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R

Razqallah Hakem

University of Toronto
H指数:56
被引数:1.7万

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PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents

PRMT1 抑制剂 MS023 抑制 RNA 剪接以增强小细胞肺癌对 DNA 损伤剂的治疗敏感性

Neoplasia
IF7.7
2025-05-230
PRE
Mansi K. Aparnathi; Sami Ul Haq; Jonathan St-Germain; Kevin C.J. Nixon; Joseph Walton; Lifang Song; Safa Majeed; Parasvi S. Patel; Ratheesh Subramaniam; Vivek Philip; Richard Marcellus; Dalia Barsyte-Lovejoy; Rima Al-Awar; Razqallah Hakem; Cheryl H. Arrowsmith; Laurie Ailles; Brian Raught; Benjamin H. Lok
Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment
NAR CANCER
IF3.2
2025-03-070
OAAI
Espin, Roderic; Medina-Jover, Ferran; Siguenza-Andrade, Javier; Farran-Matas, Sonia; Mateo, Francesca; Figueras, Agnes; Sanz, Rosario T.; Vicent, Guillermo Pablo; Shabbir, Arzoo; Ruiz-Auladell, Lara; Racionero-Andres, Emilio; Garcia, Irene; Baiges, Alexandra; Franco-Luzon, Lidia; Martinez-Tebar, Adrian; Pardo-Cea, Miguel Angel; Martinez-Iniesta, Maria; Wang, Xieng Chen; Cuyas, Elisabet; Menendez, Javier A.; Lopez-Cerda, Marta; Munoz, Purificacion; Richaud, Ivonne; Raya, Angel; Fabregat, Isabel; Villanueva, Alberto; Serrat, Xenia; Ceron, Julian; Alemany, Montserrat; Guix, Ines; Herencia-Ropero, Andrea; Serra, Violeta; Krishnan, Rehna; Mekhail, Karim; Hakem, Razqallah; Bruna, Jordi; Barcellos-Hoff, Mary Helen; Vinals, Francesc; Aytes, Alvaro; Pujana, Miquel Angel
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages (vol 42, 113256, 2023)
CELL REPORTS
IF6.9
2023-11-012
OAAI
Kim, Hyeyeon; Aliar, Kazeera; Tharmapalan, Pirashaanthy; Mccloskey, Curtis W.; Kuttanamkuzhi, Abhijith; Grunwald, Barbara T.; Palomero, Luis; Mahendralingam, Mathepan J.; Waas, Matthew; Mer, Arvind S.; Elliott, Mitchell J.; Zhang, Bowen; Al-Zahrani, Khalid N.; Langille, Ellen R.; Parsons, Michael; Narala, Swami; Hofer, Stefan; Waterhouse, Paul D.; Hakem, Razqallah; Haibe-Kains, Benjamin; Kislinger, Thomas; Schramek, Daniel; Cescon, David W.; Pujana, Miquel A.; Berman, Hal K.; Khokha, Rama
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages
CELL REPORTS
IF6.9
2023-10-011
OA
Kim, Hyeyeon; Aliar, Kazeera; Tharmapalan, Pirashaanthy; McCloskey, Curtis W.; Kuttanamkuzhi, Abhijith; Grunwald, Barbara T.; Palomero, Luis; Mahendralingam, Mathepan J.; Waas, Matthew; Mer, Arvind S.; Elliott, Mitchell J.; Zhang, Bowen; Al-Zahrani, Khalid N.; Langille, Ellen R.; Parsons, Michael; Narala, Swami; Hofer, Stefan; Waterhouse, Paul D.; Hakem, Razqallah; Haibe-Kains, Benjamin; Kislinger, Thomas; Schramek, Daniel; Cescon, David W.; Pujana, Miquel A.; Berman, Hal K.; Khokha, Rama
Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation
DIABETES
IF7.5
2023-09-129
OA
Luk, Cynthia T.; Chan, Carmen K.; Chiu, Felix; Shi, Sally Yu; Misra, Paraish S.; Li, Yu Zhe; Pollock-Tahiri, Evan; Schroer, Stephanie A.; Desai, Harsh R.; Sivasubramaniyam, Tharini; Cai, Erica P.; Krishnamurthy, Mansa; Han, Daniel J.; Chowdhury, Apu; Aslam, Rukhsana; Yuen, Darren A.; Hakem, Anne; Hakem, Razqallah; Woo, Minna
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

XRN2的RNF8泛素化促进R环解析并抑制BRCA1突变细胞中的基因组不稳定性

NUCLEIC ACIDS RESEARCH
IF13.1
2023-09-117
OAAI
Krishnan, Rehna; Lapierre, Mariah; Gautreau, Brandon; Nixon, Kevin C. J.; El Ghamrasni, Samah; Patel, Parasvi S.; Hao, Jun; Yerlici, V. Talya; Guturi, Kiran Kumar Naidu; St-Germain, Jonathan; Mateo, Francesca; Saad, Amine; Algouneh, Arash; Earnshaw, Rebecca; Shili, Duan; Seitova, Alma; Miller, Joshua; Khosraviani, Negin; Penn, Adam; Ho, Brandon; Sanchez, Otto; Hande, M. Prakash; Masson, Jean-Yves; Brown, Grant W.; Alaoui-Jamali, Moulay; Reynolds, John J.; Arrowsmith, Cheryl; Raught, Brian; Pujana, Miguel A.; Mekhail, Karim; Stewart, Grant S.; Hakem, Anne; Hakem, Razqallah
Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers

过度的转录复制冲突是BRCA1-mutant癌症的脆弱性

NUCLEIC ACIDS RESEARCH
IF13.1
2023-03-176
OAAI
Patel, Parasvi S.; Algouneh, Arash; Krishnan, Rehna; Reynolds, John J.; Nixon, Kevin C. J.; Hao, Jun; Lee, Jihoon; Feng, Yue; Fozil, Chehronai; Stanic, Mia; Yerlici, Talya; Su, Peiran; Soares, Fraser; Liedtke, Elisabeth; Prive, Gil; Baider, Gary D.; Pujana, Miquel Angel; Mekhail, Karim; He, Housheng Hansen; Hakem, Anne; Stewart, Grant S.; Hakem, Razqallah
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

RNF168调节BRCA1/2缺陷肿瘤的R环分辨率和基因组稳定性

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2021-02-0142
OA
Patel, Parasvi S.; Abraham, Karan Joshua; Guturi, Kiran Kumar Naidu; Halaby, Marie-Jo; Khan, Zahra; Palomero, Luis; Ho, Brandon; Duan, Shili; St-Germain, Jonathan; Algouneh, Arash; Mateo, Francesca; El Ghamrasni, Samah; Barbour, Haithem; Barnes, Daniel R.; Beesley, Jonathan; Sanchez, Otto; Berman, Hal K.; Brown, Grant W.; Affar, El Bachir; Chenevix-Trench, Georgia; Antoniou, Antonis C.; Arrowsmith, Cheryl H.; Raught, Brian; Pujana, Miquel Angel; Mekhail, Karim; Hakem, Anne; Hakem, Razqallah
DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration

DICER1/Alu RNA代谢异常在年龄相关性黄斑变性中诱导Caspase-8-mediated细胞死亡

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2014-10-2785
OAAI
Kim, Younghee; Tarallo, Valeria; Kerur, Nagaraj; Yasuma, Tetsuhiro; Gelfand, Bradley D.; Bastos-Carvalho, Ana; Hirano, Yoshio; Yasuma, Reo; Mizutani, Takeshi; Fowler, Benjamin J.; Li, Shengjian; Kaneko, Hiroki; Bogdanovich, Sasha; Ambati, Balamurali K.; Hinton, David R.; Hauswirth, William W.; Hakem, Razqallah; Wright, Charles; Ambati, Jayakrishna

研究方向

暂未获取到该数据
A
Anne Hakem
H 指数:30论文数:60被引数:7,538
S
Samah El Ghamrasni
H 指数:17论文数:73被引数:1,457
L
Leonardo Salmena
H 指数:36论文数:200被引数:2.1万
T
Tak W. Mak
H 指数:181论文数:1,561被引数:12.9万
M
M. Prakash Hande
H 指数:60论文数:265被引数:1.7万
M
Minna Woo
H 指数:37论文数:103被引数:6,982
M
Miguel Ángel Pujana
H 指数:46论文数:351被引数:8,928
O
Otto Sánchez
H 指数:26论文数:91被引数:3,353
K
Karim Mekhail
H 指数:28论文数:74被引数:3,366
B
Brian Raught
H 指数:75论文数:395被引数:2.9万