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E

Evert Homan

science for life laboratory
H指数:24
被引数:2,327

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Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1

核碱基催化剂用于酶促激活8-oxoguanine DNA glycosylase 1

RSC Chem. Biol.
IF3.1
2025-10-290
OAAI
Emily C. Hank; Nicholas D'Arcy-Evans; Emma Rose Scaletti; Carlos Benítez-Buelga; Olov Wallner; Florian Ortis; Kaixin Zhou; Liuzhen Meng; Alicia del Prado; Patricia Calvo; Ingrid Almlöf; Elisee Wiita; Karen Nierlin; Sara Kosenina; Andreas Krämer; Alice Eddershaw; Mario Kehler; Maeve Long; AnnSofie Jemth; Holly Dawson; Josephine Stewart; Adam Dickey; Mikhael Elijah Astorga; Marek Varga; Evert Homan; Martin Scobie; Stefan Knapp; Leandro Sastre; Pål Stenmark; Miguel de Vega; Thomas Helleday; Maurice Michel
Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-10-010
PRE
Varga, Marek; Ortis, Florian; Del Prado, Alicia; Eddershaw, Alice; Scaletti Hutchinson, Emma; Hank, Emily C.; Zhou, Kaixin; Rudolfova, Natalie; Dodaro, Alessia; Wiita, Elisee; Almlof, Ingrid; Karsten, Stella; Mamonov, Kirill; Ahmed, Sara H.; Bentley, Kirsty; Wallner, Olov; Homan, Evert J.; Scobie, Martin; Helleday, Thomas; Prejano, Mario; Stenmark, Pal; de Vega, Miguel; Watson, Allan J. B.; Michel, Maurice
MTHFD1/2 inhibitor TH9619 targets the DNA damage response and causes cancer-specific folate trapping with an unprecedented therapeutic window
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Martilla, Petra; Green, Alanna C.; Kiweler, Nicole; Chalkiadaki, Christina; Wiita, Elisee; Cookson, Victoria; Lesur, Antoine; Eiden, Kim; Bernhardin, Francois; Long, Maeve; Jemth, Ann-Sofie; Mortusewicz, Oliver; Homan, Evert; Bonagas, Nadilly; Ramos, Louise; Sanjiv, Kumar; Mancina, Emilio Guillen; Pham, Therese; Slipicevic, Ana; Henriksson, Martin; Meiser, Johannes; Helleday, Thomas
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

甲酸盐溢出驱动MTHFD1抑制的癌细胞中的有毒叶酸捕获

NATURE METABOLISM
IF20.8
2023-04-0311
OAAI
Green, Alanna C.; Marttila, Petra; Kiweler, Nicole; Chalkiadaki, Christina; Wiita, Elisee; Cookson, Victoria; Lesur, Antoine; Eiden, Kim; Bernardin, Francois; Vallin, Karl S. A.; Borhade, Sanjay; Long, Maeve; Ghahe, Elahe Kamali; Jimenez-Alonso, Julio J.; Jemth, Ann-Sofie; Loseva, Olga; Mortusewicz, Oliver; Meyers, Marianne; Viry, Elodie; Johansson, Annika I.; Hodek, Ondrej; Homan, Evert; Bonagas, Nadilly; Ramos, Louise; Sandberg, Lars; Frodin, Morten; Moussay, Etienne; Slipicevic, Ana; Letellier, Elisabeth; Paggetti, Jerome; Sorensen, Claus Storgaard; Helleday, Thomas; Henriksson, Martin; Meiser, Johannes
Target 2035-an update on private sector contributions
RSC MEDICINAL CHEMISTRY
IF3.6
2023-01-015
OAAI
Ackloo, Suzanne; Antolin, Albert A.; Bartolome, Jose Manuel; Beck, Hartmut; Bullock, Alex; Betz, Ulrich A. K.; Boettcher, Jark.; Brown, Peter J.; Chaturvedi, Menorca; Crisp, Alisa; Daniels, Danette; Dreher, Jan; Edfeldt, Kristina; Edwards, Aled M.; Egner, Ursula; Elkins, Jon; Fischer, Christian; Glendorf, Tine; Goldberg, Steven; Hartung, Ingo V.; Hillisch, Alexander; Homan, Evert; Knapp, Stefan; Koester, Markus; Kraemer, Oliver; Llaveria, Josep; Lessel, Uta; Lindemann, Sven; Linderoth, Lars; Matsui, Hisanori; Michel, Maurice; Montel, Florian; Mueller-Fahrnow, Anke; Mueller, Susanne; Owen, Dafydd R.; Saikatendu, Kumar Singh; Santhakumar, Vijayaratnam; Sanderson, Wendy; Scholten, Cora; Schapira, Matthieu; Sharma, Sujata; Shireman, Brock; Sundstrom, Michael; Todd, Matthew H.; Tredup, Claudia; Venable, Jennifer; Willson, Timothy M.; Arrowsmith, Cheryl H.
Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1
CHEMMEDCHEM
IF3.4
2022-10-133
OAAI
Wallner, Olov; Cazares-Korner, Armando; Scaletti, Emma Rose; Masuyer, Geoffrey; Bekkhus, Tove; Visnes, Torkild; Mamonov, Kirill; Ortis, Florian; Lundback, Thomas; Volkova, Maria; Koolmeister, Tobias; Wiita, Elisee; Loseva, Olga; Pandey, Monica; Homan, Evert; Benitez-Buelga, Carlos; Davies, Jonathan; Scobie, Martin; Berglund, Ulrika Warpman; Kalderen, Christina; Stenmark, Pal; Helleday, Thomas; Michel, Maurice
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
NATURE CANCER
IF28.5
2022-02-2837
OAAI
Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra; Gustafsson, Robert; Wiita, Elisee; Borhade, Sanjay; Green, Alanna C.; Vallin, Karl S. A.; Sarno, Antonio; Svensson, Richard; Gokturk, Camilla; Pham, Therese; Jemth, Ann-Sofie; Loseva, Olga; Cookson, Victoria; Kiweler, Nicole; Sandberg, Lars; Rasti, Azita; Unterlass, Judith E.; Haraldsson, Martin; Andersson, Yasmin; Scaletti, Emma R.; Bengtsson, Christoffer; Paulin, Cynthia B. J.; Sanjiv, Kumar; Abdurakhmanov, Eldar; Pudelko, Linda; Kunz, Ben; Desroses, Matthieu; Iliev, Petar; Farnegardh, Katarina; Kramer, Andreas; Garg, Neeraj; Michel, Maurice; Haggblad, Sara; Jarvius, Malin; Kalderen, Christina; Jensen, Amanda Bogedahl; Almlof, Ingrid; Karsten, Stella; Zhang, Si Min; Haggblad, Maria; Eriksson, Anders; Liu, Jianping; Glinghammar, Bjorn; Nekhotiaeva, Natalia; Klingegard, Fredrik; Koolmeister, Tobias; Martens, Ulf; Llona-Minguez, Sabin; Moulson, Ruth; Nordstrom, Helena; Parrow, Vendela; Dahllund, Leif; Sjoberg, Birger; Vargas, Irene L.; Vo, Duy Duc; Wannberg, Johan; Knapp, Stefan; Krokan, Hans E.; Arvidsson, Per, I; Scobie, Martin; Meiser, Johannes; Stenmark, Pal; Berglund, Ulrika Warpman; Homan, Evert J.; Helleday, Thomas
Target 2035-update on the quest for a probe for every protein
RSC MEDICINAL CHEMISTRY
IF3.6
2022-01-0151
OAAI
Mueller, Susanne; Ackloo, Suzanne; Al Chawaf, Arij; Al-Lazikani, Bissan; Antolin, Albert; Baell, Jonathan B.; Beck, Hartmut; Beedie, Shaunna; Betz, Ulrich A. K.; Bezerra, Gustavo Arruda; Brennan, Paul E.; Brown, David; Brown, Peter J.; Bullock, Alex N.; Carter, Adrian J.; Chaikuad, Apirat; Chaineau, Mathilde; Ciulli, Alessio; Collins, Ian; Dreher, Jan; Drewry, David; Edfeldt, Kristina; Edwards, Aled M.; Egner, Ursula; Frye, Stephen, V; Fuchs, Stephen M.; Hall, Matthew D.; Hartung, Ingo, V; Hillisch, Alexander; Hitchcock, Stephen H.; Homan, Evert; Kannan, Natarajan; Kiefer, James R.; Knapp, Stefan; Kostic, Milka; Kubicek, Stefan; Leach, Andrew R.; Lindemann, Sven; Marsden, Brian D.; Matsui, Hisanori; Meier, Jordan L.; Merk, Daniel; Michel, Maurice; Morgan, Maxwell R.; Mueller-Fahrnow, Anke; Owen, Dafydd R.; Perry, Benjamin G.; Rosenberg, Saul H.; Saikatendu, Kumar Singh; Schapira, Matthieu; Scholten, Cora; Sharma, Sujata; Simeonov, Anton; Sundstrom, Michael; Superti-Furga, Giulio; Todd, Matthew H.; Tredup, Claudia; Vedadi, Masoud; von Delft, Frank; Willson, Timothy M.; Winter, Georg E.; Workman, Paul; Arrowsmith, Cheryl H.
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
Science
IF45.8
2022-01-010
OA
Maurice Michel; Carlos Benitéz‐Buelga; Patricia A. Calvo; Bishoy Magdy Fekry Hanna; Oliver Mortusewicz; Geoffrey Masuyer; Jonathan R. Davies; Olov A. Wallner; Kumar Sanjiv; Julian J. Albers; Sergio Castañeda‐Zegarra; Ann‐Sofie Jemth; Torkild Visnes; Ana Sastre-Perona; Akhilesh Nagesh Danda; Evert J. Homan; Karthick Marimuthu; Zhao Zhenjun; N. Celestine; Antonio Sarno; Elisée Wiita; Catharina Von Nicolai; Anna J. Komor; Varshni Rajagopal; Sarah Müller; Emily C. Hank; Marek Varga; Emma Rose Scaletti; Monica Pandey; Stella Karsten; Hanne Haslene‐Hox; Simon Loevenich; Petra Marttila; Azita Rasti; Kirill Mamonov; Florian Ortis; Fritz Schömberg; Olga Loseva; Josephine Stewart; Nicholas D. D’Arcy-Evans; Tobias Koolmeister; Martin Henriksson; Dana Michel; Ana de Ory; Lucía Acero-Riaguas; Oriol Calvete; Martin Scobie; Christian Hertweck; Ivan Vilotijević; Christina Kalderén; Ana Osório; Rosario Perona; Alexandra Stolz; Pål Stenmark; Ulrika Warpman Berglund; Miguel de Vega; Thomas Helleday
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
NUCLEIC ACIDS RESEARCH
IF13.1
2020-11-1937
OAAI
Visnes, Torkild; Benitez-Buelga, Carlos; Cazares-Korner, Armando; Sanjiv, Kumar; Hanna, Bishoy M. F.; Mortusewicz, Oliver; Rajagopal, Varshni; Albers, Julian J.; Hagey, Daniel W.; Bekkhus, Tove; Eshtad, Saeed; Baquero, Juan Miguel; Masuyer, Geoffrey; Wallner, Olov; Muller, Sarah; Pham, Therese; Gokturk, Camilla; Rasti, Azita; Suman, Sharda; Torres-Ruiz, Raul; Sarno, Antonio; Wiita, Elisee; Homan, Evert J.; Karsten, Stella; Marimuthu, Karthick; Michel, Maurice; Koolmeister, Tobias; Scobie, Martin; Loseva, Olga; Almlof, Ingrid; Unterlass, Judith Edda; Pettke, Aleksandra; Bostrom, Johan; Pandey, Monica; Gad, Helge; Herr, Patrick; Jemth, Ann-Sofie; El Andaloussi, Samir; Kalderen, Christina; Rodriguez-Perales, Sandra; Benitez, Javier; Krokan, Hans E.; Altun, Mikael; Stenmark, Pal; Berglund, Ulrika Warpman; Helleday, Thomas
Development of a chemical probe against NUDT15
NATURE CHEMICAL BIOLOGY
IF13.7
2020-07-2012
OAAI
Zhang, Si Min; Desroses, Matthieu; Hagenkort, Anna; Valerie, Nicholas C. K.; Rehling, Daniel; Carter, Megan; Wallner, Olov; Koolmeister, Tobias; Throup, Adam; Jemth, Ann-Sofie; Almlof, Ingrid; Loseva, Olga; Lundback, Thomas; Axelsson, Hanna; Regmi, Shruti; Sarno, Antonio; Kraemer, Andreas; Pudelko, Linda; Brautigam, Lars; Rasti, Azita; Gottmann, Mona; Wiita, Elisee; Kutzner, Juliane; Schaller, Torsten; Kalderen, Christina; Cazares-Korner, Armando; Page, Brent D. G.; Krimpenfort, Rosa; Eshtad, Saeed; Altun, Mikael; Rudd, Sean G.; Knapp, Stefan; Scobie, Martin; Homan, Evert J.; Berglund, Ulrika Warpman; Stenmark, Pal; Helleday, Thomas
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (vol 9, 250, 2018)
NATURE COMMUNICATIONS
IF15.7
2019-11-013
OAAI
Page, Brent D. G.; Valerie, Nicholas C. K.; Wright, Roni H. G.; Wallner, Olov; Isaksson, Rebecka; Carter, Megan; Rudd, Sean G.; Loseva, Olga; Jemth, Ann-Sofie; Almlof, Ingrid; Font-Mateu, Jofre; Llona-Minguez, Sabin; Baranczewski, Pawel; Jeppsson, Fredrik; Homan, Evert; Almqvist, Helena; Axelsson, Hanna; Regmi, Shruti; Gustavsson, Anna-Lena; Lundback, Thomas; Scobie, Martin; Stromberg, Kia; Stenmark, Pal; Beato, Miguel; Helleday, Thomas

研究方向

暂未获取到该数据
T
Thomas Helleday
H 指数:84论文数:690被引数:3.5万
A
Ann‐Sofie Jemth
H 指数:28论文数:111被引数:4,134
M
Martin Scobie
H 指数:25论文数:125被引数:2,574
P
Pål Stenmark
H 指数:41论文数:289被引数:6,538
U
Ulrika Warpman Berglund
H 指数:32论文数:151被引数:3,804
E
Elisée Wiita
H 指数:21论文数:87被引数:1,970
I
Ingrid Almlöf
H 指数:19论文数:87被引数:1,502
O
Olov Wallner
H 指数:26论文数:97被引数:2,709
O
Olga Loseva
H 指数:30论文数:118被引数:4,240
M
Maurice Michel
H 指数:17论文数:82被引数:865