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Pharmacological characterization of a clinical candidate, TG-0 054, a small molecule inverse agonist targeting CXCR4 TG-0 054临床候选药物的药理学表征，TG-0 054是一种靶向CXCR4的小分子反向激动剂 Pan, Kylie S.; Wang, Ziming; Pfeil, Cy; Bergkamp, Nick D.; Mobach, Simon; Roth, Susanne; Rizk, Aurelien; Lohse, Martin J.; Annibale, Paolo; Siderius, Marco; Zimmermann, Mirjam; Smit, Martine J.; Bosma, Reggie 分享 收藏
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Nanobody against SARS-CoV-2 non-structural protein Nsp9 inhibits viral replication in human airway epithelia Venit, Tomas; Blavier, Jeremy; Maseko, Sibusiso B.; Shu, Sam; Espada, Lilia; Breunig, Christopher; Holthoff, Hans-Peter; Desbordes, Sabrina C.; Lohse, Martin; Esposito, Gennaro; Twizere, Jean-Claude; Percipalle, Piergiorgio 分享 收藏
ADAM19 cleaves the PTH receptor and associates with brachydactyly type E ADAM19裂解PTH受体并与E型短指结合 Aydin, Atakan; Klenk, Christoph; Nemec, Katarina; Isbilir, Ali; Martin, Lisa M.; Zauber, Henrik; Rrustemi, Trendelina; Toka, Hakan R.; Schuster, Herbert; Gong, Maolian; Stricker, Sigmar; Bock, Andreas; Baehring, Sylvia; Selbach, Matthias; Lohse, Martin J.; Luft, Friedrich C. 分享 收藏
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Phosphodiesterase 3a Catalytic-domain Mutants Cause Hypertension With Brachydactyly 磷酸二酯酶3a催化结构域突变体导致高血压伴短指 Kayser, Charlotte; Bock, Andreas; Leeuwen, Lisette; Herkert, Johanna; Vos, Yvonne; Kidd, Alexa; Aydin, Atakan; Daumke, Oliver; Lohse, Martin; Luft, Friedrich C. 分享 收藏
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Development of an Indole-Amide-Based Photoswitchable Cannabinoid Receptor Subtype 1 (CB1R) ?Cis-On? Agonist 基于吲哚酰胺的光转换大麻素受体亚型1 (CB1R) 的开发？Cis-On?激动剂 Rodriguez-Soacha, Diego A.; Steinmueller, Sophie A. M.; Isbilir, Ali; Fender, Julia; Deventer, Marie H.; Ramirez, Yesid A.; Tutov, Anna; Sotriffer, Christoph; Stove, Christophe P.; Lorenz, Kristina; Lohse, Martin J.; Hislop, James N.; Decker, Michael 分享 收藏
Unraveling the hidden temporal range of fast β2-adrenergic receptor mobility by time-resolved fluorescence 通过时间分辨荧光解开快速 β2-肾上腺素能受体迁移率的隐藏时间范围 Balakrishnan, Ashwin; Hemmen, Katherina; Choudhury, Susobhan; Krohn, Jan-Hagen; Jansen, Kerstin; Friedrich, Mike; Beliu, Gerti; Sauer, Markus; Lohse, Martin J.; Heinze, Katrin G. 分享 收藏
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A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor 通用的亚纳摩尔荧光配体可在组胺H3受体上进行NanoBRET结合研究和单分子显微镜检查 Rosier, Niklas; Graetz, Lukas; Schihada, Hannes; Moeller, Jan; Isbilir, Ali; Humphrys, Laura J.; Nagl, Martin; Seibel, Ulla; Lohse, Martin J.; Pockes, Steffen 分享 收藏
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Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors 跨膜结构域之间相互作用的差异调节代谢型谷氨酸受体的激活 Thibado, Jordana K.; Tano, Jean-Yves; Lee, Joon; Salas-Estrada, Leslie; Provasi, Davide; Strauss, Alexa; Ribeiro, Joao Marcelo Lamim; Xiang, Guoqing; Broichhagen, Johannes; Filizola, Marta; Lohse, Martin J.; Levitz, Joshua 分享 收藏
Determination of G-protein-coupled receptor oligomerization by molecular brightness analyses in single cells 通过单细胞中的分子亮度分析确定g蛋白偶联受体寡聚 Isbilir, Ali; Serfling, Robert; Moeller, Jan; Thomas, Romy; De Faveri, Chiara; Zabel, Ulrike; Scarselli, Marco; Beck-Sickinger, Annette G.; Bock, Andreas; Coin, Irene; Lohse, Martin J.; Annibale, Paolo 分享 收藏
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Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists 先进的荧光显微镜揭示了亚口袋特异性反向激动剂对动态CXCR4二聚化的破坏 Isbilir, Ali; Moeller, Jan; Arimont, Marta; Bobkov, Vladimir; Perpina-Viciano, Cristina; Hoffmann, Carsten; Inoue, Asuka; Heukers, Raimond; de Graaf, Chris; Smit, Martine J.; Annibale, Paolo; Lohse, Martin J. 分享 收藏
Establishing a sensitive fluorescence-based quantification method for cyclic nucleotides 建立一种灵敏的基于荧光的环核苷酸定量方法 Gruteser, Nadine; Kohlhas, Viktoria; Balfanz, Sabine; Franzen, Arne; Guenther, Anne; Offenhaeusser, Andreas; Mueller, Frank; Nikolaev, Viacheslav; Lohse, Martin J.; Baumann, Arnd 分享 收藏
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