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C

Carlotta Costa

Harvard University
H指数:29
被引数:5,347

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USP10/GSK3β-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer

USP10/GSK3β介导的PTEN抑制驱动乳腺癌对PI3K抑制剂的耐药性

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2025-11-170
OAAI
Kumari, Nishi; Wright, Sarah C. E.; Witham, Christopher M.; Monserrat, Laia; Palafox, Marta; Richard, John L. C.; Costa, Carlotta; Elkabets, Moshe; Agostino, Mark; Klemm, Theresa; Eccles, Melissa; Garnham, Alex; Wu, Ting; Nilsson, Jonas A.; Walz, Nikita; Venugopal, Veena; Cerra, Anthony; Vasilevski, Natali; Bridgeman, Stephanie; Bassi, Sona; Saei, Azad; Helal, Moutaz; Neundorf, Philipp; Riedel, Angela; Rosenfeldt, Mathias; Gill, Jespal; Pahor, Nikolett; Hartmann, Oliver; Chung, Jacky; Sidhu, Sachdev S.; Moderau, Nina; Jha, Sudhakar; Rodon, Jordi; Diefenbacher, Markus E.; Komander, David; Serra, Violeta; Eichhorn, Pieter Johan Adam
Targeting CCR7-PI3K? overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-06-286
PRE
Mastini, Cristina; Campisi, Marco; Patrucco, Enrico; Mura, Giulia; Ferreira, Antonio; Costa, Carlotta; Ambrogio, Chiara; Germena, Giulia; Martinengo, Cinzia; Peola, Silvia; Mota, Ines; Vissio, Elena; Molinaro, Luca; Arigoni, Maddalena; Olivero, Martina; Calogero, Raffaele; Prokoph, Nina; Tabbo, Fabrizio; Shoji, Brent; Brugieres, Laurence; Geoerger, Birgit; Turner, Suzanne D.; Cuesta-Mateos, Carlos; D'Aliberti, Deborah; Mologni, Luca; Piazza, Rocco; Gambacorti-Passerini, Carlo; Inghirami, Giorgio G.; Chiono, Valeria; Kamm, Roger D.; Hirsch, Emilio; Koch, Raphael; Weinstock, David M.; Aster, Jon C.; Voena, Claudia; Chiarle, Roberto
Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer models
PNAS NEXUS
IF3.8
2022-10-115
OAAI
Jacob, Sheeba; Turner, Tia H.; Cai, Jinyang; Floros, Konstantinos V.; Yu, Ann K.; Coon, Colin M.; Khatri, Rishabh; Alzubi, Mohammad A.; Jakubik, Charles T.; Bouck, Ynes M.; Puchalapalli, Madhavi; Shende, Mayuri; Dozmorov, Mikhail G.; Boikos, Sosipatros A.; Hu, Bin; Harrell, J. Chuck; Benes, Cyril H.; Koblinski, Jennifer E.; Costa, Carlotta; Faber, Anthony C.
SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms
SCIENTIFIC REPORTS
IF3.9
2021-01-1444
OAAI
Wang, Ye; Mohseni, Morvarid; Grauel, Angelo; Diez, Javier Estrada; Guan, Wei; Liang, Simon; Choi, Jiyoung Elizabeth; Pu, Minying; Chen, Dongshu; Laszewski, Tyler; Schwartz, Stephanie; Gu, Jane; Mansur, Leandra; Burks, Tyler; Brodeur, Lauren; Velazquez, Roberto; Kovats, Steve; Pant, Bhavesh; Buruzula, Giri; Deng, Emily; Chen, Julie T.; Sari-Sarraf, Farid; Dornelas, Christina; Varadarajan, Malini; Yu, Haiyan; Liu, Chen; Lim, Joanne; Hao, Huai-Xiang; Jiang, Xiaomo; Malamas, Anthony; LaMarche, Matthew J.; Geyer, Felipe Correa; McLaughlin, Margaret; Costa, Carlotta; Wagner, Joel; Ruddy, David; Jayaraman, Pushpa; Kirkpatrick, Nathaniel D.; Zhang, Pu; Iartchouk, Oleg; Aardalen, Kimberly; Cremasco, Viviana; Dranoff, Glenn; Engelman, Jeffrey A.; Silver, Serena; Wang, Hongyun; Hastings, William D.; Goldoni, Silvia
PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Ka inhibitors in breast cancer
CANCER RESEARCH
IF16.6
2020-08-151
PRE
Costa, Carlotta; Wang, Ye; Ly, Amy; Hosono, Yasuyuki; Murchie, Ellen; Walmsley, Charlotte S.; Huynh, Tiffany; Healy, Christopher; Peterson, Rachel; Yanase, Shogo; Jakubik, Charles T.; Henderson, Laura E.; Damon, Leah J.; Timonina, Daria; Sanidas, Ioannis; Pinto, Christopher J.; Mino-Kenudson, Mari; Stone, James; Dyson, Nicholas J.; Ellisen, Leif W.; Bardia, Aditya; Ebi, Hiromichi; Benes, Cyril H.; Engelman, Jeffrey A.; Juric, Dejan
PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer

PTEN缺失介导乳腺癌对CDK4/6和PI3Kα 抑制剂的临床交叉耐药

CANCER DISCOVERY
IF33.3
2020-01-09176
OAAI
Costa, Carlotta; Wang, Ye; Ly, Amy; Hosono, Yasuyuki; Murchie, Ellen; Walmsley, Charlotte S.; Huynh, Tiffany; Healy, Christopher; Peterson, Rachel; Yanase, Shogo; Jakubik, Charles T.; Henderson, Laura E.; Damon, Leah J.; Timonina, Daria; Sanidas, Ioannis; Pinto, Christopher J.; Mino-Kenudson, Mari; Stone, James R.; Dyson, Nicholas J.; Ellisen, Leif W.; Bardia, Aditya; Ebi, Hiromichi; Benes, Cyril H.; Engelman, Jeffrey A.; Juric, Dejan
Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2018-02-2327
OAAI
Floros, Konstantinos V.; Lochmann, Timothy L.; Hu, Bin; Monterrubio, Carles; Hughes, Mark T.; Wells, Jason D.; Bernado Morales, Cristina; Ghotra, Maninderjit S.; Costa, Carlotta; Souers, Andrew J.; Boikos, Sosipatros A.; Leverson, Joel D.; Tan, Ming; Serra, Violeta; Koblinski, Jennifer E.; Arribas, Joaquin; Prat, Aleix; Pare, Laia; Miller, Todd W.; Dozmorov, Mikhail G.; Harada, Hisashi; Windle, Brad E.; Scaltriti, Maurizio; Faber, Anthony C.
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
CANCER RESEARCH
IF16.6
2017-07-010
PRE
Ferraro, Gino B.; Kodack, David P.; Askoxylakis, Vasileios; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Alexander Z.; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Youngchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, Ryan C.; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Valeria M.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K.
The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2017-05-2483
OAAI
Kodack, David P.; Askoxylakis, Vasileios; Ferraro, Gino B.; Sheng, Qing; Badeaux, Mark; Goel, Shom; Qi, Xiaolong; Shankaraiah, Ram; Cao, Z. Alexander; Ramjiawan, Rakesh R.; Bezwada, Divya; Patel, Bhushankumar; Song, Yongchul; Costa, Carlotta; Naxerova, Kamila; Wong, Christina S. F.; Kloepper, Jonas; Das, Rita; Tam, Angela; Tanboon, Jantima; Duda, Dan G.; Miller, C. Ryan; Siegel, Marni B.; Anders, Carey K.; Sanders, Melinda; Estrada, Monica V.; Schlegel, Robert; Arteaga, Carlos L.; Brachtel, Elena; Huang, Alan; Fukumura, Dai; Engelman, Jeffrey A.; Jain, Rakesh K.
EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor
CANCER RESEARCH
IF16.6
2016-03-14113
OAAI
Jia, Yong; Juarez, Jose; Li, Jie; Manuia, Mari; Niederst, Matthew J.; Tompkins, Celin; Timple, Noelito; Vaillancourt, Mei-Ting; Pferdekamper, AnneMarie Culazzo; Lockerman, Elizabeth L.; Li, Chun; Anderson, Jennifer; Costa, Carlotta; Liao, Debbie; Murphy, Eric; DiDonato, Michael; Bursulaya, Badry; Lelais, Gerald; Barretina, Jordi; McNeill, Matthew; Epple, Robert; Marsilje, Thomas H.; Pathan, Nuzhat; Engelman, Jeffrey A.; Michellys, Pierre-Yves; McNamara, Peter; Harris, Jennifer; Bender, Steven; Kasibhatla, Shailaja
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

肿瘤细胞可以遵循不同的进化路径，对表皮生长因子受体抑制产生抗性

NATURE MEDICINE
IF50
2016-02-01768
OAAI
Hata, Aaron N.; Niederst, Matthew J.; Archibald, Hannah L.; Gomez-Caraballo, Maria; Siddiqui, Faria M.; Mulvey, Hillary E.; Maruvka, Yosef E.; Ji, Fei; Bhang, Hyo-eun C.; Radhakrishna, Viveksagar Krishnamurthy; Siravegna, Giulia; Hu, Haichuan; Raoof, Sana; Lockerman, Elizabeth; Kalsy, Anuj; Lee, Dana; Keating, Celina L.; Ruddy, David A.; Damon, Leah J.; Crystal, Adam S.; Costa, Carlotta; Piotrowska, Zofia; Bardelli, Alberto; Iafrate, Anthony J.; Sadreyev, Ruslan I.; Stegmeier, Frank; Getz, Gad; Sequist, Lecia V.; Faber, Anthony C.; Engelman, Jeffrey A.

研究方向

暂未获取到该数据
J
Jeffrey A. Engelman
H 指数:131论文数:874被引数:8.5万
C
Cyril H. Benes
H 指数:74论文数:691被引数:3.1万
A
Anthony C. Faber
H 指数:38论文数:299被引数:7,527
E
Emilio Hirsch
H 指数:87论文数:560被引数:2.7万
H
Hiromichi Ebi
H 指数:42论文数:236被引数:8,579
Y
Youngchul Song
H 指数:20论文数:76被引数:1.0万
A
Anahita Dastur
H 指数:12论文数:63被引数:4,539
C
Charles T. Jakubik
H 指数:6论文数:19被引数:784
M
Mari Mino–Kenudson
H 指数:115论文数:1,048被引数:6.5万
E
Elisa Ciraolo
H 指数:26论文数:41被引数:2,411