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Loss of p62 Binding Allows TIF-IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype p62结合丢失导致TIF-IA在衰老中积累，进而促进核仁表型变化及衰老相关分泌表型的形成 Thoms, Hazel C.; Brant, Tyler S.; Duckett, Katie; Yang, Yizheng; Dong, Jinxi; Wang, Hongfei; Derby, Freya; Akeke, Oluwatumilara F.; Al-alayeen, Faizah; Newell, Amy; Manasterski, Piotr; Gopalakrishnan, Aishwarya; Mann, Derek; Millar, Fraser R.; Von Kriegsheim, Alex; Acosta, Juan Carlos; Oakley, Fiona; Stark, Lesley A. 分享 收藏
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Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ Kiourtis, Christos; Terradas-Terradas, Maria; Gee, Lucy M.; May, Stephanie; Georgakopoulou, Anastasia; Collins, Amy L.; O'Sullivan, Eoin D.; Baird, David P.; Hassan, Mohsin; Shaw, Robin; Tan, Ee Hong; Mueller, Miryam; Engelmann, Cornelius; Andreola, Fausto; Hsieh, Ya-Ching; Reed, Lee H.; Borthwick, Lee A.; Nixon, Colin; Clark, William; Hanson, Peter S.; Sumpton, David; Mackay, Gillian; Suzuki, Toshiyasu; Najumudeen, Arafath K.; Inman, Gareth J.; Campbell, Andrew; Barry, Simon T.; Quaglia, Alberto; Morris, Christopher M.; Lebeau, Fiona E. N.; Sansom, Owen J.; Kirschner, Kristina; Jalan, Rajiv; Oakley, Fiona; Bird, Thomas G. 分享 收藏
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Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health 肝脏X受体-α 的破坏性突变具有肝毒性，并暗示肝脏健康中的胆固醇感应 Lockhart, Sam M.; Muso, Milan; Zvetkova, Ilona; Lam, Brian Y. H.; Ferrari, Alessandra; Schoenmakers, Erik; Duckett, Katie; Leslie, Jack; Collins, Amy; Romartinez-Alonso, Beatriz; Tadross, John A.; Jia, Raina; Gardner, Eugene J.; Kentistou, Katherine; Zhao, Yajie; Day, Felix; Moerseburg, Alexander; Rainbow, Kara; Rimmington, Debra; Mastantuoni, Matteo; Harrison, James; Nus, Meritxell; Guma'a, Khalid; Sherratt-Mayhew, Sam; Jiang, Xiao; Smith, Katherine R.; Paul, Dirk S.; Jenkins, Benjamin; Koulman, Albert; Pietzner, Maik; Langenberg, Claudia; Wareham, Nicholas; Yeo, Giles S.; Chatterjee, Krishna; Schwabe, John; Oakley, Fiona; Mann, Derek A.; Tontonoz, Peter; Coll, Anthony P.; Ong, Ken; Perry, John R. B.; O'Rahilly, Stephen 分享 收藏
UCHL1-dependent control of hypoxia-inducible factor transcriptional activity during liver fibrosis Collins, Amy; Scott, Rebecca; Wilson, Caroline L.; Abbate, Giuseppe; Ecclestone, Gabrielle B.; Albanese, Adam G.; Biddles, Demi; White, Steven; French, Jeremy; Moir, John; Alrawashdeh, Wasfi; Wilson, Colin; Pandanaboyana, Sanjay; Hammond, John S.; Thakkar, Rohan; Oakley, Fiona; Mann, Jelena; Mann, Derek A.; Kenneth, Niall S. 分享 收藏
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD) 基于与人类代谢功能障碍相关的脂肪变性肝病 (MASLD) 的接近程度，对小鼠饮食模型进行无偏排名 Vacca, Michele; Kamzolas, Ioannis; Harder, Lea Morch; Oakley, Fiona; Trautwein, Christian; Hatting, Maximilian; Ross, Trenton; Bernardo, Barbara; Oldenburger, Anouk; Hjuler, Sara Toftegaard; Ksiazek, Iwona; Linden, Daniel; Schuppan, Detlef; Rodriguez-Cuenca, Sergio; Tonini, Maria Manuela; Castaneda, Tamara R.; Kannt, Aimo; Rodrigues, Cecilia M. P.; Cockell, Simon; Govaere, Olivier; Daly, Ann K.; Allison, Michael; de Lichtenberg, Kristian Honnens; Kim, Yong Ook; Lindblom, Anna; Oldham, Stephanie; Andreasson, Anne-Christine; Schlerman, Franklin; Marioneaux, Jonathon; Sanyal, Arun; Afonso, Marta B.; Younes, Ramy; Amano, Yuichiro; Friedman, Scott L.; Wang, Shuang; Bhattacharya, Dipankar; Simon, Eric; Paradis, Valerie; Burt, Alastair; Grypari, Ioanna Maria; Davies, Susan; Driessen, Ann; Yashiro, Hiroaki; Pors, Susanne; Andersen, Maja Worm; Feigh, Michael; Yunis, Carla; Bedossa, Pierre; Stewart, Michelle; Cater, Heather L.; Wells, Sara; Schattenberg, Joern M.; Anstee, Quentin M.; Tiniakos, Dina; Perfield, James W.; Petsalaki, Evangelia; Davidsen, Peter; Vidal-Puig, Antonio; Anstee, Quentin M.; Daly, Ann K.; Cockell, Simon; Tiniakos, Dina; Bedossa, Pierre; Burt, Alastair; Oakley, Fiona; Cordell, Heather J.; Day, Christopher P.; Wonders, Kristy; Missier, Paolo; McTeer, Matthew; Vale, Luke; Oluboyede, Yemi; Breckons, Matt; Boyle, Jo; Bossuyt, Patrick M.; Zafarmand, Hadi; Vali, Yasaman; Lee, Jenny; Nieuwdorp, Max; Holleboom, Adriaan G.; Angelakis, Athanasios; Verheij, Joanne; Ratziu, Vlad; Clement, Karine; Patino-Navarrete, Rafael; Pais, Raluca; Paradis, Valerie; Schuppan, Detlef; Schattenberg, Joern M.; Surabattula, Rambabu; Myneni, Sudha; Kim, Yong Ook; Straub, Beate K.; Vidal-Puig, Antonio; Vacca, Michele; Rodrigues-Cuenca, Sergio; Allison, Mike; Kamzolas, Ioannis; Petsalaki, Evangelia; Campbell, Mark; Lelliott, Chris J.; Davies, Susan; Oresic, Matej; Hyotylainen, Tuulia; McGlinchey, Aidan; Mato, Jose M.; Millet, Oscar; Dufour, Jean-Francois; Berzigotti, Annalisa; Masoodi, Mojgan; Lange, Naomi F.; Pavlides, Michael; Harrison, Stephen; Neubauer, Stefan; Cobbold, Jeremy; Mozes, Ferenc; Akhtar, Salma; Olodo-Atitebi, Seliat; Banerjee, Rajarshi; Shumbayawonda, Elizabeth; Dennis, Andrea; Andersson, Anneli; Wigley, Ioan; Romero-Gomez, Manuel; Gomez-Gonzalez, Emilio; Ampuero, Javier; Castell, Javier; Gallego-Duran, Rocio; Fernandez-Lizaranzu, Isabel; Montero-Vallejo, Rocio; Karsdal, Morten; Rasmussen, Daniel Guldager Kring; Leeming, Diana Julie; Sinisi, Antonia; Musa, Kishwar; Sandt, Estelle; Tonini, Maria Manuela; Bugianesi, Elisabetta; Rosso, Chiara; Armandi, Angelo; Marra, Fabio; Gastaldelli, Amalia; Svegliati, Gianluca; Boursier, Jerome; Francque, Sven; Vonghia, Luisa; Verrijken, An; Dirinck, Eveline; Driessen, Ann; Ekstedt, Mattias; Kechagias, Stergios; Yki-Jarvinen, Hannele; Porthan, Kimmo; Arola, Johanna; van Mil, Saskia; Papatheodoridis, George; Cortez-Pinto, Helena; Silva, Ana Paula; Rodrigues, Cecilia M. P.; Valenti, Luca; Pelusi, Serena; Petta, Salvatore; Pennisi, Grazia; Miele, Luca; Liguori, Antonio; Geier, Andreas; Rau, Monika; Trautwein, Christian; Reissing, Johanna; Aithal, Guruprasad P.; Francis, Susan; Palaniyappan, Naaventhan; Bradley, Christopher; Hockings, Paul; Schneider, Moritz; Newsome, Philip N.; Hubscher, Stefan; Wenn, David; Magnanensi, Jeremy; Trylesinski, Aldo; Mayo, Rebeca; Alonso, Cristina; Duffin, Kevin; Perfield, James W.; Chen, Yu; Hartman, Mark L.; Yunis, Carla; Miller, Melissa; Chen, Yan; McLeod, Euan James; Ross, Trenton; Bernardo, Barbara; Schoelch, Corinna; Ertle, Judith; Younes, Ramy; Coxson, Harvey; Simon, Eric; Gogain, Joseph; Ostroff, Rachel; Alexander, Leigh; Biegel, Hannah; Kjaer, Mette Skalshoi; Harder, Lea Morch; Al-Sari, Naba; Veidal, Sanne Skovgard; Oldenburger, Anouk; Ellegaard, Jens; Balp, Maria-Magdalena; Jennings, Lori; Martic, Miljen; Loffler, Jurgen; Applegate, Douglas; Torstenson, Richard; Linden, Daniel; Fournier-Poizat, Celine; Llorca, Anne; Kalutkiewicz, Michael; Pepin, Kay; Ehman, Richard; Horan, Gerald; Ho, Gideon; Tai, Dean; Chng, Elaine; Xiao, Teng; Patterson, Scott D.; Billin, Andrew; Doward, Lynda; Twiss, James; Thakker, Paresh; Derdak, Zoltan; Yashiro, Hiroaki; Landgren, Henrik; Lackner, Carolin; Gouw, Annette; Hytiroglou, Prodromos; Govaere, Olivier; Brass, Clifford 分享 收藏
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c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis Leslie, Jack; Hunter, Jill E.; Collins, Amy; Rushton, Amelia; Russell, Lauren G.; Ramon-Gil, Erik; Laszczewska, Maja; McCain, Misti; Zaki, Marco Y. W.; Knox, Amber; Seow, Yixin; Sabater, Laura; Geh, Daniel; Perkins, Neil D.; Reeves, Helen L.; Tiniakos, Dina; Mann, Derek A.; Oakley, Fiona 分享 收藏
Sublethal necroptosis signaling promotes inflammation and liver cancer 亚致死坏死性凋亡信号促进炎症和肝癌 Vucur, Mihael; Ghallab, Ahmed; Schneider, Anne T.; Adili, Arlind; Cheng, Mingbo; Castoldi, Mirco; Singer, Michael T.; Buettner, Veronika; Keysberg, Leonie S.; Kuesgens, Lena; Kohlhepp, Marlene; Goerg, Boris; Gallage, Suchira; Avila, Jose Efren Barragan; Unger, Kristian; Kordes, Claus; Leblond, Anne-Laure; Albrecht, Wiebke; Loosen, Sven H.; Lohr, Carolin; Joerdens, Markus S.; Babler, Anne; Hayat, Sikander; Schumacher, David; Koenen, Maria T.; Govaere, Olivier; Boekschoten, Mark, V; Joers, Simone; Villacorta-Martin, Carlos; Mazzaferro, Vincenzo; Llovet, Josep M.; Weiskirchen, Ralf; Kather, Jakob N.; Starlinger, Patrick; Trauner, Michael; Luedde, Mark; Heij, Lara R.; Neumann, Ulf P.; Keitel, Verena; Bode, Johannes G.; Shneider, Rebekka K.; Tacke, Frank; Levkau, Bodo; Lammers, Twan; Fluegen, Georg; Alexandrov, Theodore; Collins, Amy L.; Nelson, Glyn; Oakley, Fiona; Mann, Derek A.; Roderburg, Christoph; Longerich, Thomas; Weber, Achim; Villanueva, Augusto; Samson, Andre L.; Murphy, James M.; Kramann, Rafael; Geisler, Fabian; Costa, Ivan G.; Hengstle, Jan G.; Heikenwalder, Mathias; Luedde, Tom 分享 收藏
Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation Zadran, Bassier; Sudhindar, Praveen Dhondurao; Wainwright, Daniel; Bury, Yvonne; Luli, Saimir; Howarth, Rachel; McCain, Misti Vanette; Watson, Robyn; Huet, Hannah; Palinkas, Fanni; Palmini, Rolando Berlinguer; Casement, John; Mann, Derek A.; Oakley, Fiona; Lunec, John; Reeves, Helen; Faulkner, Geoffrey J.; Shukla, Ruchi 分享 收藏
The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection E3泛素连接酶RNF115调节吞噬体成熟和宿主对细菌感染的反应 Bilkei-Gorzo, Orsolya; Heunis, Tiaan; Marin-Rubio, Jose Luis; Cianfanelli, Francesca Romana; Raymond, Benjamin Bernard Armando; Inns, Joseph; Fabrikova, Daniela; Peltier, Julien; Oakley, Fiona; Schmid, Ralf; Hartlova, Anetta; Trost, Matthias 分享 收藏
Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential Madgwick, Suzanne; Luli, Saimir; Sellier, Helene; Butterworth, Jacqueline A.; Leslie, Jack; Moore, Adam J.; Corbin, Emma K.; Yemm, Adrian I.; Chiremba, Robson T.; Tiniakos, Dina; Oakley, Fiona; Perkins, Neil D.; Hunter, Jill E. 分享 收藏
A neutrophil-B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4 Gawish, Riem; Maier, Barbara; Obermayer, Georg; Watzenboeck, Martin L.; Gorki, Anna-Dorothea; Quattrone, Federica; Farhat, Asma; Lakovits, Karin; Hladik, Anastasiya; Korosec, Ana; Alimohammadi, Arman; Mesteri, Ildiko; Oberndorfer, Felicitas; Oakley, Fiona; Brain, John; Boon, Louis; Lang, Irene; Binder, Christoph J.; Knapp, Sylvia 分享 收藏
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Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma? Zaki, Marco Y. W.; Alhasan, Sari F.; Shukla, Ruchi; McCain, Misti; Laszczewska, Maja; Geh, Daniel; Patman, Gillian L.; Televantou, Despina; Whitehead, Anna; Mauricio, Joao P.; Barksby, Ben; Gee, Lucy M.; Paish, Hannah L.; Leslie, Jack; Younes, Ramy; Burt, Alastair D.; Borthwick, Lee A.; Thomas, Huw; Beale, Gary S.; Govaere, Olivier; Sia, Daniela; Anstee, Quentin M.; Tiniakos, Dina; Oakley, Fiona; Reeves, Helen L. 分享 收藏
A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis Garcia-Macia, Marina; Santos-Ledo, Adrian; Leslie, Jack; Paish, Hannah L.; Collins, Amy L.; Scott, Rebecca S.; Watson, Abigail; Burgoyne, Rachel A.; White, Steve; French, Jeremy; Hammond, John; Borthwick, Lee A.; Mann, Jelena; Bolanos, Juan P.; Korolchuk, Viktor, I; Oakley, Fiona; Mann, Derek A. 分享 收藏
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