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汪秀星 封面图

汪秀星 (Xiuxing Wang)

nanjing medical university教授邮箱:drxiuxingwang@163.com
H指数:41
被引数:6,650

个人简介

"汪秀星 作者：基础医学院 日期：2020-01-03 点击：28652 汪秀星，教授，博士，博士生导师，细胞生物学系科研副主任科学研究方向胶质瘤干细胞及其微环境调控联系方式通讯：江苏省南京市江宁区龙眠大道101号细胞生物学系，邮编211166电话：025-86869340电邮：xiuxingwang@njmu.edu.cn简介汪秀星，教授，博士，博士生导师。国家自然科学基金青年科学基金A类[原国家杰出青年科学基金]获得者，国家级海外高层次青年人才，江苏省特聘教授。中国神经科学学会神经肿瘤分会常务理事、中国细胞生物学学会肿瘤细胞生物学分会委员、中国抗癌协会低氧肿瘤学专委会常务委员、中国抗癌协会肿瘤节律专委会委员、中国细胞生物学会医学细胞生物学分会委员、中国医师协会脑胶质瘤专业委员会基础与转化委员。南京医科大学基础医学院细胞生物学系/国家卫生健康委员会抗体技术重点实验室教授。主要从事免疫微环境组分维持胶质瘤干细胞自我更新的功能和机制研究，为胶质母细胞瘤临床治疗提供新策略和干预靶点。以最后通讯作者在Cancer Cell (2025)、Science Translational Medicine (2024a)、Developmental Cell (2025)、Nature Communications (2025)、Cell Death & Differentiation (2024)、Clinical Cancer Research (2023)、Neuro-Oncology (2023a, 2023b)、Cancer Research (2022)上发表论文。同时以共同通讯在Cancer Discovery (2021)、Science Translational Medicine (2024b)、Nature Communications (2022, 2023)、Cancer Letters (2023)上发表论文学术兼职中国神经科学学会神经肿瘤分会常务委员中国细胞生物学会肿瘤细胞生物学分会委员中国细胞生物学会医学细胞生物学会委员中国医师协会脑胶质瘤专业委员会基础与转化委员江苏省细胞与发育生物学会理事承担科研课题1. 国家自然科学基金青年科学基金A类项目[原国家杰出青年科学基金]，胶质瘤干细胞自我更新机制与干预策略（82525047），2026-2030，在研，主持2. 肿瘤干细胞微环境“国家级高层次青年人才”2020-2023，主持3. 肿瘤干细胞微环境“江苏省特聘教授” 2020-2023，主持4. 国家自然基金面上项目， CXCL8和C1ORF61对胶质母细胞瘤异质性调控机制及联合靶向治疗的研究 （81570499），2021-2024，在研，主持5. 肿瘤个体化医学省部共建协同创新中心恒瑞医药临床研究基金，TNFAIP6维持胶质瘤干细胞炎性压力下重塑微环境的机制研究，2024/10-2026/09，在研，主持代表性论文通讯作者（含共同通讯作者）15篇：1. Jiancheng Gao#, Danling Gu#, Kailin Yang#, Junxia Zhang#, Qiankun Lin#, Wei Yuan#, Xu Zhu#, Deobrat Dixit, Ryan C. Gimple, Hao You, Qian Zhang, Zhumei Shi, Xiao Fan, Qiulian Wu, Chenfei Lu, Zhangchun Cheng, Daqi Li, Linjie Zhao, Bin Xue, Zhu Zhu, Zhe Zhu, Hui Yang, Ningwei Zhao, Wei Gao, Yingmei Lu, Junfei Shao, Chuandong Cheng, Dapeng Hao, Shuo Yang, Yun Chen, Xiaoming Wang, Chunsheng Kang, Jing Ji, Jianghong Man, Sameer Agnihotri,Qianghu Wang, Fan Lin, Xu Qian, Stephen C. Mack, Zhibin Hu, Chaojun Li, Michael D. Taylor, Yan Li*, Nu Zhang*, Jeremy N. Rich*, Yongping You*, Xiuxing Wang*. Infiltrating Plasma Cells Maintain Glioblastoma Stem Cells through IgG-Tumor Binding. (Corresponding author, Cancer Cell). 01/2025. IF: 48.8. 中科院一区.2. Daqi Li, Gaoyuan Cui, Kailin Yang, Chenfei Lu, Yuhan Jiang, Le Zhang, Qiulian Wu, Deobrat Dixit, Zhe Zhu, Ryan C. Gimple, Danling Gu, Jiancheng Gao, Qiankun Lin, Hang Yu, Zhumei Shi, Yun Chen, Qianghu Wang, Guangfu Jin, Fan Lin, Junfei Shao, Qigang Zhou, Chong Liu, Chaojun Li, Yongping You, Nu Zhang, Junxia Zhang*, Xu Qian*, Qian Zhang*, Jeremy N. Rich*, Xiuxing Wang*. Inhibition of macrophage-derived lactate impairs KU70 lactylation and enhances anti-tumour immunity in glioblastoma (Nature Cell Biology, Accept in Principle)3. Fanying Li#, Kailin Yang#, Xinya Gao#, Maolei Zhang#, Danling Gu#, Xujia Wu, Chenfei Lu, Qiulian Wu, Deobrat Dixit, Ryan C. Gimple, Yongping You, Stephen C. Mack, Yu Shi, Tiebang Kang, Sameer A. Agnihotri, Michael D. Taylor, Jeremy N. Rich*, Nu Zhang*, Xiuxing Wang*. A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice. (Corresponding author, Science Translational Medicine, Cover Story) 10/2024. IF: 19.343. 中科院一区.4. Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Qiulian Wu, Yang Wang, Reilly L. Kidwell, Hui Xian Poh, Leo J. Y. Kim, Zhixin Qiu, Qi Xie, Kristoffer Vitting-Seerup, Shruti Bhargava, Zhen Dong, Li Jiang, Zhe Zhu, Petra Hamerlik, Samie R. Jaffrey, Crystal Zhao*, Xiuxing Wang*, Jeremy N. Rich*. The RNA m6A reader YTHDF2 maintains oncogenes expression and is a targetable dependency in glioblastoma stem cells. (Co-corresponding author, Cancer Discovery，高被引论文)02/2021; 11(2). IF: 38.272. 中科院一区. 5. Danling Gu# Lang Hu#, Kailing Yang#, Wei Yuan#, Danyang Shan#, Jiancheng Gao#, Jiahuang Li, Ryan C. Gimple, Deobrat Dixit, Zhe Zhu, Daqi Li, Qiulian Wu, Zhumei Shi, Yingyi Wang, Ningwei Zhao, Kun Yang, Junfei Shao, Fan Lin, Qianghu Wang, Guangfu Jin, Yun Chen, Xu Qian, Zhibin Hu, Chaojun Li, Nu Zhang, Yongping You, Jian Liu*, Qian Zhang*, Junxia Zhang*, Jeremy N. Rich*, Xiuxing Wang*. Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages. (Corresponding author, Developmental Cell) 05/2025. IF: 10.7. 中科院一区.6. Chenfei Lu, Tao Kang, Junxia Zhang, Kailin Yang, Yang Liu, Kefan Song, Qiankun Lin, Deobrat Dixit, Ryan C. Gimple, Qian Zhang, Zhumei Shi, Xiao Fan, Qiulian Wu, Daqi Li, Danyang Shan, Jiancheng Gao, Danling Gu, Lu Li, Hao You, Yangqing Li, Linjie Zhao, Hui Yang, Ningwei Zhao, Wei Gao, Weiwei Tao, Yingmei Lu, Yun Chen, Jing Ji, Zhe Zhu, Chunsheng Kang, Jianghong Man, Sameer Agnihotr, Qianghu Wang, Fan Lin, Xu Qian, Stephen C. Mack, Zhibin Hu, Chaojun Li, Michael D Taylor, Ning Liu, Nu Zhang, Ming Lu, Wei Zhang, Jeremy Rich*, Yongping You*, Xiuxing Wang*. Combined targeting of glioblastoma heterogeneity as a novel therapeutic strategy. (Corresponding author, Nature Communications) 03/2025. IF: 14.7. 中科院一区.7. Daqi Li #, Xiefeng Wang #, Kexin Chen #, Danyang Shan #, Gaoyuan Cui #, Wei Yuan, Qiankun Lin, Ryan C Gimple, Deobrat Dixit, Chenfei Lu, Danling Gu, Hao You, Jiancheng Gao, Yangqing Li, Tao Kang, Junlei Yang, Hang Yu, Kefan Song, Zhumei Shi, Xiao Fan, Qiulian Wu, Wei Gao, Zhe Zhu, Jianghong Man, Qianghu Wang, Fan Lin, Weiwei Tao, Stephen C Mack, Yun Chen, Junxia Zhang, Chaojun Li, Nu Zhang, Yongping You, Xu Qian, Kailin Yang*, Jeremy N Rich*, Qian Zhang*, Xiuxing Wang*. IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages. (Corresponding author, Cell Death & Differentiation)04/2024. IF: 13.3. 中科院一区.8. Wei Yuan#, Qian Zhang#, Danling Gu#, Chenfei Lu#, Deobrat Dixit, Ryan C. Gimple, Yisu Gao, Jiancheng Gao, Daqi Li, Danyang Shan, Lang Hu, Lu Li, Yangqing Li, Hao You, Linping Yan, Kexin Chen, Ningwei Zhao, Chuanhai Xu, Jianyun Lan, Dong Liu, Junxia Zhang, Zhumei Shi, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu,, Deguang Lv, Wei Gao, Hui Yang, Fan Lin, Qianghu Wang, Jianghong Man, Chaojun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian, Stephen C. Mack, Nu Zhang, Yongping Yo"

教育背景

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工作经历

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荣誉奖项

  1. 国家自然科学基金青年科学基金A类[原国家杰出青年科学基金]获得者
  2. 国家级海外高层次青年人才
  3. 江苏省特聘教授
Author Correction: Inhibiting macrophage-derived lactate transport restores cGAS–STING signalling and enhances antitumour immunity in glioblastoma

作者更正：抑制巨噬细胞衍生的乳酸转运可恢复cGAS–STING信号通路并增强胶质母细胞瘤的抗肿瘤免疫

Nature Cell Biology
IF19.1
2026-09-160
PRE
Daqi Li; Gaoyuan Cui; Kailin Yang; Chenfei Lu; Yuhan Jiang; Le Zhang; Qiulian Wu; Deobrat Dixit; Zhe Zhu; Ryan C. Gimple; Danling Gu; Jiancheng Gao; Qiankun Lin; Hang Yu; Zhumei Shi; Yun Chen; Qianghu Wang; Guangfu Jin; Fan Lin; Junfei Shao; Qigang Zhou; Chong Liu; Chaojun Li; Yongping You; Nu Zhang; Junxia Zhang; Xu Qian; Qian Zhang; Jeremy N. Rich; Xiuxing Wang
NAD(P)H: quinone oxidoreductase 1-mediated oxidative stress resistance and tumor microenvironment remodeling in glioblastoma

NQO1介导的氧化应激抵抗及胶质母细胞瘤微环境重塑

Neuro-Oncology
IF13.4
2026-04-011
PRE
Li, Yangqing; Kang, Tao; Jia, Zhen; Lu, Chenfei; Cui, Gaoyuan; Song, Kefan; Yu, Hang; Dixit, Deobrat; Jin, Fangshu; Shan, Danyang; Lin, Qiankun; Li, Daqi; You, Hao; Gu, Danling; Gao, Jiancheng; Shi, Zhumei; Gao, Wei; Lin, Fan; Zhu, Zhe; Wang, Qianghu; Tao, Weiwei; Zhang, Junxia; Liang, Jingshan; Zhu, Zhu; You, Yongping; Qian, Xu; Yang, Kailin; Wang, Xiuxing; Rich, Jeremy N.; Yang, Kun; Sun, Luan; Li, Chaojun; Zhang, Qian
Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages

压力诱导的促炎胶质母细胞瘤干细胞分泌TNFAIP6以增强肿瘤生长并诱导产生抑制性巨噬细胞

Developmental Cell
IF8.7
2025-05-210
PRE
Danling Gu; Lang Hu; Kailin Yang; Wei Yuan; Danyang Shan; Jiancheng Gao; Jiahuang Li; Ryan C. Gimple; Deobrat Dixit; Zhe Zhu; Daqi Li; Qiulian Wu; Zhumei Shi; Yingyi Wang; Ningwei Zhao; Kun Yang; Junfei Shao; Fan Lin; Qianghu Wang; Guangfu Jin; Yun Chen; Xu Qian; Zhibin Hu; Chaojun Li; Nu Zhang; Yongping You; Jian Liu; Qian Zhang; Junxia Zhang; Jeremy N. Rich; Xiuxing Wang
Postoperative Injection of a Triptolide-Preloaded Hydrogel Prevents the Recurrence of Glioblastoma by Dual-Pathway Activation of Ferroptosis

术后注射雷公藤甲素预加载的水凝胶可通过铁死亡的双途径激活来防止胶质母细胞瘤的复发

SMALL
IF12.1
2024-10-070
OA
Wu, Hongshuai; Cao, Pingping; Wang, Haiyang; Wang, Wenhong; Yu, Hangyang; You, Chaoqun; Shen, Tianqi; Yang, Suisui; Hu, Ziyi; Zhou, Tingting; Wang, Jing; Wang, Qianghu; Qian, Xu; Zhang, Junxia; Wang, Xiuxing; Cao, Yuandong; Ning, Like; Lin, Fan
A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice

由MYC上游开放阅读框编码的肽与原肌球蛋白受体激酶B结合并促进小鼠胶质母细胞瘤的生长

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-10-021
PRE
Li, Fanying; Yang, Kailin; Gao, Xinya; Zhang, Maolei; Gu, Danling; Wu, Xujia; Lu, Chenfei; Wu, Qiulian; Dixit, Deobrat; Gimple, Ryan C.; You, Yongping; Mack, Stephen C.; Shi, Yu; Kang, Tiebang; Agnihotri, Sameer A.; Taylor, Michael D.; Rich, Jeremy N.; Zhang, Nu; Wang, Xiuxing
IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages
CELL DEATH AND DIFFERENTIATION
IF15.4
2024-04-092
PRE
Li, Daqi; Wang, Xiefeng; Chen, Kexin; Shan, Danyang; Cui, Gaoyuan; Yuan, Wei; Lin, Qiankun; Gimple, Ryan C.; Dixit, Deobrat; Lu, Chenfei; Gu, Danling; You, Hao; Gao, Jiancheng; Li, Yangqing; Kang, Tao; Yang, Junlei; Yu, Hang; Song, Kefan; Shi, Zhumei; Fan, Xiao; Wu, Qiulian; Gao, Wei; Zhu, Zhe; Man, Jianghong; Wang, Qianghu; Lin, Fan; Tao, Weiwei; Mack, Stephen C.; Chen, Yun; Zhang, Junxia; Li, Chaojun; Zhang, Nu; You, Yongping; Qian, Xu; Yang, Kailin; Rich, Jeremy N.; Zhang, Qian; Wang, Xiuxing
Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer
NATURE COMMUNICATIONS
IF15.7
2023-09-1111
OAAI
Sun, Handong; Zhang, Lishen; Wang, Zhonglin; Gu, Danling; Zhu, Mengyan; Cai, Yun; Li, Lu; Tang, Jiaqi; Huang, Bin; Bosco, Bakwatanisa; Li, Ning; Wu, Lingxiang; Wu, Wei; Li, Liangyu; Liang, Yuan; Luo, Lin; Liu, Quanzhong; Zhu, Yanhui; Sun, Jie; Shi, Liang; Xia, Tiansong; Yang, Chuang; Xu, Qitong; Han, Xue; Zhang, Weiming; Liu, Jianxia; Meng, Dong; Shao, Hua; Zheng, Xiangxin; Li, Shuqin; Pan, Hua; Ke, Jing; Jiang, Wenying; Zhang, Xiaolan; Han, Xuedong; Chu, Jian; An, Hongyin; Ge, Juyan; Pan, Chi; Wang, Xiuxing; Li, Kening; Wang, Qianghu; Ding, Qiang
Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake
NEURO-ONCOLOGY
IF13.4
2023-03-195
PRE
Gu, Danling; Zhou, Fengqi; You, Hao; Gao, Jiancheng; Kang, Tao; Dixit, Deobrat; Wu, Qiulian; Yang, Kailin; Ci, Shusheng; Shan, Danyang; Fan, Xiao; Yuan, Wei; Zhang, Qian; Lu, Chenfei; Li, Daqi; Zhao, Ningwei; Shi, Zhumei; Gao, Wei; Lin, Fan; Man, Jianghong; Wang, Qianghu; Qian, Xu; Mack, Stephen C.; Tao, Weiwei; Agnihotri, Sameer; Zhang, Nu; You, Yongping; Rich, Jeremy N.; Zhang, Junxia; Wang, Xiuxing
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma
CANCER DISCOVERY
IF33.3
2023-01-1727
OA
Ye, Zengpanpan; Ai, Xiaolin; Yang, Kailin; Yang, Zhengnan; Fei, Fan; Liao, Xiaoling; Qiu, Zhixin; Gimple, Ryan C.; Yuan, Huairui; Huang, Hao; Gong, Yanqiu; Xiao, Chaoxin; Yue, Jing; Huang, Liang; Saulnier, Olivier; Wang, Wei; Zhang, Peidong; Dai, Lunzhi; Wang, Xin; Wang, Xiuxing; Ha Ahn, Young; You, Chao; Xu, Jianguo; Wan, Xiaoxiao; Taylor, Michael D.; Zhao, Linjie; Rich, Jeremy N.; Zhou, Shengtao
Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow- Derived Macrophages

胶质瘤细胞的吞噬作用增强了骨髓源性巨噬细胞的免疫抑制表型

CANCER RESEARCH
IF16.6
2023-01-0916
OAAI
Wu, Min; Wu, Lingxiang; Wu, Wei; Zhu, Mengyan; Li, Jianyu; Wang, Ziyu; Li, Jie; Ding, Rong; Liang, Yuan; Li, Liangyu; Zhang, Tingting; Huang, Bin; Cai, Yun; Li, Kening; Li, Lu; Zhang, Rui; Hu, Baoli; Lin, Fan; Wang, Xiuxing; Zheng, Siyuan; Chen, Jian; You, Yongping; Jiang, Tao; Zhang, Junxia; Chen, Hongshan; Wang, Qianghu

研究方向

(2022)上发表论文同时以共同通讯在Cancer Discovery(2021)Science Translational Medicine(2024b)Nature Communications(2022, 2023)Cancer Letters(2023)
J
Jeremy N. Rich
H 指数:127论文数:1,484被引数:6.0万
Q
Qiulian Wu
H 指数:57论文数:134被引数:2.0万
R
Ryan C. Gimple
H 指数:35论文数:224被引数:6,500
S
Stephen C. Mack
H 指数:61论文数:529被引数:1.8万
B
Briana C. Prager
H 指数:33论文数:168被引数:6,830
S
Shideng Bao
H 指数:59论文数:181被引数:2.4万
L
Leo J.Y. Kim
H 指数:26论文数:113被引数:4,521
D
Deobrat Dixit
H 指数:30论文数:126被引数:3,754
K
Kailin Yang
H 指数:46论文数:258被引数:1.2万
Z
Zhe Zhu
H 指数:36论文数:340被引数:6,052