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L

Loredana Puca

Weill Cornell Medicine
H指数:23
被引数:5,783

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荣誉奖项

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Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes
NATURE COMMUNICATIONS
IF15.7
2024-08-082
OAAI
Venkadakrishnan, Varadha Balaji; Presser, Adam G.; Singh, Richa; Booker, Matthew A.; Traphagen, Nicole A.; Weng, Kenny; Voss, Nathaniel C. E.; Mahadevan, Navin R.; Mizuno, Kei; Puca, Loredana; Idahor, Osasenaga; Ku, Sheng-Yu; Bakht, Martin K.; Borah, Ashir A.; Herbert, Zachary T.; Tolstorukov, Michael Y.; Barbie, David A.; Rickman, David S.; Brown, Myles; Beltran, Himisha
Notch signaling suppresses neuroendocrine differentiation and alters the immune microenvironment in advanced prostate cancer
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2024-07-185
OAAI
Ku, Sheng-Yu; Wang, Yanqing; Garcia, Maria Mica; Yamada, Yasutaka; Mizuno, Kei; Long, Mark D.; Rosario, Spencer; Chinnam, Meenalakshmi; Al Assaad, Majd; Puca, Loredana; Kim, Min Jin; Bakht, Martin K.; Venkadakrishnan, Varadha Balaji; Robinson, Brian D.; Acosta, Andres M.; Wadosky, Kristine M.; Mosquera, Juan Miguel; Goodrich, David W.; Beltran, Himisha
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Tang, Fanying; Xu, Duo; Wang, Shangqian; Wong, Chen Khuan; Martinez-Fundichely, Alexander; Lee, Cindy J.; Cohen, Sandra; Park, Jane; Hill, Corinne E.; Eng, Kenneth; Bareja, Rohan; Han, Teng; Liu, Eric Minwei; Palladino, Ann; Di, Wei; Gao, Dong; Abida, Wassim; Beg, Shaham; Puca, Loredana; Meneses, Maximiliano; de Stanchina, Elisa; Berger, Michael F.; Gopalan, Anuradha; Dow, Lukas E.; Mosquera, Juan Miguel; Beltran, Himisha; Sternberg, Cora N.; Chi, Ping; Scher, Howard I.; Sboner, Andrea; Chen, Yu; Khurana, Ekta
LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models

LOXO-783: 一种有效的，高度突变的选择性和脑渗透变构PI3Kα H1047R抑制剂与临床前PI3Kα H1047R-mutant乳腺癌模型的护理标准 (SOC) 联合治疗

CANCER RESEARCH
IF16.6
2023-03-013
PRE
Puca, Loredana; Dowless, Michele S.; Perez-Ferreiro, Carmen M.; Ortiz-Ruiz, Maria Jesus; Donoho, Gregory P.; Capen, Andrew; Huber, Lysiane; Bogner, Sarah M.; Fei, Dongling; Manro, Jason R.; Yu, Chun Ping; Xu, Wei Guo; Wang, Rui; Chen, Shuang; Hicks, Mark A.; Zolfaghari, Parisa; Faber, Andrew; Gilmour, Raymond; Ramstetter, Monica D.; Chang, Matthew T.; Lallena, Maria Jose; Gong, Xuequian; Hyman, David M.; Smyth, Lillian M.; Brandhuber, Barbara J.; Taylor, Barry S.; Klippel, Anke
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
Science
IF45.8
2022-01-010
OA
Fanying Tang; Duo Xu; Shangqian Wang; Chen Khuan Wong; Alexander Martinez‐Fundichely; Cindy J. Lee; Sandra M. Cohen; Jane Park; Corinne E. Hill; Kenneth Wha Eng; Rohan Bareja; Teng Han; Eric Minwei Liu; Ann C. Palladino; Wei Di; Dong Gao; Wassim M. Abida; Shaham Beg; Loredana Puca; Maximiliano Meneses; Elisa de Stanchina; Michael F. Berger; Anuradha Gopalan; Lukas E. Dow; Juan Miguel Mosquera; Himisha Beltran; Cora Nanette Sternberg; Ping Chi; Howard I. Scher; Andrea Sboner; Yu Chen; Ekta Khurana
Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor
MOLECULAR CANCER THERAPEUTICS
IF5.5
2021-12-019
PRE
Klippel, Anke; Wang, Rui; Puca, Loredana; Faber, Andrew Lee; Shen, Weihua; Bhagwat, Shripad V.; Karukurichi, Kannan; Zhang, Feiyu Fred; Perez, Carmen; Rama, Ramon; Ramos, Ana; Zheng, Yi; Bonday, Zahid; Thomas, James; Brooks, Harold B.; Kindler, Lisa J.; Bogner, Sarah M.; Zolfaghari, Parisa; Hicks, Mark, II; Callies, Sophie; Mattioni, Brian; LeBrun, Laurie; Durbin, Jim; Anderson, Erin; Mayne, Chris; Kesicki, Edward; Kolakowski, Gabrielle; Andrews, Steven W.; Brandhuber, Barbara J.
Extracellular Matrix in Synthetic Hydrogel-Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors
ADVANCED MATERIALS
IF26.8
2021-11-1435
OA
Mosquera, Matthew J.; Kim, Sungwoong; Bareja, Rohan; Fang, Zhou; Cai, Shuangyi; Pan, Heng; Asad, Muhammad; Martin, Maria Laura; Sigouros, Michael; Rowdo, Florencia M.; Ackermann, Sarah; Capuano, Jared; Bernheim, Jacob; Cheung, Cynthia; Doane, Ashley; Brady, Nicholas; Singh, Richa; Rickman, David S.; Prabhu, Varun; Allen, Joshua E.; Puca, Loredana; Coskun, Ahmet F.; Rubin, Mark A.; Beltran, Himisha; Mosquera, Juan Miguel; Elemento, Olivier; Singh, Ankur
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer
NATURE COMMUNICATIONS
IF15.7
2021-11-0419
OAAI
Che, Meixia; Chaturvedi, Aashi; Munro, Sarah A.; Pitzen, Samuel P.; Ling, Alex; Zhang, Weijie; Mentzer, Josh; Ku, Sheng-Yu; Puca, Loredana; Zhu, Yanyun; Bergman, Andries M.; Severson, Tesa M.; Forster, Colleen; Liu, Yuzhen; Hildebrand, Jacob; Daniel, Mark; Wang, Ting-You; Selth, Luke A.; Hickey, Theresa; Zoubeidi, Amina; Gleave, Martin; Bareja, Rohan; Sboner, Andrea; Tilley, Wayne; Carroll, Jason S.; Tan, Winston; Kohli, Manish; Yang, Rendong; Hsieh, Andrew C.; Murugan, Paari; Zwart, Wilbert; Beltran, Himisha; Huang, R. Stephanie; Dehm, Scott M.
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
NATURE COMMUNICATIONS
IF15.7
2020-11-0377
OAAI
Cyrta, Joanna; Augspach, Anke; De Filippo, Maria Rosaria; Prandi, Davide; Thienger, Phillip; Benelli, Matteo; Cooley, Victoria; Bareja, Rohan; Wilkes, David; Chae, Sung-Suk; Cavaliere, Paola; Dephoure, Noah; Uldry, Anne-Christine; Lagache, Sophie Braga; Roma, Luca; Cohen, Sandra; Jaquet, Muriel; Brandt, Laura P.; Alshalalfa, Mohammed; Puca, Loredana; Sboner, Andrea; Feng, Felix; Wang, Shangqian; Beltran, Himisha; Lotan, Tamara; Spahn, Martin; Kruithof-de Julio, Marianna; Chen, Yu; Ballman, Karla V.; Demichelis, Francesca; Piscuoglio, Salvatore; Rubin, Mark A.
N-Myc mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2019-08-19137
OA
Berger, Adeline; Brady, Nicholas J.; Bareja, Rohan; Robinson, Brian; Conteduca, Vincenza; Augello, Michael A.; Ruca, Loredana; Ahmed, Adnan; Dardenne, Etienne; Lu, Xiaodong; Hwang, Inah; Bagadion, Alyssa M.; Sboner, Andrea; Elemento, Olivier; Paik, Jihye; Yu, Jindan; Barbieri, Christopher E.; Dephoure, Noah; Beltran, Himisha; Rickman, David S.
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer

Delta样蛋白3在神经内分泌前列腺癌中的表达及靶向治疗

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2019-03-20139
OAAI
Puca, Loredana; Gavyert, Katie; Sailer, Verena; Conteduca, Vincenza; Dardenne, Etienne; Sigouros, Michael; Isse, Kumiko; Kearney, Megan; Vosoughi, Aram; Fernandez, Luisa; Pan, Heng; Motanagh, Samaneh; Hess, Judy; Donoghue, Adam J.; Sboner, Andrea; Wang, Yuzhuo; Dittamore, Ryan; Rickman, David; Nanus, David M.; Tagawa, Scott T.; Elemento, Olivier; Mosquera, Juan Miguel; Saunders, Laura; Beltran, Himisha
ONECUT2 is a driver of neuroendocrine prostate cancer

ONECUT2是神经内分泌前列腺癌的驱动因素

NATURE COMMUNICATIONS
IF15.7
2019-01-17196
OAAI
Guo, Haiyang; Ci, Xinpei; Ahmed, Musaddeque; Hua, Junjie Tony; Soares, Fraser; Lin, Dong; Puca, Loredana; Vosoughi, Aram; Xue, Hui; Li, Estelle; Su, Peiran; Chen, Sujun; Tran Nguyen; Liang, Yi; Zhang, Yuzhe; Xu, Xin; Xu, Jing; Sheahan, Anjali V.; Ba-Alawi, Wail; Zhang, Si; Mahamud, Osman; Vellanki, Ravi N.; Gleave, Martin; Bristow, Robert G.; Haibe-Kains, Benjamin; Poirier, John T.; Rudin, Charles M.; Tsao, Ming-Sound; Wouters, Bradly G.; Fazli, Ladan; Feng, Felix Y.; Ellis, Leigh; van der Kwast, Theo; Berlin, Alejandro; Koritzinsky, Marianne; Boutros, Paul C.; Zoubeidi, Amina; Beltran, Himisha; Wang, Yuzhuo; He, Housheng Hansen
A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers

Aurora激酶A抑制剂Alisertib治疗去势抵抗性和神经内分泌前列腺癌患者的II期临床试验: 疗效和生物标志物

CLINICAL CANCER RESEARCH
IF10.2
2019-01-03252
OAAI
Beltran, Himisha; Oromendia, Clara; Danila, Daniel C.; Montgomery, Bruce; Hoimes, Christopher; Szmulewitz, Russell Z.; Vaishampayan, Ulka; Armstrong, Andrew J.; Stein, Mark; Pinski, Jacek; Mosquera, Juan M.; Sailer, Verena; Bareja, Rohan; Romanel, Alessandro; Gumpeni, Naveen; Sboner, Andrea; Dardenne, Etienne; Puca, Loredana; Prandi, Davide; Rubin, Mark A.; Scher, Howard I.; Rickman, David S.; Demichelis, Francesca; Nanus, David M.; Ballman, Karla V.; Tagawa, Scott T.

研究方向

暂未获取到该数据
H
Himisha Beltran
H 指数:87论文数:901被引数:4.0万
A
Andrea Sboner
H 指数:71论文数:521被引数:3.7万
J
Juan Miguel Mosquera
H 指数:53论文数:467被引数:2.2万
M
Mark A. Rubin
H 指数:186论文数:1,525被引数:16.5万
O
Olivier Elemento
H 指数:117论文数:1,686被引数:6.3万
R
Rohan Bareja
H 指数:31论文数:194被引数:4,744
陈瑜 封面图
陈瑜
H 指数:66论文数:557被引数:2.9万
高
高栋
H 指数:41论文数:146被引数:1.1万
S
Scott T. Tagawa
H 指数:69论文数:814被引数:2.6万
D
David S. Rickman
H 指数:44论文数:184被引数:1.0万