Fereshteh Talebi; Fabiana Gregucci; Jalal Ahmed; Nir Ben Chetrit; Brian D. Brown; Timothy A. Chan; Dhan Chand; Julie Constanzo; Sandra Demaria; Dmitry I. Gabrilovich; Encouse Golden; Andrew Godkin; Chandan Guha; Gaorav P. Gupta; Aisha Hasan; Fernanda G. Herrera; Howard Kaufman; Donna Li; Alan A. Melcher; Sierra McDonald; Taha Merghoub; Arta M. Monjazeb; Sébastien Paris; Sean Pitroda; Anguraj Sadanandam; Dörthe Schaue; Laura Santambrogio; Phillippe Szapary; Julien Sage; James W. Welsh; Anna Wilkins; Kristina H. Young; Eric Wennerberg; Laurence Zitvogel; Lorenzo Galluzzi; Eric Deutsch; Silvia C. Formenti

Botensilimab, an Fc-Enhanced Anti-CTLA-4 Antibody, Is Effective against Tumors Poorly Responsive to Conventional Immunotherapy

CANCER DISCOVERY

IF33.3

2024-07-311

OAAI

Chand, Dhan; Savitsky, David A.; Krishnan, Shanmugarajan; Mednick, Gabriel; Delepine, Chloe; Garcia-Broncano, Pilar; Soh, Kah Teong; Wu, Wei; Wilkens, Margaret K.; Udartseva, Olga; Vincent, Sylvia; Joshi, Bishnu; Keith, Justin G.; Manrique, Mariana; Marques, Marilyn; Tanne, Antoine; Levey, Daniel L.; Han, Haiyong; Ng, Serina; Ridpath, Jackson; Huber, Olivia; Morin, Benjamin; Galand, Claire; Bourdelais, Sean; Gombos, Randi B.; Ward, Rebecca; Qin, Yu; Waight, Jeremy D.; Costa, Matthew R.; Sebastian-Yague, Alvaro; Rudqvist, Nils-Petter; Pupecka-Swider, Malgorzata; Venkatraman, Vignesh; Slee, Andrew; Patel, Jaymin M.; Grossman, Joseph E.; Wilson, Nicholas S.; Von Hoff, Daniel D.; Stebbing, Justin; Curiel, Tyler J.; Buell, Jennifer S.; O'Day, Steven J.; Stein, Robert B.

Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood-brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas

NEURO-ONCOLOGY

IF13.4

2024-07-191

PRE

Kim, Kwang-Soo; Habashy, Karl; Gould, Andrew; Zhao, Junfei; Najem, Hinda; Amidei, Christina; Saganty, Ruth; Arrieta, Victor A.; Dmello, Crismita; Chen, Li; Zhang, Daniel Y.; Castro, Brandyn; Billingham, Leah; Levey, Daniel; Huber, Olivia; Marques, Marilyn; Savitsky, David A.; Morin, Benjamin M.; Muzzio, Miguel; Canney, Michael; Horbinski, Craig; Zhang, Peng; Miska, Jason; Padney, Surya; Zhang, Bin; Rabadan, Raul; Phillips, Joanna J.; Butowski, Nicholas; Heimberger, Amy B.; Hu, Jian; Stupp, Roger; Chand, Dhan; Lee-Chang, Catalina; Sonabend, Adam M.

Botensilimab plus balstilimab in relapsed/refractory microsatellite stable metastatic colorectal cancer: a phase 1 trial

NATURE MEDICINE

IF50

2024-06-1310

OAAI

Bullock, Andrea J.; Schlechter, Benjamin L.; Fakih, Marwan G.; Tsimberidou, Apostolia M.; Grossman, Joseph E.; Gordon, Michael S.; Wilky, Breelyn A.; Pimentel, Agustin; Mahadevan, Daruka; Balmanoukian, Ani S.; Sanborn, Rachel E.; Schwartz, Gary K.; Abou-Alfa, Ghassan K.; Segal, Neil H.; Bockorny, Bruno; Moser, Justin C.; Sharma, Sunil; Patel, Jaymin M.; Wu, Wei; Chand, Dhan; Rosenthal, Katherine; Mednick, Gabriel; Delepine, Chloe; Curiel, Tyler J.; Stebbing, Justin; Lenz, Heinz-Josef; O'Day, Steven J.; El-Khoueiry, Anthony B.

MiNK-215, an IL-15 armored FAP-targeting CAR iNKT cell therapy, effectively treats human organoid models of treatment-refractory MSS colorectal cancer (CRC) liver metastases

CANCER RESEARCH

IF16.6

2024-03-220

PRE

BMS-986442 ( AGEN1777), a novel TIGIT/CD96 bispecific antibody, demonstrates superior monotherapy and combination activity versus conventional anti-TIGIT antibodies in preclinical models

CANCER RESEARCH

IF16.6

2024-03-220

PRE

Celecoxib and chloroquine enhance the antitumor effect of immune checkpoint blockade therapy, in a syngeneic mouse model for pancreatic cancer

CANCER RESEARCH

IF16.6

2024-03-220

PRE

A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome

中重度急性呼吸窘迫综合征不变自然杀伤T细胞治疗的1/2期临床试验

NATURE COMMUNICATIONS

IF15.7

2024-02-066

OAAI

Hammond, Terese C.; Purbhoo, Marco A.; Kadel, Sapana; Ritz, Jerome; Nikiforow, Sarah; Daley, Heather; Shaw, Kit; van Besien, Koen; Gomez-Arteaga, Alexandra; Stevens, Don; Ortuzar, Waldo; Michelet, Xavier; Smith, Rachel; Moskowitz, Darrian; Masakayan, Reed; Yigit, Burcu; Boi, Shannon; Soh, Kah Teong; Chamberland, John; Song, Xin; Qin, Yu; Mishchenko, Ilya; Kirby, Maurice; Nasonenko, Valeriia; Buffa, Alexa; Buell, Jennifer S.; Chand, Dhan; van Dijk, Marc; Stebbing, Justin; Exley, Mark A.

Next-generation CTLA-4 targeting molecules and combination therapy: promising strategies for improving cancer immunotherapy

下一代CTLA-4靶向分子和联合治疗: 改善癌症免疫治疗的有希望的策略

ONCOIMMUNOLOGY

IF6.3

2023-11-053