G.; Dalla-Pozza, Luciano; Moore, Andrew S.; Khaw, Seong-Lin; Eisenstat, David D.; Gottardo, Nicholas G.; Wood, Paul J.; Tapp, Heather; Alvaro, Frank; McCowage, Geoffrey; Nicholls, Wayne; Hansford, Jordan R.; Manoharan, Neevika; Kotecha, Rishi S.; Mateos, Marion K.; Lock, Richard B.; Tyrrell, Vanessa; Haber, Michelle; Trahair, Toby N.; Cowley, Mark J.; Ekert, Paul G.; Marshall, Glenn M.; Ziegler, David S. 分享 收藏
The ROR1 antibody-drug conjugate, MK-2140, enhances the efficacy of established drugs in preclinical models of pediatric acute lymphoblastic leukemia Lock, Richard B.; Evans, Kathryn; Watts, Ben; Bowman, Edward P.; Neuhauser, Steven; Stearns, Timothy; Chuang, Jeffrey H.; Phillip, Vivek M.; Jessen, Katti A.; Jocoy, Emily L.; Bult, Carol J.; Teicher, Beverly A.; Smith, Malcolm A. 分享 收藏
ETV6::ACSL6 translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression Xu, Wenqian; Tian, Feng; Tai, Xiaolu; Song, Gaoxian; Liu, Yuanfang; Fan, Liquan; Weng, Xiangqin; Yang, Eunjeong; Wang, Meng; Bornhaeuser, Martin; Zhang, Chao; Lock, Richard B.; Wong, Jason W. H.; Wang, Jin; Jing, Duohui; Mi, Jian-Qing 分享 收藏
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The menin inhibitor VTP-50469 enhances the in vivo efficacy of established drugs against preclinical models of aggressive infant MLL-r acute lymphoblastic leukemia Lock, Richard B.; Evans, Kathryn; Gawan-Taylor, Sophia; Watts, Ben; Stearns, Timothy; Earley, Eric J.; Jocoy, Emily L.; Bult, Carol J.; Teicher, Beverly A.; McGeehan, Gerard M.; Smith, Malcolm A. 分享 收藏
PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia Shah, Kinjal; Nasimian, Ahmad; Ahmed, Mehreen; Al Ashiri, Lina; Denison, Linn; Sime, Wondossen; Bendak, Katerina; Kolosenko, Iryna; Siino, Valentina; Levander, Fredrik; Palm-Apergi, Caroline; Massoumi, Ramin; Lock, Richard B.; Kazi, Julhash U. 分享 收藏
High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer 原发性肿瘤细胞的高通量药物筛选确定治疗高危癌症儿童的治疗策略 Mayoh, Chelsea; Mao, Jie; Xie, Jinhan; Tax, Gabor; Chow, Shu-Oi; Cadiz, Roxanne; Pazaky, Karina; Barahona, Paulette; Ajuyah, Pamela; Trebilcock, Peter; Malquori, Angela; Gunther, Kate; Avila, Anica; Yun, Doo Young; Alfred, Stephanie; Gopalakrishnan, Anjana; Kamili, Alvin; Wong, Marie; Cowley, Mark J.; Jessop, Sophie; Lau, Loretta M. S.; Trahair, Toby N.; Ziegler, David S.; Fletcher, Jamie I.; Gifford, Andrew J.; Tsoli, Maria; Marshall, Glenn M.; Haber, Michelle; Tyrrell, Vanessa; Failes, Timothy W.; Arndt, Greg M.; Lock, Richard B.; Ekert, Paul G.; Dolman, M. Emmy M. 分享 收藏
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Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia Moles, Ernest; Howard, Christopher B.; Huda, Pie; Karsa, Mawar; McCalmont, Hannah; Kimpton, Kathleen; Duly, Alastair; Chen, Yongjuan; Huang, Yizhou; Tursky, Melinda L.; Ma, David; Bustamante, Sonia; Pickford, Russell; Connerty, Patrick; Omari, Sofia; Jolly, Christopher J.; Joshi, Swapna; Shen, Sylvie; Pimanda, John E.; Dolnikov, Alla; Cheung, Laurence C.; Kotecha, Rishi S.; Norris, Murray D.; Haber, Michelle; de Bock, Charles E.; Somers, Klaartje; Lock, Richard B.; Thurecht, Kristofer J.; Kavallaris, Maria 分享 收藏
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