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T

Thomas M. Schmitt

fred hutchinson cancer center
H指数:32
被引数:5,651

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Reprogramming engineered autologous T cells to overcome resistance in patients with Merkel cell carcinoma

将工程化自体T细胞重编程以克服 Merkel细胞癌患者的耐药性

Science Translational Medicine
IF14.6
2026-09-090
PRE
Yuta Asano; Joshua R. Veatch; Cheng-Jung Sung; Tzu-Hao Tang; Francesco Mazziotta; Seiji Natsuki; Megan McAfee; Jakob Bakhtiari; Bo Lee; Lauren Martin; Alessandro Rizzi; Tianzi Zhang; Colton W. Smith; Kelly G. Paulson; Thomas M. Schmitt; Evan W. Newell; Anna E. Elz; Daniel G. Chen; Yapeng Su; Heather H. Gustafson; Cecilia C. S. Yeung; Brandon Seaton; Daniel Hunter; David M. Koelle; Shailender Bhatia; Evan T. Hall; Valentin Voillet; Jianhong Cao; Ted Gooley; Philip D. Greenberg; Raphael Gottardo; Shannon K. Oda; Paul Nghiem; Aude G. Chapuis
A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands

一种经过修饰以包含细胞内CD28信号尾部的CD8αβ共受体，能够独立于实体瘤相关共刺激配体而增强TCR工程化T细胞的功能。

Nature Communications
IF15.7
2026-01-030
OA
Shihong Zhang; Tzu-Hao Tang; Sinéad Kinsella; Francesco Mazziotta; Michael T. Schweizer; Megan S. McAfee; Ariunaa Munkhbat; Yapeng Su; Valentin Voillet; Lauren E. Martin; Colton W. Smith; Yuta Asano; Menna Hailemariam; Jakob Bakhtiari; Bo Lee; Cecilia Yeung; Hung Chen; Alessandro M. Rizzi; Daniel G. Chen; Kelsey Furiya; Nick Horst; Tianzi Zhang; Phung Le; Kelly McKenna; Shannon K. Oda; Anthony Rongvaux; Phillip D. Greenberg; Thomas M. Schmitt; Aude G. Chapuis
Pancreatic cancer-restricted cryptic antigens are targets for T cell recognition

胰腺癌特异性隐蔽抗原是T细胞识别的靶点

SCIENCE
IF45.8
2025-05-080
PRE
Ely, Zackery A.; Kulstad, Zachary J.; Gunaydin, Gurcan; Addepalli, Sudarsana; Verzani, Eva K.; Casarrubios, Marta; Clauser, Karl R.; Wang, Xilin; Lippincott, Isabelle E.; Louvet, Cedric; Schmitt, Thomas; Kapner, Kevin S.; Agus, Miles P.; Hennessey, Connor J.; Cleary, James M.; Hadrup, Sine R.; Klaeger, Susan; Su, Jennifer; Jaeger, Alex M.; Wolpin, Brian M.; Raghavan, Srivatsan; Smith, Eric L.; Greenberg, Philip D.; Aguirre, Andrew J.; Abelin, Jennifer G.; Carr, Steven A.; Jacks, Tyler; Freed-Pastor, William A.
AFNT-212: A TRAC-knocked-in KRASG12D-specific TCR-T cell product enhanced with CD8αß and a chimeric cytokine receptor for treatment of solid cancers
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Drain, Allison; Rouillard, Nicholas; Swanson, Nathaniel; Canestraro, Martina; Narayan, Santosh; Warner, Tyler; Danek, Nicole; Gareau, Ken; Liang, Jinsheng; Shen, Luhua; Tetrault, Tanya; Priyata, Iqraa; Vidyasagar, Sarah; Riggins-Walker, Taylor; Liu, Hui-Wen; Pechhold, Klaus; Brown, Lauren; Francis, Joshua; He, Xingyue; Browne, Patrick; Lamothe, Rebecca; Storlie, Meghan; Cost, Gregory; Schmitt, Thomas M.; Greenberg, Philip D.; Chandran, Smita S.; Klebanoff, Christopher A.; Lam, Hubert; Gupta, Ankit; Hallet, Damien; Shapiro, Gary; Nguyen, Kim; Vincent, Loic
Non-viral engineered T cell therapy specific for the hotspot mutation p53 R175H that integrates signal 1 (TCR), signal 2 ( co-stimulation) and signal 3 (cytokine) and co-opts FasL-dependent apoptosis to achieve a coordinated antitumor CD4/8 T cell response
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Narayan, Santosh; Gareau, Ken; Gupta, Ankit; Ferrell, Josh; Rouillard, Nicholas; Warner, Tyler; Liang, Jinsheng; Shen, Luhua; Tetrault, Tanya; Francis, Joshua; He, Xingyue; Browne, Patrick J.; Lamothe, Rebecca; Storlie, Meghan D.; Cost, Gregory J.; Schmitt, Thomas M.; Greenberg, Philip D.; Chandran, Smita S.; Hallet, Damien; Gormally, Michael; Klebanoff, Chistopher A.; Shapiro, Gary; Nguyen, Kim; Vincent, Loic
Unveiling CXCR2 as a promising therapeutic target in renal cell carcinoma: exploring the immunotherapeutic paradigm shift through its inhibition by RCT001
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
2024-03-196
OAAI
Montemagno, Christopher; Jacquel, Arnaud; Pandiani, Charlotte; Rastoin, Olivia; Dawaliby, Rosie; Schmitt, Thomas; Bourgoin, Maxence; Palenzuela, Heliciane; Rossi, Anne-Laure; Ambrosetti, Damien; Durivault, Jerome; Luciano, Frederic; Borchiellini, Delphine; Le Du, Julie; Goncalves, Leticia Christina Pires; Auberger, Patrick; Benhida, Rachid; Kinget, Lisa; Beuselinck, Benoit; Ronco, Cyril; Pages, Gilles; Dufies, Maeva
Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+T cell discovery and analysis
COMMUNICATIONS BIOLOGY
IF5.1
2023-05-165
OAAI
Chour, William; Choi, Jongchan; Xie, Jingyi; Chaffee, Mary E. E.; Schmitt, Thomas M. M.; Finton, Kathryn; DeLucia, Diana C. C.; Xu, Alexander M. M.; Su, Yapeng; Chen, Daniel G. G.; Zhang, Rongyu; Yuan, Dan; Hong, Sunga; Ng, Alphonsus H. C.; Butler, Jonah Z. Z.; Edmark, Rick A. A.; Jones, Lesley C. C.; Murray, Kim M. K. M.; Peng, Songming; Li, Guideng; Strong, Roland K. K.; Lee, John K. K.; Goldman, Jason D. D.; Greenberg, Philip D. D.; Heath, James R. R.
Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2022-02-0916
OA
Lahman, Miranda C.; Schmitt, Thomas M.; Paulson, Kelly G.; Vigneron, Nathalie; Buenrostro, Denise; Wagener, Felecia D.; Voillet, Valentin; Martin, Lauren; Gottardo, Raphael; Bielas, Jason; McElrath, Julie M.; Stirewalt, Derek L.; Pogosova-Agadjanyan, Era L.; Yeung, Cecilia C.; Pierce, Robert H.; Egan, Daniel N.; Bar, Merav; Hendrie, Paul C.; Kinsella, Sinead; Vakil, Aesha; Butler, Jonah; Chaffee, Mary; Linton, Jonathan; McAfee, Megan S.; Hunter, Daniel S.; Bleakley, Marie; Rongvaux, Anthony; Van den Eynde, Benoit J.; Chapuis, Aude G.; Greenberg, Philip D.
T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant
NATURE MEDICINE
IF50
2019-06-24248
OAAI
Chapuis, Aude G.; Egan, Daniel N.; Bar, Merav; Schmitt, Thomas M.; McAfee, Megan S.; Paulson, Kelly G.; Voillet, Valentin; Gottardo, Raphael; Ragnarsson, Gunnar B.; Bleakley, Marie; Yeung, Cecilia C.; Muhlhauser, Petri; Nguyen, Hieu N.; Kropp, Lara A.; Castelli, Luca; Wagener, Felecia; Hunter, Daniel; Lindberg, Marcus; Cohen, Kristen; Seese, Aaron; McElrath, M. Juliana; Duerkopp, Natalie; Gooley, Ted A.; Greenberg, Philip D.

研究方向

暂未获取到该数据
P
Philip D. Greenberg
H 指数:85论文数:433被引数:3.2万
A
Aude G. Chapuis
H 指数:30论文数:189被引数:4,720
J
Juan Carlos Zúñiga‐Pflücker
H 指数:70论文数:319被引数:1.8万
K
Kelly G. Paulson
H 指数:33论文数:187被引数:5,448
C
Cecilia C.S. Yeung
H 指数:28论文数:349被引数:9,698
V
Valentin Voillet
H 指数:19论文数:148被引数:3,324
M
Megan S. McAfee
H 指数:9论文数:40被引数:1,050
R
Raphaël Gottardo
H 指数:68论文数:485被引数:4.2万
M
Merav Bar
H 指数:29论文数:136被引数:4,687
I
Ingunn M. Stromnes
H 指数:32论文数:139被引数:5,911