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梁
梁超 (Chao Liang)
H指数:38
被引数:4,988
个人简介
"研究领域 骨关节相关疾病以及肿瘤的机制研究、转化医学和精准医学。 教学 《基因工程学》、《 前沿基因工程技术与应用》 学术成果 查看更多 Huang J*, Fu X*#, Zhang R, Wang Z, Qiu F, Chen X, Fan J, Cao C, Yang X, Li J, Liang Y, He D#, Lu A#, Liang C#. snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice. Sci Transl Med. In press. DOI: 10.1126/scitranslmed.adt5340. Xu Y*, Xie D*, Cao C*, Wang Z*, Yue Ju, Chen X, Guan L, Li X, Zhang L#, Liang C#, Yin X#. PSMA-targeted CAR-macrophages drive glycolytic reprogramming for enhanced prostate cancer immunotherapy. J Hematol Oncol18, 95 (2025). https://doi.org/10.1186/s13045-025-01743-w. Fu X*, Yang X#, Huang J*, Huang Y*, Patrick Ryan Potts. Liang C#. A Cancer-Specific Antigen Drives Histone Acetylation by Stabilizing the Acetyltransferases. Cell Rep 44, 116408. https://doi.org/10.1016/j.celrep.2025.116408. Shan Y, Guo M, Liu J, Wang L, Shen Y, Zhao J, Wei K, Jiang P, Shi Y, Chang C, Zheng Y, Zhao F, Li Y, Zhou M, Li C, Guo S, Liang C#, Qu H#, He D#. Comparative Analysis Revealed Circulating Methylation of PDGFRB Highly Related with Rheumatoid Arthritis Related Diseases. Endocr Metab Immune Disord Drug Targets.2025 Sep 16. doi: 10.2174/0118715303377879250831134649. Epub ahead of print. PMID: 40965028. Wang Z*, Xie D*, Zhu P*, Guo J, Cao C, Du Y#, Lu A#, Liang C#. An aptamer specifically targeting mCRP ameliorates experimental arthritis. J Orthop Translat. https://doi.org/10.1016/j.jot.2025.08.010. Zhao J, Chen H*, Liang C#. Dual functionality of MDM2 in PROTACs expands the horizons of targeted protein degradation. Biomark Res13, 111 (2025). https://doi.org/10.1186/s40364-025-00826-7 Yue S*, Fan J*, Xie D*, Cao C, Wang Z, Huang J, Qiu F, Yang X, He D#, Lu A#, Liang C#. Unveiling the Therapeutic Potential: Targeting Fibroblast-Like Synoviocytes in Rheumatoid Arthritis. Expert Rev Mol Med. 2025 Jun 5:1-24. doi: 10.1017/erm.2025.11. Epub ahead of print. PMID: 40468839. Fu X*, Zhong C*, Liu W*, Ren F#, Liang C#. Development of Injectable Aldehyde Hyaluronic Acid Hydrogels Loaded with CRISPRa Reprogrammed Elite Macrophages for the Treatment of Osteoarthritis. ACS Appl Mater Interfaces. 2025 May 21. doi: 10.1021/acsami.5c04355. Epub ahead of print. PMID: 40397763. Huang J*, Fu X*, Qiu F*, Liang Z, Cao C, Wang Z, Chen H, Yue S, Xie D, Liang Y, Lu A#, Liang C#. Discovery of a Natural Ent-Kaurene Diterpenoid Oridonin as an E3 Ligase Recruiter for PROTACs. J Am Chem Soc. 2025 Jan 15;147(2):1920-1937. doi: 10.1021/jacs.4c14650. Qiu F*, Xie D*, Chen H, Wang Z, Huang J, Cao C, Liang Y, Yang X, He DY, Fu X#, Lu A#, Liang C#. Generation of cytotoxic aptamers specifically targeting fibroblast-like synoviocytes by CSCT-SELEX for treatment of rheumatoid arthritis. Ann Rheum Dis.2024 Sep 4:ard-2024-225565. doi: 10.1136/ard-2024-225565. Epub ahead of print. PMID: 39237134. Du Y*,Gao X*, Chen J, Chen X, Liu H, He W, Liu L, Jiang Y, He B, Deng Z, Liang C#, Guo F#. OGT mediated HDAC5 O-GlcNAcylation promotes osteogenesis by regulating the homeostasis of epigenetic modifications and proteolysis. J Orthop Translat 2025, 50, 14-29. Cao C*, Yue S, Lu A#, Liang C#. Host-Gut Microbiota Metabolic Interactions and Their Role in Precision Diagnosis and Treatment of Gastrointestinal Cancers. Pharmacol Res.2024 Sep;207:107321. doi: 10.1016/j.phrs.2024.107321. Epub 2024 Jul 20. PMID: 39038631. Liang C. Proximod as a potential therapy for rheumatoid arthritis. Lancet Rheumatol.2024 Oct 22:S2665-9913(24)00237-6. doi: 10.1016/S2665-9913(24)00237-6. Epub ahead of print. PMID: 39454618. Wang Z*, Yue S*, Chen X*, Li J*, Zhu P, Chen H, Qiu F, Xie D, Liang Y, Li D#, Lu A#, Liang C#. Design of Murine Double Minute 2 Proteolysis Targeting Chimera Degraders with a Built-In Tumor-Targeting Ability. J Med Chem. 2024 Oct 22. doi: 10.1021/acs.jmedchem.4c01228. Epub ahead of print. PMID: 39437434. Feng Z*, Xie D*, Qiu F, Huang J, Wang Z, Liang C#. Development of hybrid aptamers-engineered PROTACs for degrading VEGF165 in both tumor- and vascular endothelial cells. Eur J Med Chem.2024 Nov 2;281:117027. doi: 10.1016/j.ejmech.2024.117027. Epub ahead of print. PMID: 39504794. Fu X*, Huang J*, Chen X, Xie D, Chen H, Liang Z, Wang Z, Liang Y, Lu A#, Liang C#. Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma. Theranostics 2025; 15(1):103-121. doi:10.7150/thno.99588. Xu Y*, Xie D*, Cao C*, Yue Ju, Chen X, Guan L, Li X, Zhang L#, Liang C#, Yin X#. PSMA-specific CAR-engineered macrophages for therapy of prostate cancer. bioRxiv 09.07.611792; doi: https://doi.org/10.1101/2024.09.07.611792. Li J, Liang C#. Protocol for constructing tumor-targeting ANM-PROTACs for degradation of transcription factors. STAR Protoc.2024 Sep 20;5(3):103220. doi: 10.1016/j.xpro.2024.103220. Epub 2024 Jul 27. PMID: 39068654; PMCID: PMC11339245. Chen H*, Fu X*, Wu X*, Zhao J, Qiu F, Wang Z, Wang Z, Chen X, Xie D, Huang J, Fan J, Yang X, Song Y, Li J, He D, Xiao G#, Lu A#, Liang C#. Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis. Bone Res.2024 May 23;12(1):31. doi: 10.1038/s41413-024-00336-6. PMID: 38782893; PMCID: PMC11116389. Huang Y*., Wang Z*., Zhong C*., Chen H, Chen X, Cao C, Qiu F, Xie D, Li J, Li J, Yang X, Lu A#, Fu X#, Liang C#, (2024). CRISPRa engineered Elite macrophages enable adoptive cell therapy for rheumatoid arthritis. The Innovation Medicine2(1): 100050. https://doi.org/10.59717/j.xinn-med.2024.100050. Fu X*, Li J*, Chen X*, Chen H*, Wang Z, Qiu F, Xie D, Huang J, Yue S, Cao C, Liang Y, Lu A#, Liang C#.Repurposing AS1411 for constructing ANM-PROTACs. Cell Chem Biol. 2024 Apr 12:S2451-9456(24)00127-2. doi: 10.1016/j.chembiol.2024.03.011. Epub ahead of print. PMID: 38657608. Mi C#*, Zhang X*, Yang C, Wu J, Chen X, Ma C, Wu S, Yang Z, Qiao P, Liu Y, Wu W, Guo Z, Liao J, Zhou J, Guan M, Liang C#, Liu C#, Jin D#. Bone disease imaging through the near-infrared-II window. Nat Commun. 2023 Oct 9;1"
教育背景
2016.12
香港浸会大学 博士
工作经历
2020.01 – 至今
南方科技大学生物系
副教授
2016.01 – 2020.12
香港浸会大学
博士后及研究助理教授
荣誉奖项
暂无内容
多技术整合鉴定成纤维样滑膜细胞中的O-GlcNAc转移酶为类风湿关节炎的治疗靶点
Advanced Science
IF14.1
细胞外囊泡介导的核纤层蛋白转移在胶质母细胞瘤中：一个可靶向轴驱动血-肿瘤屏障形成
一项关于针刺和艾灸足三里(ST36)作为中老年人群预防性治疗的1/2期初步研究
snoRNA Snord3通过在 mice 的成纤维样滑膜细胞中对ESM1进行表观遗传调控来促进类风湿关节炎。
过氧化物还原酶4作为调节肺泡巨噬细胞活化中PTEN/AKT轴的开关
一种癌症特异性抗原通过稳定乙酰转移酶来驱动组蛋白乙酰化。
Cell Reports
IF6.9
一种特异性靶向mCRP的适体可改善实验性关节炎
揭示治疗潜力：靶向类风湿关节炎中的成纤维样滑膜细胞
开发负载经CRISPRa重编程的精英巨噬细胞的注射用醛基透明质酸水凝胶，用于治疗骨关节炎
发现一种天然赤霉素类二萜化合物Oridonin作为PROTACs的E3泛素连接酶招募剂（2025,147,2, 1920）
NATURE GENETICS
IF31.8
NATURE COMMUNICATIONS
IF15.7
MOLECULAR DIVERSITY
IF3.8
整合多组学分析和机器学习以改善肺腺癌的分子亚型，预后和免疫治疗
