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Single-cell RNA sequencing defines distinct disease subtypes and reveals hypo-responsiveness to interferon in asymptomatic Waldenstrom's Macroglobulinemia 单细胞RNA测序定义了不同的疾病亚型，并揭示了无症状华氏巨球蛋白血症中干扰素低反应性。 Sklavenitis-Pistofidis, Romanos; Konishi, Yoshinobu; Heilpern-Mallory, Daniel; Wu, Ting; Tsakmaklis, Nicholas; Aranha, Michelle P.; Hunter, Zachary R.; Ali, Alaa K.; Tsuji, Junko; Haradhvala, Nicholas J.; Lightbody, Elizabeth D.; Towle, Katherine; Hevenor, Laura; Romee, Rizwan; Briercheck, Edward L.; Smith, Eric L.; Liacos, Christine-Ivy; Kastritis, Efstathios; Dimopoulos, Meletios A.; Treon, Steven P.; Getz, Gad 分享 收藏
Single-Cell RNA-Sequencing of 6 Million Tumor and Immune Cells in 365 Patients with MGUS and SMM Demonstrates Complex Progressive Changes in Immune Cell Functionality with a Distinct Footprint on Tumor Cell Biology and Disease Control 对365例MGUS和SMM患者中600万肿瘤和免疫细胞进行单细胞RNA测序，揭示了免疫细胞功能发生复杂进展性变化，并对肿瘤细胞生物学和疾病控制产生独特影响。 Sklavenitis-Pistofidis, Romanos; Wu, Ting; Lightbody, Elizabeth D.; Konishi, Yoshinobu; Rahmat, Mahshid; Agius, Michael P.; Tsuji, Junko; Alberge, Jean-Baptiste; Timonian, Michael; Dutta, Ankit K.; Aranha, Michelle P.; Bidikian, Nayda; Barr, Hadley; Haradhvala, Nicholas J.; Sade-Feldman, Moshe; Getz, Gad; Ghobrial, Irene 分享 收藏
Single-Cell Profiling of ∼1.7 Million Plasma Cells across > 250 Individuals Reveals Transcriptional Signatures of Progression and Clonal Expansion in Multiple Myeloma and Its Precursor Stages 单细胞图谱分析约170万个浆细胞，跨越超过250个个体，揭示了多发性骨髓瘤及其前体阶段的进展和克隆扩增的转录特征 Tsuji, Junko; Lightbody, Elizabeth D.; Sklavenitis-Pistofidis, Romanos; Wu, Ting; Agius, Michael P.; Firer, Danielle T.; Rahmat, Mahshid; Barr, Hadley; Konishi, Yoshinobu; Dutta, Ankit K.; Alberge, Jean-Baptiste; Su, Nang Kham; Boehner, Cody J.; Aranha, Michelle P.; Hevenor, Laura; Towle, Katherine; Horowitz, Erica M.; Davis, Maya; Perry, Jacqueline F.; Aguet, Francois; Li, Ruitong; Kim, Sungjae; Haradhvala, Nicholas J.; Boiarsky, Rebecca; Getz, Gad; Ghobrial, Irene 分享 收藏
Comparative analysis of Bcl-2 family protein overexpression in CAR T cells alone and in combination with BH3 mimetics Korell, Felix; Olson, Michael L.; Salas-Benito, Diego; Leick, Mark B.; Larson, Rebecca C.; Bouffard, Amanda; Silva, Harrison; Gasparetto, Alessandro; Berger, Trisha R.; Kann, Michael C.; Mergen, Markus; Kienka, Tamina; Wehrli, Marc; Haradhvala, Nicholas J.; Bailey, Stefanie R.; Letai, Anthony; Maus, Marcela V. 分享 收藏
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Overlapping expression landscape of antibody drug conjugate targets, trophoblast cell surface antigen 2 (Trop-2) & human epidermal growth factor receptor 2 (HER2), in breast cancer Medford, Arielle J.; Haradhvala, Nicholas J.; Vidula, Neelima; Abelman, Rachel; Spring, Laura M.; Ellisen, Leif W.; Getz, Gad; Bardia, Aditya 分享 收藏
Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis Boiarsky, Rebecca; Haradhvala, Nicholas J.; Alberge, Jean-Baptiste; Sklavenitis-Pistofidis, Romanos; Mouhieddine, Tarek H.; Zavidij, Oksana; Shih, Ming-Chieh; Firer, Danielle; Miller, Mendy; El-Khoury, Habib; Anand, Shankara K.; Aguet, Francois; Sontag, David; Ghobrial, Irene M.; Getz, Gad 分享 收藏
Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma 与难治性b细胞淋巴瘤car-t治疗反应相关的独特细胞动力学 Haradhvala, Nicholas J.; Leick, Mark B.; Maurer, Katie; Gohil, Satyen H.; Larson, Rebecca C.; Yao, Ning; Gallagher, Kathleen M. E.; Katsis, Katelin; Frigault, Matthew J.; Southard, Jackson; Li, Shuqiang; Kann, Michael C.; Silva, Harrison; Jan, Max; Rhrissorrakrai, Kahn; Utro, Filippo; Levovitz, Chaya; Jacobs, Raquel A.; Slowik, Kara; Danysh, Brian P.; Livak, Kenneth J.; Parida, Laxmi; Ferry, Judith; Jacobson, Caron; Wu, Catherine J.; Getz, Gad; Maus, Marcela, V 分享 收藏
Loss of IFNgR1 signaling glioblastoma drives resistance to CAR T cell binding avidity and cytotoxicity due to lower downstream expression of ICAM-1 Larson, Rebecca; Kann, Michael; Bailey, Stefanie; Haradhvala, Nicholas; Stewart, Kai; Bouffard, Amanda; Scarfo, Irene; Leick, Mark; Berger, Trisha R.; Jan, Max; Joung, Julia; Ouspenskaia, Tamara; Law, Travis; Regev, Aviv; Getz, Gad; Maus, Marcela 分享 收藏
Designing sensitive viral diagnostics with machine learning 用机器学习设计敏感的病毒诊断 Metsky, Hayden C.; Welch, Nicole L.; Pillai, Priya P.; Haradhvala, Nicholas J.; Rumker, Laurie; Mantena, Sreekar; Zhang, Yibin B.; Yang, David K.; Ackerman, Cheri M.; Weller, Juliane; Blainey, Paul C.; Myhrvold, Cameron; Mitzenmacher, Michael; Sabeti, Pardis C. 分享 收藏
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DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells DNA聚合酶和错配修复在正常和恶性人类细胞中发挥不同的微卫星不稳定性特征 Chung, Jiil; Maruvka, Yosef E.; Sudhaman, Sumedha; Kelly, Jacalyn; Haradhvala, Nicholas J.; Bianchi, Vanessa; Edwards, Melissa; Forster, Victoria J.; Nunes, Nuno M.; Galati, Melissa A.; Komosa, Martin; Deshmukh, Shriya; Cabric, Vanja; Davidson, Scott; Zatzman, Matthew; Light, Nicholas; Hayes, Reid; Brunga, Ledia; Anderson, Nathaniel D.; Ho, Ben; Hodel, Karl P.; Siddaway, Robert; Morrissy, A. Sorana; Bowers, Daniel C.; Larouche, Valerie; Bronsema, Annika; Osborn, Michael; Cole, Kristina A.; Opocher, Enrico; Mason, Gary; Thomas, Gregory A.; Ben George; Ziegler, David S.; Lindhorst, Scott; Vanan, Magimairajan; Yalon-Oren, Michal; Reddy, Alyssa T.; Massimino, Maura; Tomboc, Patrick; Van Damme, An; Lossos, Alexander; Durno, Carol; Aronson, Melyssa; Morgenstern, Daniel A.; Bouffet, Eric; Huang, Annie; Taylor, Michael D.; Villani, Anita; Malkin, David; Hawkins, Cynthia E.; Pursell, Zachary F.; Shlien, Adam; Kunkel, Thomas A.; Getz, Gad; Tabori, Uri 分享 收藏
Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma 单细胞RNA测序揭示了多发性骨髓瘤前体阶段的免疫微环境受损 Zavidij, Oksana; Haradhvala, Nicholas J.; Mouhieddine, Tarek H.; Sklavenitis-Pistofidis, Romanos; Cai, Songjie; Reidy, Mairead; Rahmat, Mahshid; Flaifel, Abdallah; Ferland, Benjamin; Su, Nang K.; Agius, Michael P.; Park, Jihye; Manier, Salomon; Bustoros, Mark; Huynh, Daisy; Capelletti, Marzia; Berrios, Brianna; Liu, Chia-Jen; He, Meng Xiao; Braggio, Esteban; Fonseca, Rafael; Maruvka, Yosef; Guerriero, Jennifer L.; Goldman, Melissa; van Allen, Eliezer; McCarroll, Steven A.; Azzi, Jamil; Getz, Gad; Ghobrial, Irene M. 分享 收藏
A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells Lee, Sooncheol; Micalizzi, Douglas; Truesdell, Samuel S.; Bukhari, Syed I. A.; Boukhali, Myriam; Lombardi-Story, Jennifer; Kato, Yasutaka; Choo, Min-Kyung; Dey-Guha, Ipsita; Ji, Fei; Nicholson, Benjamin T.; Myers, David T.; Lee, Dongjun; Mazzola, Maria A.; Raheja, Radhika; Langenbucher, Adam; Haradhvala, Nicholas J.; Lawrence, Michael S.; Gandhi, Roopali; Tiedje, Christopher; Diaz-Munoz, Manuel D.; Sweetser, David A.; Sadreyev, Ruslan; Sykes, David; Haas, Wilhelm; Haber, Daniel A.; Maheswaran, Shyamala; Vasudevan, Shobha 分享 收藏
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis 癌症LncRNA普查揭示了长非编码rna在肿瘤发生中的深度功能保守性的证据 Carlevaro-Fita, Joana; Lanzos, Andres; Feuerbach, Lars; Hong, Chen; Mas-Ponte, David; Pedersen, Jakob Skou; Johnson, Rory; Abascal, Federico; Amin, Samirkumar B.; Bader, Gary D.; Barenboim, Jonathan; Beroukhim, Rameen; Bertl, Johanna; Boroevich, Keith A.; Brunak, Soren; Campbell, Peter J.; Carlevaro-Fita, Joana; Chakravarty, Dimple; Chan, Calvin Wing Yiu; Chen, Ken; Choi, Jung Kyoon; Deu-Pons, Jordi; Dhingra, Priyanka; Diamanti, Klev; Feuerbach, Lars; Fink, J. Lynn; Fonseca, Nuno A.; Frigola, Joan; Gambacorti-Passerini, Carlo; Garsed, Dale W.; Gerstein, Mark; Getz, Gad; Gonzalez-Perez, Abel; Guo, Qianyun; Gut, Ivo G.; Haan, David; Hamilton, Mark P.; Haradhvala, Nicholas J.; Harmanci, Arif O.; Helmy, Mohamed; Herrmann, Carl; Hess, Julian M.; Hobolth, Asger; Hodzic, Ermin; Hong, Chen; Hornshoj, Henrik; Isaev, Keren; Izarzugaza, Jose M. G.; Johnson, Todd A.; Juul, Malene; Juul, Randi Istrup; Kahles, Andre; Kahraman, Abdullah; Kellis, Manolis; Khurana, Ekta; Kim, Jaegil; Kim, Jong K.; Kim, Youngwook; Komorowski, Jan; Korbel, Jan O.; Kumar, Sushant; Lanzos, Andres; Larsson, Erik; Lawrence, Michael S.; Lee, Donghoon; Lehmann, Kjong-Van; Li, Shantao; Li, Xiaotong; Lin, Ziao; Liu, Eric Minwei; Lochovsky, Lucas; Lou, Shaoke; Madsen, Tobias; Marchal, Kathleen; Martincorena, Inigo; Martinez-Fundichely, Alexander; Maruvka, Yosef E.; McGillivray, Patrick D.; Meyerson, William; Muinos, Ferran; Mularoni, Loris; Nakagawa, Hidewaki; Nielsen, Morten Muhlig; Paczkowska, Marta; Park, Keunchil; Park, Kiejung; Pedersen, Jakob Skou; Pich, Oriol; Pons, Tirso; Pulido-Tamayo, Sergio; Raphael, Benjamin J.; Reimand, Juri; Reyes-Salazar, Iker; Reyna, Matthew A.; Rheinbay, Esther; Rubin, Mark A.; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Sahinalp, S. Cenk; Saksena, Gordon; Salichos, Leonidas; Sander, Chris; Schumacher, Steven E.; Shackleton, Mark; Shapira, Ofer; Shen, Ciyue; Shrestha, Raunak; Shuai, Shimin; Sidiropoulos, Nikos; Sieverling, Lina; Sinnott-Armstrong, Nasa; Stein, Lincoln D.; Stuart, Joshua M.; Tamborero, David; Tiao, Grace; Tsunoda, Tatsuhiko; Umer, Husen M.; Uuskula-Reimand, Liis; Valencia, Alfonso; Vazquez, Miguel; Verbeke, Lieven P. C.; Wadelius, Claes; Wadi, Lina; Wang, Jiayin; Warrell, Jonathan; Waszak, Sebastian M.; Weischenfeldt, Joachim; Wheeler, David A.; Wu, Guanming; Yu, Jun; Zhang, Jing; Zhang, Xuanping; Zhang, Yan; Zhao, Zhongming; Zou, Lihua; von Mering, Christian 分享 收藏
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