Geoffrey McCowage

hospital for sick children (sickkids)

H指数:32

被引数:4,447

个人简介

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教育背景

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工作经历

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荣誉奖项

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Harnessing liquid biopsy to unveil RAS-MEK pathway somatic pathogenic variants in extracranial arterio-venous malformations

利用液体活检揭示体外的动静脉畸形中RAS-MEK通路体细胞致病性变异

Communications Medicine

IF6.3

2025-12-050

OAAI

Biological Medicines for Diffuse Intrinsic Pontine Gliomas (DIPG) Eradication (BIOMEDE). An International Randomized Phase II Biomarker-driven Platform Trial Comparing Three Targeted Therapies in Combination with Radiotherapy

弥漫性内生性脑桥胶质瘤（DIPG）清除的生物制剂（BIOMEDE）。一项国际性、随机化、II期、生物标志物驱动的平台试验，比较三种靶向疗法联合放射治疗的效果。

NEURO-ONCOLOGY

IF13.4

2025-11-010

OAAI

Debily, Marie-Anne; Le Teuff, Gwenael; Kergrohen, Thomas; Varlet, Pascale Pascale; Castel, David; Leblond, Pierre; Hargrave, Darren; Nysom, Karsten; Blomgren, Klas; McCowage, Geoffrey Brian; Bautista, Francisco; Van Vuurden, Dannis; Jones, Chris; Ziegler, David; Moussa, Angokai; Barret, Emilie; Puget, Stephanie; Beccaria, Kevin; Aquilina, Kristian; Riffaud, Laurent; Bolle, Stephanie; Bertozzi, Anne-Isabelle; Abbou, Samuel; De Carli, Emilie; Boddaert, Nathalie; Calmon, Raphael; Blanc, Patricia; Vassal, Gilles; Grill, Jacques; Le Marie-Cecile, Deley

Molecular characterization of the SJMB12 clinical trial for children and young adults with newly diagnosed medulloblastoma

SJMB12临床试验的分子特征分析：针对新诊断髓母细胞瘤的儿童及青少年患者

NEURO-ONCOLOGY

IF13.4

2025-11-010

PRE

The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial (vol 30, pg 207, 2024)

复发/难治性小儿低度神经胶质瘤中的II型RAF抑制剂tovorafenib: 2期FIREFLY-1试验 (第30卷，207页，2024)

NATURE MEDICINE

IF50

2025-04-160

Kilburn, Lindsay B.; Khuong-Quang, Dong-Anh; Hansford, Jordan R.; Landi, Daniel; van der Lugt, Jasper; Leary, Sarah E. S.; Driever, Pablo Hernaiz; Bailey, Simon; Perreault, Sebastien; McCowage, Geoffrey; Waanders, Angela J.; Ziegler, David S.; Witt, Olaf; Baxter, Patricia A.; Kang, Hyoung Jin; Hassall, Timothy E.; Han, Jung Woo; Franson, Andrea T.; Yalon Oren, Michal; Toledano, Helen; Larouche, Valerie; Kline, Cassie; Abdelbaki, Mohamed S.; Jabado, Nada; Gottardo, Nicholas G.; Gerber, Nicolas U.; Whipple, Nicholas S.; Segal, Devorah; Chi, Susan N.; Oren, Liat; Tan, Enrica E. K.; Mueller, Sabine; Cornelio, Izzy; McLeod, Lisa; Zhao, Xin; Walter, Ashley; Da Costa, Daniel; Manley, Peter; Blackman, Samuel C.; Packer, Roger J.; Nysom, Karsten

Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial

在FIREFLY-1试验中，托瓦雷芬尼（tovorafenib）这种II型RAF抑制剂对复发性/难治性视神经通路胶质瘤患儿的放射学和视觉反应。

NEURO-ONCOLOGY

IF13.4

2024-12-190

PRE

Nysom, Karsten; Kilburn, Lindsay B.; Leary, Sarah E. S.; Landi, Daniel B.; de Vos-Kerkhof, Evelien; Perreault, Sebastien; Witt, Olaf; Ziegler, David S.; Hernaiz Driever, Pablo; Franson, Andrea T.; Baxter, Patricia A.; Whipple, Nicholas S.; Kline, Cassie; Segal, Devorah; Jabado, Nada; Bailey, Simon; Mccowage, Geoffrey; Hansford, Jordan R.; Khuong-Quang, Dong-Anh; Gottardo, Nicholas G.; Hassall, Timothy; Han, Jung Woo; Yalon Oren, Michal; Chi, Susan N.; Qiu, Jiaheng; Da Costa, Daniel; Raju, Sandya Govinda; Manley, Peter

TYPE II RAF INHIBITOR TOVORAFENIB IN RELAPSED/REFRACTORY (R/R) PEDIATRIC LOW-GRADE GLIOMA (PLGG): RESULTS FROM PATIENTS ON A DRUG HOLIDAY (DH) IN THE PHASE 2 FIREFLY-1 TRIAL

NEURO-ONCOLOGY

IF13.4

2024-11-110

PRE

Perreault, Sebastien; Khuong-Quang, Dong-Anh; Kilburn, Lindsay B.; Landi, Daniel B.; Leary, Sarah E. S.; Bailey, Simon; Larouche, Valerie; Nysom, Karsten; Driever, Pablo Hernaiz; Baxter, Patricia A.; Witt, Olaf; Oren, Michal Yalon; Abdelbaki, Mohamed S.; Kline, Cassie; Whipple, Nicholas S.; Ziegler, David S.; van der Lugt, Jasper; Hassall, Timothy E.; Gerber, Nicolas U.; Segal, Devorah; Hansford, Jordan R.; Mccowage, Geoffrey; Kang, Hyoung Jin; Han, Jung Woo; Hargrave, Darren; Franson, Andrea T.; Toledano, Helen; Jabado, Nada; Gottardo, Nicholas G.; Chi, Susan N.; Oren, Liat; Tan, Enrica E. K.; Mueller, Sabine; Hoke, Molly E.; Kim, Yeonhee; Walter, Ashley; Da Costa, Daniel; Manley, Peter; Waanders, Angela J.

NEURO-ONCOLOGY

IF13.4

2024-11-110

PRE

Peipert, John (Devin); Baxter, Patricia A.; Oestreicher, Nina; Zelt, Susan; Driever, Pablo Hernaiz; Yu, Sandie; Bailey, Simon; McCowage, Geoffrey; Ziegler, David S.; Witt, Olaf; Kang, Hyoung Jin; Hassall, Timothy E.; Han, Jung Woo; Franson, Andrea T.; Oren, Michal Yalon; Toledano, Helen; Larouche, Valerie; Abdelbaki, Mohamed S.; Jabado, Nada; Gottardo, Nicholas G.; Gerber, Nicolas U.; Whipple, Nicholas S.; Segal, Devorah; Chi, Susan N.; Oren, Liat; Tan, Enrica E. K.; Mueller, Sabine; Kilburn, Lindsay B.; Nysom, Karsten; Khuong-Quang, Dong-Anh; Landi, Daniel B.; van der Lugt, Jasper; Leary, Sarah E. S.; Perreault, Sebastien; Waanders, Angela J.; Hargrave, Darren; Kline, Cassie; McKenna, Chris; Manley, Peter; Raju, Sandya Govinda; Hansford, Jordan R.

DEVELOPING NOVEL, MORE STRINGENT EVALUATION PLATFORMS TO ACCELERATE RESEARCH TRANSLATION AND INCREASE SURVIVAL FROM BRAIN CANCER

NEURO-ONCOLOGY

IF13.4

2024-10-170

PRE

OUTCOMES OF SONIC HEDGEHOG (SHH) MEDULLOBLASTOMA (MB) IN CHILDREN AND ADULTS TREATED WITH RISK-ADAPTED THERAPY ON A PROSPECTIVE INTERNATIONAL PROTOCOL (SJMB12)

NEURO-ONCOLOGY

IF13.4

2024-06-180

OAAI

Gajjar, Amar J.; Orr, Brent; Ellison, David; Lafay-Cousin, Lucie; Minturn, Jane; Fisher, Michael; Bendel, Anne; Hwang, Eugene; Murray, Jeffrey; Landi, Daniel; Smith, Amy; Gottardo, Nicholas; Valvi, Santhosh; Hassal, Tim; Elster, Jennifer; Perrault, Sebastian; Ramaswamy, Vijay; Partap, Sonia; Laughton, Stephen; Cohn, Richard; Chintagumpala, Murali; McCowage, Geoffrey; Hansford, Jordan; Sullivan, Michael; Sayour, Elias; Bowers, Daniel; Marks, Asher; Huang, Jie; Lucas, John; Tinkle, Christopher; Pinto, Soniya; Bag, Asim; Sabin, Noah; Northcott, Paul; Klimo, Paul; Merchant, Thomas E.; Onar-Thomas, Arzu; Robinson, Giles W.

TYPE II RAF INHIBITOR TOVORAFENIB IN RELAPSED/REFRACTORY PEDIATRIC LOW-GRADE GLIOMA (PLGG): REVERSIBLE DECREASES IN GROWTH VELOCITY IN THE PHASE 2 FIREFLY-1 TRIAL

复发/难治性小儿低级别神经胶质瘤 (PLGG) 中的II型RAF抑制剂TOVORAFENIB: 2期FIREFLY-1试验中生长速度的可逆降低

NEURO-ONCOLOGY

IF13.4

2024-06-180

OAAI

Kline, Cassie; Waanders, Angela J.; Ziegler, David S.; Kilburn, Lindsay B.; Nysom, Karsten; van der Lugt, Jasper; Hassall, Timothy E.; Gerber, Nicolas U.; Segal, Devorah; Larouche, Valerie; Khuong-Quang, Dong-Anh; Hansford, Jordan R.; Leary, Sarah E. S.; Driever, Pablo Hernaiz; Bailey, Simon; Perreault, Sebastien; McCowage, Geoffrey; Witt, Olaf; Baxter, Patricia A.; Kang, Hyoung Jin; Han, Jung Woo; Hargrave, Darren; Franson, Andrea T.; Oren, Michal Yalon; Toledano, Helen; Abdelbaki, Mohamed S.; Jabado, Nada; Gottardo, Nicholas G.; Whipple, Nicholas S.; Chi, Susan N.; Oren, Liat; Tan, Enrica E. K.; Mueller, Sabine; Wright, Karen D.; Blackman, Samuel C.; Qiu, Jiaheng; Podesta, Dolores; Walter, Ashley; Da Costa, Daniel; Manley, Peter; McLeod, Lisa; Landi, Daniel B.

PNOC022 REPORT: A COMBINATION THERAPY TRIAL USING AN ADAPTIVE PLATFORM DESIGN FOR PATIENTS WITH DIFFUSE MIDLINE GLIOMA AT INITIAL DIAGNOSIS, POST-RADIATION THERAPY, OR PROGRESSION

NEURO-ONCOLOGY

IF13.4

2024-06-180

OAAI

Kline, Cassie; Franson, Andrea; Banerjee, Anuradha; Reddy, Alyssa T.; Raber, Shannon; Hoffman, Carly; Minturn, Jane; van der Lugt, Jasper; de Vos-Kerkhof, Evelien; van Vuurden, Dannis; Gerber, Nicolas; Stucklin, Ana S. Guerreiro; Kilburn, Lindsay; Elster, Jennifer; Whipple, Nicholas; Cohen, Kenneth; Oren, Michal Yalon; Gardner, Sharon; Cluster, Andrew; Chi, Susan; Landi, Daniel; McCowage, Geoffrey; Vo, Josh; Resnick, Adam; Phillips, Joanna; Bhatia, Aashim; George, Elizabeth; Vossough, Arastoo; Nabavizadeh, Ali; Braunstein, Steve; Gupta, Nalin; Prados, Michael; Waszak, Sebastian; Long-Boyle, Janel; Molinaro, Annette; Dun, Matthew; Koschmann, Carl; Nazarian, Javad; Mueller, Sabine

EFFECT OF REDUCED-DOSE CRANIOSPINAL IRRADIATION AND REDUCED-DOSE ADJUVANT CHEMOTHERAPY ON CHILDREN AND ADOLESCENTS WITH WNT MEDULLOBLASTOMA WITHOUT RESIDUAL OR METASTATIC DISEASE: RESULTS FROM THE SJMB12 CLINICAL TRIAL

NEURO-ONCOLOGY

IF13.4

2024-06-180

OAAI

Robinson, Giles W.; Merchant, Thomas E.; Orr, Brent A.; Bass, Johnnie K.; Conklin, Heather M.; Bag, Asim; Dhanda, Sandeep K.; Pinto, Soniya; Delaney, Angela; Mikkelsen, Margit; Reddick, Wilburn; Huang, Jie; Ashford, Jason; Edwards, Angela; Christy, Leigh Ann; Soans, Eroica; Clarke, Molly; Strother, Doug; Fisher, Michael J.; Bendel, Anne; Hwang, Eugene, I; Zhao, Sibo; Smith, Amy; Gottardo, Nicholas G.; Hassall, Timothy E. G.; Elster, Jennifer; Perreault, Sebastien; Ramaswamy, Vijay; Partap, Sonia; Laughton, Stephen; Cohn, Richard; Chintagumpala, Murali; Mccowage, Geoffrey; Sullivan, Michael; Sayour, Elias; Bowers, Daniel; Marks, Asher; Lucas, John; Tinkle, Christopher; Sabin, Noah D.; Klimo, Paul; Ellison, David W.; Northcott, Paul A.; Onar-Thomas, Arzu; Gajjar, Amar

Precision-guided treatment in high-risk pediatric cancers

NATURE MEDICINE

IF50

2024-06-067

OAAI

Lau, Loretta M. S.; Khuong-Quang, Dong-Anh; Mayoh, Chelsea; Wong, Marie; Barahona, Paulette; Ajuyah, Pamela; Senapati, Akanksha; Nagabushan, Sumanth; Sherstyuk, Alexandra; Altekoester, Ann-Kristin; Fuentes-Bolanos, Noemi A.; Yeung, Veronica; Sullivan, Ashleigh; Omer, Natacha; Diamond, Yonatan; Jessop, Sophie; Battaglia, Lauren; Zhukova, Nataliya; Cui, Louise; Lin, Angela; Gifford, Andrew J.; Fleuren, Emmy D. G.; Dalla-Pozza, Luciano; Moore, Andrew S.; Khaw, Seong-Lin; Eisenstat, David D.; Gottardo, Nicholas G.; Wood, Paul J.; Tapp, Heather; Alvaro, Frank; McCowage, Geoffrey; Nicholls, Wayne; Hansford, Jordan R.; Manoharan, Neevika; Kotecha, Rishi S.; Mateos, Marion K.; Lock, Richard B.; Tyrrell, Vanessa; Haber, Michelle; Trahair, Toby N.; Cowley, Mark J.; Ekert, Paul G.; Marshall, Glenn M.; Ziegler, David S.

Management of patients with diffuse intrinsic pontine glioma in Australia and New Zealand: Australian and New Zealand Children's Haematology/Oncology Group position statement

MEDICAL JOURNAL OF AUSTRALIA

IF8.5

2024-05-031

OAAI

A Phase 1 Study of Intravenous EGFR-ErbituxEDVsMIT in Children with Solid or CNS Tumours Expressing Epidermal Growth Factor Receptor

TARGETED ONCOLOGY

IF4

2024-03-282

OAAI

The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial (vol 30, pg 207, 2024)

复发/难治性小儿低度神经胶质瘤中的II型RAF抑制剂tovorafenib: 2期FIREFLY-1试验 (第30卷，207页，2024)

NATURE MEDICINE

IF50

2024-03-111

OAAI

Kilburn, Lindsay B.; Khuong-Quang, Dong-Anh; Hansford, Jordan R.; Landi, Daniel; van der Lugt, Jasper; Leary, Sarah E. S.; Driever, Pablo Hernaiz; Bailey, Simon; Perreault, Sebastien; McCowage, Geoffrey; Waanders, Angela J.; Ziegler, David S.; Witt, Olaf; Baxter, Patricia A.; Kang, Hyoung Jin; Hassall, Timothy E.; Han, Jung Woo; Hargrave, Darren; Franson, Andrea T.; Yalon Oren, Michal; Toledano, Helen; Larouche, Valerie; Kline, Cassie; Abdelbaki, Mohamed S.; Jabado, Nada; Gottardo, Nicholas G.; Gerber, Nicolas U.; Whipple, Nicholas S.; Segal, Devorah; Chi, Susan N.; Oren, Liat; Tan, Enrica E. K.; Mueller, Sabine; Cornelio, Izzy; Mcleod, Lisa; Zhao, Xin; Walter, Ashley; Da Costa, Daniel; Manley, Peter; Blackman, Samuel C.; Packer, Roger J.; Nysom, Karsten

The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial

复发/难治性小儿低级别神经胶质瘤的II型RAF抑制剂tovorafenib: 2期FIREFLY-1试验

NATURE MEDICINE

IF50

2023-11-1740

OAAI

Kilburn, Lindsay B.; Khuong-Quang, Dong-Anh; Hansford, Jordan R.; Landi, Daniel; van der Lugt, Jasper; Leary, Sarah E. S.; Driever, Pablo Hernaiz; Bailey, Simon; Perreault, Sebastien; Mccowage, Geoffrey; Waanders, Angela J.; Ziegler, David S.; Witt, Olaf; Baxter, Patricia A.; Kang, Hyoung Jin; Hassall, Timothy E.; Han, Jung Woo; Hargrave, Darren; Franson, Andrea T.; Yalon Oren, Michal; Toledano, Helen; Larouche, Valerie; Kline, Cassie; Abdelbaki, Mohamed S.; Jabado, Nada; Gottardo, Nicholas G.; Gerber, Nicolas U.; Whipple, Nicholas S.; Segal, Devorah; Chi, Susan N.; Oren, Liat; Tan, Enrica E. K.; Mueller, Sabine; Cornelio, Izzy; Mcleod, Lisa; Zhao, Xin; Walter, Ashley; Da Costa, Daniel; Manley, Peter; Blackman, Samuel C.; Packer, Roger J.; Nysom, Karsten

Implementation of DNA Methylation Array Profiling in Pediatric Central Nervous System Tumors The AIM BRAIN Project: An Australian and New Zealand Children's Haematology/Oncology Group Study

AIM BRAIN项目: 澳大利亚和新西兰儿童血液学/肿瘤学小组研究

JOURNAL OF MOLECULAR DIAGNOSTICS

IF3.4

2023-10-014

OAAI

White, Christine L.; Kinross, Kathryn M.; Moore, Molly K.; Rasouli, Elnaz; Strong, Robyn; Jones, Janelle M.; Cain, Jason E.; Sturm, Dominik; Sahm, Felix; Jones, David T. W.; Pfister, Stefan M.; Robertson, Thomas; D'Arcy, Colleen; Rodriguez, Michael L.; Dyke, Jason M.; Junckerstorff, Reimar; Bhuva, Dharmesh D.; Davis, Melissa J.; Wood, Paul; Hassall, Tim; Ziegler, David S.; Kellie, Stewart; McCowage, Geoffrey; Alvaro, Frank; Kirby, Maria; Heath, John A.; Tsui, Karen; Dodgshun, Andrew; Eisenstat, David D.; Khuong-Quang, Dong-Anh; Wall, Meaghan; Algar, Elizabeth M.; Gottardo, Nicholas G.; Hansford, Jordan R.

CLINICAL ACTIVITY OF PAN-RAF INHIBITOR TOVORAFENIB IN THE REGISTRATIONAL PEDIATRIC LOWGRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY

泛RAF抑制剂TOVORAFENIB在2期FIREFLY-1 (PNOC026) 研究的注册儿科低级别神经胶质瘤组中的临床活性

NEURO-ONCOLOGY

IF13.4

2023-06-122

OAAI

BRAF-mediated brain tumors in adults and children: A review and the Australian and New Zealand experience

FRONTIERS IN ONCOLOGY

IF3.3

2023-04-145

OAAI

Trinder, Sarah M.; McKay, Campbell; Power, Phoebe; Topp, Monique; Chan, Bosco; Valvi, Santosh; McCowage, Geoffrey; Govender, Dinisha; Kirby, Maria; Ziegler, David S.; Manoharan, Neevika; Hassall, Tim; Kellie, Stewart; Heath, John; Alvaro, Frank; Wood, Paul; Laughton, Stephen; Tsui, Karen; Dodgshun, Andrew; Eisenstat, David D.; Endersby, Raelene; Luen, Stephen J.; Koh, Eng-Siew; Sim, Hao-Wen; Kong, Benjamin; Gottardo, Nicholas G.; Whittle, James R.; Khuong-Quang, Dong-Anh; Hansford, Jordan R.

Geoffrey McCowage

个人简介

教育背景

工作经历

荣誉奖项

研究方向