未登录 Pharmacologic inhibition of YTHDC1 biomolecular condensates as a novel approach to targeting L-MYC driven small cell lung cancer Centore, R.; Charles, M.; Arora, M.; Chen, Y.; Watson, M.; Kelley, C.; Czekalska, M.; Rebmann, M.; Ghandi, M.; Cattin, J.; Bharatham, N.; Radhakrishnan, P.; Howarth, A.; Arter, W.; Qamar, S.; Saar, K.; Seeber, A.; Kulander, M.; Knowles, T.; Arora, S. 分享 收藏
RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4 Weinstein, Hannah N. W.; Hu, Kevin; Fish, Lisa; Chen, Yih-An; Allegakoen, Paul; Pham, Julia H.; Hui, Keliana S. F.; Chang, Chih-Hao; Tutar, Meltem; Benitez-Rivera, Lorena; Baco, Maria B.; Song, Hanbing; Giacomelli, Andrew O.; Vazquez, Francisca; Ghandi, Mahmoud; Goodarzi, Hani; Huang, Franklin W. 分享 收藏
Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools Saar, Kadi L.; Rebmann, Marius; Kanchwala, Mohammed; Qamar, Seema; Radhakrishnan, Prathima; Cornish, Jasmine; Doh, Julia; Cattin, Jerome; Rotem, Assaf; Ghandi, Mahmoud; Seeber, Andrew; Centore, Richard C.; Teichmann, Sarah A.; Knowles, Tuomas; Arora, Shilpi 分享 收藏
Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer Centore, Richard C.; Charles, Mark; Arora, Mansi; Chen, Yiwen; Watson, Matthew; Kelley, Charlotte; Czekalska, Magdalena; Rebmann, Marius; Ghandi, Mahmoud; Cattin, Jerome; Bharatham, Nagakumar; Radhakrishnan, Prathima; Howarth, Alex; Rudlaff, Gale; Arter, William E.; Qamar, Seema; Saar, Kadi; Williamson, Douglas; Seeber, Andrew; Knowles, Tuomas; Arora, Shilpi 分享 收藏
RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4 Weinstein, Hannah N.; Hu, Kevin; Fish, Lisa; Chen, Yih-An; Allegakoen, Paul; Hui, Keliana S.; Pham, Julia H.; Baco, Maria B.; Song, Hanbing; Giacomelli, Andrew O.; Vazquez, Francisca; Ghandi, Mahmoud; Goodarzi, Hani; Huang, Franklin W. 分享 收藏
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Development of MRT-2359, an orally bioavailable GSPT1 molecular glue degrader, for the treatment of lung cancers with MYC-induced translational addiction Gavory, Gerald; Ghandi, Mahmoud; d'Alessandro, Anne-Cecile; Bonenfant, Debora; Cabanski, Maciej; Cantagallo, Lisa; Chicas, Agustin; Chen, Qian; Diesslin, Anna; King, Christopher; Massafra, Vittoria; Narayan, Rajiv; Osmont, Arnaud; Peck, Dave; Ortiz, Carolina Perdomo; Schillo, Martin; Singh, Ambika; Tiedt, Ralph; Tortoioli, Simone; Buonamici, Silvia; Janku, Filip; Wallace, Owen; Fasching, Bernhard 分享 收藏
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Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer Gavory, Gerald; Fasching, Bernhard; Bonenfant, Debora; Sadok, Amine; Singh, Ambika; Schillo, Martin; Massafra, Vittoria; d'Alessandro, Anne-Cecile; Castle, John; Ghandi, Mahmoud; Chicas, Agustin; Delobel, Frederic; Flohr, Alexander; Ottaviani, Giorgio; Ryckmans, Thomas; Laine, Anne-Laure; Eidam, Oliv; Wang, Hannah; Bernett, Ilona; Chan, Laura; Gorrini, Chiara; Roumiliotis, Theo; Choudhary, Jyoti; LeBihan, Yann-Vai; Cabry, Marc; Stubbs, Mark; Burke, Rosemary; Van Montfort, Rob; Caldwell, John; Chopra, Rajesh; Collins, Ian; Buonamici, Silvia 分享 收藏
Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis Togami, Katsuhiro; Chung, Sun Sook; Madan, Vikas; Booth, Christopher A. G.; Kenyon, Christopher M.; Cabal-Hierro, Lucia; Taylor, Justin; Kim, Sunhee S.; Griffin, Gabriel K.; Ghandi, Mahmoud; Li, Jia; Li, Yvonne Y.; Angelot-Delettre, Fanny; Biichle, Sabeha; Seiler, Michael; Buonamici, Silvia; Lovitch, Scott B.; Louissaint, Abner, Jr.; Morgan, Elizabeth A.; Jardin, Fabrice; Piccaluga, Pier Paolo; Weinstock, David M.; Hammerman, Peter S.; Yang, Henry; Konopleva, Marina; Pemmaraju, Naveen; Garnache-Ottou, Francine; Abdel-Wahab, Omar; Koeffler, H. Phillip; Lane, Andrew A. 分享 收藏
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Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action 多重单细胞转录反应分析以定义癌症脆弱性和治疗作用机制 McFarland, James M.; Paolella, Brenton R.; Warren, Allison; Geiger-Schuller, Kathryn; Shibue, Tsukasa; Rothberg, Michael; Kuksenko, Olena; Colgan, William N.; Jones, Andrew; Chambers, Emily; Dionne, Danielle; Bender, Samantha; Wolpin, Brian M.; Ghandi, Mahmoud; Tirosh, Itay; Rozenblatt-Rosen, Orit; Roth, Jennifer A.; Golub, Todd R.; Regev, Aviv; Aguirre, Andrew J.; Vazquez, Francisca; Tsherniak, Aviad 分享 收藏
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DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance Togami, Katsuhiro; Pastika, Timothy; Stephansky, Jason; Ghandi, Mahmoud; Christie, Amanda L.; Jones, Kristen L.; Johnson, Carl A.; Lindsay, Ross W.; Brooks, Christopher L.; Letai, Anthony; Craig, Jeffrey W.; Pozdnyakova, Olga; Weinstock, David M.; Montero, Joan; Aster, Jon C.; Johannessen, Cory M.; Lane, Andrew A. 分享 收藏
Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors 小分子和CRISPR筛选融合揭示小儿横纹肌样瘤中受体酪氨酸激酶的依赖性 Oberlick, Elaine M.; Rees, Matthew G.; Seashore-Ludlow, Brinton; Vazquez, Francisca; Nelson, Geoffrey M.; Dharia, Neekesh V.; Weir, Barbara A.; Tsherniak, Aviad; Ghandi, Mahmoud; Krill-Burger, John M.; Meyers, Robin M.; Wang, Xiaofeng; Montgomery, Phil; Root, David E.; Bieber, Jake M.; Radko, Sandi; Cheah, Jaime H.; Hon, C. Suk-Yee; Shamji, Alykhan F.; Clemons, Paul A.; Park, Peter J.; Dyer, Michael A.; Golub, Todd R.; Stegmaier, Kimberly; Hahn, William C.; Stewart, Elizabeth A.; Schreiber, Stuart L.; Roberts, Charles W. M. 分享 收藏
The landscape of cancer cell line metabolism Li, Haoxin; Ning, Shaoyang; Ghandi, Mahmoud; Kryukov, Gregory V.; Gopal, Shuba; Deik, Amy; Souza, Amanda; Pierce, Kerry; Keskula, Paula; Hernandez, Desiree; Ann, Julie; Shkoza, Dojna; Apfel, Verena; Zou, Yilong; Vazquez, Francisca; Barretina, Jordi; Pagliarini, Raymond A.; Galli, Giorgio G.; Root, David E.; Hahn, William C.; Tsherniak, Aviad; Giannakis, Marios; Schreiber, Stuart L.; Clish, Clary B.; Garraway, Levi A.; Sellers, William R. 分享 收藏
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models Ng, Samuel Y.; Yoshida, Noriaki; Christie, Amanda L.; Ghandi, Mahmoud; Dharia, Neekesh V.; Dempster, Joshua; Murakami, Mark; Shigemori, Kay; Morrow, Sara N.; Van Scoyk, Alexandria; Cordero, Nicolas A.; Stevenson, Kristen E.; Puligandla, Maneka; Haas, Brian; Lo, Christopher; Meyers, Robin; Gao, Galen; Cherniack, Andrew; Louissaint, Abner, Jr.; Nardi, Valentina; Thorner, Aaron R.; Long, Henry; Qiu, Xintao; Morgan, Elizabeth A.; Dorfman, David M.; Fiore, Danilo; Jang, Julie; Epstein, Alan L.; Dogan, Ahmet; Zhang, Yanming; Horwitz, Steven M.; Jacobsen, Eric D.; Santiago, Solimar; Ren, Jian-Guo; Guerlavais, Vincent; Annis, D. Allen; Aivado, Manuel; Saleh, Mansoor N.; Mehta, Amitkumar; Tsherniak, Aviad; Root, David; Vazquez, Francisca; Hahn, William C.; Inghirami, Giorgio; Aster, Jon C.; Weinstock, David M.; Koch, Raphael 分享 收藏
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Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States Kim, Jong Wook; Abudayyeh, Omar O.; Yeerna, Huwate; Yeang, Chen-Hsiang; Stewart, Michelle; Jenkins, Russell W.; Kitajima, Shunsuke; Konieczkowski, David J.; Medetgul-Ernar, Kate; Cavazos, Taylor; Mah, Clarence; Ting, Stephanie; Van Allen, Eliezer M.; Cohen, Ofir; Mcdermott, John; Damato, Emily; Aguirre, Andrew J.; Liang, Jonathan; Liberzon, Arthur; Alexe, Gabriella; Doench, John; Ghandi, Mahmoud; Vazquez, Francisca; Weir, Barbara A.; Tsherniak, Aviad; Subramanian, Aravind; Meneses-Cime, Karina; Park, Jason; Clemons, Paul; Garraway, Levi A.; Thomas, David; Boehm, Jesse S.; Barbie, David A.; Hahn, William C.; Mesirov, Jill P.; Tamayo, Pablo 分享 收藏
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