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高

高栋 (Dong Gao)

Memorial Sloan Kettering Cancer Center研究员，研究组长，博士生导师
H指数:41
被引数:1.1万

个人简介

"2005年毕业于东北林业大学，获生物技术专业学士学位。2011年毕业于北京大学，获细胞生物学专业博士学位。2011年至2016年先后在美国约翰霍普金斯大学 (The Johns Hopkins University) 和纪念斯隆凯特琳癌症研究所 (Memorial Solan Kerttering Cancer Center) 接受博士后训练，从事肿瘤生物学研究。2016年8月受聘于中科院分子细胞科学卓越创新中心（原中科院上海生物化学与细胞生物学研究所），任研究员，研究组长，博士生导师。获得国家杰出青年科学基金，中组部“国家高层次人才”青年项目，中科院创新交叉团队，上海市优秀青年学术带头人等项目的支持。"

教育背景

  • 2006.09 – 2011.07

    北京大学 博士学位 细胞生物学

  • 2001.09 – 2005.07

    东北林业大学 学士学位 生物技术

工作经历

  • 2016.08 – 至今

    中科院分子细胞科学卓越创新中心（原中科院上海生物化学与细胞生物学研究所）

    研究员，研究组长，博士生导师

  • 2011.01 – 2016.12

    美国约翰霍普金斯大学 (The Johns Hopkins University)

    博士后

  • 2011.01 – 2016.12

    纪念斯隆凯特琳癌症研究所 (Memorial Solan Kerttering Cancer Center)

    博士后

荣誉奖项

  1. 国家杰出青年科学基金
  2. 中组部“国家高层次人才”青年项目
  3. 中科院创新交叉团队
  4. 上海市优秀青年学术带头人
CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8+ T cells

病理激活的中性粒细胞上的CD300ld通过结合CD8 T细胞上的磷脂酰丝氨酸促进肿瘤免疫抑制

Nature Cancer
IF28.5
2026-05-150
PRE
Chaoxiong Wang; Peixuan Zheng; Anhui Wang; Xinrui Fan; Tianxiang Li; Jingjing Hong; Runze Wang; Chunyan Zhang; Chaogui Luo; Weiwei Yang; Dong Gao; Adili Salai; Min Luo; Zhigang Lu; Dianfan Li; Moubin Lin; Jiayin Peng; Guohui Li; Shuo Han; Yun Zhao
A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy

胰腺癌类器官生物样本库将多组学特征与治疗反应及他汀类药物联合疗法的临床评估相联系

Cell Stem Cell
IF20.4
2025-08-130
OAAI
Yunguang Li; Shijie Tang; Huan Wang; Hongwen Zhu; Yurun Lu; Yehan Zhang; Shiwei Guo; Juan He; Yikai Li; Yi Zhang; Xiaohan Shi; Yuanxiang Miao; Chaoliang Zhong; Yiqin Zhu; Yi Ju; Yuejia Liu; Maoyuan Sun; Yong Wang; Luonan Chen; Hu Zhou; Gang Jin; Dong Gao
KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy

KMT2C缺陷驱动前列腺癌双阴性细胞的转分化，并赋予其抵抗AR靶向治疗的特性

Cancer Cell
IF44.5
2025-04-240
PRE
Jiacheng Guo; Ni Li; Qiuli Liu; Zongyao Hao; Guanghui Zhu; Xuege Wang; Hanling Wang; Qiang Pan; Beitao Xu; Ying Han; Guoying Zhang; Yannan Lian; Wei Zhang; Yongqiang Gu; Naiheng Lin; Xin Zeng; Zige Jin; Weihua Lan; Jun Jiang; Dong Gao; Liang Dong; Huairui Yuan; Chaozhao Liang; Jun Qin
Pathogenic germline variants in Chinese pancreatic adenocarcinoma patients

中国胰腺腺癌患者中的致病性胚系变异

NATURE COMMUNICATIONS
IF15.7
2025-03-050
OA
Yin, Xiaoyi; Shen, Hui; Wang, Huan; Wang, Qingchen; Zhang, Shan; Zhang, Chunming; Jia, Qi; Guo, Shiwei; Xu, Xiongfei; Zhang, Wenhui; Li, Bo; Shi, Xiaohan; Gao, Suizhi; Shi, Meilong; Zhao, Xuenan; Wang, Sheng; Han, Jiawei; Zhang, Guoxiao; Li, Yikai; Li, Penghao; Jing, Wei; Song, Bin; Zheng, Kailian; Li, Gang; Zhang, Yijie; Jiang, Hui; Wu, Cong; Song, Zhijian; Niu, Gang; Zhang, Qiangzu; Guo, Jianglong; Sun, Zhen; Han, Fengxian; Li, Yunguang; Gao, Dong; Jin, Haojie; Li, Jing
Standard: Human gastric organoids

标准: 人胃类器官

CELL REGENERATION
IF4.7
2025-01-141
OAAI
Hong, Fan; Tan, Ronghui; Wang, Ting; Zhong, Nanshan; Zhao, Hongling; Xu, Rui-hua; Shen, Lin; Liu, Yingbin; Yao, Xuebiao; Xiang, Dongxi; Hui, Lijian; Xiong, Jianping; Gao, Dong; Zhao, Bing; Miao, Zhifeng; Hao, Jie; Li, Yong; Hu, Shijun; Fu, Boqiang; Hua, Guoqiang; Wang, Lei; Zeng, Zhao-Lei; Chen, Chong; Wu, Jianmin; Wang, Changlin; Wang, Chunnian; Zhan, Xianbao; Song, Chen; Yu, Chunping; Yang, Yingying; Niu, Gengming; Wang, Yalong; Zhao, Tongbiao; Chen, Ye-Guang
Standard: Human gastric cancer organoids

标准: 人胃癌类器官

CELL REGENERATION
IF4.7
2024-12-270
OAAI
Tan, Ronghui; Hong, Fan; Wang, Ting; Zhong, Nanshan; Zhao, Hongling; Xu, Rui-hua; Shen, Lin; Liu, Yingbin; Yao, Xuebiao; Xiang, Dongxi; Gao, Dong; Xiong, Jianping; Hui, Lijian; Zhao, Bing; Miao, Zhifeng; Hao, Jie; Li, Yong; Hu, Shijun; Fu, Boqiang; Hua, Guoqiang; Wang, Lei; Zeng, Zhao-Lei; Chen, Chong; Wu, Jianmin; Wang, Changlin; Wang, Chunnian; Zhan, Xianbao; Song, Chen; Sun, Zhijian; Yu, Chunping; Yang, Yingying; Niu, Gengming; Wang, Yalong; Zhao, Tongbiao; Chen, Ye-Guang
Deep whole-genome analysis of 494 hepatocellular carcinomas
Nature
IF48.5
2024-02-140
PRE
Lei Chen; Chong Zhang; Ruidong Xue; Mo Liu; Jian Bai; Jinxia Bao; Yin Wang; Nanhai Jiang; Zhixuan Li; Wenwen Wang; Ruiru Wang; Bo Zheng; Airong Yang; Ji Hu; Ke Liu; Siyun Shen; Yangqianwen Zhang; Mixue Bai; Yan Wang; Yanjing Zhu; Shuai Yang; Qiang Gao; Jin Gu; Dong Gao; Xin Wei Wang; Hidewaki Nakagawa; Ning Zhang; Lin Wu; Steven G. Rozen; Fan Bai; Hongyang Wang
Integrated characterization of hepatobiliary tumor organoids provides a potential landscape of pharmacogenomic interactions
CELL REPORTS MEDICINE
IF10.6
2024-02-014
OAAI
Zhu, Yanjin; Tang, Shiji; Yuan, Qiuyu; Fu, Jing; He, Juan; Liu, Zhuang; Zhao, Xiaofang; Li, Yunguang; Zhao, Yan; Zhang, Yani; Zhang, Xiaoyu; Zhang, Yangqianwen; Zhu, Yiqin; Wang, Wenwen; Zheng, Bo; Wu, Rui; Wu, Tong; Yang, Shuai; Qiu, Xinyao; Shen, Siyun; Hu, Ji; Chen, Luonan; Wang, Yong; Wang, Hongyang; Gao, Dong; Chen, Lei
Correction to: Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis (10, nwac224, 2023)
NATIONAL SCIENCE REVIEW
IF17.1
2023-12-280
OAAI
Jin, Yujuan; Zhao, Qiqi; Zhu, Weikang; Feng, Yan; Xiao, Tian; Zhang, Peng; Jiang, Liyan; Hou, Yingyong; Guo, Chenchen; Huang, Hsinyi; Chen, Yabin; Tong, Xinyuan; Cao, Jiayu; Li, Fei; Zhu, Xueliang; Qin, Jun; Gao, Dong; Liu, Xin-Yuan; Zhang, Hua; Chen, Luonan; Thomas, Roman K.; Wong, Kwok-Kin; Zhang, Lei; Wang, Yong; Hu, Liang; Ji, Hongbin

研究方向

成体干细胞类器官与组织重建前列腺癌胰腺癌细胞可塑性与肿瘤抗药性肿瘤类器官模型库
陈瑜 封面图
陈瑜
H 指数:66论文数:557被引数:2.9万
F
Fei Li
H 指数:47论文数:355被引数:8,567
陈
陈洛南
H 指数:84论文数:811被引数:2.3万
A
Andrea Sboner
H 指数:71论文数:521被引数:3.7万
J
Juan He
H 指数:15论文数:38被引数:1,247
M
Mark A. Rubin
H 指数:186论文数:1,525被引数:16.5万
H
Himisha Beltran
H 指数:87论文数:901被引数:4.0万
J
Juan Miguel Mosquera
H 指数:53论文数:467被引数:2.2万
Y
Yunguang Li
H 指数:18论文数:62被引数:1,344
L
Loredana Puca
H 指数:23论文数:127被引数:5,783