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Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas 表观遗传靶向SMARCB1缺乏性肉瘤中PGBD5依赖性的DNA损伤 Kazansky, Yaniv; Mueller, Helen S.; Cameron, Daniel; Demarest, Phillip; Zaffaroni, Nadia; Arrighetti, Noemi; Zuco, Valentina; Mundi, Prabhjot S.; Kuwahara, Yasumichi; Somwar, Romel; Qu, Rui; Califano, Andrea; De Stanchina, Elisa; Dela Cruz, Filemon S.; Kung, Andrew L.; Gounder, Mrinal M.; Kentsis, Alex 分享 收藏
Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance 表观遗传机制调控人类白血病干细胞及治疗抵抗 Takao, Sumiko; Morell, Victor; Uni, Masahiro; Slavit, Alicia; Rha, Sophia; Cheng, Shuyuan; Schmalbrock, Laura K.; Brown, Fiona C.; Beneyto-Calabuig, Sergi; Koche, Richard P.; Velten, Lars; Kentsis, Alex 分享 收藏
BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid-dendritic cell leukemia Booth, Christopher A. G.; Bouyssou, Juliette M.; Togami, Katsuhiro; Armand, Olivier; Rivas, Hembly G.; Yan, Kezhi; Rice, Siobhan; Cheng, Shuyuan; Lachtara, Emily M.; Bourquin, Jean-Pierre; Kentsis, Alex; Rheinbay, Esther; Decaprio, James A.; Lane, Andrew A. 分享 收藏
Proteolytic Control and Therapeutic Targeting of Oncogenic Gene Expression in Acute Myeloid Leukemia 蛋白酶控制及靶向治疗在急性髓系白血病癌基因表达中的作用 Uni, Masahiro; Steinberg, Asher Preska; Slavit, Alicia; Rha, Sophia; Cheng, Shuyuan; Schmalbrock, Laura K.; Su, Jiayu; Ma, Jing; Mcpherson, Andrew; Mullighan, Charles G.; Haferlach, Torsten; Iacobucci, Ilaria; Klco, Jeffery M.; Rabadan, Raul; Kentsis, Alex 分享 收藏
Targeting PERK Arm of Unfolded Protein Response Helps to Eliminate Therapy-Induced Residual Senescent-like Acute Myeloid Leukemia Cells 靶向未折叠蛋白反应的PERK通路有助于消除疗法诱导的残留衰老样急性髓系白血病细胞 Poigaialwar, Gowri; Takao, Sumiko; Chaudhry, Sovira; Schmalbrock, Laura K.; Gupta, Varun; Kentsis, Alex; Aguirre-Ghiso, Julio A.; Konopleva, Marina; Sosa, Maria S.; Skwarska, Anna 分享 收藏
The Histone Acetyltransferase MOZ (KAT6A) Is a Molecular Dependency and Therapeutic Target in NUP98-Rearranged Acute Myeloid Leukemia 组蛋白乙酰转移酶MOZ（KAT6A）是NUP98重排急性髓系白血病中的分子依赖性和治疗靶点 Michmerhuizen, Nicole L.; Heikamp, Emily; Umeda, Masayuki; Iacobucci, Ilaria; Arthur, Bright; Di Giacomo, Danika; Hiltenbrand, Ryan; Radko-Juettner, Sandi; Portola, Pablo; Claquin, Aurelie; Chandra, Bappaditya; Baggett, David W.; Huang, Hongling; Zhou, Peipei; Long, Lingyun; Shi, Hao; Sun, Yu; Papachristou, Evangelia K.; Chilamakuri, Chandra Sekhar Reddy; Vitorino, Francisca N. de L.; Gongora, Joanna M.; D'Santos, Clive S.; Garcia, Benjamin A.; Kriwacki, Richard W.; Chi, Hongbo; Kentsis, Alex; Armstrong, Scott A.; Klco, Jeffery M.; Mullighan, Charles G. 分享 收藏
MYCN overexpression biases human sympatho-adrenergic development towards progenitor cells causing neuroblastoma-like tumor xenografts Van Haver, Stephane; Bekaert, Sarah-Lee; Luz, Jubierre; Everaert, Celine; Maestre, Ines Fernandez; De Preter, Katleen; Zhou, Ting; Kentsis, Alex; Studer, Lorenz; Shimada, Hiroyuki; Speleman, Frank; Roberts, Stephen 分享 收藏
Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination Therapy Kazansky, Yaniv; Cameron, Daniel; Mueller, Helen S.; Demarest, Phillip; Zaffaroni, Nadia; Arrighetti, Noemi; Zuco, Valentina; Kuwahara, Yasumichi; Somwar, Romel; Ladanyi, Marc; Qu, Rui; de Stanchina, Elisa; Dela Cruz, Filemon S.; Kung, Andrew L.; Gounder, Mrinal M.; Kentsis, Alex 分享 收藏
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Childhood cancer mutagenesis caused by transposase-derived PGBD5 Yamada, Makiko; Keller, Ross R.; Gutierrez, Rodrigo Lopez; Cameron, Daniel; Suzuki, Hiromichi; Sanghrajka, Reeti; Vaynshteyn, Jake; Gerwin, Jeffrey; Maura, Francesco; Hooper, William; Shah, Minita; Robine, Nicolas; Demarest, Phillip; Bayin, N. Sumru; Zapater, Luz Jubierre; Reed, Casie; Hebert, Steven; Masilionis, Ignas; Chaligne, Ronan; Socci, Nicholas D.; Taylor, Michael D.; Kleinman, Claudia L.; Joyner, Alexandra L.; Raju, G. Praveen; Kentsis, Alex 分享 收藏
Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia Myb过表达与Pten缺失协同作用，是T淋巴细胞白血病的依赖因子和治疗靶点 Almeida, Andre; T'Sas, Sara; Pagliaro, Luca; Fijalkowski, Igor; Sleeckx, Wouter; Van Steenberge, Hannah; Zamponi, Raffaella; Lintermans, Beatrice; Van Loocke, Wouter; Palhais, Bruno; Reekmans, Alexandra; Bardelli, Valentina; Demoen, Lisa; Reunes, Lindy; Deforce, Dieter; Van Nieuwerburgh, Filip; Kentsis, Alex; Ntziachristos, Panagiotis; Van Roy, Nadine; De Moerloose, Barbara; Mecucci, Cristina; La Starza, Roberta; Roti, Giovanni; Goossens, Steven; Van Vlierberghe, Pieter; Pieters, Tim 分享 收藏
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SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3 Perlee, Sarah; Kikuchi, Sota; Nakadai, Tomoyoshi; Masuda, Takeshi; Ohtsuki, Sumio; Matsumoto, Makoto; Rahmutulla, Bahityar; Fukuyo, Masaki; Cifani, Paolo; Kentsis, Alex; Roeder, Robert G.; Kaneda, Atsushi; Hoshii, Takayuki 分享 收藏
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells Herrejon Chavez, Florisela; Luo, Hanzhi; Cifani, Paolo; Pine, Alli; Chu, Karen L.; Joshi, Suhasini; Barin, Ersilia; Schurer, Alexandra; Chan, Mandy; Chang, Kathryn; Han, Grace Y. Q.; Pierson, Aspen J.; Xiao, Michael; Yang, Xuejing; Kuehm, Lindsey M.; Hong, Yuning; Nguyen, Diu T. T.; Chiosis, Gabriela; Kentsis, Alex; Leslie, Christina; Vu, Ly P.; Kharas, Michael G. 分享 收藏
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