Paul T. Edlefsen - Publications, H-index & Citations

Paul T. Edlefsen

Fred Hutchinson Cancer Center

31H指数

111论文数

5.3K被引数

收录论文 52

发表时间

Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials 抗体介导预防试验中，使用广谱中和抗体VRC01进行预防性治疗会在感染后选择逃逸突变体

Nature Microbiology

IF19.4

2026-09-28

OAAI

Carolyn Williamson; Lyle Curry; Nonhlanhla N. Mkhize; Elena E. Giorgi; Craig A. Magaret; Bronwen E. Lambson; Sinethemba Bhebhe; Haajira Kaldine; Thandeka Moyo-Gwete; Morgane Rolland; Raabya Rossenkhan; Nina Marie G. Garcia; Chivonne Moodley; Anna Yssel; Yunda Huang; Alaine A. Marsden; Daniel B. Reeves; Bryan T. Mayer; Roger E. Bumgarner; Nicolas Beaume; Dylan H. Westfall; Michal Juraska; Allan C. DeCamp; Hugh Murrell; Hongjun Bai; Wenjie Deng; Alec P. Pankow; Tanmoy Bhattacharya; Talita York; Nonkululeko Ndabambi; Lennie Chen; Hong Zhao; Asanda Gwashu-Nyangiri; Ruwayhida Thebus; Paula Cohen; Ben Murrell; Shelly Karuna; John Hural; Nyaradzo Mgodi; Srilatha Edupuganti; Lynn Morris; David Montefiori; M. Juliana McElrath; Myron S. Cohen; Lawrence Corey; Paul T. Edlefsen; Peter B. Gilbert; Penny L. Moore; James I. Mullins

VRC01 Exerted Differential Pressure on HIV-1 Envelope From Subtypes B and C That Continued in the First Weeks Postdiagnosis in the Antibody Mediated Prevention Trials VRC01 对 B 和 C 亚型 HIV-1 包膜施加的差异压力在抗体介导的预防试验中确诊后的前几周持续存在

The Journal of Infectious Diseases

IF0

2026-09-08

OAAI

Hongjun Bai; Michal Juraska; Craig A Magaret; Anna Yssel; Raabya Rossenkhan; Ben Murrell; Bethany L Dearlove; Eric Lewitus; Allan C deCamp; Elena E Giorgi; James Ludwig; Dylan H Westfall; Wenjie Deng; Lennie Chen; Hong Zhao; Alec Pankow; Tanmoy Bhattacharya; Talita York; Asanda Gwashu-Nyangiwe; Nonkululeko Ndabambi; Ruwayhida Thebus; Julie A Ake; Sandhya Vasan; April Randhawa; John A Hural; Sri Edupuganti; Nyaradzo Mgodi; Shelly T Karuna; Lynn Morris; David C Montefiori; Myron S Cohen; Lawrence Corey; Paul T Edlefsen; M Julianna McElrath; Peter B Gilbert; Carolyn Williamson; James I Mullins; Morgane Rolland; null

Quantifying how HIV-1 envelope sequence features impact vaccine efficacy in the HVTN 705/HPX2008 randomised trial in southern African women 量化HIV-1包膜序列特征如何影响HVTN 705/HPX2008随机试验中南部非洲女性的疫苗效果

EBioMedicine

IF10.8

2026-08-01

PREAI

Juraska, Michal; Li, Li; Magaret, Craig A.; Peng, James; Giorgi, Elena E.; Ludwig, James; Carpp, Lindsay N.; deCamp, Allan C.; Kee, Jia J.; Molitor, Cindy; Mandig, Marthin; Edlefsen, Paul T.; Rossenkhan, Raabya; Westfall, Dylan H.; Deng, Wenjie; Chen, Lennie; Zhao, Hong; Galvao, Bruna; Adams, Craig; Yssel, Anna; Matten, David; York, Talita; Gwashu-Nyangiwe, Asanda; Ndabambi, Nonkululeko; Thebus, Ruwayhida; Swann, Edith M.; Hural, John A.; van Duijn, Janine; Buchbinder, Susan; Tomaka, Frank; Corey, Lawrence; Mngadi, Kathryn; Gray, Glenda E.; Gilbert, Peter B.; Williamson, Carolyn; Mullins, James I.

Long-read deep sequencing reveals high rates of multilineage transmission and rapid viral population changes in acute HIV infection 长读长深度测序揭示急性HIV感染中多谱系传播的高速率和病毒群体的快速变化

Nature Communications

IF15.7

2026-05-25

OAAI

James I. Mullins; Wenjie Deng; Elena E. Giorgi; Craig A. Magaret; Morgane Rolland; Tanmoy Bhattacharya; Dylan H. Westfall; Anna E. J. Yssel; Roger E. Bumgarner; Ben Murrell; Thumbi Ndung’u; Merlin L. Robb; Raabya Rossenkhan; Paul T. Edlefsen; Krista L. Dong; Lennie Chen; Asanda Gwashu-Nyangiwe; Hong Zhao; Ruwayhida Thebus; Nonkululeko Ndabambi; Bruna Galvao; Fredrick Sawe; Sorachai Nitayaphan; Talita York; David Matten; Hugh Murrell; Alec P. Pankow; Michal Juraska; James Ludwig; John Hural; Myron S. Cohen; Lawrence Corey; M. Juliana McElrath; Peter B. Gilbert; Carolyn Williamson

Maternal microchimerism at birth associates with reduced odds of non-malarial fever and respiratory tract infections in Tanzanian children 新生儿母体微嵌合现象与非疟疾发热及呼吸道感染风险降低相关：坦桑尼亚儿童研究

PLOS Global Public Health

IF2.5

2026-05-13

PREAI

Petersen, Gitte L.; Edlefsen, Paul T.; Li, Xiaohong; Morrison, Robert; Kabyemela, Edward; Nelson, J. Lee; Duffy, Patrick E.; Fried, Michal; Harrington, Whitney E.

Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials 在抗体介导的预防试验中，广泛中和抗体VRC01对HIV突破性病毒人群的影响

Nature Communications

IF15.7

2026-04-03

OAAI

Carolyn Williamson; Chivonne Moodley; Craig A. Magaret; Elena E. Giorgi; Morgane Rolland; Dylan H. Westfall; Anna Yssel; Wenjie Deng; Raabya Rossenkhan; Nonhlanhla N. Mkhize; Lennie Chen; Hong Zhao; Tanmoy Bhattacharya; Alec Pankow; Ben Murrell; Talita York; Asanda Gwashu-Nyangiwe; Nonkululeko Ndabambi; Ruwayhida Thebus; Paula Cohen; Bronwen Lambson; Haajira Kaldine; Sinethemba Bhebhe; Michal Juraska; Hongjun Bai; Allan C. deCamp; Maurine D. Miner; James Ludwig; Cindy Molitor; Nicolas Beaume; David Matten; Yunda Huang; Lily Zhang; Daniel B. Reeves; Bryan Mayer; Shelly T. Karuna; John A. Hural; Lynn Morris; David Montefiori; Roger E. Bumgarner; Penny L. Moore; Paul T. Edlefsen; Srilatha Edupuganti; Nyaradzo Mgodi; M. Juliana McElrath; Myron S. Cohen; Lawrence Corey; Peter B. Gilbert; James I. Mullins

Bayesian estimation of HIV acquisition dates for prevention trials 贝叶斯方法估计HIV感染日期用于预防试验

MBIO

IF4.7

2025-09-01

OAAI

Rossenkhan, Raabya; Giorgi, Elena E.; Shao, Danica; Ludwig, James; Labuschagne, Phillip; Magaret, Craig A.; Ndung'u, Thumbi; Muema, Daniel; Gounder, Kamini; Dong, Krista L.; Walker, Bruce D.; Rolland, Morgane; Robb, Merlin L.; Eller, Leigh Anne; Sawe, Fredrick; Nitayaphan, Sorachai; Grebe, Eduard; Busch, Michael P.; Delaney, Kevin P.; Facente, Shelley; Carpp, Lindsay N.; Decamp, Allan C.; Huang, Yunda; Korber, Bette; Juraska, Michal; Rudnicki, Erika; Kosmider, Ewelina; Reeves, Daniel B.; Mayer, Bryan T.; Hural, John; Deng, Wenjie; Westfall, Dylan H.; Yssel, Anna; Matten, David; Bhattacharya, Tanmoy; Corey, Lawrence; Gilbert, Peter B.; Williamson, Carolyn; Mullins, James I.; Edlefsen, Paul T.

Persistent innate immune dysfunction and ZIKV replication in the gastrointestinal tract during SIV infection in pigtail macaques

FRONTIERS IN IMMUNOLOGY

IF5.9

2025-03-04

OAAI

Tisoncik-Go, Jennifer; Lewis, Thomas B.; Whitmore, Leanne S.; Voss, Kathleen; Niemeyer, Skyler; Dai, Jin; Kim, Paul; Hubbell, Kai; Iwayama, Naoto; Ahrens, Chul; Wangari, Solomon; Murnane, Robert; Edlefsen, Paul T.; Guerriero, Kathryn A.; Gale Jr, Michael; Fuller, Deborah H.; O'Connor, Megan A.

Glycoprotein L-deleted single-cycle rhesus cytomegalovirus vectors elicit MHC-E-restricted CD8+ T cells that protect against SIV 缺失糖蛋白L的单轮复制猴疱疹病毒载体可诱导MHC-E限制性CD8+ T细胞，从而对SIV产生保护作用。

JOURNAL OF IMMUNOLOGY

IF3.4

2025-02-27

OAAI

Hansen, Scott G.; Schell, John B.; Marshall, Emily E.; Ojha, Sohita; Feltham, Shana; Morrow, David; Hughes, Colette M.; Gilbride, Roxanne M.; Ford, Julia C.; Cleveland-Rubeor, Hilary C.; McArdle, Matthew R.; Whitmer, Travis; Barber-Axthelm, Aaron; Bochart, Rachelle; Smedley, Jeremy; Oswald, Kelli; Fast, Randy; Shoemaker, Rebecca; Kosmider, Ewelina; Edlefsen, Paul T.; Lifson, Jeffrey D.; Malouli, Daniel; Fruh, Klaus; Picker, Louis J.

Antigen specificities and proviral integration sites differ in HIV-infected cells by timing of antiretroviral treatment initiation

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2024-06-04

OAAI

Joy, Jaimy; Gervassi, Ana; Chen, Lennie; Kirshenbaum, Brent; Styrchak, Sheila; Ko, Daisy; McLaughlin, Sherry; Shao, Danica; Kosmider, Ewelina; Edlefsen, Paul T.; Maenza, Janine; Collier, Ann C.; Mullins, James I.; Horton, Helen; Frenkel, Lisa M.

High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials ( vol 14 , 8299 , 2023)

NATURE COMMUNICATIONS

IF15.7

2024-03-22

OAAI

Reeves, Daniel B.; Mayer, Bryan T.; DeCamp, Allan C.; Huang, Yunda; Zhang, Bo; Carpp, Lindsay N.; Magaret, Craig A.; Juraska, Michal; Gilbert, Peter B.; Montefiori, David C.; Bar, Katharine J.; Cardozo-Ojeda, E. Fabian; Schiffer, Joshua T.; Rossenkhan, Raabya; Edlefsen, Paul; Morris, Lynn; Mkhize, Nonhlanhla N.; Williamson, Carolyn; Mullins, James I.; Seaton, Kelly E.; Tomaras, Georgia D.; Andrew, Philip; Mgodi, Nyaradzo; Ledgerwood, Julie E.; Cohen, Myron S.; Corey, Lawrence; Naidoo, Logashvari; Orrell, Catherine; Goepfert, Paul A.; Casapia, Martin; Sobieszczyk, Magdalena E.; Karuna, Shelly T.; Edupuganti, Srilatha

Prevention efficacy of the broadly neutralizing antibody VRC01 depends on HIV-1 envelope sequence features 广泛中和抗体VRC01的预防功效取决于HIV-1的包膜序列特征

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-01-19

OAAI

Juraska, Michal; Bai, Hongjun; deCamp, Allan C.; Magaret, Craig A.; Li, Li; Gillespie, Kevin; Carpp, Lindsay N.; Giorgi, Elena E.; Ludwig, James; Molitor, Cindy; Hudson, Aaron; Williamson, Brian D.; Espy, Nicole; Simpkins, Brian; Rudnicki, Erika; Shao, Danica; Rossenkhan, Raabya; Edlefsen, Paul T.; Westfall, Dylan H.; Deng, Wenjie; Chen, Lennie; Zhao, Hong; Bhattacharya, Tanmoy; Pankow, Alec; Murrell, Ben; Yssel, Anna; Matten, David; York, Talita; Beaume, Nicolas; Gwashu-Nyangiwe, Asanda; Ndabambi, Nonkululeko; Thebus, Ruwayhida; Karuna, Shelly T.; Morris, Lynn; Montefiori, David C.; Hural, John A.; Cohen, Myron S.; Corey, Lawrence; Rolland, Morgane; Gilbert, Peter B.; Williamson, Carolyn; Mullins, James I.

High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials

NATURE COMMUNICATIONS

IF15.7

2023-12-14

OAAI

Reeves, Daniel B.; Mayer, Bryan T.; Decamp, Allan C.; Huang, Yunda; Zhang, Bo; Carpp, Lindsay N.; Magaret, Craig A.; Juraska, Michal; Gilbert, Peter B.; Montefiori, David C.; Bar, Katharine J.; Cardozo-Ojeda, E. Fabian; Schiffer, Joshua T.; Rossenkhan, Raabya; Edlefsen, Paul; Morris, Lynn; Mkhize, Nonhlanhla N.; Williamson, Carolyn; Mullins, James I.; Seaton, Kelly E.; Tomaras, Georgia D.; Andrew, Philip; Mgodi, Nyaradzo; Ledgerwood, Julie E.; Cohen, Myron S.; Corey, Lawrence; Naidoo, Logashvari; Orrell, Catherine; Goepfert, Paul A.; Casapia, Martin; Sobieszczyk, Magdalena E.; Karuna, Shelly T.; Edupuganti, Srilatha

Assessing vaccine-mediated protection in an ultra-low dose Mycobacterium tuberculosis murine model

PLOS PATHOGENS

IF4.9

2023-11-27

OAAI

Plumlee, Courtney R.; Barrett, Holly W.; Shao, Danica E.; Lien, Katie A.; Cross, Lauren M.; Cohen, Sara B.; Edlefsen, Paul T.; Urdahl, Kevin B.

Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition

EBIOMEDICINE

IF10.8

2023-07-01

OAAI

Seaton, Kelly E.; Huang, Yund; Karuna, Shelly; Heptinstall, Jack R.; Brackett, Caroline; Chiong, Kelvin; Zhang, Lily; Yates, Nicole L.; Sampson, Mark; Rudnicki, Erika; Juraska, Michal; deCamp, Allan C.; Edlefsen, Paul T.; Mullins, James I.; Williamson, Carolyn; Rossenkhan, Raabya; Giorgi, Elena E.; Kenny, Avi; Angier, Heather; Randhawa, April; Weiner, Joshua A.; Rojas, Michelle; Sarzotti-Kelsoe, Marcella; Zhang, Lu; Sawant, Sheetal; Ackerman, Margaret E.; McDermott, Adrian B.; Mascola, John R.; Hural, John; McElrath, M. Julianna; Andrew, Philip; Hidalgo, Jose A.; Clark, Jesse; Laher, Fatima; Orrell, Catherine; Frank, Ian; Gonzales, Pedro; Edupuganti, Srilatha; Mgodi, Nyaradzo; Corey, Lawrence; Morris, Lynn; Monte, David; Cohen, Myron S.; Gilbert, Peter B.; Tomaras, Georgia D.

T-SPOT.TB Reactivity in Southern African Children With and Without in Utero HIV Exposure

CLINICAL INFECTIOUS DISEASES

IF7.3

2023-06-09

OAAI

Iwase, Saori C.; Edlefsen, Paul T.; Bhebhe, Lynnette; Motsumi, Kesego; Moyo, Sikhulile; Happel, Anna-Ursula; Shao, Danica; Mmasa, Nicholas; Schenkel, Sara; Gasper, Melanie A.; Dubois, Melanie; Files, Megan A.; Seshadri, Chetan; Duffy, Fergal; Aitchison, John; Netea, Mihai G.; Jao, Jennifer; Cameron, Donald W.; Gray, Clive M.; Jaspan, Heather B.; Powis, Kathleen M.

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

PLOS PATHOGENS

IF4.9

2023-04-19

OAAI

O'Connor, Megan A.; Hawman, David W.; Meade-White, Kimberly; Leventhal, Shanna; Song, Wenjun; Randall, Samantha; Archer, Jacob; Lewis, Thomas B.; Brown, Brieann; Fredericks, Megan N.; Sprouse, Kaitlin R.; Tunggal, Hillary C.; Maughan, Mara; Iwayama, Naoto; Ahrens, Chul; Garrison, William; Wangari, Solomon; Guerriero, Kathryn A.; Hanley, Patrick; Lovaglio, Jamie; Saturday, Greg; Veesler, David; Edlefsen, Paul T.; Khandhar, Amit P.; Feldmann, Heinz; Fuller, Deborah Heydenburg; Erasmus, Jesse H.

Coimmunization with Preerythrocytic Antigens alongside Circumsporozoite Protein Can Enhance Sterile Protection against Plasmodium Sporozoite Infection

MICROBIOLOGY SPECTRUM

IF3.8

2023-04-13

OAAI

Vigdorovich, Vladimir; Patel, Hardik; Watson, Alexander; Raappana, Andrew; Reynolds, Laura; Selman, William; Beeman, Suzannah; Edlefsen, Paul T.; Kappe, Stefan H. I.; Sather, D. Noah

Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated Simian Immunodeficiency Virus-Positive Macaques Treated with N-803

JOURNAL OF VIROLOGY

IF3.8

2022-12-14

OAAI

Harwood, Olivia E.; Balgeman, Alexis J.; Weaver, Abigail J.; Ellis-Connell, Amy L.; Weiler, Andrea M.; Erickson, Katrina N.; Matschke, Lea M.; Golfinos, Athena E.; Vezys, Vaiva; Skinner, Pamela J.; Safrit, Jeffrey T.; Edlefsen, Paul T.; Reynolds, Matthew R.; Friedrich, Thomas C.; O'Connor, Shelby L.

Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition

NATURE MEDICINE

IF50

2022-08-22

OAAI

Gilbert, Peter B.; Huang, Yunda; deCamp, Allan C.; Karuna, Shelly; Zhang, Yuanyuan; Magaret, Craig A.; Giorgi, Elena E.; Korber, Bette; Edlefsen, Paul T.; Rossenkhan, Raabya; Juraska, Michal; Rudnicki, Erika; Kochar, Nidhi; Huang, Ying; Carpp, Lindsay N.; Barouch, Dan H.; Mkhize, Nonhlanhla N.; Hermanus, Tandile; Kgagudi, Prudence; Bekker, Valerie; Kaldine, Haajira; Mapengo, Rutendo E.; Eaton, Amanda; Domin, Elize; West, Carley; Feng, Wenhong; Tang, Haili; Seaton, Kelly E.; Heptinstall, Jack; Brackett, Caroline; Chiong, Kelvin; Tomaras, Georgia D.; Andrew, Philip; Mayer, Bryan T.; Reeves, Daniel B.; Sobieszczyk, Magdalena E.; Garrett, Nigel; Sanchez, Jorge; Gay, Cynthia; Makhema, Joseph; Williamson, Carolyn; Mullins, James I.; Hural, John; Cohen, Myron S.; Corey, Lawrence; Montefiori, David C.; Morris, Lynn

研究方向