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D

David S. Ziegler

copenhagen university hospital
H指数:45
被引数:8,572

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Precision-guided therapy in H3K27-altered diffuse midline glioma

H3K27-改变的弥漫性中线胶质瘤中的精准导向疗法

Nature Communications
IF15.7
2026-05-190
OAAI
Campbell J. L. McKay; Chelsea Mayoh; Phoebe Power; Sophie Jessop; Shampavi Sriharan; Jordan Staunton; Sarah Trinder; Nataliya Zhukova; Cristina Mignone; Dinisha Govender; Frank Alvaro; Peter Downie; Jordan R. Hansford; Tim Hassall; Santosh Valvi; Marion K. Mateos; Paulette Barahona; Andrew J. Gifford; Gabor Tax; Maria Tsoli; Emmy M. Dolman; Marie Wong; Mark Cowley; Glenn M. Marshall; Toby N. Trahair; Paul G. Ekert; Michelle Haber; Vanessa Tyrell; Loretta M. S. Lau; Neevika Manoharan; David S. Ziegler; Dong-Anh Khuong-Quang
Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial
Nature Medicine
IF50
2026-04-011
PRE
Debily, Marie-Anne; Le Teuff, Gwenael; Kergrohen, Thomas; Varlet, Pascale; Castel, David; Leblond, Pierre; Hargrave, Darren; Nysom, Karsten; Blomgren, Klas; McCowage, Geoffrey Brian; Bautista, Francisco; van Vuurden, Dannis; Jones, Chris; Mackay, Alan; Izquierdo, Elisa; Ziegler, David S.; Moussa, Angokai; Barret, Emilie; Puget, Stephanie; Beccaria, Kevin; Aquilina, Kristian; Riffaud, Laurent; Bolle, Stephanie; Abbou, Samuel; Bertozzi, Anne-Isabelle; De Carli, Emilie; Boddaert, Nathalie; Dangouloff-Ros, Volodia; Calmon, Raphael; Blanc, Patricia; Vassal, Gilles; Le Deley, Marie-Cecile; Grill, Jacques
Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma

联合抑制FACT和BET破坏转录以抑制弥漫性中线胶质瘤小鼠模型的肿瘤生长

Science Translational Medicine
IF14.6
2026-01-140
PRE
Holliday, Holly; Khan, Aaminah; Ehteda, Anahid; Nguyen, Hieu; Ross, Samuel E.; Jayatilleke, Nisitha; Gopalakrishnan, Anjana; Wang, Eyden; Sanguino, Yolanda Colino; Kavanagh, Daisy; Guo, Xinyi; Liu, Jie; Lawrence, David; Sun, Claire X.; Lehmann, Rebecca; Ip, Chi Kin; Lee, Alvin; Rangel-Sanchez, Laura; Li, Wenyan; Salomon, Robert; Firestein, Ron; Weatheritt, Robert J.; Valdes-Mora, Fatima; Dinger, Marcel E.; Phoenix, Timothy N.; Mayoh, Chelsea; Rayner, Benjamin S.; Tsoli, Maria; Ziegler, David S.
TIP-30. Molecularly-guided phase 2 umbrella trial for children and young adults with newly-diagnosed high-grade glioma (HGG) including diffuse intrinsic pontine glioma (DIPG): CONNECT TarGeT (Targeted pediatric HGG therapy) trial in progress

TIP-30. 分子引导的针对新诊断的高级别胶质瘤（HGG，包括弥漫性内生性脑桥胶质瘤（DIPG）的儿童及青少年患者的二期伞式临床试验：正在进行的CONNECT TarGeT（靶向儿科HGG疗法）试验。

Neuro-Oncology
IF13.4
2025-11-110
OA
Margot Lazow; Kathleen Schieffer; Diana Thomas; Vera Paulson; Bonnie Cole; Christine Fuller; Santosh Valvi; Nicholas Gottardo; Michael Fisher; Ashley Plant; Ralph Salloum; Erin Crotty; Eugene Hwang; Anirban Das; Uri Tabori; Hamza Gorsi; Susan Chi; Sarah Leary; Patricia Baxter; Cynthia Hawkins; Michael Hubank; Thomas Jacques; David Jones; Felix Sahm; Mark Cowley; David Ziegler; Michael Rodriguez; Jason Dyke; Thomas Robertson; Joshua Palmer; Kelsey Troyer; Anna Harr; Rachid Drissi; Elaine Mardis; Darren Hargrave; Chris Jones; Maryam Fouladi
Clinical stability following tovorafenib treatment in relapsed/refractory pediatric low-grade glioma: updated results from the phase 2 FIREFLY-1 trial

托伐拉芬治疗后复发/难治性儿童低级别胶质瘤的临床稳定性：更新来自2期FIREFLY-1试验的结果

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Kline, Cassie; Hargrave, Darren; Khong-Quang, Dong-Anh; Landi, Daniel; Leary, Sarah; Van Der Lugt, Jasper; Mueller, Sabine; Nysom, Karsten; Perreault, Sebastien; Waanders, Angela; Witt, Olaf; Ziegler, David; Manley, Peter; Zhang, Jingyang; Barry, Elly; Kilburn, Lindsay
The development of ACT001 with Mcl-1 inhibitors as a novel combination therapy for the treatment of paediatric diffuse midline glioma

ACT001与Mcl-1抑制剂联合开发作为一种新型联合疗法，用于治疗儿童弥漫性中线胶质瘤

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Lawrence, David; Upton, Dannielle; Tax, Gabor; Holliday, Holly; Ung, Caitlin; Gopalakrishnan, Anjana; Liu, Jie; Dolman, M. Emmy M.; Mao, Jie; Sivanathan, Acadia; Cai, Dongpo Doug; Su, Steven Yung-Chang; Rayner, Benjamin Rayner; Tsoli, Maria; Ziegler, David S.
CHROMATIN REMODELING WITH COMBINED FACT AND BET INHIBITION DISRUPTS ONCOGENIC TRANSCRIPTION IN DIFFUSE MIDLINE GLIOMA

联合FACT和BET抑制的染色质重塑破坏弥漫性中线胶质瘤中的致癌转录

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Holliday, Holly; Khan, Aaminah; Ehteda, Anahid; Nguyen, Hieu; Ross, Samuel; Jayatilleke, Nisitha; Gopalakrishnan, Anjana; Wang, Eyden; Guo, Xinyi; Sanguino, Yolanda Colino; Kavanagh, Daisy; Liu, Jie; Lawrence, David; Sun, Claire; Lehmann, Rebecca; Ip, Chi Kin; Lee, Alvin; Li, Wenyan; Salomon, Robert; Firestein, Ron; Weatheritt, Robert; Valdes-Mora, Fatima; Dinger, Marcel; Phoenix, Timothy; Mayoh, Chelsea; Rayner, Benjamin; Tsoli, Maria; Ziegler, David
Biological Medicines for Diffuse Intrinsic Pontine Gliomas (DIPG) Eradication (BIOMEDE). An International Randomized Phase II Biomarker-driven Platform Trial Comparing Three Targeted Therapies in Combination with Radiotherapy

弥漫性内生性脑桥胶质瘤（DIPG）清除的生物制剂（BIOMEDE）。一项国际性、随机化、II期、生物标志物驱动的平台试验，比较三种靶向疗法联合放射治疗的效果。

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Debily, Marie-Anne; Le Teuff, Gwenael; Kergrohen, Thomas; Varlet, Pascale Pascale; Castel, David; Leblond, Pierre; Hargrave, Darren; Nysom, Karsten; Blomgren, Klas; McCowage, Geoffrey Brian; Bautista, Francisco; Van Vuurden, Dannis; Jones, Chris; Ziegler, David; Moussa, Angokai; Barret, Emilie; Puget, Stephanie; Beccaria, Kevin; Aquilina, Kristian; Riffaud, Laurent; Bolle, Stephanie; Bertozzi, Anne-Isabelle; Abbou, Samuel; De Carli, Emilie; Boddaert, Nathalie; Calmon, Raphael; Blanc, Patricia; Vassal, Gilles; Grill, Jacques; Le Marie-Cecile, Deley
The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial (vol 30, pg 207, 2024)

复发/难治性小儿低度神经胶质瘤中的II型RAF抑制剂tovorafenib: 2期FIREFLY-1试验 (第30卷，207页，2024)

NATURE MEDICINE
IF50
2025-04-160
OA
Kilburn, Lindsay B.; Khuong-Quang, Dong-Anh; Hansford, Jordan R.; Landi, Daniel; van der Lugt, Jasper; Leary, Sarah E. S.; Driever, Pablo Hernaiz; Bailey, Simon; Perreault, Sebastien; McCowage, Geoffrey; Waanders, Angela J.; Ziegler, David S.; Witt, Olaf; Baxter, Patricia A.; Kang, Hyoung Jin; Hassall, Timothy E.; Han, Jung Woo; Franson, Andrea T.; Yalon Oren, Michal; Toledano, Helen; Larouche, Valerie; Kline, Cassie; Abdelbaki, Mohamed S.; Jabado, Nada; Gottardo, Nicholas G.; Gerber, Nicolas U.; Whipple, Nicholas S.; Segal, Devorah; Chi, Susan N.; Oren, Liat; Tan, Enrica E. K.; Mueller, Sabine; Cornelio, Izzy; McLeod, Lisa; Zhao, Xin; Walter, Ashley; Da Costa, Daniel; Manley, Peter; Blackman, Samuel C.; Packer, Roger J.; Nysom, Karsten
The Super Enhancer-Driven Long Noncoding RNA PRKCQ-AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

超增强子驱动的长链非编码RNA PRKCQ-AS1通过与其SI2蛋白相互作用促进神经母细胞瘤肿瘤发生，且可被小分子化合物靶向。

ADVANCED SCIENCE
IF14.1
2025-03-180
OAAI
Mondal, S; Liu, PY; Seneviratne, J; De Weck, A; Venkat, P; Mayoh, C; Wu, J; Maag, J; Chen, JW; Wong, M; Bartonicek, N; Khoo, P; Jin, L; Ludlow, LE; Ziegler, DS; Trahair, T; Mestdagh, P; Cheung, BB; Li, JY; Dinger, ME; Street, I; Zhang, XD; Marshall, GM; Liu, T
Germline analysis of an international cohort of pediatric diffuse midline glioma patients

对国际队列儿童弥漫性中线胶质瘤患者的生殖系分析

NEURO-ONCOLOGY
IF13.4
2025-03-120
PRE
Marion K Mateos; Pamela Ajuyah; Noemi Fuentes-Bolanos; Sam El-Kamand; Paulette Barahona; Ann-Kristin Altekoester; Chelsea Mayoh; Holly Holliday; Jie Liu; Louise Cui; Elke Pfaff; Alan Mackay; Adam C Resnick; Mark Pinese; Loretta M S Lau; Dong-Anh Khuong-Quang; Kimberly Dias; Catherine Goudie; Alison Salkeld; Jo Lynne Rokita; David T W Jones; Nikoleta Juretic; Elisha Hayden; Stefan M Pfister; Christof M Kramm; Mirjam Blattner-Johnson; Nada Jabado; Maria Tsoli; Orazio Vittorio; Sabine Mueller; Yiran Guo; Katherine Tucker; Sebastian M Waszak; Sebastien Perreault; Chris Jones; Marie Wong-Erasmus; Mark J Cowley; David S Ziegler
High-throughput in vitro drug screening and in vivo studies identify fenretinide as a brain-penetrant DMG therapeutic

高通量体外药物筛选和体内研究将fenretinide确定为一种能够穿透血脑屏障的DMG治疗药物。

NEURO-ONCOLOGY
IF13.4
2025-02-120
PRE
Upton, Dannielle H.; Liu, Jie; George, Sandra M.; Valvi, Santosh; Ung, Caitlin; Rayner, Benjamin S.; Gopalakrishnan, Anjana; Pandher, Ruby; Khan, Aaminah; Venkat, Pooja; Mayoh, Chelsea; Holliday, Holly; Yeung, Nicole; Nguyen, Hieu; Franshaw, Laura; Ehteda, Anahid; Shen, Han; Farruggia, Giovanna; Orienti, Isabella; Reynolds, C. Patrick; Tsoli, Maria; Ziegler, David S.
Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial

在FIREFLY-1试验中，托瓦雷芬尼（tovorafenib）这种II型RAF抑制剂对复发性/难治性视神经通路胶质瘤患儿的放射学和视觉反应。

NEURO-ONCOLOGY
IF13.4
2024-12-190
PRE
Nysom, Karsten; Kilburn, Lindsay B.; Leary, Sarah E. S.; Landi, Daniel B.; de Vos-Kerkhof, Evelien; Perreault, Sebastien; Witt, Olaf; Ziegler, David S.; Hernaiz Driever, Pablo; Franson, Andrea T.; Baxter, Patricia A.; Whipple, Nicholas S.; Kline, Cassie; Segal, Devorah; Jabado, Nada; Bailey, Simon; Mccowage, Geoffrey; Hansford, Jordan R.; Khuong-Quang, Dong-Anh; Gottardo, Nicholas G.; Hassall, Timothy; Han, Jung Woo; Yalon Oren, Michal; Chi, Susan N.; Qiu, Jiaheng; Da Costa, Daniel; Raju, Sandya Govinda; Manley, Peter

研究方向

暂未获取到该数据
M
Maria Tsoli
H 指数:27论文数:249被引数:3,627
C
Chelsea Mayoh
H 指数:33论文数:324被引数:4,004
M
Michelle Haber
H 指数:65论文数:666被引数:1.6万
J
Jordan R. Hansford
H 指数:45论文数:331被引数:1.1万
L
Loretta M. S. Lau
H 指数:43论文数:201被引数:1.8万
M
Mark J. Cowley
H 指数:63论文数:409被引数:1.9万
G
Glenn M. Marshall
H 指数:62论文数:528被引数:1.1万
P
Paul G. Ekert
H 指数:55论文数:367被引数:1.4万
A
Andrew J. Gifford
H 指数:32论文数:198被引数:6,478
S
Sarah Leary
H 指数:43论文数:287被引数:8,583