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J

Jorge J. Palop

Gladstone Institute of Neurological Disease
H指数:36
被引数:1.5万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Carboxyl-terminal blockade of sortilin binding enhances progranulin gene therapy in a mouse model of frontotemporal dementia

-sortilin结合的羧基末端阻断增强了小鼠额颞叶痴呆模型中的progranulin基因治疗

Science Translational Medicine
IF14.6
2026-08-190
PRE
Shreya N. Kashyap; Stephanie N. Fox; Vivianna R. DeNittis; Katherine I. Wilson; Nicholas R. Boyle; Mary Bullock; Aniketh S. Tadepalli; Stephanie R. Miller; Jorge J. Palop; Yohannes A. Ambaw; Tobias C. Walther; Robert V. Farese; Charles F. Murchison; Andrew E. Arrant; Erik D. Roberson
cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsy

cGAS介导的I型IFN信号通路促进耐药性癫痫疾病进展

Nature Neuroscience
IF20
2026-07-290
OA
Yige Huang; Li Fan; Man Ying Wong; Zhuofan Lei; Balaji Krishnamachary; Daphne Zhu; Mika P. Cadiz; Ravi Kumar Nagiri; Pearly Ye; Kendra Norman; Maitreyee Bhagwat; Young Jae Lee; Hui Li; Jingjie Zhu; Sadaf Amin; Kelli Lauderdale; Hao Chen; Wenjie Luo; Shiaoching Gong; Benjamin L. Liechty; Jorge J. Palop; Subhash C. Sinha; Junfang Wu; Mingrui Zhao; Li Gan
Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity and gradual electrochemical maturation

人源干细胞来源的GABA能中间神经元发育揭示了早期亚型多样性的出现和逐渐的电化学成熟

Neuron
IF15
2025-07-110
OAAI
Marina Bershteyn; Hongjun Zhou; Luis Fuentealba; Chun Chen; Geetha Subramanyam; Daniel Cherkowsky; Eric Steven Sevilla; Philip Hampel; Juan Salvatierra; Meliz Sezan; Yves Maury; Steven Havlicek; Sonja Kriks; Seonok Lee; Wai Au; Michael Watson; Olga Kuzmenko; Maria Elena Grimmett; Alexandra Vogel; Fiona Porkka; Yuechen Qiu; Anastasia Nesterova; Derek Anderson; Brianna G. Feld; Victoria Hosford; Ji-Hye Jung; Tia Kowal; Alessandro Bulfone; Gautam Banik; Catherine Priest; Jorge J. Palop; Cory R. Nicholas
Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models

机器学习在人源化和转基因阿尔茨海默病模型中揭示了显着的自发行为变化和治疗效果

CELL REPORTS
IF6.9
2024-11-010
OAAI
Miller, Stephanie R.; Luxem, Kevin; Lauderdale, Kelli; Nambiar, Pranav; Honma, Patrick S.; Ly, Katie K.; Bangera, Shreya; Bullock, Mary; Shin, Jia; Kaliss, Nick; Qiu, Yuechen; Cai, Catherine; Shen, Kevin; Mallen, K. Dakota; Yan, Zhaoqi; Mendiola, Andrew S.; Saito, Takashi; Saido, Takaomi C.; Pico, Alexander R.; Thomas, Reuben; Roberson, Erik D.; Akassoglou, Katerina; Bauer, Pavol; Remy, Stefan; Palop, Jorge J.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
MOLECULAR NEURODEGENERATION
IF17.5
2022-06-1146
OAAI
Xia, Dan; Lianoglou, Steve; Sandmann, Thomas; Calvert, Meredith; Suh, Jung H.; Thomsen, Elliot; Dugas, Jason; Pizzo, Michelle E.; DeVos, Sarah L.; Earr, Timothy K.; Lin, Chia-Ching; Davis, Sonnet; Ha, Connie; Leung, Amy Wing-Sze; Hoang Nguyen; Chau, Roni; Yulyaningsih, Ernie; Lopez, Isabel; Solanoy, Hilda; Masoud, Shababa T.; Liang, Chun-chi; Lin, Karin; Astarita, Giuseppe; Khoury, Nathalie; Zuchero, Joy Yu; Thorne, Robert G.; Shen, Kevin; Miller, Stephanie; Palop, Jorge J.; Garceau, Dylan; Sasner, Michael; Whitesell, Jennifer D.; Harris, Julie A.; Hummel, Selina; Gnorich, Johannes; Wind, Karin; Kunze, Lea; Zatcepin, Artem; Brendel, Matthias; Willem, Michael; Haass, Christian; Barnett, Daniel; Zimmer, Till S.; Orr, Anna G.; Scearce-Levie, Kimberly; Lewcock, Joseph W.; Di Paolo, Gilbert; Sanchez, Pascal E.
Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1

人类APP转基因小鼠的行为和神经网络异常类似于App敲入小鼠，并且受家族性阿尔茨海默氏病突变的调节，但不受BACE1抑制的调节。

MOLECULAR NEURODEGENERATION
IF17.5
2020-09-1444
OAAI
Johnson, Erik C. B.; Ho, Kaitlyn; Yu, Gui-Qiu; Das, Melanie; Sanchez, Pascal E.; Djukic, Biljana; Lopez, Isabel; Yu, Xinxing; Gill, Michael; Zhang, Weiping; Paz, Jeanne T.; Palop, Jorge J.; Mucke, Lennart
A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease

第二条X染色体有助于阿尔茨海默病小鼠模型的恢复

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2020-08-26116
OAAI
Davis, Emily J.; Broestl, Lauren; Abdulai-Saiku, Samira; Worden, Kurtresha; Bonham, Luke W.; Minones-Moyano, Elena; Moreno, Arturo J.; Wang, Dan; Chang, Kevin; Williams, Gina; Garay, Bayardo, I; Lobach, Iryna; Devidze, Nino; Kim, Daniel; Anderson-Bergman, Cliff; Yu, Gui-Qiu; White, Charles C.; Harris, Julie A.; Miller, Bruce L.; Bennett, David A.; Arnold, Arthur P.; De Jager, Phil L.; Palop, Jorge J.; Panning, Barbara; Yokoyama, Jennifer S.; Mucke, Lennart; Dubal, Dena B.
What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons

关于阿尔茨海默氏病的电生理学告诉我们: 大脑神经元同步和连接的窗口

NEUROBIOLOGY OF AGING
IF3.5
2020-01-01174
OAAI
Babiloni, Claudio; Blinowska, Katarzyna; Bonanni, Laura; Cichocki, Andrej; De Haan, Willem; Del Percio, Claudio; Dubois, Bruno; Escudero, Javier; Fernandez, Alberto; Frisoni, Giovanni; Guntekin, Bahar; Hajos, Mihaly; Hampel, Harald; Ifeachor, Emmanuel; Kilborn, Kerry; Kumar, Sanjeev; Johnsen, Kristinn; Johannsson, Magnus; Jeong, Jaeseung; LeBeau, Fiona; Lizio, Roberta; da Silva, Fernando Lopes; Maestu, Fernando; McGeown, William J.; McKeith, Ian; Moretti, Davide Vito; Nobili, Flavio; Olichney, John; Onofrj, Marco; Palop, Jorge J.; Rowan, Michael; Stocchi, Fabrizio; Struzik, Zbigniew M.; Tanila, Heikki; Teipel, Stefan; Taylor, John Paul; Weiergraeber, Marco; Yener, Gorsev; Young-Pearse, Tracy; Drinkenburg, Wilhelmus H.; Randall, Fiona
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models
CELL REPORTS
IF6.9
2020-01-0156
OAAI
Hanson, Jesse E.; Ma, Keran; Elstrott, Justin; Weber, Martin; Saillet, Sandrine; Khan, Abdullah S.; Simms, Jeffrey; Liu, Benjamin; Kim, Thomas A.; Yu, Gui-Qiu; Chen, Yelin; Wang, Tzu-Ming; Jiang, Zhiyu; Liederer, Bianca M.; Deshmukh, Gauri; Solanoy, Hilda; Chan, Connie; Sellers, Benjamin D.; Volgraf, Matthew; Schwarz, Jacob B.; Hackos, David H.; Weimer, Robby M.; Sheng, Morgan; Gill, T. Michael; Scearce-Levie, Kimberly; Palop, Jorge J.
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

左乙拉西坦在阿尔茨海默病模型中抑制神经元网络功能障碍并逆转突触和认知缺陷

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2012-08-06530
OA
Sanchez, Pascal E.; Zhu, Lei; Verret, Laure; Vossel, Keith A.; Orr, Anna G.; Cirrito, John R.; Devidze, Nino; Ho, Kaitlyn; Yu, Gui-Qiu; Palop, Jorge J.; Mucke, Lennart

研究方向

暂未获取到该数据
L
Lennart Mucke
H 指数:108论文数:251被引数:5.2万
G
Gui-Qiu Yu
H 指数:29论文数:75被引数:9,175
N
Nga Bien‐Ly
H 指数:23论文数:62被引数:6,088
S
Stephanie R. Miller
H 指数:8论文数:29被引数:585
L
Laure Verret
H 指数:25论文数:55被引数:4,759
I
Irene H. Cheng
H 指数:27论文数:69被引数:5,146
K
Kaitlyn Ho
H 指数:21论文数:44被引数:5,578
E
Erik D. Roberson
H 指数:78论文数:330被引数:3.2万
E
Eliezer Masliah
H 指数:195论文数:1,230被引数:17.8万
J
Jeannie Chin
H 指数:31论文数:95被引数:6,652