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Ann-Sofie Jemth

science for life laboratory
H指数:28
被引数:4,134

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Structural basis for uracil removal from DNA by human SMUG1

人类SMUG1介导DNA中尿嘧啶去除的结构基础

Nature Communications
IF15.7
2026-06-020
OAAI
Julian M. Ludäscher; Emma Scaletti Hutchinson; Guillem Vila-Julià; Ann-Sofie Jemth; Saher Shahid; Elisee Wiita; Israel Cabeza de Vaca; Szymon Pach; Lukas Gajdos; Swati Aggarwal; Ellen Walse; Oliver Mortusewicz; Thomas Helleday; Jens Carlsson; Pål Stenmark
Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1

核碱基催化剂用于酶促激活8-oxoguanine DNA glycosylase 1

RSC Chem. Biol.
IF3.1
2025-10-290
OAAI
Emily C. Hank; Nicholas D'Arcy-Evans; Emma Rose Scaletti; Carlos Benítez-Buelga; Olov Wallner; Florian Ortis; Kaixin Zhou; Liuzhen Meng; Alicia del Prado; Patricia Calvo; Ingrid Almlöf; Elisee Wiita; Karen Nierlin; Sara Kosenina; Andreas Krämer; Alice Eddershaw; Mario Kehler; Maeve Long; AnnSofie Jemth; Holly Dawson; Josephine Stewart; Adam Dickey; Mikhael Elijah Astorga; Marek Varga; Evert Homan; Martin Scobie; Stefan Knapp; Leandro Sastre; Pål Stenmark; Miguel de Vega; Thomas Helleday; Maurice Michel
MTHFD1/2 inhibitor TH9619 targets the DNA damage response and causes cancer-specific folate trapping with an unprecedented therapeutic window
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Martilla, Petra; Green, Alanna C.; Kiweler, Nicole; Chalkiadaki, Christina; Wiita, Elisee; Cookson, Victoria; Lesur, Antoine; Eiden, Kim; Bernhardin, Francois; Long, Maeve; Jemth, Ann-Sofie; Mortusewicz, Oliver; Homan, Evert; Bonagas, Nadilly; Ramos, Louise; Sanjiv, Kumar; Mancina, Emilio Guillen; Pham, Therese; Slipicevic, Ana; Henriksson, Martin; Meiser, Johannes; Helleday, Thomas
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

甲酸盐溢出驱动MTHFD1抑制的癌细胞中的有毒叶酸捕获

NATURE METABOLISM
IF20.8
2023-04-0311
OAAI
Green, Alanna C.; Marttila, Petra; Kiweler, Nicole; Chalkiadaki, Christina; Wiita, Elisee; Cookson, Victoria; Lesur, Antoine; Eiden, Kim; Bernardin, Francois; Vallin, Karl S. A.; Borhade, Sanjay; Long, Maeve; Ghahe, Elahe Kamali; Jimenez-Alonso, Julio J.; Jemth, Ann-Sofie; Loseva, Olga; Mortusewicz, Oliver; Meyers, Marianne; Viry, Elodie; Johansson, Annika I.; Hodek, Ondrej; Homan, Evert; Bonagas, Nadilly; Ramos, Louise; Sandberg, Lars; Frodin, Morten; Moussay, Etienne; Slipicevic, Ana; Letellier, Elisabeth; Paggetti, Jerome; Sorensen, Claus Storgaard; Helleday, Thomas; Henriksson, Martin; Meiser, Johannes
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
NATURE CANCER
IF28.5
2022-02-2837
OAAI
Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra; Gustafsson, Robert; Wiita, Elisee; Borhade, Sanjay; Green, Alanna C.; Vallin, Karl S. A.; Sarno, Antonio; Svensson, Richard; Gokturk, Camilla; Pham, Therese; Jemth, Ann-Sofie; Loseva, Olga; Cookson, Victoria; Kiweler, Nicole; Sandberg, Lars; Rasti, Azita; Unterlass, Judith E.; Haraldsson, Martin; Andersson, Yasmin; Scaletti, Emma R.; Bengtsson, Christoffer; Paulin, Cynthia B. J.; Sanjiv, Kumar; Abdurakhmanov, Eldar; Pudelko, Linda; Kunz, Ben; Desroses, Matthieu; Iliev, Petar; Farnegardh, Katarina; Kramer, Andreas; Garg, Neeraj; Michel, Maurice; Haggblad, Sara; Jarvius, Malin; Kalderen, Christina; Jensen, Amanda Bogedahl; Almlof, Ingrid; Karsten, Stella; Zhang, Si Min; Haggblad, Maria; Eriksson, Anders; Liu, Jianping; Glinghammar, Bjorn; Nekhotiaeva, Natalia; Klingegard, Fredrik; Koolmeister, Tobias; Martens, Ulf; Llona-Minguez, Sabin; Moulson, Ruth; Nordstrom, Helena; Parrow, Vendela; Dahllund, Leif; Sjoberg, Birger; Vargas, Irene L.; Vo, Duy Duc; Wannberg, Johan; Knapp, Stefan; Krokan, Hans E.; Arvidsson, Per, I; Scobie, Martin; Meiser, Johannes; Stenmark, Pal; Berglund, Ulrika Warpman; Homan, Evert J.; Helleday, Thomas
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
Science
IF45.8
2022-01-010
OA
Maurice Michel; Carlos Benitéz‐Buelga; Patricia A. Calvo; Bishoy Magdy Fekry Hanna; Oliver Mortusewicz; Geoffrey Masuyer; Jonathan R. Davies; Olov A. Wallner; Kumar Sanjiv; Julian J. Albers; Sergio Castañeda‐Zegarra; Ann‐Sofie Jemth; Torkild Visnes; Ana Sastre-Perona; Akhilesh Nagesh Danda; Evert J. Homan; Karthick Marimuthu; Zhao Zhenjun; N. Celestine; Antonio Sarno; Elisée Wiita; Catharina Von Nicolai; Anna J. Komor; Varshni Rajagopal; Sarah Müller; Emily C. Hank; Marek Varga; Emma Rose Scaletti; Monica Pandey; Stella Karsten; Hanne Haslene‐Hox; Simon Loevenich; Petra Marttila; Azita Rasti; Kirill Mamonov; Florian Ortis; Fritz Schömberg; Olga Loseva; Josephine Stewart; Nicholas D. D’Arcy-Evans; Tobias Koolmeister; Martin Henriksson; Dana Michel; Ana de Ory; Lucía Acero-Riaguas; Oriol Calvete; Martin Scobie; Christian Hertweck; Ivan Vilotijević; Christina Kalderén; Ana Osório; Rosario Perona; Alexandra Stolz; Pål Stenmark; Ulrika Warpman Berglund; Miguel de Vega; Thomas Helleday
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses

针对致病性RNA病毒复制所必需的宿主因子的新型广谱抗病毒抑制剂

VIRUSES-BASEL
IF3.5
2020-12-1024
OAAI
Tampere, Marianna; Pettke, Aleksandra; Salata, Cristiano; Wallner, Olov; Koolmeister, Tobias; Cazares-Korner, Armando; Visnes, Torkild; Hesselman, Maria Carmen; Kunold, Elena; Wiita, Elisee; Kalderen, Christina; Lightowler, Molly; Jemth, Ann-Sofie; Lehtio, Janne; Rosenquist, Asa; Warpman-Berglund, Ulrika; Helleday, Thomas; Mirazimi, Ali; Jafari, Rozbeh; Puumalainen, Marjo-Riitta
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
NUCLEIC ACIDS RESEARCH
IF13.1
2020-11-1937
OAAI
Visnes, Torkild; Benitez-Buelga, Carlos; Cazares-Korner, Armando; Sanjiv, Kumar; Hanna, Bishoy M. F.; Mortusewicz, Oliver; Rajagopal, Varshni; Albers, Julian J.; Hagey, Daniel W.; Bekkhus, Tove; Eshtad, Saeed; Baquero, Juan Miguel; Masuyer, Geoffrey; Wallner, Olov; Muller, Sarah; Pham, Therese; Gokturk, Camilla; Rasti, Azita; Suman, Sharda; Torres-Ruiz, Raul; Sarno, Antonio; Wiita, Elisee; Homan, Evert J.; Karsten, Stella; Marimuthu, Karthick; Michel, Maurice; Koolmeister, Tobias; Scobie, Martin; Loseva, Olga; Almlof, Ingrid; Unterlass, Judith Edda; Pettke, Aleksandra; Bostrom, Johan; Pandey, Monica; Gad, Helge; Herr, Patrick; Jemth, Ann-Sofie; El Andaloussi, Samir; Kalderen, Christina; Rodriguez-Perales, Sandra; Benitez, Javier; Krokan, Hans E.; Altun, Mikael; Stenmark, Pal; Berglund, Ulrika Warpman; Helleday, Thomas
Development of a chemical probe against NUDT15
NATURE CHEMICAL BIOLOGY
IF13.7
2020-07-2012
OAAI
Zhang, Si Min; Desroses, Matthieu; Hagenkort, Anna; Valerie, Nicholas C. K.; Rehling, Daniel; Carter, Megan; Wallner, Olov; Koolmeister, Tobias; Throup, Adam; Jemth, Ann-Sofie; Almlof, Ingrid; Loseva, Olga; Lundback, Thomas; Axelsson, Hanna; Regmi, Shruti; Sarno, Antonio; Kraemer, Andreas; Pudelko, Linda; Brautigam, Lars; Rasti, Azita; Gottmann, Mona; Wiita, Elisee; Kutzner, Juliane; Schaller, Torsten; Kalderen, Christina; Cazares-Korner, Armando; Page, Brent D. G.; Krimpenfort, Rosa; Eshtad, Saeed; Altun, Mikael; Rudd, Sean G.; Knapp, Stefan; Scobie, Martin; Homan, Evert J.; Berglund, Ulrika Warpman; Stenmark, Pal; Helleday, Thomas
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (vol 9, 250, 2018)
NATURE COMMUNICATIONS
IF15.7
2019-11-013
OAAI
Page, Brent D. G.; Valerie, Nicholas C. K.; Wright, Roni H. G.; Wallner, Olov; Isaksson, Rebecka; Carter, Megan; Rudd, Sean G.; Loseva, Olga; Jemth, Ann-Sofie; Almlof, Ingrid; Font-Mateu, Jofre; Llona-Minguez, Sabin; Baranczewski, Pawel; Jeppsson, Fredrik; Homan, Evert; Almqvist, Helena; Axelsson, Hanna; Regmi, Shruti; Gustavsson, Anna-Lena; Lundback, Thomas; Scobie, Martin; Stromberg, Kia; Stenmark, Pal; Beato, Miguel; Helleday, Thomas
MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
CANCER RESEARCH
IF16.6
2019-07-012
OA
Sanjiv, Kumar; Gad, Helge; Rudd, Sean G.; Mortusewicz, Oliver; Stolz, Ailine; Amaral, Nuno; Brautigham, Lars; Pudelko, Linda; Kalderen, Christina; Jemth, Ann-Sofie; Almlof, Ingrid; Visnes, Torkild; Schultz, Niklas; Bostrom, Johan; Montano, Jose Manuel Calderon; Hagenkort, Anna; Groth, Petra; Gokturk, Camilla; Koolmeister, Tobias; Wakchaure, Prasad; Homan, Evert; Altun, Mikael; Strom, Cecilia; Scobie, Martin; Bastians, Holger; Berglund, Ulrika Warpman; Helleday, Thomas

研究方向

暂未获取到该数据
T
Thomas Helleday
H 指数:84论文数:690被引数:3.5万
P
Pål Stenmark
H 指数:41论文数:289被引数:6,538
E
Evert Homan
H 指数:24论文数:100被引数:2,327
U
Ulrika Warpman Berglund
H 指数:32论文数:151被引数:3,804
O
Olga Loseva
H 指数:30论文数:118被引数:4,240
M
Martin Scobie
H 指数:25论文数:125被引数:2,574
I
Ingrid Almlöf
H 指数:19论文数:87被引数:1,502
E
Elisée Wiita
H 指数:21论文数:87被引数:1,970
N
Nicholas C.K. Valerie
H 指数:16论文数:90被引数:1,607
K
Kumar Sanjiv
H 指数:25论文数:70被引数:3,037