David S. Ziegler - Publications, H-index & Citations

David S. Ziegler

copenhagen university hospital

45H指数

632论文数

8.4K被引数

收录论文 178

发表时间

Precision-guided therapy in H3K27-altered diffuse midline glioma H3K27-改变的弥漫性中线胶质瘤中的精准导向疗法

Nature Communications

IF15.7

2026-05-19

OAAI

Campbell J. L. McKay; Chelsea Mayoh; Phoebe Power; Sophie Jessop; Shampavi Sriharan; Jordan Staunton; Sarah Trinder; Nataliya Zhukova; Cristina Mignone; Dinisha Govender; Frank Alvaro; Peter Downie; Jordan R. Hansford; Tim Hassall; Santosh Valvi; Marion K. Mateos; Paulette Barahona; Andrew J. Gifford; Gabor Tax; Maria Tsoli; Emmy M. Dolman; Marie Wong; Mark Cowley; Glenn M. Marshall; Toby N. Trahair; Paul G. Ekert; Michelle Haber; Vanessa Tyrell; Loretta M. S. Lau; Neevika Manoharan; David S. Ziegler; Dong-Anh Khuong-Quang

Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial

Nature Medicine

IF50

2026-04-01

PREAI

Debily, Marie-Anne; Le Teuff, Gwenael; Kergrohen, Thomas; Varlet, Pascale; Castel, David; Leblond, Pierre; Hargrave, Darren; Nysom, Karsten; Blomgren, Klas; McCowage, Geoffrey Brian; Bautista, Francisco; van Vuurden, Dannis; Jones, Chris; Mackay, Alan; Izquierdo, Elisa; Ziegler, David S.; Moussa, Angokai; Barret, Emilie; Puget, Stephanie; Beccaria, Kevin; Aquilina, Kristian; Riffaud, Laurent; Bolle, Stephanie; Abbou, Samuel; Bertozzi, Anne-Isabelle; De Carli, Emilie; Boddaert, Nathalie; Dangouloff-Ros, Volodia; Calmon, Raphael; Blanc, Patricia; Vassal, Gilles; Le Deley, Marie-Cecile; Grill, Jacques

RNA N6-methyladenosine (m6A) regulates cell cycle progression in diffuse midline glioma (DMG) and confers sensitivity to FTO inhibition RNA N6-甲基腺苷（m6A）调控弥漫性中线胶质瘤（DMG）中的细胞周期进程，并赋予对FTO抑制的敏感性。

Cell Death & Disease

IF9.6

2026-03-26

OAAI

Samuel E. Ross; Holly Holliday; Eyden Wang; Mahdi Zeraati; Maria Tsoli; David S. Ziegler; Marcel E. Dinger

A New Hope: Clinical Advances in Targeted Therapies for Pediatric Diffuse Midline Glioma 新希望：儿童弥漫性中线胶质瘤靶向治疗领域的临床进展

Neuro-Oncology Advances

IF4.1

2026-03-11

OAAI

Joshua Zhu; Maria Tsoli; Jean Bertoldo; Sabine Mueller; David S Ziegler

Combined inhibition of FACT and BET disrupts transcription to suppress tumor growth in mouse models of diffuse midline glioma 联合抑制FACT和BET破坏转录以抑制弥漫性中线胶质瘤小鼠模型的肿瘤生长

Science Translational Medicine

IF14.6

2026-01-14

PREAI

Holliday, Holly; Khan, Aaminah; Ehteda, Anahid; Nguyen, Hieu; Ross, Samuel E.; Jayatilleke, Nisitha; Gopalakrishnan, Anjana; Wang, Eyden; Sanguino, Yolanda Colino; Kavanagh, Daisy; Guo, Xinyi; Liu, Jie; Lawrence, David; Sun, Claire X.; Lehmann, Rebecca; Ip, Chi Kin; Lee, Alvin; Rangel-Sanchez, Laura; Li, Wenyan; Salomon, Robert; Firestein, Ron; Weatheritt, Robert J.; Valdes-Mora, Fatima; Dinger, Marcel E.; Phoenix, Timothy N.; Mayoh, Chelsea; Rayner, Benjamin S.; Tsoli, Maria; Ziegler, David S.

Animated videos for childhood cancer precision medicine: development and evaluation with parents and patients 儿童癌症精准医学的动画视频：与家长和患者共同开发与评估

Supportive Care in Cancer

IF3

2025-11-21

PREAI

Jessica M. Gereis; Kate Hetherington; Eden G. Robertson; Rebecca Daly; Brittany C. McGill; David S. Ziegler; Claire E. Wakefield

TIP-30. Molecularly-guided phase 2 umbrella trial for children and young adults with newly-diagnosed high-grade glioma (HGG) including diffuse intrinsic pontine glioma (DIPG): CONNECT TarGeT (Targeted pediatric HGG therapy) trial in progress TIP-30. 分子引导的针对新诊断的高级别胶质瘤（HGG，包括弥漫性内生性脑桥胶质瘤（DIPG）的儿童及青少年患者的二期伞式临床试验：正在进行的CONNECT TarGeT（靶向儿科HGG疗法）试验。

Neuro-Oncology

IF13.4

2025-11-11

OAAI

Margot Lazow; Kathleen Schieffer; Diana Thomas; Vera Paulson; Bonnie Cole; Christine Fuller; Santosh Valvi; Nicholas Gottardo; Michael Fisher; Ashley Plant; Ralph Salloum; Erin Crotty; Eugene Hwang; Anirban Das; Uri Tabori; Hamza Gorsi; Susan Chi; Sarah Leary; Patricia Baxter; Cynthia Hawkins; Michael Hubank; Thomas Jacques; David Jones; Felix Sahm; Mark Cowley; David Ziegler; Michael Rodriguez; Jason Dyke; Thomas Robertson; Joshua Palmer; Kelsey Troyer; Anna Harr; Rachid Drissi; Elaine Mardis; Darren Hargrave; Chris Jones; Maryam Fouladi

Data Sharing, Biopsies and Patient Confidentiality in a Precision Medicine Trial for Childhood Cancer: A Mixed Method Study of Parents, Oncologists, and Scientists’ Perspectives

Journal of Personalized Medicine

IF3

2025-11-02

OAAI

Yvanna Lei; Kate Hetherington; Rebecca Daly; Niki Rensen; Brittany C. McGill; David S. Ziegler; Loretta M. S. Lau; Vanessa Tyrrell; Jonathan Karpelowsky; Claire E. Wakefield

Clinical stability following tovorafenib treatment in relapsed/refractory pediatric low-grade glioma: updated results from the phase 2 FIREFLY-1 trial 托伐拉芬治疗后复发/难治性儿童低级别胶质瘤的临床稳定性：更新来自2期FIREFLY-1试验的结果

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Kline, Cassie; Hargrave, Darren; Khong-Quang, Dong-Anh; Landi, Daniel; Leary, Sarah; Van Der Lugt, Jasper; Mueller, Sabine; Nysom, Karsten; Perreault, Sebastien; Waanders, Angela; Witt, Olaf; Ziegler, David; Manley, Peter; Zhang, Jingyang; Barry, Elly; Kilburn, Lindsay

The development of ACT001 with Mcl-1 inhibitors as a novel combination therapy for the treatment of paediatric diffuse midline glioma ACT001与Mcl-1抑制剂联合开发作为一种新型联合疗法，用于治疗儿童弥漫性中线胶质瘤

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Lawrence, David; Upton, Dannielle; Tax, Gabor; Holliday, Holly; Ung, Caitlin; Gopalakrishnan, Anjana; Liu, Jie; Dolman, M. Emmy M.; Mao, Jie; Sivanathan, Acadia; Cai, Dongpo Doug; Su, Steven Yung-Chang; Rayner, Benjamin Rayner; Tsoli, Maria; Ziegler, David S.

CHROMATIN REMODELING WITH COMBINED FACT AND BET INHIBITION DISRUPTS ONCOGENIC TRANSCRIPTION IN DIFFUSE MIDLINE GLIOMA 联合FACT和BET抑制的染色质重塑破坏弥漫性中线胶质瘤中的致癌转录

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Holliday, Holly; Khan, Aaminah; Ehteda, Anahid; Nguyen, Hieu; Ross, Samuel; Jayatilleke, Nisitha; Gopalakrishnan, Anjana; Wang, Eyden; Guo, Xinyi; Sanguino, Yolanda Colino; Kavanagh, Daisy; Liu, Jie; Lawrence, David; Sun, Claire; Lehmann, Rebecca; Ip, Chi Kin; Lee, Alvin; Li, Wenyan; Salomon, Robert; Firestein, Ron; Weatheritt, Robert; Valdes-Mora, Fatima; Dinger, Marcel; Phoenix, Timothy; Mayoh, Chelsea; Rayner, Benjamin; Tsoli, Maria; Ziegler, David

Biological Medicines for Diffuse Intrinsic Pontine Gliomas (DIPG) Eradication (BIOMEDE). An International Randomized Phase II Biomarker-driven Platform Trial Comparing Three Targeted Therapies in Combination with Radiotherapy 弥漫性内生性脑桥胶质瘤（DIPG）清除的生物制剂（BIOMEDE）。一项国际性、随机化、II期、生物标志物驱动的平台试验，比较三种靶向疗法联合放射治疗的效果。

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Debily, Marie-Anne; Le Teuff, Gwenael; Kergrohen, Thomas; Varlet, Pascale Pascale; Castel, David; Leblond, Pierre; Hargrave, Darren; Nysom, Karsten; Blomgren, Klas; McCowage, Geoffrey Brian; Bautista, Francisco; Van Vuurden, Dannis; Jones, Chris; Ziegler, David; Moussa, Angokai; Barret, Emilie; Puget, Stephanie; Beccaria, Kevin; Aquilina, Kristian; Riffaud, Laurent; Bolle, Stephanie; Bertozzi, Anne-Isabelle; Abbou, Samuel; De Carli, Emilie; Boddaert, Nathalie; Calmon, Raphael; Blanc, Patricia; Vassal, Gilles; Grill, Jacques; Le Marie-Cecile, Deley

A Phase 1 trial of Deflexifol™ in pediatric patients with relapsed or refractory brain tumors Deflexifol™在复发性或难治性脑肿瘤儿科患者中的Ⅰ期临床试验

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Mateos, Marion K.; Chuah, Joanne; Mitchell, Laura; Mayoh, Chelsea; Valvi, Santosh; Hassall, Timothy; Martin, Michelle; Hansford, Jordan R.; Khuong-Quang, Dong-Anh; Ziegler, David S.

POLYAMINE PATHWAY BLOCKADE SENSITISES MYC-DRIVEN MEDULLOBLASTOMA TO CHEMOTHERAPY 多胺通路阻断使MYC驱动的髓母细胞瘤对化疗更敏感

NEURO-ONCOLOGY

IF13.4

2025-10-01

OAAI

Khan, A.; Gopalakrishnan, A.; Liu, J.; Mayoh, C.; Burns, M. R.; Tsoli, M.; Ziegler, D. S.

From Sequencing to Survival: The Growing Role of Precision Medicine in Paediatric Oncology 从测序到生存：精准医学在儿科肿瘤学中日益增长的作用

Targeted Oncology

IF4

2025-09-27

OAAI

Sarah M. Trinder; David S. Ziegler; Loretta M. S. Lau

The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial (vol 30, pg 207, 2024)复发/难治性小儿低度神经胶质瘤中的II型RAF抑制剂tovorafenib: 2期FIREFLY-1试验 (第30卷，207页，2024)

NATURE MEDICINE

IF50

2025-04-16

OAAI

Kilburn, Lindsay B.; Khuong-Quang, Dong-Anh; Hansford, Jordan R.; Landi, Daniel; van der Lugt, Jasper; Leary, Sarah E. S.; Driever, Pablo Hernaiz; Bailey, Simon; Perreault, Sebastien; McCowage, Geoffrey; Waanders, Angela J.; Ziegler, David S.; Witt, Olaf; Baxter, Patricia A.; Kang, Hyoung Jin; Hassall, Timothy E.; Han, Jung Woo; Franson, Andrea T.; Yalon Oren, Michal; Toledano, Helen; Larouche, Valerie; Kline, Cassie; Abdelbaki, Mohamed S.; Jabado, Nada; Gottardo, Nicholas G.; Gerber, Nicolas U.; Whipple, Nicholas S.; Segal, Devorah; Chi, Susan N.; Oren, Liat; Tan, Enrica E. K.; Mueller, Sabine; Cornelio, Izzy; McLeod, Lisa; Zhao, Xin; Walter, Ashley; Da Costa, Daniel; Manley, Peter; Blackman, Samuel C.; Packer, Roger J.; Nysom, Karsten

The Super Enhancer-Driven Long Noncoding RNA PRKCQ-AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds 超增强子驱动的长链非编码RNA PRKCQ-AS1通过与其SI2蛋白相互作用促进神经母细胞瘤肿瘤发生，且可被小分子化合物靶向。

ADVANCED SCIENCE

IF14.1

2025-03-18

OAAI

Mondal, S; Liu, PY; Seneviratne, J; De Weck, A; Venkat, P; Mayoh, C; Wu, J; Maag, J; Chen, JW; Wong, M; Bartonicek, N; Khoo, P; Jin, L; Ludlow, LE; Ziegler, DS; Trahair, T; Mestdagh, P; Cheung, BB; Li, JY; Dinger, ME; Street, I; Zhang, XD; Marshall, GM; Liu, T

Germline analysis of an international cohort of pediatric diffuse midline glioma patients 对国际队列儿童弥漫性中线胶质瘤患者的生殖系分析

NEURO-ONCOLOGY

IF13.4

2025-03-12

PREAI

Marion K Mateos; Pamela Ajuyah; Noemi Fuentes-Bolanos; Sam El-Kamand; Paulette Barahona; Ann-Kristin Altekoester; Chelsea Mayoh; Holly Holliday; Jie Liu; Louise Cui; Elke Pfaff; Alan Mackay; Adam C Resnick; Mark Pinese; Loretta M S Lau; Dong-Anh Khuong-Quang; Kimberly Dias; Catherine Goudie; Alison Salkeld; Jo Lynne Rokita; David T W Jones; Nikoleta Juretic; Elisha Hayden; Stefan M Pfister; Christof M Kramm; Mirjam Blattner-Johnson; Nada Jabado; Maria Tsoli; Orazio Vittorio; Sabine Mueller; Yiran Guo; Katherine Tucker; Sebastian M Waszak; Sebastien Perreault; Chris Jones; Marie Wong-Erasmus; Mark J Cowley; David S Ziegler

High-throughput in vitro drug screening and in vivo studies identify fenretinide as a brain-penetrant DMG therapeutic 高通量体外药物筛选和体内研究将fenretinide确定为一种能够穿透血脑屏障的DMG治疗药物。

NEURO-ONCOLOGY

IF13.4

2025-02-12

PREAI

Upton, Dannielle H.; Liu, Jie; George, Sandra M.; Valvi, Santosh; Ung, Caitlin; Rayner, Benjamin S.; Gopalakrishnan, Anjana; Pandher, Ruby; Khan, Aaminah; Venkat, Pooja; Mayoh, Chelsea; Holliday, Holly; Yeung, Nicole; Nguyen, Hieu; Franshaw, Laura; Ehteda, Anahid; Shen, Han; Farruggia, Giovanna; Orienti, Isabella; Reynolds, C. Patrick; Tsoli, Maria; Ziegler, David S.

Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial 在FIREFLY-1试验中，托瓦雷芬尼（tovorafenib）这种II型RAF抑制剂对复发性/难治性视神经通路胶质瘤患儿的放射学和视觉反应。

NEURO-ONCOLOGY

IF13.4

2024-12-19

PREAI

Nysom, Karsten; Kilburn, Lindsay B.; Leary, Sarah E. S.; Landi, Daniel B.; de Vos-Kerkhof, Evelien; Perreault, Sebastien; Witt, Olaf; Ziegler, David S.; Hernaiz Driever, Pablo; Franson, Andrea T.; Baxter, Patricia A.; Whipple, Nicholas S.; Kline, Cassie; Segal, Devorah; Jabado, Nada; Bailey, Simon; Mccowage, Geoffrey; Hansford, Jordan R.; Khuong-Quang, Dong-Anh; Gottardo, Nicholas G.; Hassall, Timothy; Han, Jung Woo; Yalon Oren, Michal; Chi, Susan N.; Qiu, Jiaheng; Da Costa, Daniel; Raju, Sandya Govinda; Manley, Peter

研究方向