未登录Discovery and Development of a Small-Molecule Inhibitor Targeting the GAS41 YEATS Domain in Nonsmall Cell Lung Cancer针对GAS41 YEATS结构域的非小细胞肺癌小分子抑制剂的发现与开发
Listunov, Dymytrii; Winkler, Alyssa; Ray, Joshua; Linhares, Brian M.; Clegg, Bradley; Weaver, Sidney; Kim, Eungi; Zari, Sergei; Park, Se Ra; Zolov, Sergey N.; Chuikov, Sergei; Zhao, Liang; Shah, Yatrik M.; Keshamouni, Venkateshwar G.; Grembecka, Jolanta; Cierpicki, Tomasz .png)
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收藏分享 收藏 Structure-Based Development of Novel Spiro-Piperidine ASH1L InhibitorsHuang, Guang; Stevens, Rhiannon; Hucek, Devon G.; Purohit, Trupta; Li, Shuangjiang; Miao, Hongzhi; Trost, Elise; Hewett, Geoff; Clegg, Bradley; Park, Se Ra; Rajanayake, Krishani; Wen, Bo; Sun, Duxin; Cierpicki, Tomasz; Grembecka, Jolanta 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Targeting Polycomb Repressive Complex 1 with small-molecule inhibitors as a potential therapeutic approach to combat leukemiaSimes, Miranda L.; Yao, Yiwu; Park, Se Ra; Purohit, Trupta; Miao, Hongzhi; Zhang, Xiaotian; Ying, Weijiang; Gray, Felicia; Shukla, Shirish; Zhao, Qingjie; Nikolaidis, Caroline; Winkler, Alyssa; Grembecka, Jolanta; Cierpicki, Tomasz 分享 收藏 Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid LeukemiaWang, Xue Qing David; Fan, Dandan; Han, Qinyu; Liu, Yiman; Miao, Hongzhi; Wang, Xinyu; Li, Qinglan; Chen, Dong; Gore, Haley; Himadewi, Pamela; Pfeifer, Gerd P.; Cierpicki, Tomasz; Grembecka, Jolanta; Su, Jianzhong; Chong, Shasha; Wan, Liling; Zhang, Xiaotian 分享 收藏 分享 收藏 Development of potent dimeric inhibitors of GAS41 YEATS domainListunov, Dymytrii; Linhares, Brian M.; Kim, EunGi; Winkler, Alyssa; Simes, Miranda L.; Weaver, Sidney; Cho, Hyo Je; Rizo, Alexandrea; Zolov, Sergey; Keshamouni, Venkateshwar G.; Grembecka, Jolanta; Cierpicki, Tomasz 分享 收藏 Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domainShukla, Shirish; Ying, Weijiang; Gray, Felicia; Yao, Yiwu; Simes, Miranda L.; Zhao, Qingjie; Miao, Hongzhi; Cho, Hyo Je; Gonzalez-Alonso, Paula; Winkler, Alyssa; Lund, George; Purohit, Trupta; Kim, EunGi; Zhang, Xiaotian; Ray, Joshua M.; He, Shihan; Nikolaidis, Caroline; Ndoj, Juliano; Wang, Jingya; Jaremko, Lukasz; Jaremko, Mariusz; Ryan, Russell J. H.; Guzman, Monica L.; Grembecka, Jolanta; Cierpicki, Tomasz 分享 收藏 Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancerWan, Chunhua; Mahara, Sylvia; Sun, Claire; Doan, Anh; Chua, Hui Kheng; Xu, Dakang; Bian, Jia; Li, Yue; Zhu, Danxi; Sooraj, Dhanya; Cierpicki, Tomasz; Grembecka, Jolanta; Firestein, Ron 分享 收藏 Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activityRogawski, David S.; Deng, Jing; Li, Hao; Miao, Hongzhi; Borkin, Dmitry; Purohit, Trupta; Song, Jiho; Chase, Jennifer; Li, Shuangjiang; Ndoj, Juliano; Klossowski, Szymon; Kim, EunGi; Mao, Fengbiao; Zhou, Bo; Ropa, James; Krotoska, Marta Z.; Jin, Zhuang; Ernst, Patricia; Feng, Xiaomin; Huang, Gang; Nishioka, Kenichi; Kelly, Samantha; He, Miao; Wen, Bo; Sun, Duxin; Muntean, Andrew; Dou, Yali; Maillard, Ivan; Cierpicki, Tomasz; Grembecka, Jolanta 分享 收藏 EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing SarcomaJimenez, Jennifer A.; Apfelbaum, April A.; Hawkins, Allegra G.; Svoboda, Laurie K.; Kumar, Abhijay; Ruiz, Ramon Ocadiz; Garcia, Alessandra X.; Haarer, Elena; Nwosu, Zeribe C.; Bradin, Joshua; Purohit, Trupta; Chen, Dong; Cierpicki, Tomasz; Grembecka, Jolanta; Lyssiotis, Costas A.; Lawlor, Elizabeth R. 分享 收藏 分享 收藏 分享 收藏 分享 收藏 
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