Jeffrey R. Holt - Publications, H-index & Citations

Jeffrey R. Holt

Boston Children's Hospital

51H指数

151论文数

1.0W被引数

收录论文 48

发表时间

Assessment of auditory and vestibular function and gene therapy in the Snell’s waltzer mouse model of human deafness and balance dysfunction 评估听觉和前庭功能及基因治疗在人类耳聋和平衡功能障碍的斯内尔舞者小鼠模型中的研究

Mammalian Genome

IF2.7

2026-08-28

OAAI

Eyal Marton; Roni Hahn; Lior Bikovski; Gwenaëlle S. G. Géléoc; Jeffrey R. Holt; Matti Mintz; Karen B. Avraham

AAV-Mediated Exon Skipping Therapy for Usher Syndrome, Type 2A.AAV介导的外显子跳跃疗法治疗2A型Usher综合征。

Molecular Therapy

IF12

2025-09-23

PREAI

Stephanie A. Mauriac; Jiyoon Lee; Jingyuan Zhang; Jiahe Jin; Carl Nist-Lund; Camille T. Martin; Cristobal R. Von Muhlenbrock; Sydney O’Malley; Mary G. Chaves; Margot A. Madison; Kate Foster; Shinong Long; Chris Jacobs; Sripriya Ravindra Kumar; Silvia Ramirez; Justin Ichida; Karl R. Koehler; Jeffrey R. Holt; Gwenaëlle S.G. Géléoc

Endocochlear potential contributes to hair cell death in TMPRSS3 hearing loss 内耳电位在TMPRSS3听力损失中的毛细胞死亡中起作用。J. Clin. Invest. 135:e186395

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2025-09-16

OAAI

Shearer, A. Eliot; Chen, Yuan-Siao; Rouse, Stephanie L.; Wang, Xiaohan; Fermin, Janmaris Marin; Booth, Kevin T. A.; Moawad, Jasmine; Libiran, Nicole Bianca; Li, Jinan; Kim, Hae-Young; Hoa, Michael; Olszewski, Rafal; Lei, Jing-Yu; Cabrera, Ernesto; Totten, Douglas J.; Zhao, Bo; Holt, Jeffrey R.; Nelson, Rick F.

A contemporary view of mechanosensory transduction in auditory hair cells 听觉毛细胞机械感觉转导的现代观点

Biophysical Journal

IF3.1

2025-06-16

PREAI

Matthew Mun; Jeffrey R. Holt

Structural and functional basis of mechanosensitive TMEM63 channelopathies TMEM63机械敏感性通道病结构与功能基础

Neuron

IF15

2025-06-05

PREAI

Wang Zheng; Augustus J. Lowry; Harper E. Smith; Jiale Xie; Shaun Rawson; Chen Wang; Jin Ou; Marcos Sotomayor; Tian-Min Fu; Huanghe Yang; Jeffrey R. Holt

Mammalian TMC1 or 2 are necessary for scramblase activity in auditory hair cells 哺乳动物TMC1或TMC2对于听觉毛细胞中 scramblase 活性是必需的。

HEARING RESEARCH

IF2.5

2025-05-01

PREAI

Peineau, Thibault; Marcovich, Irina; Rodriguez, Cristobal von Muhlenbrock; O'Malley, Sydney; Cui, Runjia; Ballesteros, Angela; Holt, Jeffrey R.

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

ELIFE

IF0

2025-01-08

OAAI

Giese, Arnaud P. J.; Weng, Wei-Hsiang; Kindt, Katie S.; Chang, Hui Ho Vanessa; Montgomery, Jonathan S.; Ratzan, Evan M.; Beirl, Alisha J.; Aponte Rivera, Roberto; Lotthammer, Jeffrey M.; Walujkar, Sanket; Foster, Mark P.; Zobeiri, Omid A.; Holt, Jeffrey R.; Riazuddin, Saima; Cullen, Kathleen E.; Sotomayor, Marcos; Ahmed, Zubair M.

Sensory transduction in auditory hair cells-PIEZOs can't touch this

JOURNAL OF GENERAL PHYSIOLOGY

IF2.9

2024-05-10

OAAI

Holt, Jeffrey R.; Fettiplace, Robert; Muller, Ulrich

TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels

NEURON

IF15

2023-10-01

PREAI

Zheng, Wang; Rawson, Shaun; Shen, Zhangfei; Tamilselvan, Elakkiya; Smith, Harper E.; Halford, Julia; Shen, Chen; Murthy, Swetha E.; Ulbrich, Maximilian H.; Sotomayor, Marcos; Fu, Tian-Min; Holt, Jeffrey R.

Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2023-06-28

PREAI

Mathiesen, Barbara K.; Miyakoshi, Leo M.; Cederroth, Christopher R.; Tserga, Evangelia; Versteegh, Corstiaen; Bork, Peter A. R.; Hauglund, Natalie L.; Gomolka, Ryszard Stefan; Mori, Yuki; Edvall, Niklas K.; Rouse, Stephanie; Mollgard, Kjeld; Holt, Jeffrey R.; Nedergaard, Maiken; Canlon, Barbara

pH regulates potassium conductance and drives a constitutive proton current in human TMEM175

SCIENCE ADVANCES

IF12.5

2022-03-25

OAAI

Zheng, Wang; Shen, Chen; Wang, Longfei; Rawson, Shaun; Xie, Wen Jun; Nist-Lund, Carl; Wu, Jason; Shen, Zhangfei; Xia, Shiyu; Holt, Jeffrey R.; Wu, Hao; Fu, Tian-Min

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss

SCIENCE ADVANCES

IF12.5

2021-12-17

OAAI

Shubina-Oleinik, Olga; Nist-Lund, Carl; French, Courtney; Rockowitz, Shira; Shearer, A. Eliot; Holt, Jeffrey R.

Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses

ELIFE

IF0

2021-11-04

PREAI

Lee, John; Kawai, Kosuke; Holt, Jeffrey R.; Geleoc, Gwenaelle Sg

Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice

MOLECULAR THERAPY

IF12

2021-03-01

OAAI

Wu, Jason; Solanes, Paola; Nist-Lund, Carl; Spataro, Sofia; Shubina-Oleinik, Olga; Marcovich, Irina; Goldberg, Hannah; Schneider, Bernard L.; Holt, Jeffrey R.

Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness 新生儿AAV基因疗法可挽救SYNE4耳聋小鼠模型的听力

EMBO MOLECULAR MEDICINE

IF8.3

2020-12-22

OAAI

Taiber, Shahar; Cohen, Roie; Yizhar-Barnea, Ofer; Sprinzak, David; Holt, Jeffrey R.; Avraham, Karen B.

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2020-06-03

128

OAAI

Yeh, Wei-Hsi; Shubina-Oleinik, Olga; Levy, Jonathan M.; Pan, Bifeng; Newby, Gregory A.; Wornow, Michael; Burt, Rachel; Chen, Jonathan C.; Holt, Jeffrey R.; Liu, David R.

Continuous evolution of base editors with expanded target compatibility and improved activity (vol 37, pg 1070, 2019)

NATURE BIOTECHNOLOGY

IF41.7

2019-08-12

OAAI

Thuronyi, Benjamin W.; Koblan, Luke W.; Levy, Jonathan M.; Yeh, Wei-Hsi; Zheng, Christine; Newby, Gregory A.; Wilson, Christopher; Bhaumik, Mantu; Shubina-Oleinik, Olga; Holt, Jeffrey R.; Liu, David R.

Continuous evolution of base editors with expanded target compatibility and improved activity

NATURE BIOTECHNOLOGY

IF41.7

2019-07-22

269

OAAI

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

NATURE MEDICINE

IF50

2019-07-03

154

OAAI

Gyorgy, Bence; Nist-Lund, Carl; Pan, Bifeng; Asai, Yukako; Karavitaki, K. Domenica; Kleinstiver, Benjamin P.; Garcia, Sara P.; Zaborowski, Mikolaj P.; Solanes, Paola; Spataro, Sofia; Schneider, Bernard L.; Joung, J. Keith; Geleoc, Gwenaelle S. G.; Holt, Jeffrey R.; Corey, David P.

Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders (vol 10, 236, 2019)

NATURE COMMUNICATIONS

IF15.7

2019-02-08

OAAI

Nist-Lund, Carl A.; Pan, Bifeng; Patterson, Amy; Asai, Yukako; Chen, Tianwen; Zhou, Wu; Zhu, Hong; Romero, Sandra; Resnik, Jennifer; Polley, Daniel B.; Geleoc, Gwenaelle S.; Holt, Jeffrey R.

研究方向